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Volumn 9, Issue 6, 1998, Pages 81-87

Bisphosphonate therapy for the prevention of osteolysis in total joint replacements

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; ETIDRONIC ACID; IBANDRONIC ACID; PAMIDRONIC ACID; RISEDRONIC ACID; TILUDRONIC ACID;

EID: 0032457340     PISSN: 10419918     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001433-199812000-00014     Document Type: Article
Times cited : (8)

References (60)
  • 1
    • 0004073054 scopus 로고
    • Bethesda, MD: National Institutes of Health
    • 1. National Institutes of Health: Total hip replacement: NIH Consensus Statement. Bethesda, MD: National Institutes of Health; 1994:1-31.
    • (1994) Total Hip Replacement: NIH Consensus Statement , pp. 1-31
  • 5
    • 0027818160 scopus 로고
    • Wear: The basis of particle disease in total hip arthroplasty
    • 5. Shanbhag AS, Rubash HE: Wear: the basis of particle disease in total hip arthroplasty. Techniques Orthop 1994, 8:269-274.
    • (1994) Techniques Orthop , vol.8 , pp. 269-274
    • Shanbhag, A.S.1    Rubash, H.E.2
  • 7
    • 0028267024 scopus 로고
    • The characterization of cytokines in the interface tissue obtained from failed cementless total hip arthroplasty with and without femoral osteolysis
    • 7. Chiba J, Rubash HE, Kim KJ, Iwaki Y: The characterization of cytokines in the interface tissue obtained from failed cementless total hip arthroplasty with and without femoral osteolysis. Clin Orthop 1994, 300:304-312.
    • (1994) Clin Orthop , vol.300 , pp. 304-312
    • Chiba, J.1    Rubash, H.E.2    Kim, K.J.3    Iwaki, Y.4
  • 8
    • 0023860303 scopus 로고
    • A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles
    • 8. Howie DW, Vernon-Roberts B, Oakeshott R, Manthey B: A rat model of resorption of bone at the cement-bone interface in the presence of polyethylene wear particles. J Bone Joint Surg Am 1988, 70:257-263.
    • (1988) J Bone Joint Surg Am , vol.70 , pp. 257-263
    • Howie, D.W.1    Vernon-Roberts, B.2    Oakeshott, R.3    Manthey, B.4
  • 10
    • 0020576705 scopus 로고
    • The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis
    • 10. Goldring SR, Schiller AL, Roelke M, Rourke CM, O'Neill DA, Harris WH: The synovial-like membrane at the bone-cement interface in loose total hip replacements and its proposed role in bone lysis. J Bone Joint Surg Am 1983, 65:575-584.
    • (1983) J Bone Joint Surg Am , vol.65 , pp. 575-584
    • Goldring, S.R.1    Schiller, A.L.2    Roelke, M.3    Rourke, C.M.4    O'Neill, D.A.5    Harris, W.H.6
  • 11
    • 0027400764 scopus 로고
    • A histological and biochemical comparison of the interface tissues in cementless and cemented hip prosthesis
    • 11. Kim KJ, Rubash HE, Wilson SC, D'Antonio JA, McClain EJ: A histological and biochemical comparison of the interface tissues in cementless and cemented hip prosthesis. Clin Orthop 1993, 287:142-152.
    • (1993) Clin Orthop , vol.287 , pp. 142-152
    • Kim, K.J.1    Rubash, H.E.2    Wilson, S.C.3    D'Antonio, J.A.4    McClain, E.J.5
  • 12
    • 0025679122 scopus 로고
    • Histologic, biochemical and ion analysis of tissue and fluids retrieved during total hip arthroplasty
    • 12. Dorr LD, Bloebaum R, Emmanual J, Meldrum R: Histologic, biochemical and ion analysis of tissue and fluids retrieved during total hip arthroplasty. Clin Orthop 1990, 261:82-95.
    • (1990) Clin Orthop , vol.261 , pp. 82-95
    • Dorr, L.D.1    Bloebaum, R.2    Emmanual, J.3    Meldrum, R.4
  • 13
    • 0030199519 scopus 로고    scopus 로고
    • Heterogeneity in cellular and cytokine profiles from multiple samples of tissue surrounding revised hip prostheses
    • 13. Goodman SB, Knoblich G, O'Connor M, Song Y, Huie P, Sibley R: Heterogeneity in cellular and cytokine profiles from multiple samples of tissue surrounding revised hip prostheses. J Biomed Mater Res 1996, 31:421-428.
    • (1996) J Biomed Mater Res , vol.31 , pp. 421-428
    • Goodman, S.B.1    Knoblich, G.2    O'Connor, M.3    Song, Y.4    Huie, P.5    Sibley, R.6
  • 14
    • 0029051093 scopus 로고
    • Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasties
    • 14. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT: Cellular mediators secreted by interfacial membranes obtained at revision total hip arthroplasties. J Arthroplasty 1995, 10:498-506.
    • (1995) J Arthroplasty , vol.10 , pp. 498-506
    • Shanbhag, A.S.1    Jacobs, J.J.2    Black, J.3    Galante, J.O.4    Glant, T.T.5
  • 15
    • 0027168212 scopus 로고
    • Preventing distal voids during cementation of the femoral component in total hip arthroplasty
    • 15. Berger RA, Steel MJ, Schleiden M, Rubash HE: Preventing distal voids during cementation of the femoral component in total hip arthroplasty. J Arthroplasty 1993, 8:323-329.
    • (1993) J Arthroplasty , vol.8 , pp. 323-329
    • Berger, R.A.1    Steel, M.J.2    Schleiden, M.3    Rubash, H.E.4
  • 16
    • 0023686316 scopus 로고
    • Modern use of modern cement for total hip replacement
    • 16. Harris WH, Davies JP: Modern use of modern cement for total hip replacement. Orthop Clin North Am 1988, 19:581 -589.
    • (1988) Orthop Clin North Am , vol.19 , pp. 581-589
    • Harris, W.H.1    Davies, J.P.2
  • 17
    • 0029557806 scopus 로고
    • Total hip arthroplasty with use of socalled second-generation cementing techniques
    • 17. Mulroy WF, Estok DM, Harris WH: Total hip arthroplasty with use of socalled second-generation cementing techniques. J Bone Joint Surg Am 1995, 77:1845-1852.
    • (1995) J Bone Joint Surg Am , vol.77 , pp. 1845-1852
    • Mulroy, W.F.1    Estok, D.M.2    Harris, W.H.3
  • 18
    • 0025161599 scopus 로고
    • The effect of improved cementing techniques on component loosening in total hip replacement
    • 18. Mulroy RD Jr, Harris WH: The effect of improved cementing techniques on component loosening in total hip replacement. J Bone Joint Surg Br 1990, 72:757-760.
    • (1990) J Bone Joint Surg Br , vol.72 , pp. 757-760
    • Mulroy R.D., Jr.1    Harris, W.H.2
  • 19
    • 0029839934 scopus 로고    scopus 로고
    • Remodeling of bone around hydroxyapatite-coated femoral stems
    • 19. D'Antonio JA, Capello WN, Manley MT: Remodeling of bone around hydroxyapatite-coated femoral stems. J Bone Joint Surg Am 1996, 78:1226-1234.
    • (1996) J Bone Joint Surg Am , vol.78 , pp. 1226-1234
    • D'Antonio, J.A.1    Capello, W.N.2    Manley, M.T.3
  • 20
    • 0030471506 scopus 로고    scopus 로고
    • Total hip arthroplasty with hydroxyapatite-coated prostheses
    • 20. Jaffe WL, Scott DF: Total hip arthroplasty with hydroxyapatite-coated prostheses. J Bone Joint Surg Am 1996, 78:1918-1934.
    • (1996) J Bone Joint Surg Am , vol.78 , pp. 1918-1934
    • Jaffe, W.L.1    Scott, D.F.2
  • 21
    • 0029583841 scopus 로고
    • Effects of hydroxyapatite tricalcium phosphate coating and intracancellous placement on bone ingrowth in titanium fibermetal implants
    • 21. Dean JC, Tisdel CL, Goldberg VM, Parr J, Davy D, Stevenson S: Effects of hydroxyapatite tricalcium phosphate coating and intracancellous placement on bone ingrowth in titanium fibermetal implants. J Arthroplasty 1995, 10:830-838.
    • (1995) J Arthroplasty , vol.10 , pp. 830-838
    • Dean, J.C.1    Tisdel, C.L.2    Goldberg, V.M.3    Parr, J.4    Davy, D.5    Stevenson, S.6
  • 25
    • 0002852859 scopus 로고    scopus 로고
    • Improving the resistance to wear and oxidation of acetabular cups of UHMWPE by gamma radiation crosslinking and remelting
    • 25. Shen F-W, McKellop HA, Salovey R: Improving the resistance to wear and oxidation of acetabular cups of UHMWPE by gamma radiation crosslinking and remelting [abstract]. Trans Soc Biomater 1998, 21:3.
    • (1998) Trans Soc Biomater , vol.21 , pp. 3
    • Shen, F.-W.1    McKellop, H.A.2    Salovey, R.3
  • 26
    • 0025666674 scopus 로고
    • Tissue changes around loose prostheses: A canine model to investigate the effects of an antiinflammatory agent
    • 26. Spector M, Shortkroff S, Hsu H-P, Lane N, Sledge CB, Thornhill TS: Tissue changes around loose prostheses: a canine model to investigate the effects of an antiinflammatory agent. Clin Orthop 1990, 261:140-152.
    • (1990) Clin Orthop , vol.261 , pp. 140-152
    • Spector, M.1    Shortkroff, S.2    Hsu, H.-P.3    Lane, N.4    Sledge, C.B.5    Thornhill, T.S.6
  • 27
    • 0026336794 scopus 로고
    • 2 synthesis in the membrane surrounding particulate polymethylmethacrylate in the rabbit tibia
    • 2 synthesis in the membrane surrounding particulate polymethylmethacrylate in the rabbit tibia. Clin Orthop 1991, 271:300-304.
    • (1991) Clin Orthop , vol.271 , pp. 300-304
    • Goodman, S.B.1    Chin, R.C.2    Chiou, S.S.3    Lee, J.S.4
  • 28
    • 0013563011 scopus 로고    scopus 로고
    • Contrasting effects of gene therapy to inhibit interleukin-1 β or tumor necrosis factor alpha in the murine inflammatory response to wear particles
    • 28. Wooley PH, Sud S, Robbins PD, Whalen JD, Evans CH: Contrasting effects of gene therapy to inhibit interleukin-1 β or tumor necrosis factor alpha in the murine inflammatory response to wear particles. Trans Orthop Res Soc 1998, 23:122-122.
    • (1998) Trans Orthop Res Soc , vol.23 , pp. 122-122
    • Wooley, P.H.1    Sud, S.2    Robbins, P.D.3    Whalen, J.D.4    Evans, C.H.5
  • 29
    • 0028851590 scopus 로고
    • Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis
    • 29. Liberman UA, Weiss SR, Broll J, Minne HW, Quan H, Bell NH, et al.: Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 1995, 333:1437-1443.
    • (1995) N Engl J Med , vol.333 , pp. 1437-1443
    • Liberman, U.A.1    Weiss, S.R.2    Broll, J.3    Minne, H.W.4    Quan, H.5    Bell, N.H.6
  • 30
    • 0004851872 scopus 로고    scopus 로고
    • Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures
    • 30. Black DM, Cummings SR, Karpf DB, Cauley JA, Thompson DE, Nevitt MC, et al.: Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Lancet 1996, 348:1535-1541.
    • (1996) Lancet , vol.348 , pp. 1535-1541
    • Black, D.M.1    Cummings, S.R.2    Karpf, D.B.3    Cauley, J.A.4    Thompson, D.E.5    Nevitt, M.C.6
  • 31
    • 0028586042 scopus 로고
    • Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment
    • 31. Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD: Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment. J Clin Endocrinol Metab 1994 79:1693-1700.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1693-1700
    • Garnero, P.1    Shih, W.J.2    Gineyts, E.3    Karpf, D.B.4    Delmas, P.D.5
  • 32
    • 0029884643 scopus 로고    scopus 로고
    • Bisphosphonates: Mechanisms of action
    • 32. Rodan GA, Fleisch HA: Bisphosphonates: mechanisms of action. J Clin Invest 1996, 97:2692-2696.
    • (1996) J Clin Invest , vol.97 , pp. 2692-2696
    • Rodan, G.A.1    Fleisch, H.A.2
  • 33
    • 0031280306 scopus 로고    scopus 로고
    • Inhibition of wear debris-mediated osteolysis in a canine total hip arthroplasty (THA) model
    • 33. Shanbhag AS, Hasselman CT, Rubash HE: Inhibition of wear debris-mediated osteolysis in a canine total hip arthroplasty (THA) model. Clin Orthop 1997, 344:33-43. This study is important for two reasons. First, the investigators used clinically relevant UHMWPE wear debris and developed osteolysis around uncemented total hip replacements in a canine model. Second, in another group of canines with similar hip replacements and introduction of wear debris, an oral treatment with bisphosphonates could inhibit localized periprosthetic bone loss.
    • (1997) Clin Orthop , vol.344 , pp. 33-43
    • Shanbhag, A.S.1    Hasselman, C.T.2    Rubash, H.E.3
  • 34
    • 0030152194 scopus 로고    scopus 로고
    • Pharmacologic inhibition of particulate-induced bone resorption
    • 34. Horowitz SM, Algan SA, Purdon MA: Pharmacologic inhibition of particulate-induced bone resorption. J Biomed Mater Res 1996, 31:91-96.
    • (1996) J Biomed Mater Res , vol.31 , pp. 91-96
    • Horowitz, S.M.1    Algan, S.A.2    Purdon, M.A.3
  • 35
    • 0013593551 scopus 로고    scopus 로고
    • Short-term effects of bisphosphonates on the biomechanical properties of canine bone
    • in press
    • 35. Wang X, Shanbhag AS, Rubash HE, Agrawal CM: Short-term effects of bisphosphonates on the biomechanical properties of canine bone. J Biomed Mater Res 1998, in press.
    • (1998) J Biomed Mater Res
    • Wang, X.1    Shanbhag, A.S.2    Rubash, H.E.3    Agrawal, C.M.4
  • 36
    • 0013563097 scopus 로고    scopus 로고
    • The use of bisphosphonates to inhibit mechanically related bone loss in aseptic loosening of hip prostheses
    • 36. Goodship AE, Lawes TJ, Green J, Eldridge JD, Kenwright J: The use of bisphosphonates to inhibit mechanically related bone loss in aseptic loosening of hip prostheses [abstract]. Trans Orthop Res Soc 1998, 23:2. In this study the investigators demonstrated that bisphosphonates also have the potential to reduce bone loss associated with stress shielding around metal implants.
    • (1998) Trans Orthop Res Soc , vol.23 , pp. 2
    • Goodship, A.E.1    Lawes, T.J.2    Green, J.3    Eldridge, J.D.4    Kenwright, J.5
  • 38
    • 0013563177 scopus 로고    scopus 로고
    • Alendronate does not inhibit instability-induced bone resorption
    • 38. Astrand J, Aspenberg P: Alendronate does not inhibit instability-induced bone resorption [abstract]. Trans Orthop Res Soc 1998, 23:28.
    • (1998) Trans Orthop Res Soc , vol.23 , pp. 28
    • Astrand, J.1    Aspenberg, P.2
  • 40
    • 0028500785 scopus 로고
    • Response of three murine macrophage populations to particulate debris: Bone resorption in organ cultures
    • 40. Glant TT, Jacobs JJ: Response of three murine macrophage populations to particulate debris: bone resorption in organ cultures. J Orthop Res 1994, 12:720-731.
    • (1994) J Orthop Res , vol.12 , pp. 720-731
    • Glant, T.T.1    Jacobs, J.J.2
  • 41
    • 0030852534 scopus 로고    scopus 로고
    • Effects of particles on fibroblast proliferation and bone resorption in vitro
    • 41. Shanbhag AS, Jacobs JJ, Black J, Galante JO, Glant TT: Effects of particles on fibroblast proliferation and bone resorption in vitro. Clin Orthop 1997, 342:205-217.
    • (1997) Clin Orthop , vol.342 , pp. 205-217
    • Shanbhag, A.S.1    Jacobs, J.J.2    Black, J.3    Galante, J.O.4    Glant, T.T.5
  • 42
    • 0002645631 scopus 로고    scopus 로고
    • Alendronate prevents bone resorption by isolated cells from periprosthetic granulation tissue in hips of revision total hip arthroplasty
    • 42. Jingushi S, Yasuda K, Sakai H, Azuma Y, Ohta T, Iwamoto Y: Alendronate prevents bone resorption by isolated cells from periprosthetic granulation tissue in hips of revision total hip arthroplasty [abstract]. Trans Orthop Res Soc 1998, 23:1.
    • (1998) Trans Orthop Res Soc , vol.23 , pp. 1
    • Jingushi, S.1    Yasuda, K.2    Sakai, H.3    Azuma, Y.4    Ohta, T.5    Iwamoto, Y.6
  • 43
  • 44
    • 0031977199 scopus 로고    scopus 로고
    • Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
    • 44. Luckman SP, Hughes DE, Coxon FP, Russell RGG, Rogers MJ: Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 1998, 13:581-589.
    • (1998) J Bone Miner Res , vol.13 , pp. 581-589
    • Luckman, S.P.1    Hughes, D.E.2    Coxon, F.P.3    Russell, R.G.G.4    Rogers, M.J.5
  • 45
    • 1842405434 scopus 로고    scopus 로고
    • 1gamma-dichloromethylene) triphosphate, by mammalian cells in vitro
    • 1gamma-dichloromethylene) triphosphate, by mammalian cells in vitro. J Bone Miner Res 1997, 12:1358-1367. The studies to date had suggested that the primary action of bisphosphonates was on the osteoclasts, with minimal effect on the other cells such as the osteoblasts and macrophages. In this study the investigators demonstrated that clodronate, a first-generation bisphosphonate, can be toxic to macrophages. This effect was specific to individual drug formulations, and alendronate had no deleterious effect.
    • (1997) J Bone Miner Res , vol.12 , pp. 1358-1367
    • Frith, J.C.1    Monkkonen, J.2    Blackburn, G.M.3    Russel, R.G.G.4    Rogers, M.J.5
  • 46
    • 0014684354 scopus 로고
    • Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo
    • 46. Fleisch H, Russel RGG, Francis MD: Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo. Science 1969, 10:1262-1264.
    • (1969) Science , vol.10 , pp. 1262-1264
    • Fleisch, H.1    Russel, R.G.G.2    Francis, M.D.3
  • 48
    • 0026329441 scopus 로고
    • Inhibition of bone resorption by bisphosphonates: Interactions between bisphosphonates, osteoclasts and bone
    • 48. Flanagan AM, Chambers TJ: Inhibition of bone resorption by bisphosphonates: interactions between bisphosphonates, osteoclasts and bone. Calcif Tissue Int 1991, 49:407-415.
    • (1991) Calcif Tissue Int , vol.49 , pp. 407-415
    • Flanagan, A.M.1    Chambers, T.J.2
  • 49
    • 0026320852 scopus 로고
    • Bisphosphonate action: Alendronate localization in rat bone and effects on osteoclast ultrastructure
    • 49. Sato M, Grasser W, Endo N, Akins R, Simmons H: Bisphosphonate action: alendronate localization in rat bone and effects on osteoclast ultrastructure. J Clin Invest 1991, 88:2095-2105.
    • (1991) J Clin Invest , vol.88 , pp. 2095-2105
    • Sato, M.1    Grasser, W.2    Endo, N.3    Akins, R.4    Simmons, H.5
  • 51
    • 0029164610 scopus 로고
    • Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models
    • 51. Azuma Y, Sato H, Oue Y, Okabe K, Ohta T, Tsuchimoto M, Kiyoki M: Alendronate distributed on bone surfaces inhibits osteoclastic bone resorption in vitro and in experimental hypercalcemia models. Bone 1995, 16:235-245.
    • (1995) Bone , vol.16 , pp. 235-245
    • Azuma, Y.1    Sato, H.2    Oue, Y.3    Okabe, K.4    Ohta, T.5    Tsuchimoto, M.6    Kiyoki, M.7
  • 52
    • 0025371890 scopus 로고
    • Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy
    • 52. Sato M, Grasser W: Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy. J Bone Miner Res 1990, 5:31-39.
    • (1990) J Bone Miner Res , vol.5 , pp. 31-39
    • Sato, M.1    Grasser, W.2
  • 53
    • 0015449333 scopus 로고
    • The effect of two diphosphonates on the resorption of mouse calvaria in vitro
    • 53. Reynolds JJ, Minkin C, Morgan DB, Spycher D, Fleisch H: The effect of two diphosphonates on the resorption of mouse calvaria in vitro. Calc Tissue Res 1972, 10:302-313.
    • (1972) Calc Tissue Res , vol.10 , pp. 302-313
    • Reynolds, J.J.1    Minkin, C.2    Morgan, D.B.3    Spycher, D.4    Fleisch, H.5
  • 54
    • 0029097506 scopus 로고
    • A possible mechanism of the specific action of bisphosphonates on osteoclasts: Tiludronate preferentially affects polarized osteoclasts having ruffled borders
    • 54. Murakami H, Takahashi N, Sasaki T, Udagawa N, Tanaka S, Nakamura I, et al.: A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders. Bone 1995, 17:137-144.
    • (1995) Bone , vol.17 , pp. 137-144
    • Murakami, H.1    Takahashi, N.2    Sasaki, T.3    Udagawa, N.4    Tanaka, S.5    Nakamura, I.6
  • 55
    • 0028859369 scopus 로고
    • Acid extrusion is induced by osteoclast attachment to bone
    • 55. Zimolo Z, Wesolowski G, Rodan GA: Acid extrusion is induced by osteoclast attachment to bone. J Clin Invest 1995, 96:2277-2283.
    • (1995) J Clin Invest , vol.96 , pp. 2277-2283
    • Zimolo, Z.1    Wesolowski, G.2    Rodan, G.A.3
  • 56
    • 0026347007 scopus 로고
    • Physical characterization of acrytic bone cement cured with new accelerator systems
    • 56. Tanzi MC, Sket I, Gatti AM, Monari E: Physical characterization of acrytic bone cement cured with new accelerator systems. Clin Mater 1991, 8:131-136.
    • (1991) Clin Mater , vol.8 , pp. 131-136
    • Tanzi, M.C.1    Sket, I.2    Gatti, A.M.3    Monari, E.4
  • 57
    • 0021287134 scopus 로고
    • The subcellular distribution of [14C]dichloromethylene bisphosphonate and [14C]1-hydroxyethylidene-1,1-bisphosphonate in cultured calvaria cells
    • 57. Felix R, Guenther HL, Fleisch H: The subcellular distribution of [14C]dichloromethylene bisphosphonate and [14C]1-hydroxyethylidene-1,1-bisphosphonate in cultured calvaria cells. Calcif Tissue Int 1984, 36:108-113.
    • (1984) Calcif Tissue Int , vol.36 , pp. 108-113
    • Felix, R.1    Guenther, H.L.2    Fleisch, H.3
  • 58
    • 0027769673 scopus 로고
    • Clinical effects of bisphosphonates in involutional osteoporosis
    • 58. Ott SM: Clinical effects of bisphosphonates in involutional osteoporosis. J Bone Miner Res 1993, 8(suppl):S597-S606.
    • (1993) J Bone Miner Res , vol.8 , Issue.SUPPL.
    • Ott, S.M.1
  • 59
    • 0027193759 scopus 로고
    • Bisphosphonates act on rat bone resorption through the mediation of osteoblasts
    • 59. Sahni M, Guenther HL, Fleisch H, Collin P, Martin TJ: Bisphosphonates act on rat bone resorption through the mediation of osteoblasts. J Clin Invest 1993, 91:2004-2011.
    • (1993) J Clin Invest , vol.91 , pp. 2004-2011
    • Sahni, M.1    Guenther, H.L.2    Fleisch, H.3    Collin, P.4    Martin, T.J.5


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