Long-term supplementation with alpha-tocopherol and beta-carotene and prevalence of oral mucosal lesions in smokers

Oral Diseases

Volumn 4, Issue 2, 1998, Pages 78-83

  Liede, K ^a   Hietanen, J ^a   Saxen, L ^a   Haukka, J ^b   Timonen, T ^a   Hayrinen Immonen R ^a   Heinonen, O P ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Beta carotene; Mouth mucosa; Preventive medicine; Smoking; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE;

ADULT; AGED; ARTICLE; DIET SUPPLEMENTATION; DYSPLASIA; HUMAN; HYPOTHESIS; LEUKOPLAKIA; MAJOR CLINICAL STUDY; MALE; MOUTH LESION; MOUTH MUCOSA; PREVALENCE; PRIORITY JOURNAL; SMOKING;

EID: 0031801231     PISSN: 1354523X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1601-0825.1998.tb00261.x     Document Type: Article

References (50)

1. Axéll T (1976). A prevalence study of oral mucosal lesions in an adult Swedish population. Odontologisk Revy 27: 43-68.
2. Axéll T, Holmstrup P, Kramer IRH et al (1984). International seminar on oral leukoplakia and associated lesions related to tobacco habits. Community Dent Oral Epidemiol 12: 145-154.
3. Bánóczy J (1977). Follow-up studies in oral leukoplakia. J Maxillofac Surg 5: 69-75.
4. Bánóczy J (1982). Oral leukoplakia. Martinus Nijhoff Publishers; Budapest, pp 28-37.
5. Baric JM, Alman JE, Feldman RS et al (1982). Influence of cigarette, pipe, and cigar smoking, removable partial dentures, and age on oral leukoplakia. Oral Surg Oral Med Oral Pathol 54: 424-429.
6. Benner SE, Winn RJ, Lippman SM et al (1993). Regression of oral leukoplakia with alpha-tocopherol: a community clinical oncology program chemoprevention study. J Natl Cancer Inst 85: 44-47.
7. Bouquot JE, Gorlin RJ (1986). Leukoplakia, lichen planus and other oral keratoses in 23 616 white Americans over the age of 35 years. Oral Surg Oral Med Oral Pathol 61: 373-381.
8. Bouquot J, Weiland L, Ballard D et al (1988). Leukoplakia of the mouth and pharynx in Rochester, MN 1935-1984: Incidence, clinical features and follow-up of 463 patients from a relatively unbiased patient pool. J Oral Pathol 17: 436.
9. Bouquot JE, Whitaker SB (1994). Oral leukoplakia-Rationale for diagnosis and prognosis of its clinical subtypes or 'phases'. Quintessence Int 25: 133-140.
10. Calder JH, Curtis RC, Fore H (1963). Comparison of vitamin C in plasma and leukocytes of smokers and nonsmokers. Lancet 1: 556.
11. Chow CK, Thacker RR, Changchit C (1986). Lower levels of vitamin C and carotene in plasma of cigarette smokers. J Am Coll Nutr 5: 305-312.
12. Christen AG, McDonald JL, Christen JA (1991). The impact of tobacco use and cessation on nonmalignant and precancerous oral and dental diseases and conditions. Indiana University School of Dentistry, Indianapolis, pp 1-73.
13. Conover WJ (1980). Practical Nonparametric Statistics. 2nd ed. John Wiley & Sons: New York, p 91.
14. Diplock AT (1984). Vitamin E, selenium and free radicals. Med Biol 62: 78-80
15. Dunsche A, Kreusch T, Sauer M (1992). Die Leukoplakie der Mundschleimhaut-eine retrospektive Studie an 161 Patienten. Dtsch Zahnärztl Z 47: 869-871.
16. Garewal HS, Meyskens FL Jr, Killen D et al (1990). Response of oral leukoplakia to beta-carotene. J Clin Oncol 8: 1715-1720.
17. Garewal HS (1993). Beta-carotene and vitamin E in oral cancer prevention. J Cell Biochem Suppl 17: 262-269.
18. Garewal HS, Schantz S (1995). Emerging role of betacarotene and antioxidant nutrients in prevention of oral cancer. Arch Otolaryngol Head Neck Surg 121: 141-144.
19. Hajdu SI (1977). Cytology from antiquity to Papanicolaou. Acta Cytol 21: 668-676.
20. Hennekens CH, Buring JE, Peto R (1994). Antioxidant vitamins-benefits not yet proved. N Engl J Med 330: 1080-1081.
21. Jha P, Flather M, Lonn E et al (1995). The antioxidant vitamins and cardiovascular disease. A critical review of epidemiologic and clinical trial data. Ann Intern Med 123: 860-872.
22. Kaugars GE, Silverman S Jr, Lovas JG et al (1994). A clinical trial of antioxidant supplements in the treatment of oral leukoplakia. Oral Surg Oral Med Oral Pathol 78: 462-468.
23. Kramer IR, Lucas RB, Pindborg JJ et al (1978). Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol 46: 518-539.
24. Kramer IR, Pindborg JJ, Bezroukov V et al (1980). Guide to epidemiology and diagnosis of oral mucosal diseases and conditions. World Health Organization. Community Dent Oral Epidemiol 8: 1-26.
25. Krinsky NI, Deneke SM (1982). Interaction of oxygen and oxyradicals with carotenoids. J Natl Cancer Inst 69: 205-210.
26. La Vecchia C, Negri E, D'Avanzo B et al (1991). Dietary indicators of oral and pharyngeal cancer. Int J Epidemiol 20: 39-44.
27. Lind PO (1987). Malignant transformation in oral leukoplakia. Scand J Dent Res 95: 449-455.
28. Lippman SM, Batsakis JG, Toth BB et al (1993). Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis. N Engl J Med 328: 15-20.
29. Malaker K, Anderson BJ, Beecroft WA et al (1991). Management of oral mucosal dysplasia with betacarotene retinoic acid: A pilot cross-over study. Cancer Detect Prev 15: 335-340.
30. McCullagh P, Nellder JA (1989). Generalized linear models. In: Likelihood-ratio test. Chapman & Hall: London, p 33.
31. Omenn GS, Goodman GE, Thornquist MD et al (1996a). Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334: 1150-1155.
32. Omenn GS, Goodman GE, Thornquist MD et al (1996b). Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. J Natl Cancer Inst 88: 1550-1559.
33. Roed-Petersen B, Banoczy J, Pindborg JJ (1973). Smoking habits and histological characteristics of oral leukoplakias in Denmark and Hungary. Br J Cancer 28: 575-579.
34. Shklar G, Schwartz J, Trickler DP et al (1987). Regression by vitamin E of experimental cancer. J Natl Cancer Inst 78: 987-992.
35. Shklar G, Schwartz JL, Trickler DP er al (1990). Prevention of experimental cancer and immunostimulation by vitamin E (immunosurveillance). J Oral Pathol Med 19: 60-64.
36. Shklar G, Schwartz J (1993). Oral cancer inhibition by micronutrients. The experimental basis for clinical trials. Eur J Cancer B Oral Oncol 29B: 9-16.
37. Silverman S. JR, Gorsky M, Lozada F (1984). Oral leukoplakia and malignant transformation: a follow-up study of 257 patients. Cancer 53: 563-568.
38. Stich HF, Rosin MP, Hornby AP et al (1988). Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta-carotene and with beta-carotene plus vitamin A. Int J Cancer 42: 195-199.
39. Stryker WS, Kaplan LA, Stein EA et al (1988). The relation of diet, cigarette smoking, and alcohol consumption to plasma beta-carotene and alpha-tocopherol levels. Am J Epidemiol 127: 283-296.
40. Suda D, Schwartz J, Shklar G (1986). Inhibition of experimental oral carcinogenesis by topical beta carotene. Carcinogenesis 7: 711-715.
41. Takahashi M, Tsuchiya J, Niki E (1989). Mode of action of vitamin E as antioxidant in the membranes as studied by spin labeling. Ann NY Acad Sci 570: 521-523.
42. The Alpha-tocopherol, Beta Carotene Cancer Prevention Study Group (1994). The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330: 1029-1035.
43. The ATBC Cancer Prevention Study Group (1994). The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics and compliance. Ann Epidemiol 4: 1-10.
44. Toma S, Benso S, Albanese E et al (1992). Treatment of oral leukoplakia with beta-carotene. Oncology 49: 77-81.
45. Waldron CA, Shafer WG (1975). Leukoplakia revisited. A clinicopathologic study of 3256 oral leukoplakias. Cancer 36: 1386-1392.
46. Winn DM, Ziegler RG, Pickle LW et al (1984). Diet in the etiology of oral and pharyngeal cancer among women from the Southern US. Cancer Res 44: 1216-1222.
47. Witter FR, Blake DA, Baumgardner R et al (1982). Folate, carotene, and smoking. Am J Obstet Gynecol 144: 857.
48. World Health Organization (1987). Oral Health Surveys. Basic Methods, WHO.
49. Zaridze D, Evstifeeva T, Boyle P (1993) Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer. Ann Epidemiol 3: 225-234.
50. Zheng T, Boyle P, Willet WC et al (1993). A case-control study of oral cancer in Beijing, People's republic of China. Associations with nutrient intakes, foods and food groups. Eur J Cancer B Oral Oncol 29B: 45-55.