Stability of free and total prostate specific antigen in serum from patients with prostate carcinoma and benign hyperplasia

Journal of Urology

Volumn 159, Issue 5, 1998, Pages 1599-1605

  Paus, Elisabeth ^a   Nilsson, Olle ^a   Børmer, Ole P ^a   Fosså, Sophie D ^a   Otnes, Brynjulf ^a   Skovlund, Eva ^a  

^a NONE

Author keywords

Prostate specific antigen; Prostatic hypertrophy; Prostatic neoplasms

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ANTIGEN DETECTION; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FLUOROMETRY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE HYPERTROPHY; PROTEIN BLOOD LEVEL; PROTEIN STABILITY; RELIABILITY;

EID: 0032451176     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005392-199805000-00051     Document Type: Article

References (23)

1. Lilja, H.: A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein. J. Clin. Invest., 76: 1899, 1985.
2. Wang, M. C., Papsidero, L. D., Kuriyama, M., Valenzuela, L. A., Murphy, G. P. and Chu, T. M.: Prostate antigen: a new potential marker for prostate cancer. Prostate, 2: 89, 1981.
3. Lilja, H., Christensson, A., Dahlen, U., Matikainen, M. T., Nilsson, O., Pettersson, K. and Lovgren, T.: Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin. Clin. Chem., 37: 618, 1991.
4. Stenman, U. H., Leinonen, J., Alfthan, H., Rannikko, S., Tuhkanen, K. and Alfthan, O.: A complex between prostate-specific antigen and alpha 1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer: assay of the complex improves clinical sensitivity for cancer. Cancer Res., 51: 222, 1991.
5. Christensson, A., Bjork, T., Nilsson, O., Dahlen, U., Matikainen, M. T., Cockett, A. T., Abrahamsson, P. A. and Lilja, H.: Serum prostate specific antigen complexed to alpha 1-antichymotrypsin as an indicator of prostate cancer. J. Urol., 150: 100, 1993.
6. Hudson, M. A., Bahnson, R. R. and Catalona, W. J.: Clinical use of prostate specific antigen in patients with prostate cancer. J. Urol., 142: 1011, 1989.
7. Oesterling, J. E.: Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J. Urol., 145: 907, 1991.
8. Stamey, T. A., Yang, N., Hay, A. R., McNeal, J. E., Freiha, F. S. and Redwine, E.: Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. New Engl. J. Med., 317: 909, 1987.
9. Catalona, W. J., Smith, D. S., Wolfert, R. L., Wang, T. J., Rittenhouse, H. G., Ratliff, T. L. and Nadler, R. B.: Evaluation of percentage of free serum prostate-specific antigen to improve specificity of prostate cancer screening. J.A.M.A., 274: 214, 1995.
10. Stenman, U. H., Hakama, M., Knekt, P., Aromaa, A., Teppo, L. and Leinonen, J.: Serum concentrations of prostate specific antigen and its complex with alpha 1-antichymotrypsin before diagnosis of prostate cancer. Lancet, 344: 1594, 1994.
11. Leinonen, J., Lovgren, T., Vornanen, T. and Stenman, U. H.: Double-label time-resolved immunofluorometric assay of prostate-specific antigen and of its complex with alpha 1-antichymotrypsin. Clin. Chem., 39: 2098, 1993.
12. Leinonen, J., Zhang, W. M. and Stenman, U. H.: Complex formation between PSA isoenzymes and protease inhibitors. J. Urol., 155: 1099, 1996.
13. Paus, E., Fosså, S. D., Nilsson, O. and Eri, M.: The ratio of free to total PSA may be influenced by handling of serum samples. Anticancer Res., 15: 2402, 1995.
14. 1-antichymotrypsin in blood samples. Urology, 48: 81, 1996.
15. Nilsson, O., Peter, A., Andersson, I., Nilsson, K. and Karlsson, B.: Antigenic determinants of prostate-specific antigen (PSA) and development of assays specific for different forms of PSA. Brit. J. Cancer, 75: 789, 1997.
16. Frengen, J., Kierulf, B., Schmid, R., Lindmo, T. and Nustad, K.: Demonstration and minimization of serum interference in flow cytometric two-site immunoassays. Clin. Chem., 40: 420, 1994.
17. Dixon, W. J.: BMDP statistical software manual. Berkeley: UCLA Press, 1992.
18. Pettersson, K., Piironen, T., Seppala, M., Liukkonen, L., Christensson, A., Matikainen, M. T., Suonpaa, M., Lovgren, T. and Lilja, H.: Free and complexed prostate-specific antigen (PSA): in vitro stability, epitope map, and development of immunofluorometric assays for specific and sensitive detection of free PSA and PSA-alpha 1-antichymotrypsin complex. Clin. Chem., 41: 1480, 1995.
19. Oesterling, J. E., Jacobsen, S. J., Klee, G. G., Pettersson, K., Piironen, T., Abrahamsson, P. A., Stenman, U. H., Dowell, B., Lovgren, T. and Lilja, H.: Free, complexed and total serum prostate specific antigen: the establishment of appropriate reference ranges for their concentrations and ratios. J. Urol., 154: 1090, 1995.
20. Mitrunen, K., Pettersson, K., Piironen, T., Bjork, T., Lilja, H. and Lovgren, T.: Dual-label one-step immunoassay for simultaneous measurement of free and total prostate-specific antigen concentrations and ratios in serum. Clin. Chem., 41: 115, 1995.
21. Prestigiacomo, A. F., Lilja, H., Pettersson, K., Wolfert, R. L. and Stamey, T. A.: A comparison of the free fraction of serum prostate specific antigen in men with benign and cancerous prostates': the best case scenario. J. Urol., 156: 350, 1996.
22. Chen, Z., Komatsu, K., Prestigiacomo, A. and Stamey, T. A.: Addition of purified prostate specific antigen to serum from female subjects: studies on the relative inhibition by alpha 2-macroglobulin and alpha 1-antichymotrypsin. J. Urol., 156: 1357, 1996.
23. Sottrup Jenson, L.: Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation. J. Biol. Chem., 264: 11539, 1989.