CCK-evoked hyperemia in rat gastric mucosa involves neural mechanisms and nitric oxide

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 270, Issue 2 33-2, 1996, Pages

  Heinemann, Akos ^b   Jocic, Milana ^b   Peskar, Brigitta M ^b   Holzer, Peter ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b NONE

Author keywords

acetylcholine; atropine; calcitonin gene related peptide; calcitonin gene related peptide (8 37); capsaicin; cholecystokinin; cholecystokinin octapeptide; gastric acid secretion; gastric mucosal blood flow; indomethacin; vagotomy

Indexed keywords

ACETYLCHOLINE; ATROPINE; CALCITONIN GENE RELATED PEPTIDE DERIVATIVE; CALCITONIN GENE RELATED PEPTIDE[8-37]; CAPSAICIN; CHOLECYSTOKININ OCTAPEPTIDE; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; HYPEREMIA; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ACID SECRETION; STOMACH MUCOSA BLOOD FLOW; VAGOTOMY; VAGUS REFLEX; VASODILATATION;

EID: 0029989623     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.270.2.g253     Document Type: Article

References (32)

1. Bowen, J. C., W. Pawlik, W.-F. Fang, and E. D. Jacobson. Pharmacologic effects of gastrointestinal hormones on intestinal oxygen consumption and blood flow. Surgery 78: 515-519, 1975.
2. Choa, C. C., C. P. Hsieh, and J. M. Dabney. Comparison of vascular effects of gastrointestinal hormones on various organs. Am. J. Physiol 232 (Heart Circ. Physiol. 1): H103-H109, 1977.
3. Demling, L., and M. Classen. The influence of gastrointestinal hormones on local blood flow and H-ion concentration of the human gastric mucosa. In: The Physiology of Gastric Secretion, edited by L. S. Semb and J. Myren. Oslo: Universitetsforlaget, 1968, p. 18-22.
4. Entzeroth, M., H. N. Doods, H. A. Wieland, and W. Wienen. Adrenomedullin mediates vasodilation via CGRP1 receptors, Life Sci. 56: PL19-PL25, 1994.
5. Evangelista, S., and C. A. Maggi. Protection induced by cholecystokinin-8 (CCK-8) in ethanol-induced gastric lesions is mediated via vagal capsaicin-sensitive fibres and CCK-A receptors. Br. J. Pharmacol. 102: 119-122, 1991.
6. Fara, J. W., and K. S. Madden. Effect of secretin and cholecystokinin on small intestinal blood flow distribution. Am. J. Physiol. 229: 1365-1370, 1975.
7. Gardiner, S. M., A. M. Compton, P. A. Kemp, T. Bennett, C. Bose, R. Foulkes, and B. Hughes. Antagonistic effect of human α-calcitonin gene-related peptide-(8-37) on regional hemodynamic actions of rat islet amyloid polypeptide in conscious Long-Evans rats. Diabetes 40: 948-951, 1991.
8. Green, T., and G. J. Dockray. Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea-pig. Neuroscience 25: 181-193, 1988.
9. Guth, P. H., and E. Smith. The effect of gastrointestinal hormones on the gastric microcirculation. Gastroenterology 71: 435-438, 1976.
10. B receptors of the CCK-evoked hyperaemia in rat gastric mucosa. Br. J. Pharmacol. 116: 2274-2278, 1995.
11. Holm, L., and A. Jägare. Role of prostaglandins in the regulation of gastric mucosal blood flow and acid secretion. Am. J. Physiol. 263 (Gastrointest. Liver Physiol. 26): G446-G451, 1992.
12. Holzer, P., I. T. Lippe, and R. Amann. Participation of capsaicin-sensitive afferent neurons in gastric motor inhibition caused by laparotomy and intraperitoneal acid. Neuroscience 48: 715-722, 1992.
13. Holzer, P., I. T. Lippe, M. Joci, C. Wachter, R. Erb, and A. Heinemann. Nitric oxide-dependent and -independent hyperaemia due to calcitonin gene-related peptide in the rat stomach. Br. J. Pharmacol. 110: 404-410, 1993.
14. Holzer, P., E. H. Livingston, and P. H. Guth. Sensory neurons signal for an increase in rat gastric mucosal blood flow in the face of pending acid injury. Gastroenterology 101: 416-423, 1991.
15. Holzer, P., C. Wachter, M. Joci, and A. Heinemann. Vascular bed-dependent roles of the peptide CGRP and nitric oxide in acid-evoked hyperaemia of the rat stomach. J. Physiol. Lond. 480: 575-585, 1994.
16. Király, A., G. Sütö, E. H. Livingston, P. H. Guth, S. St. Pierre, and Y. Taché. Central vagal activation by TRH induces gastric hyperemia: role of CGRP in capsaicin-sensitive afferents in rats. Am. J. Physiol. 267 (Gastrointest. Liver Physiol 30): G1041-G1049, 1994.
17. Li, D.-S., H. E. Raybould, E. Quintero, and P. H. Guth. Role of calcitonin gene-related peptide in the gastric hyperemic response to intragastric capsaicin. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G657-G661, 1991.
18. Li, Y., and C. Owyang. Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion. J. Clin. Invest. 92: 418-424, 1993.
19. Li, Y., and C. Owyang. Endogenous cholecystokinin stimulates pancreatic enzyme secretion via vagal afferent pathway in rats. Gastroenterology 107: 525-531, 1994.
20. Livingston, E. H., T. Reedy, F. W. Leung, and P. H. Guth. Computerized curve fitting in the analysis of hydrogen gas clearance curves. Am. J. Physiol. 257 (Gastrointest. Liver Physiol. 20): G668-G675, 1989.
21. Moncada, S., R. M. J. Palmer, and E. A. Higgs. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev. 43: 109-142, 1991.
22. Mulder, H., A. C. Lindh, E. Ekblad, P. Westermark, and F. Sundler. Islet amyloid polypeptide is expressed in endocrine cells of the gastric mucosa in the rat and mouse. Gastroenterology 107: 712-719, 1994.
23. Piqué, J. M., J. V. Esplugues, and B. J. R. Whittle. Endogenous nitric oxide as a mediator of gastric mucosal vasodilatation during acid secretion. Gastroenterology 102: 168-174, 1992.
24. Raybould, H. E., and Y. Taché. Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats. Am. J. Physiol. 255 (Gastrointest. Liver Physiol. 18): G242-G246, 1988.
25. Rózsa, Z., A. Varró, and G. Jancsó. Use of imnaunoblockade to study the involvement of peptidergic afferent nerves in the intestinal vase-dilatory response to capsaicin in the dog. Eur. J. Pharmacol. 115: 59-64, 1985.
26. Stroff, T., N. Lambrecht, M. Burchert, B. A. Peskar, and B. M. Peskar. Calcitonin gene-related peptide (CGRP) is involved in the protective effect of cholecystokinin (CCK)-8 against ethanol in the rat stomach (Abstract). Gastroenterology 104: A199, 1993.
27. Stroff, T., N. Lambrecht, and B. M. Peskar. Nitric oxide as mediator of the gastroprotection by cholecystokinin-8 and pentagastrin. Eur. J. Pharmacol. 260: R1-R2, 1994.
28. Sugo, S., N. Minamino, K. Kangawa, K. Miyamoto, K. Kitamura, J. Sakata, T. Eto, and H. Matsuo. Endothelial cells actively synthesize and secrete adrenomedullin. Biochem. Biophys. Res. Commun. 201: 1160-1166, 1994.
29. Takenaga, M., H. Kawasaki, A. Wada, and T. Eto. Calcitonin gene-related peptide mediates acetylcholine-induced endothelium-independent vasodilation in mesenteric resistance blood vessels of the rat. Circ. Res. 76: 935-941, 1995.
30. Thiefin, G., H. E. Raybould, F. W. Leung, Y. Taché, and P. H. Guth. Capsaicin-sensitive afferent fibers contribute to gastric mucosal blood flow response to electrical vagal stimulation. Am. J. Physiol. 259 (Gastrointest. Liver Physiol. 22): G1037-G1043, 1990.
31. Walsh, J. H. Gastrointestinal hormones. In: Physiology of the Gastrointestinal Tract (3rd ed.), edited by L. R. Johnson. New York: Raven, 1994, p. 1-128.
32. Whittle, B. J. R., and J. R. Vane. Prostanoids as regulators of gastrointestinal function. In: Physiology of the Gastrointestinal Tract (2nd ed.), edited by L. R. Johnson. New York: Raven, 1987, p. 143-180.