β-carotene concentration in buccal mucosal cells with and without dysplastic oral leukoplakia after long-term β-carotene supplementation in male smokers

European Journal of Clinical Nutrition

Volumn 52, Issue 12, 1998, Pages 872-876

  Liede, K E ^a   Alfthan, G ^b   Hietanen, J H P ^a   Haukka, J K ^b   Saxen, L M ^a   Heinonen, O P ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Dysplasia; Long term supplementation; Oral mucosa; carotene

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE;

ADULT; AGED; ARTICLE; CANCER PREVENTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DYSPLASIA; HISTOPATHOLOGY; HUMAN; HYPERKERATOSIS; LEUKOPLAKIA; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MOUTH MUCOSA; MUCOSA CELL; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; SMOKING;

EID: 0032445130     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1600646     Document Type: Article

References (41)

1. Albanes D, Virtamo J, Rautalahti M, Haukka J, Palmgren J, Gref CG & Heinonen OP (1992): Serum beta-carotene before and after beta-carotene supplementation. Eur. J. Clin. Nutr. 46, 15-24.
2. Albanes D, Heinonen OP, Taylor PR, Virtamo J, Edwards BK, Rautalahti M, Hartman AM, Palmgren J, Freedman LS, Haapakoski J, Barrett MJ, Pietinen P, Malila N, Tala E, Liippo K, Salomaa EJ, Tangrea J, Teppo L, Askin FB, Taskinen E, Erozan Y, Greenwald PR & Huttunen J (1996): Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the Alpha-Tocopherol, Beta-carotene Cancer Prevention Study: effects of base-line characteristics and study compliance. J. Natl. Cancer Inst. 88, 1560-1570.
3. ATBC Study Group (The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group) (1994a): The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330, 1029-1035.
4. ATBC Study Group (1994b): The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics and compliance. Ann. Epidemiol. 4, 1-10.
5. Axéll T (1976): A prevalence study of oral mucosal lesions in an adult Swedish population. Odontolist Revy 27, Suppl. 36, 43-68.
6. Brown ED, Micozzi MS, Craft NE, Bieri JG, Beecher G, Edwards BK, Rose A, Taylor PR & Smith JC Jr (1989): Plasma carotenoids in normal men after a single ingestion of vegetables or purified beta-carotene. Am. J. Clin. Nutr. 49, 1258-1265.
7. Benner Se, Winn RJ, Lippman SM, Poland J, Hansen KS, Luna MA & Hong WK (1993): Regression of oral leukoplakia with alpha-tocopherol: a community clinical oncology program chemoprevention study. J. Natl. Cancer Inst. 85, 44-47.
8. Byers TE, Graham S, Haughey BP, Marshall JR & Swanson MK (1987): Diet and lung cancer risk: findings from the Western New York Diet Study. Am. J. Epidemiol. 125, 351-362.
9. Chow CK, Thacker RR, Changchit C, Bridges RB, Rehm SR, Humble J & Turbek J (1986): Lower levels of vitamin C and carotene in plasma of cigarette smokers. J. Am. Coll. Nutr. 5, 305-312.
10. Comstock GW, Menkes MS, Schober SE, Vuillemier JP & Helsing KJ (1987): Serum levels of retinol, beta-carotene, and alpha-tocopherol in older adults. Am. J. Epidemiol. 127, 114-123.
11. Cooney RV, Bertram JS, Hankin JH, Kolonel LN, Miyake A, Billings K & Bourne W (1991): Relationship between dietary, serum, and tissue levels of carotenoids. Cancer Lett. 61, 81-87.
12. Davis C, Brittain E, Hunninghake D, Graves K, Buzzard M & Tyroler H (1983): Relation between cigarette smoking and carotene in candidates for the Lipid Research Clinics Coronary Prevention Trial. Am. J. Epidemiol. 118, 445 (abstract).
13. Garewal HS & Schantz S (1995): Emerging role of beta-carotene and antioxidant nutrients in prevention of oral cancer. Arch. Otolaryngol. Head Neck Surg. 121, 141-144.
14. Garewal HS, Meyskens FL Jr, Killen D, Reeves D, Kiersch TA, Elletson H, Strosberg A, King D & Steinbrann K (1990): Response of oral leukoplakia to beta-carotene. J. Clin. Oncol. 8, 1715-1720.
15. Gilbert AM, Stich HF, Rosin MP & Davison AJ (1990): Variations in the uptake of beta-carotene in the oral mucosa of individuals after 3 days of supplementation. Int. J. Cancer 45, 855-859.
16. Johnson EJ & Russel RM (1992): Distribution of orally administered beta-carotene among lipoproteins in healthy men. Am. J. Clin. Nutr. 56, 128-135.
17. Kaugars GE, Silverman S Jr, Lovar JG, Brandt RB, Riley WT, Dao Q, Singh VN & Gallo J (1994): A clinical trial of antioxidant supplements in the treatment of oral leukoplakia. Oral Surg. Oral Med. Oral Pathol. 78, 462-468.
18. Kramer IR, Lucas RB, Pindborg JJ & Sobin LH (1978): Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg. Oral Med. Oral Pathol. 46, 518-539.
19. Kramer IR, Pindborg JJ, Bezroukov V & Infirri JS (1980): Guide to epidemiology and diagnosis of oral mucosal diseases and conditions. World Health Organization. Community Dent. Oral Epidemiol. 8, 1-26.
20. Liede K, Hietanen J, Saxen L, Haukka J, Timonen T, Häyrinen-Immonen R & Heinonen OP (1998): Long-term supplementation with alpha-tocopherol and beta-carotene and prevalence of oral mucosal lesions in smokers. Oral Dis. 4: 78-83.
21. Lippman SM, Batsakis JG, Toth BB, Weber RS, Lee JJ, Martin JW, Hays GL, Goepfert H & Hong WK (1993): Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis. N. Engl. J. Med. 328, 15-20.
22. McCullagh P & Nellder JA (1989): Generalized Linear Models. Likelihood-ratio Test, p 33. London: Chapman & Hall.
23. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR & Smith JC Jr (1992): Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Am. J. Clin. Nutr. 55, 1120-1125.
24. Murata T, Tamai H, Morinobu T, Manago M, Takenaka A, Takenaka H & Mino M (1992): Determination of β-carotene in plasma, blood cells and buccal mucosa by electrochemical detection. Lipids 27, 840-843.
25. Nierenberg DW & Nann SL (1992): A method for determining concentrations of retinol, tocopherol and five carotenoids in human plasma and tissue samples. Am. J. Clin. Nutr. 56, 417-426.
26. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr, Barnhart S, Cherniack MG, Brodkin CA & Hammar S (1996a): Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med. 334, 1150-1155.
27. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Mayskens FL, Valanis B, Williams JH Jr, Barnhart S & Hammar S (1996b): Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. J. Natl Cancer Inst. 88, 1550-1559.
28. Peng Y-S, Peng Y-M, McGee DL & Alberts DS (1994): Carotenoids, tocopherols, and retinoids in human buccal mucosal cells: intra- and interindividual variability and storage stability. Am. J. Clin. Nutr. 59, 636-643.
29. Peng Y-M, Peng Y-S, Lin Y, Moon T, Roe DJ & Ritenbaugh C (1995): Concentrations and plasma-tissue-diet relationships of carotenoids, retinoids and tocopherols in humans. Nutr. Cancer 23, 233-246.
30. Peto R, Doll R, Buckley JD & Sporn MB (1981): Can dietary beta-carotene materially reduce human cancer rates? Nature 290, 201-208.
31. Russell-Briefel R, Bates MW & Kullner LH (1985): The relationship of plasma carotenoids to health and biochemical factors in middle-aged men. Am. J. Epidemiol. 122, 741-749.
32. Shklar G, Schwartz J, Trickler DP & Niukian K (1987): Regression by vitamin E of experimental cancer. J Natl Cancer Inst. 78, 987-992.
33. Shklar G, Schwartz JL, Trickler DP & Reid S (1990): Prevention of experimental cancer and immunostimulation by vitamin E (immunosurveillance). J. Oral Pathol. Med. 19, 60-64.
34. Stich HF, Hornby AP & Dunn BP (1986): Beta-carotene levels in exfoliated human mucosa cells following its oral administration. Cancer Lett. 30, 133-141.
35. Stich HF, Rosin MP, Hornby AP, Mathew B, Sankaranarayanan R & Nair MK (1988): Remission of oral leukoplakias and micronuclei in tobacco/ betel quid chewers treated with beta-carotene and with beta-carotene plus vitamin A. Int. J. Cancer 42, 195-199.
36. Stryker WS, Kaplan LA, Stein EA, Stampfer MJ, Sober A & Willett WC (1988): The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels. Am. J. Epidemiol. 127, 283-296.
37. Toma S, Benso S, Albanese E, Palumbo R, Cantoni E, Nicolò G & Mangiante P (1992): Treatment of oral leukoplakia with beta-carotene. Oncology 49, 77-81.
38. Willett WH, Stampfer MJ, Underwood BA, Taylor JO & Hennekens CH (1983): Vitamins A, E, and carotene: effects of supplementation on their plasma levels. Am. J. Clin. Nutr. 38, 559-566.
39. Witter FR, Blake DA, Baumgardner R, Mellits ED & Niebyl JR (1982): Folate, carotene, and smoking. Am. J. Obstet. Gynecol. 144, 857.
40. WHO (1987): Oral Health Surveys, Basic Methods, p 43. Geneva: World Health Organization.
41. Zaridze D, Evstifeeva T & Boyle P (1993): Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer. Ann. Epidemiol. 3, 225-234.