Inducible anti-parasitic effector mechanisms in human uroepithelial cells: Tryptophan degradation vs. NO production

Medical Microbiology and Immunology

Volumn 187, Issue 3, 1999, Pages 143-147

  Däubener, Walter ^a   Posdziech, Vanessa ^a   Hadding, Ulrich ^a   MacKenzie, Colin R ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Encephalitis; Indolamine 2,3 dioxygenase; Interferon ; Interleukin 1; Nitric oxide; Toxoplasma

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 1; N(G) METHYLARGININE; NITRIC OXIDE; TRYPTOPHAN;

AMINO ACID METABOLISM; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME INDUCTION; HUMAN; HUMAN CELL; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL; TOXOPLASMA GONDII; TOXOPLASMOSIS; UROTHELIUM;

EID: 0032462126     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004300050086     Document Type: Article

References (25)

1. Adams LB, Hibbs JB, Taintor RR, Krahenbuhl JL (1990) Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine. J Immunol 144:2725-2729
2. Alberati-Giani D, Malherbe P, Ricciardi-Castagnoli P, Köhler C, Denis-Donini S, Cesura AM (1997) Differential regulation of indolamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-γ,-activated murine macrophages and microglial cells. J Immunol 159:419-426
3. Carlin JM, Borden EC, Sondel PM, Byrne (1989) Interferon induced indolamine 2,3 dioxygenase activity in human mononuclear phagocytes. J Leuk Biol 45:29-34
4. Chao CC, Anderson WR, Hu S, Gekker G, Martella A, Peterson PK (1993) Activated microglia inhibit multiplication of Toxoplasma gondii via a nitric oxide mechanism. Clin Immunol Immunopathol 67:178-183
5. Chao CC, Hu S, Gekker G, Novik WJ, Remington JS, Peterson PK (1993) Effects of cytokines on multiplikation of Toxoplasma gondii in microglial cells. J Immunol. 150:3404-3410
6. Däubener W, Hadding U (1997) Cellular immune reactions directed against Toxoplasma gondii with special emphasis on the central nervous system. Med Microbiol Immunol 185:195-206
7. Däubener W, Pilz K, Seghrouchni-Zennati S, Bilzer T, Fischer HG, Hadding U (1993) Induction of toxoplasmostasis in a human glioblastoma by interferon-γ. J Neuroimmunol 43:31-38
8. Däubener W, Wanagat N, Pilz K, Seghrouchni S, Fischer HG, Hadding U (1994) A new, simple, bioassay for human IFN-γ. J Immunol Meth 168:39-47
9. Ding AH, Nathan CF, Stuehr DJ (1988) Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages J Immunol 141:2407-2412
10. deGroot CJA, Ruuls SR, Theeuwes JWM, Dijkstra CD, van der Valk P (1997) Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple sclerosis lesions. J Neuropathol Exp Neurol 56:10-20
11. Kahn IA, Smith KA, Kasper LH (1990) Induction of antigen-specific human cytotoxic T cells by Toxoplasma gondii. J Clin Invest 85:1879-1886
12. Konur A, Krause SW, Rehli M, Kreutz M, Andreesen R (1996) Human monocytes induce a carzinoma cell line to secret high amounts of nitric oxide. J Immunol 157:2109-2115
13. Liu J, Zhao ML, Brosnan CF, Lee SC (1996) Expression of type II nitric oxide synthase in primary human astrocytes and microglia. J Immunol 157:3569-3576
14. McLeod R, Remington JS (1979) A method to evaluate the capacity of monocytes and macrophages to inhibit multiplication of an intracellular pathogen. J Immunol Meth 27:19-29
15. Murray HW, Szurol-Sudol A, Wellner D, Oca MJ, Granger AM, Libby DM, Rothermel CD, Rubin BY (1989) Role of tryptophan degradation in respiratory burst-independent antimicrobial activity of gamma interferon-stimulated human macrophages. Infect Immun 57:845-849
16. Murray HW, Teitelbaum RF (1992) L-arginine-dependent reactive nitrogen intermediates and the antimicrobial effect of activated human mononuclear phagocytes. J Infect Dis 165:513-517
17. Nagineni CN, Pardhasaradhi K, Martins MC, Detrick B, Hooks JJ (1996) Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells.Infect Immun 64:4188-4196
18. Nathan C (1992) Nitric oxide as a secretory product of mammalian cells. J. FASEB 6:3051-3064
19. Peterson PK, Gekker G, Hu S, Chao CC (1995) Human astrocytes inhibit intracellular multiplication of Toxoplasma gondii by a nitric oxide-mediated mechanism. J Infect Dis 171:516-518
20. Pfefferkorn ER (1984) Interferon-γblocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci USA 81:908-912
21. Schimizu T, Nomiyama S, Hirata F, Hayaishi O (1978) Indolamine 2,3-Dioxygenase. J Biol Chem 253:4700-4706
22. Schneemann M, Schoedon G, Hofer S, Blau N, Gurrero L, Schaffner A (1993) Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J Infect Dis 167:1358-1363
23. Subauste CS, Remington JS (1993) Immunity to Toxoplasma gondii. Curr Opin Immunol 5:532-537
24. Taylor MW, Feng G (1991) Relationship between interferon-γ, indolamine 2,3-dioxygenase, and tryptophan catabolism. J FASEB 5:2516-2522
25. Thomas SR, Mohr D, Stocker R (1994) Nitric oxide inhibits indolamine 2,3-dioxygenase activity in interferon-γprimed mononuclear phagocytes. J Biol Chem 269:14457-14464