Androgen replacement in children with constitutional delay of puberty: The case for aggressive therapy

Bailliere's Clinical Endocrinology and Metabolism

Volumn 12, Issue 3, 1998, Pages 427-440

  Houchin, L D ^a   Rogol, A D ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Adolescents (male); Androgen replacement; Constitutional delay of growth and adolescence (CDGA)

Indexed keywords

ANDROGEN; GROWTH HORMONE; SEX HORMONE; STEROID;

ADOLESCENCE; ADOLESCENT; ANDROGEN THERAPY; BONE DENSITY; BONE MINERAL; CHILD GROWTH; DELAYED PUBERTY; HORMONE SUBSTITUTION; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; REVIEW;

EID: 0032453612     PISSN: 0950351X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0950-351X(98)80172-9     Document Type: Article

References (60)

1. Arslanian S Kalhan S Protein turnover during puberty in normal children American Journal of Physiology 270 1996 E79 E84
2. Arslanian S Suprasangsin S Testosterone treatment in adolescents with delayed puberty: changes in body composition, protein, fat, and glucose metabolism Journal of Clinical Endocrinology and Metabolism 82 1997 3213 3220
3. Attie KM Ramirez MR Conte FA The pubertal growth spurt in eight patients with true precocious puberty and growth hormone deficiency: evidence for a direct role of sex steroids Journal of Clinical Endocrinology and Metabolism 71 1990 975 983
4. Aynsley-Green A Zachmann M Prader A Interrelation of the therapeutic effects of growth hormone and testosterone on growth in hypopituitarism Journal of Pediatrics 89 1976 992 999
5. Berelowitz M Szabo M Frohman LA Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary Science 212 1981 1279 1281
6. Bertelloni S Baroncelli GI Battini R Short-term effect of testosterone treatment on reduced bone density in boys with constitutional delay of puberty Journal of Bone and Mineral Research 10 1995 1488 1495
7. Bhasin S Bremner WJ Clinical review 85: Emerging issues in androgen replacement therapy Journal of Clinical Endocrinology and Metabolism 82 1997 3 8
8. Bhasin S Storer TW Berman N Testosterone replacement increases fat-free mass and muscle size in hypogonadal men Journal of Clinical Endocrinology and Metabolism 82 1997 407 413
9. Blizzard RM Hindmarsh PC Stanhope R Oxandrolone therapy: 25 years experience Growth Genetics and Hormones 7 1991 1 6
10. Blizzard RM Thompson RG Baghdassarian A The interrelationship of steroids, growth hormone and other hormones on pubertal growth Grumbach MM Grave GD Mayer FE The Control of the Onset of Puberty 1974 John Wiley & Sons Berlin 342
11. Bonjour JP Theintz G Buchs B Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence Journal of Clinical Endocrinology and Metabolism 73 1991 555 563
12. Bourguignon JP Vandeweghe M Vanderschueren-Lodeweyckx M Pubertal growth and final height in hypopituitary boys: a minor role of bone age at onset of puberty Journal of Clinical Endocrinology and Metabolism 63 1986 376 382
13. Brasel JA Wright JC Wilkins L Blizzard RM Evaluation of seventy-five patients with hypopituitarism beginning in childhood American Journal of Medicine 38 1965 484 498
14. Burr IM Sizonenko PC Kaplan SL Grumbach MM Hormonal changes in puberty. I. Correlation of serum luteinizing hormone and follicle stimulating hormone with stages of puberty, testicular size, and bone age in normal boys Pediatric Research 4 1970 25 35
15. Buyukgebiz A Treatment of constitutional delayed puberty with a combination of testosterone esters Hormone Research 44 supplement 3 1995 32 34
16. Cara JF Rosenfield RL Furlanetto RW A longitudinal study of the relationship of plasma somatomedin-C concentration to the pubertal growth spurt American Journal of Diseases of Childhood 141 1987 562 564
17. Crowne EC Shalet SM Wallace WBH Final height in boys with untreated constitutional delay in growth and puberty Archives of Disease in Childhood 65 1990 1109 1112
18. Duke PM Carsmith JM Jennings D Educational correlates of early and late sexual maturation in adolescence Journal of Pediatrics 100 1982 633 637
19. Finkelstein JS Klibanski A Neer RM A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty Journal of Clinical Endocrinology and Metabolism 81 1996 1152 1155
20. Finkelstein JS Neer RM Biller BMK Osteopenia in men with a history of delayed puberty New England Journal of Medicine 326 1992 600 604
21. Gross RT Duke PM The effect of early versus late physical maturation on adolescent behavior Pediatric Clinics of North America 27 1980 71 77
22. Hartman ML Clayton PE Johnson ML A low-dose-euglycemic infusion of rhIGF-I rapidly suppresses fasting-enhanced pulsatile GH secretion in humans Journal of Clinical Investigation 91 1993 2458 2462
23. Horber FF Haymond MW Human growth hormone prevents the protein catabolic side effects of prednisone in humans Journal of Clinical Investigation 86 1990 265 272
24. Jakacki RI Kelch RD Saunder Lloyd JS Pulsatile secretion of luteinizing hormone in children Journal of Clinical Endocrinology and Metabolism 55 1982 453 458
25. Joss EE Schmidt HA Zuppinger KA Oxandrolone in constitutionally delayed growth, a longitudinal study up to final height Journal of Clinical Endocrinology and Metabolism 69 1989 1109 1115
26. Kasperk CH Wergedal JE Farley JR Androgens directly stimulate proliferation of bone cells in vitro Endocrinology 124 1989 1576 1578
27. Kasperk C Fitzsimmons R Strong D Studies of the mechanism by which androgens enhance mitogenesis and differentiation in bone cells Journal of Clinical Endocrinology and Metabolism 71 1990 1322 1329
28. Keenan BS Richards GE Ponder SW Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty Journal of Clinical Endocrinology and Metabolism 76 1993 996 1001
29. Kerrigan JR Martha PM Jr Blizzard RM Variations of pulsatile growth hormone release in healthy short prepubertal boys Pediatric Research 28 1990 11 14
30. Krabbe S Hummer L Christiansen C Longitudinal study of calcium metabolism in male puberty. II. Relationship between mineralization and serum testosterone Acta Paediatrica Scandinavica 73 1984 750 755
31. Krabbe S Christiansen C Rodbro P Transbol I Effect of puberty on rates of bone growth and mineralisation with observations in male delayed puberty Archives of Disease in Childhood 54 1979 950 953
32. Laron Z Sarel R Pertzelan A Puberty in Laron type dwarfism European Journal of Pediatrics 134 1980 79 83
33. Link K Blizzard RM Evans WS The effect of androgens on the pulsatile release and the twenty-four-hour mean concentration of growth hormone in peripubertal males Journal of Clinical Endocrinology and Metabolism 62 1986 159 164
34. Marshall WA Tanner JM Variations in pattern of pubertal changes in girls Archives of Disease in Childhood 44 1969 291 303
35. Marshall WA Tanner JM Variations in the pattern of pubertal changes in boys Archives of Disease in Childhood 45 1970 13 23
36. Martha PM Jr Rogol AD Veldhuis JD Alterations in the pulsatile properties of circulating GH concentrations during puberty in boys Journal of Clinical Endocrinology and Metabolism 69 1989 563 570
37. Martha PM Jr Gorman KM Jr Blizzard RM Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: relationship to age, pubertal status, and body mass Journal of Clinical Endocrinology and Metabolism 74 1992 336 344
38. Mauras N Blizzard RM Link K Augmentation of GH secretion during puberty: evidence for a pulse amplitude-modulated phenomenon Journal of Clinical Endocrinology and Metabolism 64 1987 596 601
39. Mauras N Haymond MW Darmaun D Calcium and protein kinetics in prepubertal boys Positive effects of testosterone Journal of Clinical Investigation 93 1994 1014 1019
40. Metzger DL Kerrigan JR Androgen receptor blockade with fiutamide enhances growth hormone secretion in late pubertal males: evidence for independent actions of estrogen and androgen Journal of Clinical Endocrinology and Metabolism 76 1993 1147 1152
41. Metzger DL Kerrigan JR Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stumulatory role of endogenous estrogens during male adolescence Journal of Clinical Endocrinology and Metabolism 79 1994 513 518
42. Moorthy B Papadopolou M Shaw DG Grant DB Depot testosterone in boys with anorchia or gonadotrophin deficiency: effect on growth rate and adult height Archives of Disease in Childhood 66 1991 197 199
43. Muller EE Neural control of somatotropic function Physiology Review 67 1987 962 1053
44. Parker MW Johanson AJ Rogol AD Effect of testosterone on somatomedin-C concentrations in pubertal boys Journal of Clinical Endocrinology and Metabolism 58 1984 87 90
45. Rallison ML Growth Disorders in Infants, Children, and Adolescents 1986 John Wiley & Sons New York
46. Rivarola MA Phillips JA III Migeon CJ Phenotypic heterogeneity in familial isolated growth hormone deficiency type I-A Journal of Clinical Endocrinology and Metabolism 59 1984 34 40
47. Rosenfield RL Furlanetto RW Physiologic testosterone or estradiol induction of puberty increases plasma somatomedin-C Journal of Pediatrics 107 1985 415 417
48. Sanayama K Noda H Konda S Spontaneous growth hormone secretion and plasma somatomedin-C in children of short stature Endocrinology Japan 34 1987 627 633
49. Sclechter NL Russell SM Spencer EM Nicoll CS Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin Proceedings of the National Academy of Science of the USA 83 1986 7932 7934
50. Snyder PJ Lawrence DA Treatment of male hypogonadism with testosterone enanthate Journal of Clinical Endocrinology and Metabolism 51 1980 1335 1339
51. Soliman AT Khadir MM Asfour M Testosterone treatment in adolescent boys with constitutional delay of growth and development Metabolism: Clinical and Experimental 44 1995 1013 1015
52. Stanhope R Pringle PJ Brook CGD The mechanism of the adolescent growth spurt induced by low dose pulsatile GnRH treatment Clinical Endocrinology 28 1988 83 91
53. Tanner JM Whitehouse RH Hughes PCR Carter BS Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone-deficient children Journal of Pediatrics 89 1976 1000 1008
54. Tse WY Buyukgebiz A Hindmarsh PC Long-term outcome of oxandrolone treatment in boys with constitutional delay of growth and puberty Journal of Pediatrics 117 1990 588 591
55. Ulloa-Aguirre A Blizzard RM Garcia-Rubi E Testosterone and oxandrolone, a nonaromatizable androgen, specifically amplify the mass and rate of growth hormone (GH) secreted per burst without altering GH secretory burst duration or frequency or the GH half-life Journal of Clinical Endocrinology and Metabolism 71 1990 846 854
56. Veldhuis JD Faria A Vance ML Contemporary tools for the analysis of episodic growth hormone secretion and clearance in vivo Paediatrica Scandinavica 347 1988 63 82
57. Veldhuis JD Metzger DL Martha PM Jr Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement Journal of Clinical Endocrinology and Metabolism 82 1997 3414 3420
58. Wilson DM McCauley E Brown DR Dudley R Oxandrolone therapy in constitutionally delayed growth and puberty Bio-Technology General Corporation Cooperative Study Group Pediatrics 96 1995 1095 1100
59. Wu FC Brown DC Butler GE Early morning plasma testosterone is an accurate predictor of imminent pubertal development in prepubertal boys Journal of Clinical Endocrinology and Metabolism 76 1993 26 31
60. Zhang J, Peddada SD, Malina RM & Rogol AD (in press) A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. VI. Modeling of linear growth, serum testosterone (T) and mean growth hormone (GH mean) concentrations and of growth velocity as a function of T and GH mean. American Journal of Human Biology (submitted for publication).