Regulation of UmuD cleavage: Role of the amino-terminal tail

Journal of Molecular Biology

Volumn 282, Issue 4, 1998, Pages 721-730

  McDonald, John P ^a   Maury, Erinn E ^a   Levine, Arthur S ^a   Woodgate, Roger ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

E. coli; Protein protein interactions; S. typhimurium; Self processing reactions; SOS mutagenesis

Indexed keywords

BACTERIAL PROTEIN; CHIMERIC PROTEIN; PROLINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0032476002     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2044     Document Type: Article

References (44)

1. Bruck I., Woodgate R., McEntee K., Goodman M.F. Purification of a soluble UmuD'C complex from Escherichia coli cooperative binding of UmuD'C to single-stranded DNA. J. Biol. Chem. 271:1996;10767-10774
2. Burckhardt S.E., Woodgate R., Scheuermann R.H., Echols H. UmuD mutagenesis protein of Escherichia coli overproduction, purification and cleavage by RecA. Proc. Natl Acad. Sci. USA. 85:1988;1811-1815
3. Ennis D.G., Ossanna N., Mount D.W. Genetic separation of Escherichia coli recA functions for SOS mutagenesis and repressor cleavage. J. Bacteriol. 171:1989;2533-2541
4. Ennis D.G., Levine A.S., Koch W.H., Woodgate R. Analysis of recA mutants with altered SOS functions. Mutat. Res. 336:1995;39-48
5. Ferentz A.E., Opperman T., Walker G.C., Wagner G. Dimerization of the UmuD' protein in solution and its implications for regulation of SOS mutagenesis. Nature Struct. Biol. 4:1997;979-983
6. Frank E.G., Hauser J., Levine A.S., Woodgate R. Targeting of the UmuD, UmuD′ and MucA′ mutagenesis proteins to DNA by RecA protein. Proc. Natl Acad. Sci. USA. 90:1993;8169-8173
7. Frank E.G., Ennis D.G., Gonzalez M., Levine A.S., Woodgate R. Regulation of SOS mutagenesis by proteolysis. Proc. Natl Acad. Sci. USA. 93:1996;10291-10296
8. Friedberg E.C., Walker G.C., Siede W. DNA Repair and Mutagenesis. 1995;American Society of Microbiology, Washington, DC
9. -proteins in the autodigestion and RecA-mediated cleavage reactions. J. Mol. Biol. 192:1986;39-47
10. Gimble F.S., Sauer R.T. λ repressor mutants that are better substrates for RecA-mediated cleavage. J. Mol. Biol. 206:1989;29-39
11. Hauser J., Levine A.S., Ennis D.G., Chumakov K.M., Woodgate R. The enhanced mutagenic potential of the MucAB proteins correlates with the highly efficient processing of the MucA protein. J. Bacteriol. 174:1992;6844-6851
12. Ho C., Kulaeva O.I., Levine A.S., Woodgate R. A rapid method for cloning mutagenic DNA repair genes isolation of umu-complementing genes from multidrug resistance plasmids R391, R446b, and R471a. J. Bacteriol. 175:1993;5411-5419
13. Kim B., Little J.W. LexA and λ CI repressors as enzymes specific cleavage in an intermolecular reaction. Cell. 73:1993;1165-1173
14. Kitagawa Y., Akaboshi E., Shinagawa H., Horii T., Ogawa H., Kato T. Structural analysis of the umu operon required for inducible mutagenesis in Escherichia coli. Proc. Natl Acad. Sci. USA. 82:1985;4336-4340
15. Koffel-Schwartz N., Coin F., Veaute X., Fuchs R.P.P. Cellular strategies for accommodating replication-hindering adducts in DNA control by the SOS response inEscherichia coli. Proc. Natl Acad. Sci. USA. 93:1996;7805-7810
16. Kulaeva O.I., Wootton J.C., Levine A.S., Woodgate R. Characterization of the umu-complementing operon from R391. J. Bacteriol. 177:1995;2737-2743
17. Kulaeva O.I., Koonin E.V., Wootton J.C., Levine A.S., Woodgate R. Unusual insertion element polymorphisms in the promoter and terminator regions of the mucAB-like genes of R471a and R446b. Mutat. Res. 397:1998;247-262
18. Lee M.H., Walker G.C. Interactions of Escherichia coli UmuD with activated RecA analyzed by cross-linking UmuD monocysteine derivatives. J. Bacteriol. 178:1996;7285-7294
19. -) mutants of the LexA repressor of Escherichia coli K-12. J. Bacteriol. 170:1988;2163-2173
20. -mutant LexA proteins. J. Mol. Biol. 210:1989;439-452
21. Little J.W. Autodigestion of LexA and phage repressors. Proc. Natl Acad. Sci. USA. 81:1984;1375-1379
22. Little J.W. LexA cleavage and other self-processing reactions. J. Bacteriol. 175:1993;4943-4950
23. McDonald J.P., Frank E.G., Levine A.S., Woodgate R. Intermolecular cleavage of the UmuD-like mutagenesis proteins. Proc. Natl Acad. Sci. USA. 95:1998;1478-1483
24. Mortelmans K.E., Dousman L. Mutagenesis and plasmids. de Serres F. Chemical Mutagens Principles and Methods for their Detection. 10:1986;469-507 Plenum Press, New York
25. Nohmi T., Battista J.R., Dodson L.A., Walker G.C. RecA-mediated cleavage activates UmuD for mutagenesis mechanistic relationship between transcriptional derepression and posttranslational activation. Proc. Natl Acad. Sci. USA. 85:1988;1816-1820
26. Peat T.S., Frank E.G., McDonald J.P., Levine A.S., Woodgate R., Hendrickson W.A. Structure of the UmuD' protein and its regulation in response to DNA damage. Nature. 380:1996;727-730
27. Peat T.S., Frank E.G., McDonald J.P., Levine A.S., Woodgate R., Hendrickson W.A. The UmuD' protein filament and its potential role in damage induced mutagenesis. Structure. 4:1996;1401-1412
28. Rajagopalan M., Lu C., Woodgate R., O'Donnell M., Goodman M.F., Echols H. Activity of the purified mutagenesis proteins UmuC, UmuD' and RecA in replicative bypass of an abasic DNA lesion by DNA polymerase III. Proc. Natl Acad. Sci. USA. 89:1992;10777-10781
29. Roland K.L., Smith M.H., Rupley J.A., Little J.W. In vitro analysis of mutant LexA proteins with an increased rate of specific cleavage. J. Mol. Biol. 228:1992;395-408
30. Sambrook J., Fritsch E.F., Maniatis T. Molecular Cloning a Laboratory Manual. 1989;Cold Spring Harbor Laboratory Press, Cold Spring Harbor New York
31. Shinagawa H., Iwasaki H., Kato T., Nakata A. RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis. Proc. Natl Acad. Sci. USA. 85:1988;1806-1810
32. Slilaty S.N., Little J.W. Lysine-156 and serine-119 are needed for LexA repressor cleavage a possible mechanism. Proc. Natl Acad. Sci. USA. 84:1987;3987-3991
33. Slilaty S.N., Rupley J.A., Little J.W. Intramolecular cleavage of LexA and phage λ repressors. Dependence of kinetics on repressor concentration, pH, temperature and solvent. Biochemistry. 25:1986;6866-6875
34. Smith C.M., Koch W.H., Franklin S.B., Foster P.L., Cebula T.A., Eisenstadt E. Sequence analysis of the Salmonella typhimurium LT2 umuDC operon. J. Bacteriol. 172:1990;4964-4978
35. Sommer S., Boudsocq F., Devoret R., Bailone A. Specific RecA amino acid changes affect RecA-UmuD'C interaction. Mol. Microbiol. 28:1998;281-291
36. Strike P., Lodwick D. Plasmid genes affecting DNA repair and mutation. J. Cell Sci., Suppl. 6. 1987;303-321
37. 2C mutagenic complex and RecA. Proc. Natl Acad. Sci. USA. 95:1998;9755-9760
38. Thomas S.M., Crowne H.M., Pidsley S.C., Sedgwick S.G. Structural characterization of the Salmonella typhimurium LT2 umu operon. J. Bacteriol. 172:1990;4979-4987
39. Weiss M.A., Pabo C.O., Karplus M., Sauer R.T. Dimerization of the operator binding domain of phage lambda repressor. Biochemistry. 26:1987;897-904
40. Winterling K.W., Levine A.S., Yasbin R.E., Woodgate R. Characterization of DinR, the Bacillus subtilis SOS repressor. J. Bacteriol. 179:1997;1698-1703
41. Woodgate R., Ennis D.G. Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavage. Mol. Gen. Genet. 229:1991;10-16
42. Woodgate R., Levine A.S. Damage inducible mutagenesis recent insights into the activities of the Umu family of mutagenesis proteins. Lindahl T. Cancer Surveys Genetic Instability in Cancer. 1996;117-140 Cold Spring Harbor Laboratory Press, Cold Spring Harbor New York
43. Woodgate R., Rajagopalan M., Lu C., Echols H. UmuC mutagenesis protein of Escherichia coli purification and interaction with UmuD and UmuD′ Proc. Natl Acad. Sci. USA. 86:1989;7301-7305
44. Woodgate R., Levine A.S., Koch W.H., Cebula T.A., Eisenstadt E. Induction and cleavage of Salmonella typhimurium UmuD protein. Mol. Gen. Genet. 229:1991;81-85