Cloning and functional characterization of the human norepinephrine transporter gene promoter

Journal of Neural Transmission

Volumn 105, Issue 10-12, 1998, Pages 1341-1350

  Meyer, J ^a   Wiedemann, P ^b   Okladnova, O ^a   Bruss M ^b   Staab, T ^a   Stober G ^a   Riederer, P ^a   Bonisch H ^b   Lesch, K P ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Depression; Gene expression; Norepinephrine transporter; Promoter

Indexed keywords

ANTIDEPRESSANT AGENT; CARRIER PROTEIN; ILLICIT DRUG; LUCIFERASE; NORADRENALIN; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BINDING SITE; EXON; GENE EXPRESSION; GENE TRANSFER; HOMEOSTASIS; HUMAN; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; NORADRENALIN BRAIN LEVEL; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; START CODON;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CHROMOSOME MAPPING; CLONING, MOLECULAR; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NOREPINEPHRINE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROMOTER REGIONS (GENETICS); SEQUENCE HOMOLOGY, NUCLEIC ACID; SYMPORTERS;

EID: 0032446383     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050136     Document Type: Article

References (17)

1. Brüss M, Kunz J, Lingen B, Bönisch H (1993) Chromosomal mapping of the human gene for the tricyclicantidepressant-sensitive noradrenaline transporter. Hum Genet 91: 278-280
2. Crabbe JC, Phillips TJ, Feller DJ, Hen R, Wenger CD, Lessov CN, L SG (1994) Genetic models of alcohol and drug abuse. Science 264: 1715-1723
3. Cubells JF, Kim KS, Baker H, Volpe BT, Chung Y, Houpt TA, Wessel TC, Joh TH (1995) Differential in vivo regulation of mRNA encoding the norepinephrine transporter and tyrosine hydroxylase in rat adrenal medulla and locus ceruleus. J Neurochem 65: 502-509
4. Fang H, Fei J, Ma SK, Zhu LH, Liu ZP, Cai GQ, Ye ZC, Guo LH (1998) Analysis of the 5′ flanking sequence of the human norepinephrine transporter gene. Cell Res 8: 143-149
5. Fritz JD, Lankupalle DJ, Thoreson MA, Blakely RD (1998) Cloning and chromosomal mapping of the murine norepinephrine transporter. J Neurochem 70: 2241-2251
6. Hadley D, Hoff M, Holik J, Reimherr P, Wender P, Coon H, Byerley W (1995) Manic-depression and the norepinephrine transporter gene. Hum Hered 45: 165-168
7. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy D (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1483-1487
8. Lorang D, Amara SG, Simerly RB (1993) Cell-type specific expression of catecholamine transporters in the rat brain. J Neurosci 14: 4903-4914
9. Okladnova O, Syagailo YV, Tranitz M, Stöber G, Riederer P, Mössner R, Lesch KP (1998) A promoter-associated polymorphic repeat modulates PAX-6 expression in human brain. Biochem Biophys Res Commun 248: 402-405
10. Pacholczyk T, Blakely RD, Amara SG (1991) Expression cloning of a cocaine- and anti-depressant-sensitive human noradrenaline transporter. Nature 350: 350-354
11. Pörzgen P, Bönisch H, Brüss M (1995) Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochem Biophys Res Commun 215: 1145-1150
12. Pörzgen P, Bönisch H, Hammermann R, Brüss M (1998) The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons. Biochem Biophys Acta (in press)
13. Ramamoorthy JD, Ramamoorthy S, Leibach FH, Ganapathy V (1995a) Human placental monoamine transporters as targets for amphetamines. Am J Obstet Gynecol 173: 1782-1787
14. Ramamoorthy S, Prasad PD, Kulanthaivel P, Leibach FH, Blakely RD, Ganapathy V (1995b) Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast. Biochemistry 32: 1346-1353
15. Stöber G, Nöthen MM, Pörzgen P, Brüss M, Bönisch H, Knapp M, Beckmann H, Propping P (1996) Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association with major psychiatric disorders. Am J Med Gen 67: 523-532
16. Wakade AR, Wakade TD, Poosch M, Bannon MJ (1996) Noradrenaline transport and transporter mRNA of rat chromaffin cells are controlled by dexamethasone and nerve growth factor. J Physiol (Lond) 494: 67-75
17. Xu F, Wang YM, Gainetdinov R, Jones SR, Miller GW, JH, Caron MG (1998) Norepinephrine transporter knockout mice: alterations in depression tests and cocaine reward. Soc Neurosci Abstr 24: 479