Expression of c-fos and hsp70 mRNA in neonatal rat cerebrocortical slices during NMDA-induced necrosis and apoptosis

Brain Research

Volumn 785, Issue 2, 1998, Pages 262-278

  Hasegawa, Koh ^a   Litt, Lawrence ^a,b   Espanol, Maryceline T ^a   Sharp, Frank R ^b,c   Chan, Pak H ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Brain slices; C fos; Hsp70; Immediate early genes; Neonate; NMDA; Stress proteins; Transcription; Translation

Indexed keywords

DIZOCILPINE; HEAT SHOCK PROTEIN 70; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INJURY; BRAIN SLICE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; IMMEDIATE EARLY GENE; IN SITU HYBRIDIZATION; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CEREBRAL CORTEX; DIZOCILPINE MALEATE; DNA FRAGMENTATION; GENES, FOS; HSP70 HEAT-SHOCK PROTEINS; N-METHYLASPARTATE; NECROSIS; NEURONS; PERFUSION; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0032473586     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01410-8     Document Type: Article

References (50)

1. Akins P.T., Liu P.K., Hsu C.Y. Immediate early gene expression in response to cerebral ischemia: friend or foe? Stroke. 27:1996;1682-1687.
2. Auer R.N., Coulter K.C. The nature and time course of neuronal vacuolation induced by the N-methyl-D-aspartate antagonist MK-801. Acta Neuropathol. (Berl). 87:1994;1-7.
3. Bading H., Ginty D.D., Greenberg M.E. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science. 260:1993;181-186.
4. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., Lipton S.A. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. U.S.A. 92:1995;7162-7166.
5. Chan P.H., Fishman R.A., Lee J.L., Candelise L. Effects of excitatory neurotransmitter amino acids on swelling of rat brain cortical slices. J. Neurochem. 33:1979;1309-1315.
6. Charriaut-Marlangue C., Ben-Ari Y. A cautionary note on the use of the TUNEL stain to determine apoptosis. Neuroreport. 7:1995;61-64.
7. Choi D.W., Rothman S.M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13:1990;171-182.
8. Choi D.W. Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. 18:1995;58-60.
9. Ciutat D., Caldero J., Oppenheim R.W., Esquerda J.E. Schwann cell apoptosis during normal development and after axonal degeneration induced by neurotoxins in the chick embryo. J. Neurosci. 16:1996;3979-3990.
10. Dessi F., Charriaut-Marlangue C., Khrestchatisky M., Ben-Ari Y. Glutamate-induced neuronal death is not a programmed cell death in cerebellar culture. J. Neurochem. 60:1993;1953-1955.
11. Espanol M.T., Xu Y., Litt L., Chang L.H., James T.L., Weinstein P.R., Chan P.H. Modulation of edema by dizocilpine, kynurenate and NBQX in respiring brain slices after exposure to glutamate. Acta Neurochir. 60(Suppl.):1994;58-61.
12. Espanol M.T., Xu Y., Litt L., Yang G.Y., Chang L.H., James T.L., Weinstein P., Chan P.H. Modulation of glutamate-induced intracellular energy failure in neonatal cerebral cortical slices by kynurenic acid, dizocilpine and NBQX. J. Cereb. Blood Flow Metab. 14:1994;269-278.
13. Ferre S., Tusell J.M., Barron S., Gimenez-Llort L., Martinez E., Serratosa J. Reserpine potentiates NMDA-induced c-fos MRNA expression in the mouse brain. Neurosci. Lett. 212:1996;147-150.
14. Freeman J.K., Goldberg M.P. Confocal microscopic visualization of MK-801-induced cytoplasmic vacuoles in vitro. Psychopharmacol. Bull. 30:1994;541-547.
15. Garthwaite G., Garthwaite J. Neurotoxicity of excitatory amino acid receptor agonists in young rat hippocampal slices. J. Neurosci. Methods. 29:1989;33-42.
16. J. Garthwaite, NMDA receptors, neuronal development and neurodegeneration, in: G.L. Collingridge, J.C. Watkins (Eds.), The NMDA Receptor, 2nd edn., Oxford Univ. Press, New York, 1994, pp. 428-456.
17. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
18. Grasl-Kraupp B., Ruttkay-Nedecky B., Koudelka H., Bukowska K., Bursch W., Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis and autolytic cell death: a cautionary note. Hepatology. 21:1995;1465-1468.
19. Hargreaves R.J., Hill R.G., Iversen L.L. Neuroprotective NMDA antagonists: the controversy over their potential for adverse effects on cortical neuronal morphology. Acta Neurochir. Suppl. (Wien). 60:1994;15-19.
20. Hasegawa K., Litt L., Espanol M.T., Gregory G.A., Sharp F.R., Chan P.H. Effects of neuroprotective dose of fructose-1,6-bisphosphate on hypoxia-induced expression of c-fos and hsp70 MRNA in neonatal rat cerebrocortical slices. Brain Res. 750:1997;1-10.
21. Hisanaga K., Sagar S.M., Hicks K.J., Sharp F.R. NMDA antagonists block Fos-like nuclear protein expression induced by multiple signalling pathways in cultured cortical neurons. J. Neurochem. 58:1992;1836-1844.
22. Hsu C.Y., Liu J.S., Xue J.J., He Y.Y., Lin T.N. Expression of immediate early gene and growth factor mRNAs in a focal cerebral ischemia model in the rat. Stroke. 24:1993;178-188.
23. Hunt C., Morimoto R.I. Conserved features of eukaryotic hsp70 gene revealed by comparison to the nucleotide sequence of human hsp70. Proc. Natl. Acad. Sci. U.S.A. 82:1985;6455-6459.
24. Kinouchi H., Sharp F.R., Chan P.H., Mikawa S., Kamii H., Arai S., Yoshimoto T. MK-801 inhibits the induction of immediate early genes in cerebral cortex, thalamus and hippocampus, but not in substantia nigra following middle cerebral artery occlusion. Neurosci. Lett. 179:1994;111-114.
25. Kinouchi H., Sharp F.R., Hill M.P., Koistinaho J., Sagar S.M., Chan P.H. Induction of 70-kDa heat shock protein and hsp70 MRNA following transient focal cerebral ischemia in the rat. J. Cereb. Blood Flow Metab. 13:1993;105-115.
26. J.Y. Koh, D.W. Choi, Vulnerability of cultured cortical neurons to damage by excitotoxins: differential susceptibility of neurons containing NADPH-diaphorase, J. Neurosci., 1988, pp. 53-63.
27. Kristian T., Siesjö B.K. Calcium-related damage in ischemia. Life Sci. 59:1996;357-367.
28. Li Y., Chopp M., Jiang N., Yao F., Zaloga C. Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 15:1995;389-397.
29. Longo F.M., Wang S., Narasimhan P., Zhang J.S., Chen J., Massa S.M., Sharp F.R. CDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain. J. of Neurosci. Res. 36:1993;325-335.
30. Lowenstein D.H., Chan P.H., Miles M.F. The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity. Neuron. 7:1991;1053-1060.
31. MacManus J.P., Hill I.E., Rasquinha P.I., Walker T., Buchan A.M. Differences in DNA fragmentation following transient cerebral or decapitation ischemia in rats. J. Cereb. Blood Flow Metab. 15:1995;728-737.
32. Massa S.M., Swanson R.A. Stress gene expression in brain. Cerebrovasc. Brain Metab. Rev. 8:1996;95-158.
33. Miller F.K., Raese J.D., Morrison-Bogorad M. Expression of heat shock protein 70 and heat shock cognate messenger RNA's in rat cortex and cerebellum after heat shock or amphetamine treatment. J. Neurochem. 56:1991;2060-2071.
34. Nakki R., Koistinaho J., Sharp F.R., Sagar S.M. Cerebellar toxicity of phencyclidine. J. Neurosci. 15:1995;2097-2108.
35. Narasimhan P., Swanson R.A., Sagar S.M., Sharp F.R. Astrocyte survival and HSP70 heat shock protein induction following heat shock and acidosis. Glia. 17:1996;147-159.
36. Nowak T.S., Jacewicz M. The heat shock/stress response in focal cerebral ischemia. Brain Pathol. 4:1994;67-76.
37. Olney J.W., Labruyere J., Wang G., Wozniak D.F., Price M.T., Sesma M.A. NMDA antagonist neurotoxicity: mechanism and prevention. Science. 254:1991;1515-1518.
38. Qin Z.H., Wang Y., Chase T.N. Stimulation of N-methyl-D-aspartate receptors induces apoptosis in rat brain. Brain Res. 725:1996;166-176.
39. Robertson L.M., Kerppola T.K., Vendrell M., Luk D., Smeyne R.J., Bocchiaro C., Morgan J.I., Curran T. Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements. Neuron. 14:1995;241-252.
40. Schalling M., Dagerlind A., Brene S. Coexistence and gene expression of phenylethanolamine N-methyltransferase and neuropeptide tyrosine in the rat and bovine adrenal gland; effects of reserpine. Proc. Natl. Acad. Sci. U.S.A. 85:1988;8306-8310.
41. Sharp F.R., Butman M., Aardalen K., Nickolenko J., Nakki R., Massa S.M., Swanson R.A., Sagar S.M. Neuronal injury produced by NMDA antagonists can be detected using heat shock proteins and can be blocked with antipsychotics. Psychopharmacol. Bull. 30:1994;555-560.
42. Sharp F.R., Sagar S.M., Swanson R.A. Metabolic mapping with cellular resolution: c-fos vs. 2-deoxyglucose. Crit. Rev. Neurobiol. 7:1993;205-228.
43. Sharp J.W., Sagar S.M., Hisanaga K., Jasper P., Sharp F.R. The NMDA receptor mediates cortical induction of Fos and Fos-related antigens following cortical injury. Exp. Neurol. 109:1990;323-332.
44. States B., Honkaniemi J., Weinstein P., Sharp F.R. DNA fragmentation and HSP70 protein induction in hippocampus and cortex occur in separate neurons following permanent middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 16:1996;1165-1175.
45. Szekely A.M., Barbaccia M.L., Alho H., Costa E. In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos MRNA expression. Mol. Pharmacol. 35:1989;401-408.
46. Tecoma E.S., Monyer H., Goldberg M.P., Choi D.W. Traumatic neuronal injury in vitro is attenuated by NMDA antagonists. Neuron. 2:1989;1541-1545.
47. Xia Z., Dudek H., Miranti C.K., Greenberg M.E. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. J. Neurosci. 16(1996):1996;5425-5436.
48. Yasuda M., Umemura S., Osamura R.Y., Kenjo T., Tsutsumi Y. Apoptotic cells in the human endometrium and placental villi: pitfalls in applying the TUNEL method. Arch. Histol. Cytol. 58:1995;185-190.
49. Yee W.M., Frim D.M., Isacson O. Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex. Exp. Brain Res. 94:1993;193-202.
50. Zhang X., Boulton A.A., Zuo D.M., Yu P.H. MK-801 induces apoptotic neuronal death in the rat retrosplenial cortex; prevention by cycloheximide and R(-)-2-hexyl-N-methylpropargylamine. J. Neurosci. Res. 46:1996;82-89.