Ipsapirone, a 5-HT(1A) agonist, suppresses REM sleep equally in unmedicated depressed patients and normal controls

Neuropsychopharmacology

Volumn 15, Issue 2, 1996, Pages 109-115

  Gillin, J Christian ^a,b   Sohn, Jin Wook ^a   Stahl, Stephen M ^a   Lardon, Michael ^a   Kelsoe, John ^a   Rapaport, Mark ^a   Ruiz, Caroline ^a   Golshan, Shah ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Mood disorder; REM latency; Serotonin

Indexed keywords

ANTIDEPRESSANT AGENT; BUSPIRONE; CLOMIPRAMINE; FLESINOXAN; HYDROCORTISONE; IPSAPIRONE; PROLACTIN; SEROTONIN 1A RECEPTOR; SEROTONIN AGONIST; PYRIMIDINE DERIVATIVE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN TISSUE; LATENT PERIOD; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR DOWN REGULATION; REM SLEEP; SLEEP TIME; CHEMICAL PHENOMENA; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; POLYSOMNOGRAPHY; PSYCHOLOGICAL ASPECT; SLEEP STAGE;

ADULT; DEPRESSION, CHEMICAL; DEPRESSIVE DISORDER; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; POLYSOMNOGRAPHY; PYRIMIDINES; SEROTONIN AGONISTS; SLEEP STAGES; SLEEP, REM;

EID: 0030201336     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0893-133X(95)00159-B     Document Type: Article

References (45)

1. Anderson IM, Ware CJ, Da Roza Davis JM, Cowen PJ (1992): Decreased 5-HT mediated prolactin release in depression. Br J Psychiatr 160:372-378
2. 2 receptors in suicide victims. Biol Psychiatr 35:457-463
3. Benca RM, Obermeyer WH, Thisted RA, Gillin JC (1992): Sleep and psychiatric disorders: A meta-analysis. Arch Gen Psychiatr 49:651-668
4. Berger M, Lund R, Bronisch T. von Zerrsen D (1983): REM latency in neurotic and endogenous depression and the cholinergic REM induction test. Psychiatr Res 10:113-123
5. Berger M, Riemann D, Hoechi D, Spiegel R (1989): The cholinergic REM induction test with RS 86: State or trait marker for depression. Arch Gen Psychiatr 46:421-428
6. Bhatti T, Gillin JC, Golshan S, Clark C, Demodena A, Schlosser A, Stahl SM, Kelsoe J, Rapaport MH (1995): The effect of a tryptophan-free amino acid drink on sleep and mood in normal controls. Sleep Res 24:153 (Abstract)
7. Buzsaki G, Bickford R, Ponomareff G, Thal LJ, Mandel R, Gage FH (1988): Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J Neurosci 8:4007-4026
8. 1 binding sites in depressed suicides. Psychopharmacology 102:544-548
9. 1A receptor sensitivity in major depression. A neuroendocrine study with buspirone. Br J Psychiatr 164:372-379
10. Curtis D, Sherrington R, Brett P, Holmes DS, Kalsi G, Brynjolfsson J, Petursson H, Rifkin L, Murphy P, Moloney E, Melmer G, Gurling HMD (1993): Genetic linkage analysis of manic depression in Iceland. J Roy Soc Med 86:506-510
11. 2 receptor sensitivity in generalized anxiety disorder: A pilot study with ritanserin. Psychopharmacology (Berl) 108:387-389
12. 2 receptor sensitivity in recovered depressed patients. J Affect Disord 24:177-182
13. 1a-agonists on the sleep-wakefulness cycle in rats. In Koelle WP, Obal F, Schulz H, Visser P (eds), Sleep 86. New York: Gustav Fischer, pp 346-348
14. 2 receptors in the regulation of sleep and wakefulness in the rat. Psychopharmacology 97:436-442
15. 1A agonist and antagonist drug administration in behaving cats. JPET 270:1345-1358
16. 1A agonist, in normal volunteers. Psychopharmacology 116:433-436
17. 1A receptor agonist, in treatment-resistant depression. Int Clin Psychopharmacol 8(3):167-172
18. Jones BE (1991): Paradoxical sleep and its chemical/structural substrates in the brain. Neuroscience 40:637-656
19. Lawlor BA, Newhouse PA, Balkin TJ, Molchan SE, Mellow AM, Murphy DL, Sunderland TA (1991): A preliminary study of the effects of nighttime administration of the serotonin agonist, m-CPP, on sleep architecture and behavior in healthy volunteers. Biol Psychiatr 29:281-286
20. Lerman JA, Kaitin KA, Dement WC, Peroutka SJ (1986): The effects of buspirone on sleep in the rat. Neurosci Lett 72:64-68
21. 1A) receptor activation: Effects of 5-HT receptor and beta-adrenergic antagonists. J. Clin Endocrinol Metab 70:670-674.
22. 1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression. Life Sci 46(18): 1271-1277
23. 7) implicated in the regulation of mammalian circadian rhythms. Neuron 11:449-458
24. Luebke JI, Greene RW, Semba K, Kamondi A, McCarley RW, Reiner PB (1992): Serotonin hyperpolarizes cholinergic low-threshold burst neurons in the rat laterodorsal tegmental nucleus in vitro. Proc Natl Acad Sci U S A 89:743-747
25. McGinty DJ, Harper RM (1976): Dorsal raphe neurons: Depression of firing during sleep in cats. Brain Res 101: 569-575
26. Meltzer HY, Maes M (1994): Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects. Biol Psychiatr 35(5):316-323
27. Moeller FG, Steinberg JL, Fulton M, Kramer G, Petty F (1994): A preliminary neuroendocrine study with buspirone in major depression. Neuropsychopharmacology 10:75-83
28. Quattrochi JJ, Mamelak AN, Binder D, Williams J, Hobson JA (1993): Dose-related suppression of REM sleep and PGO waves by the serotonin-1 agonist eltoprazine. Neuropsychopharmacology 8:7-13
29. 1A agonist gepirone in depressed patients. Biol Psychiatr 28:73-78
30. Rechtschaffen A, Kales A (1968): A manual of standard techniques and scoring system for sleep stages in human subjects. Washington, DC, U.S. Government Printing Office
31. Riemann D, Hohagan F, Bahro M, Berger M (1994): Sleep in depression: The influence of age, gender and diagnostic subtype on baseline sleep and the cholinergic REM induction test with RS 86. Eur Arch Psychiatr Clin Neurosci 243:279-290
32. 1A partial agonists in depression: A composite analysis of buspirone in the treatment of depression. J Clin Psychopharmacol 10(3): 67S-76S
33. Sanford LD, Seggos AE, Ross RJ, Morrison AR, Ball WA, Mann EL (1994): Central administration of two 5-HT receptor agonists: Effects on REM sleep initiation and PGO waves. Pharmacol Biochem Behavior 49:93-100.
34. Schittecatte M, Ansseau M, Charles G, Machowski R, Papart P, Pichot W, Wilmotte J (1992): Growth hormone response to clonidine in male patients with panic disorder untreated by antidepressants. Psychol Med 22:1059-1062
35. Schreiber W, Lauer CJ, Krumrey K, Holsboer F, Krieg JC (1992): Cholinergic REM sleep induction test in subjects at high risk for psychiatric disorders. Biol Psychiatr 32:79-90
36. Seidel WF, Cohen SA, Bliwise NG, Dement WC (1985): Buspirone: An anxiolytic without sedative effect. Psychopharmacol 87:371-373
37. 2 receptor sensitivity during maintenance tricyclic antidepressant treatment. J Affect Dis 19:273-277
38. Shiromani PJ, Armstrong DM, Gillin JC (1988): Cholinergic neurons from the dorsolateral pons project to the medial pons: A WGA-HRP and choline acetyltransferase immunohistochemical study. Neurosci Lett 95:19-23
39. Siegel JM (1989): Brainstem mechanisms generating REM sleep. In Kryger MH, Roth T, Dement WC (eds), Principles and Practice of Sleep Medicine. Philadelphia, Saunders, pp 104-120
40. Sitaram N, Nurnberger J, Gershon E, Gillin JC (1980): Faster cholinergic REM sleep induction in euthymic patients with primary affective illness. Science 108:200-202
41. Stahl SM (1992): Neuroendocrine markers of serotonin responsivity in depression. Prog Neuropsychopharmacol Biol Psychiatr 16(5):655-659
42. 2 receptor antagonism and slow-wave sleep in major depression. Acta Psychiatr Scand 86(2):133-137
43. Steriade M, McCarley RW (1990): Brainstem Control of Wakefulness and Sleep. New York: Plenum
44. Steriade M, Dossi RC, Nunez A (1991): Network modulation of a slow intrinsic oscillation of cat thalamocortkal neurons implicated in sleep delta waves: Cortically induced synchronization and brainstem cholinergic suppression. J Neurosci 11:3200-3217
45. 2C receptor sensitivity during treatment with selective serotonin reuptake inhibitors. J Psychopharmacol 8:168-170