Clinical effects of low-level exposures to chemical warfare agents in mice and chickens

Drug and Chemical Toxicology

Volumn 21, Issue SUPPL. 1, 1998, Pages 183-190

  Wilson, Barry W ^a   Henderson, John D ^a   Spencer, Peter S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUNGAROTOXIN; CHEMICAL WARFARE AGENT; DYFLOS; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; MIPAFOX; PYRIDOSTIGMINE; SARIN; SOMAN; TABUN; TRI ORTHO CRESYL PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CHEMICAL WARFARE; CHICKEN; CONTROLLED STUDY; EXPOSURE; HEN; MOUSE; MYOPATHY; NEUROTOXICITY; NONHUMAN; REVIEW;

EID: 0032452608     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.3109/01480549809007410     Document Type: Review

References (30)

1. M. Lotti, Organophosphorus esters. In Experimental and Clinical Neurotoxicology, 2nd edition, ed. by P.S. Spencer, H.H. Schaumburg, and A.C.Ludolph, Oxford, N.Y. (In Press)
2. J.R.Keeler and C.G. Hurst, Pyridostigmine Used as a Nerve Agent Pretreatment Under Wartime Conditions. JAMA 266, 693-695 (1991).
3. S.M. Somani, Chemical Warfare Agents, Academic Pres, San Diego (1992)
4. P.J. Landrigan, Illness in Gulf War Veterans: Causes and Consequences. JAMA 277, 259-261 (1997)
5. P. Taylor, Anticholinesterase Agents. In Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th Edition, ed. by J.G. Hardman, L.E. Limbird, P.B. Moklinoff, R.W. Ruddon and A.G. Goodman, pp 161-176. McGraw-Hill, NY (1996)
6. 6. M. Lotti, The Pathogenesis of Organophosphate Delayed Neuropathy. CRC Crit. Rev. Toxicol. 21 465- (1992)
7. W .D. Dettbarn, Pesticide Induced Muscle Necrosis: Mechanisms and Prevention. Fundamental and Applied Toxicology 4(2Pt2):S 18-26 (1984)
8. N. Senanayake and L. Karalliedde, Neurotoxic effects of organophosphorus insecticides. An Intermediate Syndrome. New England Journal of Medicine, 316 761-763 (1987)
9. J.J. Gordon, R.H. Inns, M.K. Johnson, L. Leadbeater, M.P. Maidment, D.G. Upshall, G.H. Cooper and R.L. Rickard. The Delayed Effects of Nerve Agents and Some Other Organophopshoras Compounds. Arch. Toxicol. 52 71-83 (1983)
10. B.W. Wilson, J.D. Henderson, E. Chow, J.Schreider, M. Goldman, R. Culbertson and J.C. Dacre, Toxicity of an Acute Dose of Agent VX and Other Organophosphorus Esters in the Chicken. J. Toxicol. Env. Health 23 103-113 (1988)
11. J.D. Henderson, R.J. Higgins, J.C. Dacre and B.W. Wilson, Neurotoxicity of Acute and Repeated Treatments of Tabun, Paraoxon, Diisopropyl Fluorophosphate and Isofenphos to the Hen. Toxicology 72 117-129 (1992)
12. K. Husain, R. Vijayaraghavan, S.C. Pant, S.K. Raza and K.S. Pandey, Delayed Neurotoxic Effect of Sarin in Mice After Repeated Inhalation Exposure. J. Applied Toxicol. 13 143-145 (1993)
13. 13 T.Kadar, S. Shapira, G. Cohen, R. Sahar, D. Alkalay and L. Raveh, Sarin-induced Neuropathology in Rats. Human and Exp Toxicol. 14 252-259 (1995)
14. G.T. Patterson, R.C.Gupta, K.E. Misulis and W.D. Dettbarn, Prevention of Diisopropylphosphorofluoridate (DFP)-Induced Skeletal Muscle Fiber Lesions in the Rat. Toxicology 48 237-244 (1988)
15. J.P. Leonard and M.M. Salpeter, Agonist-Induced Myopathy at the Neuromuscular Junction is Mediated by Calcium. J. Cell Biology 82 811-819 (1979)
16. C.K. Meshul, Calcium Channel Blocker Reverses Anticholinesterase-Induced Myopathy. Brain Research 497 142-148 (1989)
17. D. Sket, W.D. Dettbarn, M.E. Clinton, K.E. Misulis, J. Sketelj, D. Cucke and M. Brzin, Prevention of Diisopropylphosphorofluoridate-Induced Myopathy by Botulinum Toxin Type A Blockage of Quantal Release of Acetylcholine. Acta Neuropathologia 82 134-142 (1991)
18. L. Wecker, R.E. Mrak, W-D Dettbarn, Evidence of Necrosis in Human Intercostal Muscle Following Inhalation of an Organophosphate Insecticide. Journal of Environmental Pathology Toxicology and Oncology 6 171-176 (1986)
19. J. De Bleecker, De Reuck J. and J. Willems, Neurological Aspects of Organophosphate Poisoning. Clinical Neurology and Surgery. 94 93-103 (1992)
20. H. Morita, N. Yanagisawa, T. Nakajima, M. Shimizu, H. Hirabayashi, H. Okudera, M. Nohara, Y. Midorikawa and S. Mimur, Sarin Poisoning on Matsumoto, Japan. The Lancet 346 290-293 (1995)
21. M.B. Abou-Donia, K.R. Wilmarth, A.A. Abdel-Rahman, K.F. Jensen, F.W. Oehme and T. L. Kurt, Increased Neurotoxicity Following Concurrent Exposure to Pyridostigmine bromide, DEET and Chlorpyrifos. Fund. Appl. Toxicol. 34 201-222 (1996)
22. I. Koplovitz, L.W. Harris, D.R. Anderson, W.J. Lennox. and J.R. Stewart, Reduction by Pyridostigmine Pretreatment of the Efficacy of Atropine and 2-PAM Treatment of Sarin and VX Poisoning in Rodents. Fundament. Appl. Toxicol. 18 102-106 (1992)
23. A. Friedman, D. Kaufer, J. Shemer, I. Hendler, H. Soreq, I. Tur-Kaspa, Pyridostigmine Brain Penetration Under Stress Enhances Neuronal Excitability and Induces Early Immediate Transcriptional Response. Nature Medicine. 12 1382-1385 (1996)
24. J.E. Cook, M.A. Kolka and C.B. Wenger, Chronic Pyridostigmine Bromide Administration: Side Effects Among Soldiers Working in a Desert Environment. Military Medicine. 157 250-254 (1992)
25. A.A. Amato, A. McVey, C. Cha, E.C. Matthews, C.E. Jackson, R. Kleingunther, L. Worley, E. Cornman, and K. Kagan-Hallet, Evaluation of Neuromuscular Symptoms in Veterans of the Persian Gulf War. Neurology 48 4-12 (1997)
26. R.W. Haley, J. Hom, P.S. Roland, W.B. Wilson, P.C.Van Ness, F.J. Bonte, M.D. Devous Sr, D. Mathews, J.L. Fleckenstein, F.W. Wians Jr, G.I. Wolfe and T.L. Kurt, Evaluation of Neurologic Function in Gulf War Veterans. JAMA 277 223-230 (1997)
27. B.W. Wilson, J.D. Henderson, T.P. Kellner, S.F. Mceuen, and L.C. Griffis, Acetylcholinesterase and Neuropathy Target Esterase in Chickens Treated with Acephate. Neurotoxicology 11 483-492 (1990)
28. B.W. Wilson, J.D. Henderson, T.P. Kellner, M. Goldman, R.J. Higgins and J.C. Dacre, Toxicity of Repeated Doses of Organophosphorus Esters in the Chicken. J. Toxicol. Env. Health 23 115-126 (1988)
29. P.S. Spencef, M.S. Miller, S.M. Ross, B.W. Schwab, and M.I. Sabri, Biochemical Mechanisms Underlying Primary Degeneration of Axons. In Handbook of Neurochemistry, vol. 9, ed. by Lajtha, A., pp 31-65. Plenum, New York (1985)
30. P.S. Spencer, M.C. Bischoff and H.H. Schaumburg, Neuropathological Methods for the Detection of Neurotoxic Disease. In Experimental and Clinical Neurotoxicology, ed. by Spencer, P.S. and Schaumburg, H.H., pp 296-308. Williams and Wilkins, Baltimore (1980)