Ultrastructural localization of immunoglobulin G and complement C9 in the brain stem and spinal cord following peripheral nerve injury: An immunoelectron microscopic study

Journal of Neurocytology

Volumn 27, Issue 10, 1998, Pages 737-748

  Liu, Li ^a   Aldskogius, Håkan ^a   Svensson, Mikael ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C9; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN STEM; CELL INTERACTION; CONTROLLED STUDY; FEMALE; GRACILE NUCLEUS; HYPOGLOSSAL NUCLEUS; IMMUNOELECTRON MICROSCOPY; IMMUNOREACTIVITY; MICROGLIA; MOTONEURON; NERVE TRANSECTION; NEUROPIL; NONHUMAN; PERIKARYON; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SPINAL CORD; TISSUE DISTRIBUTION;

ANIMALS; AXOTOMY; BRAIN STEM; COMPLEMENT C9; FEMALE; HYPOGLOSSAL NERVE; IMMUNOGLOBULIN G; MICROGLIA; MICROSCOPY, IMMUNOELECTRON; NERVE DEGENERATION; NEURONAL PLASTICITY; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SPINAL CORD;

ANIMALIA;

EID: 0032456016     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006950917973     Document Type: Article

References (40)

1. ALDSKOGIUS, H. & KOZLOVA, E.N. (1998) Central neuron-glial and glial-glial interactions following axon injury. Progress in Neurobiology 54, 1-26.
2. ALDSKOGIUS, H. & SVENSSON, M. (1993) Neuronal and glial cell responses to axon injury. In: Advances in Structural Biology, Vol. 2 (edited by MALHOTRA, S. K.), pp. 191-223. Greenwich, CT: JAI Press,
3. BELLANDER, B.M., von HOLST, H., FREDMAN, P. & SVENSSON, M. (1996) Activation of the complement cascade and increase of clusterin in the brain following a cortical contusion in the adult rat. Journal of Neurosurgery 85, 468-75.
4. BLINZINGER, K. & KREUTZBERG, G. (1968) Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Zeitschrift für Zellforschung und Mikroskopische Anatomie 85, 145-57.
5. BROADWELL, R.D. & SOFRONIEW, M.V. (1993) Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system. Experimental Neurology 120, 245-63.
6. BROWN, E.J. (1991) Complement receptors and phagocytosis. Current Opinion in Immunology 3, 76-82.
7. BRÜCK, W. & FRIEDE, R.L. (1991) The role of complement in myelin phagocytosis during PNS wallerian degeneration. Journal of the Neurological Sciences 103, 182-7.
8. DANKERT, J.R. & ESSER, A.F. (1987) Bacterial killing by complement. C9-mediated killing in the absence of C5b-8. Biochemical Journal 244, 393-9.
9. FABIAN, R.H. (1988) Uptake of plasma IgG by CNS motoneurons: comparison of antineuronal and normal IgG. Neurology 38, 1775-80.
10. FABIAN, R.H. & PETROFF, G. (1987) Intraneuronal IgG in the central nervous system: uptake by retrograde axonal transport. Neurology 37, 1780-4.
11. FRANK, M.M. & FRIES, L.F. (1991) The role of complement in inflammation and phagocytosis. Immunology Today 12, 322-6.
12. GASQUE, P., CHAN, P., FONTAINE, M., ISCHENKO, A., LAMACZ, M., GOTZE, O. & MORGAN, B.P. (1995a) Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes. Journal of Immunology 155, 4882-9.
13. GASQUE, P., FONTAINE, M. & MORGAN, B.P. (1995b) Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. Journal of Immunology 154, 4726-33.
14. GASQUE, P., SINGHRAO, S.K., NEAL, J.W., WANG, P., SAYAH, S., FONTAINE, M. & MORGAN, B.P. (1998) The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system - analysis in multiple sclerosis and bacterial meningitis. Journal of Immunology 160, 3543-54.
15. HOL, E.M., GISPEN, W.H. & BÄR, P.R. (1995) ACTH-related peptides: receptors and signal transduction systems involved in their neurotrophic and neuroprotective action. Peptides 16, 979-93.
16. HURLEY, S.D. & STREIT, W.J. (1996) Microglia and the mononuclear phagocyte system. In: Topical Issues in Microglial Research (edited by LING, E.A., TAN, C.K. & TAN, C.B.C.), pp. 1-19, Singapore Neuroscience Association,
17. ITAGAKI, S., AKIYAMA, H., SAITO, H. & MCGEER, P.L. (1994) Ultrastructural localization of complement membrane attack complex (MAC)-like immunoreactivity in brains of patients with Alzheimer's disease. Brain Research 645, 78-84.
18. JOHNSON, S., YOUNG CHAN, C.S., LAPING, N.J. & FINCH, C.E. (1996) Perforant path transection induces complement C9 deposition in hippocampus. Experimental Neurology 138, 198-205.
19. LISZEWSKI, M.K. & ATKINSON, J.F. (1993) The complement system. In: Fundamental Immunology (edited by PAUL, W.E.), pp. 917-39. New York: Raven Press,
20. LIU, L., TÖRNQVIST, E., MATTSSON, P., ERIKSSON, N.P., PERSSON, J.K., MORGAN, B.P., ALDSKOGIUS, H. & SVENSSON, M. (1995) Complement and clusterin in the spinal cord dorsal horn and gracile nucleus following sciatic nerve injury in the adult rat. Neuroscience 68, 167-79.
21. MACKAY, S.L. & DANKERT, J.R. (1990) Bacterial killing and inhibition of inner membrane activity by C5b-9 complexes as a function of the sequential addition of C9 to C5b-8 sites. Journal of Immunology 145, 3367-71.
22. MATTSSON, P., MORGAN, B.P. & SVENSSON, M. (1998) Complement activation and CD59 expression in the motor facial nucleus following intracranial transection of the facial nerve in the adult rat. Journal of Neuroimmunology, in press.
23. McGEER, E.G. & McGEER, P.L. (1997) The role of the immune system in neurodegenerative disorders. Movement Disorders 12, 855-88.
24. McPHADEN, A.R. & WHALEY, K. (1993) Complement biosynthesis by mononuclear phagocytes. Immunology Research 12, 213-32.
25. MOOS, T., STAGAARD, M. & MOLLGARD, K. (1991) Immunocytochemical evidence for retrograde axonal transport of exogenous albumin in adult rat brain stem motor neurons. Neuroscience Letters 127, 1-4.
26. MORGAN, B.P. (1992) Effects of the membrane attack complex of complement on nucleated cells. Current Topics in Microbiology and Immunology 178, 115-40.
27. MORGAN, B.P., GASQUE, P., SINGHRAO, S.K. & PIDDLESDEN, S.J. (1997) Role of complement in inflammation and injury in the nervous system. Experimental and Clinical Immunogenetics 14, 19-23.
28. MITIN, Y.V., NAVOLOTSKAYA, E.V., VASILENKO, R.N., ABRAMOV, V.M. & ZAV'YALOV, V.P. (1993) Synthesis and properties of the peptide corresponding to the ACTH-like sequence of human immunoglobulin G1. International Journal of Peptide & Protein Research 41, 517-21.
29. PERRY, V.H., BELL, M.D., BROWN, H.C. & MATYSZAK, M.K. (1995) Inflammation in the nervous system. Current Opinion in Neurobiology 5, 636-41.
30. PIDDLESDEN, S.J., STORCH, M.K., HIBBS, M., FREEMAN, A.M., LASSMANN, H. & MORGAN, B.P. (1994) Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis. Journal of Immunology 152, 5477-84.
31. SAYAH, S., PATTE, C., GASQUE, P., CHAN, P., ISCHENKO, A., VAUDRY, H. & FONTAINE, M. (1997) Characterization of rat C5a anaphylatoxin receptor (C5aR): cloning of rat C5aR cDNA and study of C5aR expression by rat astrocytes. Molecular Brain Research 48, 215-22.
32. STRAND, F.L., WILLIAMS, K.A., ALVER, S.E., ANTONAWICH, F.J., LEE, T.S, LEE, S.J., KUME, J. & ZUCCARELLI, L.A. (1994) Melanocortins as factors in somatic neuromuscular growth and regrowth. Pharmacology and Therapeutics 62, 1-27.
33. SVENSSON, M. & ALDSKOGIUS, H. (1992) Evidence for activation of the complement cascade in the hypoglossal nucleus following peripheral nerve injury. Journal of Neuroimmunology 40, 99-109.
34. SVENSSON, M., LIU, L., MATTSSON, P., MORGAN, B.P. & ALDSKOGIUS, H. (1995) Evidence for activation of the terminal pathway of complement and upregulation of sulfated glycoprotein (SGP)-2 in the hypoglossal nucleus following peripheral nerve injury. Molecular and Chemical Neuropathology 24, 53-68.
35. TERAl, K., WALKER, D.G., McGEER, E.G. & McGEER, P.L. (1997) Neurons express proteins of the classical complement pathway in Alzheimer disease. Brain Research 769, 385-90.
36. TYOR, W.R., WESSELINGH, S., LEVINE, B. & GRIFFIN, D.E. (1992) Long term intraparenchymal Ig secretion after acute viral encephalitis in mice. Journal of Immunology 149, 4016-20.
37. WALPORT, M. (1993) Complement. Chapter 12. In: Immunology (edited by ROITT, I.), Chapter 12. St Louis, London: Mosby.
38. WOOD, A., WING, M.G., BENHAM, C.D. & COMPSTON, D.A. (1993) Specific induction of intracellular calcium oscillations by complement membrane attack on oligodendroglia. Journal of Neuroscience 13, 3319-32.
39. YAO, J., HARVATH, L., GILBERT, D.L. & COLTON, C.A. (1990) Chemotaxis by a CNS macrophage, the microglia. Journal of Neuroscience Research 27, 36-42.
40. YOUNG, J.D. & YOUNG, T.M. (1990) Channel fluctuations induced by membrane attack complex C5b-9. Molecular Immunology 27, 1001-7.