Heterolignanolides. Synthesis of a new family of Thienolignanolides

Tetrahedron Letters

Volumn 39, Issue 14, 1998, Pages 2001-2004

  Medarde, Manuel ^a   Ramos, Angel C ^a   Caballero, Esther ^a   López, Jose Luis ^a   Peláez Lamamié De Clairac, Rafael ^a   San Feliciano, Arturo ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; FURANONE DERIVATIVE; HETEROCYCLIC COMPOUND; LIGNAN DERIVATIVE; PODOPHYLLIN; PODOPHYLLOTOXIN; PODOPHYLLOTOXIN DERIVATIVE; TENIPOSIDE; TETRALIN DERIVATIVE;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONJUGATION; CYCLIZATION; DRUG SYNTHESIS; RACEMIC MIXTURE; STEREOCHEMISTRY; STEREOISOMERISM;

EID: 0032473901     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00116-6     Document Type: Article

References (38)

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36. 3, 20C MHz) δ 7.27 (d, J = 5.1, 1H); 6.67 (d, J = 5.1, 1H); 6.37 (s, 2H); 4.97 (d, J = 7.7, 1H); 4.60 (d J = 4.0, 1H); 4.50 (dd, J = 6.6, 8.4, 1H); 4.01 (dd, J = 6.8, 8.7, 1H); 3.02-2.86 (m, 2H); 0.94 (s, 9H); 0.27 (s, 3H); 0.11 (s, 3H)
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38. 3 in 2,3-disubstituted thiophene are 125.68° and 123.28° respectively, higher than those for benzene (120° each), further increasing the strain of the 7',8-cis-8,8'-trans cyclolignanolides.