Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 2-amino-6-substituted purine and 8-azapurine

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 11, 1998, Pages 1349-1352

  Santana, L ^a   Teijeira, M ^a   Uriarte, E ^a   Balzarini, J ^a   De Clercq, E ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CARBOCYCLIC NUCLEOSIDE; NUCLEOSIDE ANALOG; PURINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CYTOPATHOGENIC EFFECT; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKEMIA L 1210; MOUSE; NONHUMAN; REACTION ANALYSIS; STRUCTURE ANALYSIS; T LYMPHOCYTE;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; PURINE NUCLEOSIDES; TUMOR CELLS, CULTURED; VIRUSES;

EID: 0032474494     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00216-9     Document Type: Article

References (25)

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17. 5O: C, 49.34; H, 5.23; Cl, 13.27; N, 26.17. Found: C, 49.58; H, 5.31; Cl, 13.02; N, 25.98.
18. 6O: C, 44.69; H, 4.84, Cl, 13.22; N, 31.28. Found: C, 44.62; H, 4.70; Cl, 13.00; N, 31.15.
19. 2: C, 53.01; H, 6.02; N, 28.11. Found: C, 53.38; H, 5.99; N, 27.80.
20. 2: C, 48.00; H, 5.60; N, 33.60. Found: C, 47.90; H, 5.64; N, 33.46.
21. 6O: C, 53.22; H, 6.45; N, 33.87. Found: C, 53.18; H, 6.58; N, 33.57.
22. 7O: C, 48.19; H, 6.02; N, 39.35. Found: C, 48.03; H, 6.20; N, 39.22.
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