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Volumn 287, Issue 1, 1998, Pages 1-7

LY353381.HCl: A novel raloxifene analog with improved SERM potency and efficacy in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ARZOXIFENE; BENZOTHIOPHENE DERIVATIVE; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; RALOXIFENE; UNCLASSIFIED DRUG;

EID: 0032462194     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (133)

References (46)
  • 1
    • 0031171316 scopus 로고    scopus 로고
    • Activity of raloxifene in immature and ovariectomized rat uterotrophic assays
    • Ashby J, Odum J and Foster JR (1997) Activity of raloxifene in immature and ovariectomized rat uterotrophic assays. Regul Toxicol Pharmacol 25(3):226-31.
    • (1997) Regul Toxicol Pharmacol , vol.25 , Issue.3 , pp. 226-231
    • Ashby, J.1    Odum, J.2    Foster, J.R.3
  • 2
    • 0004801989 scopus 로고
    • Centchroman, a non-steroidal antiestrogen, is a bone-specific estrogen agonist in the ovariectomized rat
    • Abstr.
    • Bain SD, Celino DL, Baily MC, Strachan MJ, Piggott JR, Labroo VM (1995) Centchroman, a non-steroidal antiestrogen, is a bone-specific estrogen agonist in the ovariectomized rat. Calcif Tissue Int 54:338 (Abstr.)
    • (1995) Calcif Tissue Int , vol.54 , pp. 338
    • Bain, S.D.1    Celino, D.L.2    Baily, M.C.3    Strachan, M.J.4    Piggott, J.R.5    Labroo, V.M.6
  • 3
    • 0020694796 scopus 로고
    • Antagonism of estrogen action with a new benzothiophene derived antiestrogen
    • Black LJ, Jones CD and Facone JR (1983) Antagonism of estrogen action with a new benzothiophene derived antiestrogen. Life Sci 32:1031-1036.
    • (1983) Life Sci , vol.32 , pp. 1031-1036
    • Black, L.J.1    Jones, C.D.2    Facone, J.R.3
  • 8
  • 9
    • 0026034365 scopus 로고
    • Menopausal estrogen replacement therapy and breast cancer
    • Dupont WD and Page DL (1991) Menopausal estrogen replacement therapy and breast cancer. Arch Int Med 151:67-72.
    • (1991) Arch Int Med , vol.151 , pp. 67-72
    • Dupont, W.D.1    Page, D.L.2
  • 11
    • 0026733404 scopus 로고
    • On the rat model of human osteopenias and osteoporoses
    • Frost HM and Jee Wss (1992) On the rat model of human osteopenias and osteoporoses. Bone Miner 18:227-236.
    • (1992) Bone Miner , vol.18 , pp. 227-236
    • Frost, H.M.1    Jee, W.S.S.2
  • 14
    • 0019122379 scopus 로고
    • Pharmacology of tamoxifen in laboratory animals
    • Jordan VC, Allen KE and Dix CJ (1980) Pharmacology of tamoxifen in laboratory animals. Cancer Treat Rep 64:745-759.
    • (1980) Cancer Treat Rep , vol.64 , pp. 745-759
    • Jordan, V.C.1    Allen, K.E.2    Dix, C.J.3
  • 15
    • 0026068145 scopus 로고
    • The ovariectomized rat model of postmenopausal bone loss
    • Kalu DN (1991) The ovariectomized rat model of postmenopausal bone loss. Bone Miner 15:175-192.
    • (1991) Bone Miner , vol.15 , pp. 175-192
    • Kalu, D.N.1
  • 16
    • 0026001976 scopus 로고
    • A comparative study of the actions of tamoxifen, estrogen and progesterone in the ovariectomized rat
    • Kalu DN, Salerno E, Liu CC, Echon R, Ray M, Garza-Zapata M and Hollis BW (1991) A comparative study of the actions of tamoxifen, estrogen and progesterone in the ovariectomized rat. Bone Miner 15:109-124.
    • (1991) Bone Miner , vol.15 , pp. 109-124
    • Kalu, D.N.1    Salerno, E.2    Liu, C.C.3    Echon, R.4    Ray, M.5    Garza-Zapata, M.6    Hollis, B.W.7
  • 17
    • 0029560877 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators
    • Kaufman RF and Bryant HU (1996) Selective estrogen receptor modulators. DN&P 8:531-539.
    • (1996) DN&P , vol.8 , pp. 531-539
    • Kaufman, R.F.1    Bryant, H.U.2
  • 19
    • 0019159483 scopus 로고
    • Prevention of spinal osteoporosis in oophorectomized women
    • Lindsay R, Hart DM, Forrest C and Baird C (1980) Prevention of spinal osteoporosis in oophorectomized women. Lancet 2:1151-1154.
    • (1980) Lancet , vol.2 , pp. 1151-1154
    • Lindsay, R.1    Hart, D.M.2    Forrest, C.3    Baird, C.4
  • 21
    • 0029038986 scopus 로고
    • Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens
    • McDonnell DP, Clemm DL, Hermann T, Goldman ME and Pike JW (1995) Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol Endo 9:659-669.
    • (1995) Mol Endo , vol.9 , pp. 659-669
    • McDonnell, D.P.1    Clemm, D.L.2    Hermann, T.3    Goldman, M.E.4    Pike, J.W.5
  • 22
    • 0026051934 scopus 로고
    • Dose-dependent effects of tamoxifen on long bones in growing rats: Influence of ovarian status
    • Moon LY, Wakley GK and Turner RT (1991) Dose-dependent effects of tamoxifen on long bones in growing rats: Influence of ovarian status. Endocrinology 129:1568-1574.
    • (1991) Endocrinology , vol.129 , pp. 1568-1574
    • Moon, L.Y.1    Wakley, G.K.2    Turner, R.T.3
  • 25
    • 0028784631 scopus 로고
    • Comparative x-ray densitometry of bones from ovariectomized rats
    • Sato M (1995) Comparative x-ray densitometry of bones from ovariectomized rats. Bone 17(Suppl 4):157S-162S.
    • (1995) Bone , vol.17 , Issue.4 SUPPL.
    • Sato, M.1
  • 26
    • 0343301849 scopus 로고    scopus 로고
    • Raloxifene efficacy in nonreproductive and reproductive tissues in rat models in vivo and in vitro
    • (Kuramoto H and Gurpide E. eds) Churchill Livingstone, Tokyo
    • Sato M and Bryant HU (1996) Raloxifene efficacy in nonreproductive and reproductive tissues in rat models in vivo and in vitro, in In vitro Biology of Sex Steroid Hormone Action (Kuramoto H and Gurpide E. eds) pp. 406-421, Churchill Livingstone, Tokyo.
    • (1996) In Vitro Biology of Sex Steroid Hormone Action , pp. 406-421
    • Sato, M.1    Bryant, H.U.2
  • 27
    • 12644279864 scopus 로고    scopus 로고
    • Advantages of raloxifene over alendronate or estrogen on Non-reproductive and reproductive tissues in the long-term dosing of ovariectomized rats
    • Sato M, Bryant H, Iversen P, Helterbrand J, Smietana F, Bemis K, Higgs R, Owan I, Takano T and Burr D (1996a) Advantages of raloxifene over alendronate or estrogen on Non-reproductive and reproductive tissues in the long-term dosing of ovariectomized rats. JPET 279:298-305.
    • (1996) JPET , vol.279 , pp. 298-305
    • Sato, M.1    Bryant, H.2    Iversen, P.3    Helterbrand, J.4    Smietana, F.5    Bemis, K.6    Higgs, R.7    Owan, I.8    Takano, T.9    Burr, D.10
  • 28
    • 0028951607 scopus 로고
    • Longitudinal and cross-sectional analysis of Raloxifene effects on tibiae from ovariectomized aged rats
    • Sato M, Kim J, Short LL, Slemenda CW and Bryant HU (1995) Longitudinal and cross-sectional analysis of Raloxifene effects on tibiae from ovariectomized aged rats. JPET 272:1252-1259.
    • (1995) JPET , vol.272 , pp. 1252-1259
    • Sato, M.1    Kim, J.2    Short, L.L.3    Slemenda, C.W.4    Bryant, H.U.5
  • 29
    • 0028322946 scopus 로고
    • Dual-energy x-ray absorptiometry of Raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats
    • Sato M, McClintock C, Kim J, Turner C, Bryant H, Magee D and Slemenda C (1994) Dual-energy x-ray absorptiometry of Raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats. J Bone Miner Res 9:715-724.
    • (1994) J Bone Miner Res , vol.9 , pp. 715-724
    • Sato, M.1    McClintock, C.2    Kim, J.3    Turner, C.4    Bryant, H.5    Magee, D.6    Slemenda, C.7
  • 30
    • 0029994748 scopus 로고    scopus 로고
    • Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and non-reproductive tissues in ovariectomized rats
    • Sato M, Rippy MK and Bryant HU (1996b) Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and non-reproductive tissues in ovariectomized rats. FASEB J 10:905-912
    • (1996) FASEB J , vol.10 , pp. 905-912
    • Sato, M.1    Rippy, M.K.2    Bryant, H.U.3
  • 31
    • 0030930869 scopus 로고    scopus 로고
    • Biosynthetic human PTH (1-34) effects on bone quality in aged ovariectomized rats
    • Sato M, Zeng GQ and Turner CH (1997) Biosynthetic human PTH (1-34) effects on bone quality in aged ovariectomized rats. Endocrinology 10:4330-4337.
    • (1997) Endocrinology , vol.10 , pp. 4330-4337
    • Sato, M.1    Zeng, G.Q.2    Turner, C.H.3
  • 32
  • 34
    • 0025726582 scopus 로고
    • A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer
    • Steinberg KK, Thacker SB and Smith SC (1991) A meta-analysis of the effect of estrogen replacement therapy on the risk of breast cancer. JAMA 265:1985-1990.
    • (1991) JAMA , vol.265 , pp. 1985-1990
    • Steinberg, K.K.1    Thacker, S.B.2    Smith, S.C.3
  • 35
    • 0027175806 scopus 로고
    • Basic biomechanical measurments of bone: A tutorial
    • Turner CH and Burr DB (1993) Basic biomechanical measurments of bone: A tutorial. Bone 14:595-608.
    • (1993) Bone , vol.14 , pp. 595-608
    • Turner, C.H.1    Burr, D.B.2
  • 36
    • 0028061884 scopus 로고
    • Raloxifene preserves bone strength and bone mass in ovariectomized rats
    • Turner CH, Sato M and Bryant HU (1994) Raloxifene preserves bone strength and bone mass in ovariectomized rats. Endocrinology 135:2001-2005
    • (1994) Endocrinology , vol.135 , pp. 2001-2005
    • Turner, C.H.1    Sato, M.2    Bryant, H.U.3
  • 37
    • 0023320347 scopus 로고
    • The effects of ovariectomy and 17β estradiol on cortical bone histomorphometry in growing rats
    • Turner RT, Vandersteenhoven JJ and Bell NH (1987) The effects of ovariectomy and 17β estradiol on cortical bone histomorphometry in growing rats. J Bone Miner Res 2:115-122.
    • (1987) J Bone Miner Res , vol.2 , pp. 115-122
    • Turner, R.T.1    Vandersteenhoven, J.J.2    Bell, N.H.3
  • 38
    • 0023930991 scopus 로고
    • Tamoxifen inhibits osteoclast mediated resorption of trabecular bone in ovarian hormone deficient rats
    • Turner RT, Wakley GK, Hannon KS and Bell NH (1988) Tamoxifen inhibits osteoclast mediated resorption of trabecular bone in ovarian hormone deficient rats. Endocrinology 122:1146-1150.
    • (1988) Endocrinology , vol.122 , pp. 1146-1150
    • Turner, R.T.1    Wakley, G.K.2    Hannon, K.S.3    Bell, N.H.4
  • 40
    • 0021684411 scopus 로고
    • Exogenous hormones in the aetiology of cancer in women
    • Vesey MP (1984) Exogenous hormones in the aetiology of cancer in women. J Roy Soc Med 77:542-549.
    • (1984) J Roy Soc Med , vol.77 , pp. 542-549
    • Vesey, M.P.1
  • 41
    • 0019208916 scopus 로고
    • Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen
    • Weiss NS, Ure Cl, Ballard JH, Williams AR and Daling JR (1980) Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N Engl J Med 303:1195-1198.
    • (1980) N Engl J Med , vol.303 , pp. 1195-1198
    • Weiss, N.S.1    Ure, Cl.2    Ballard, J.H.3    Williams, A.R.4    Daling, J.R.5
  • 43
    • 0023690523 scopus 로고
    • Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats
    • Wronski TJ, Cintron M, Doherty AL and Dann LM (1988) Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123:681-686.
    • (1988) Endocrinology , vol.123 , pp. 681-686
    • Wronski, T.J.1    Cintron, M.2    Doherty, A.L.3    Dann, L.M.4
  • 44
    • 0002081094 scopus 로고
    • The ovariectomized rat as an animal model for postmenopausal bone loss
    • Wronski TJ and Yen CF (1991) The ovariectomized rat as an animal model for postmenopausal bone loss. Cell and Mater S 1:69-74.
    • (1991) Cell and Mater S , vol.1 , pp. 69-74
    • Wronski, T.J.1    Yen, C.F.2
  • 46
    • 0016826567 scopus 로고
    • Increased risk of endometrial carcinoma among users of conjugated estrogens
    • Ziel HK and Finkle WD (1975) Increased risk of endometrial carcinoma among users of conjugated estrogens. N Engl J Med 293:1167-1170.
    • (1975) N Engl J Med , vol.293 , pp. 1167-1170
    • Ziel, H.K.1    Finkle, W.D.2


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