Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs

Cytotechnology

Volumn 27, Issue 1-3, 1998, Pages 71-79

  Váradi, András ^a   Tusnády, Gábor E ^a   Bakos, Éva ^a   Sarkadi, Balázs ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

ABC transporters; Topology prediction; Transmembrane domains

Indexed keywords

MEMBRANE STRUCTURE; MULTIDRUG RESISTANCE; MULTIDRUG RESISTANCE PROTEIN;

EID: 0032444409     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-94-017-2374-9_4     Document Type: Article

References (41)

1. Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM and Deeley RG (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654.
2. Loe DW, Deeley RG and Cole SP (1996) Biology of the multidrug resistance-associated protein, MRP. Eur J Cancer 32A: 945-957.
3. Barrand MA, Bagrij T and Neo SY (1997) Multidrug resistance-associated protein: a protein distinct from P-glycoprotein involved in cytotoxic drug expulsion. Gen Pharmacol 28: 639-645.
4. Lautier D, Canitrot Y, Deeley RG and Cole S P (1996) Multidrug resistance mediated by the multidrug resistance protein (MRP) gene. Biochem Pharmacol 52: 967-977.
5. Cole SP and Deeley RG (1996) Multidrug resistance associated with overexpression of MRP. In: Drug Resistance, Hait, WN (ed) pp. 39-62, Kluwer Academic Press, Norwell, MA.
6. Zaman GJ, Flens MJ, van Leusden MR, de Haas M, Mulder HS, Lankelma J, Pinedo HM, Scheper RJ, Baas F and Broxterman HJ, et al. (1994) The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Proc Natl Acad Sci USA 91: 8822-8826.
7. Jedlitschky G, Leier I, Buchholz U, Center M and Keppler D (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res 54: 4833-4836.
8. Zaman GJ, Lankelma J, van Tellingen O, Beijnen J, Dekker H, Paulusma C, Oude Elferink RP, Baas F and Borst P (1995) Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc Natl Acad Sci USA 92: 7690-7694.
9. Hollo Z, Homolya L, Hegedus T, Sarkadi B (1996) Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells. FEBS Lett 383: 99-104.
10. Decottignies A and Goffeau A (1996) Complete inventory of the yeast ABC proteins. Nature Genetics 15: 137-145.
11. Szczypka MS, Wemmie JA, Moye-Rowley WS and Thiele DJ (1994) A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein. J Biol Chem 269: 22853-22857.
12. Li ZS, Szczypka M, Lu YP, Thiele DJ and Rea PA (1996) The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J Biol Chem 271: 6509-6517.
13. Cui Z, Hirata D, Tsuchiya E, Osada H and Miyakawa T (1996) The multidrug resistance-associated protein (MRP) subfamily (Yrsl/Yorl) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions. J Biol Chem 271: 14712-14716.
14. Broeks A, Gerrard B, Allikmets R, Dean M and Plasterk RH (1996) Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J 15: 6132-6143.
15. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement IV, JP, Boyd III, AE, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J and Nelson DA (1995) Cloning of the b-cell high-affinity sulfonylurea receptor: a reulator of insulin secretion. Science 268: 423-426.
16. Inagaki N, Gonoi T, Clement IV, JP, Wang C-Z, Aguilar-Bryan L, Bryan J and Seino S (1996) A family of sulfonylurea receptors determines yhe pharmacological properties of ATP-sensitive K+channels. Neuron 16: 1011-1017.
17. Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper RJ, Borst P and Elferink RPJO (1996) Congenital jaundice in ratss with mutation in a multidrug resistance-associated protein gene. Science 271: 1126-1128.
18. Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T and Keppler D (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resitance-associated protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutants rat. J Biol Chem 271: 15091-15098.
19. van Kuijck MA, van Aubel RA, Busch AE, Lang F, Russel FG, Bindels RJ, van Os CH and Deen PM (1996) Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter. Proc Natl Acad Sci USA 93: 5401-5406.
20. Allikmets R, Gerrard B, Hutchinson A and Dean M (1996) Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the Expressed Sequence Tags database. Human Molecular Genetics 5: 1649-1655.
21. Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJT, Juijn JA, Baas F and Borst P (1997) Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5, homologs of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57: 3537-3547.
22. Hipfner DR, Gauldie SD, Deeley RG, Cole SP(1994) Detection of the M(r) 190 000 multidrug resistance protein, MRP, with monoclonal antibodies. Cancer Res 54: 5788-5792.
23. Hipfner DR, Almquist KC, Stride BD, Deeley RG and Cole SP (1996) Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1. Cancer Res 56:3307-3314.
24. Flens MJ, Izquierdo MA, Scheffer GL, Fritz JM, Meijer CJ, Scheper RJ and Zaman GJ (1994) Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res 54: 4557-4563.
25. Bakos E, Hegedus T, Hollo Zs, Welker E, Tusnädy GE, Zaman G, Scheper RJ, Väradi A and Sarkadi B (1996) Membrane topolgy and glycosylation of the human multidrug resistance associated protein (MRP) J Biol Chem 271: 12322-12326.
26. Fasman GD and Gilbert WA (1990) The prediction of transmembrane protein sequences and their conformation: an evaluation. TIBS 15: 89-92.
27. Keppler D and Konig J (1997) Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J 11: 509-516.
28. Stride BD, Valdimarsson G, Gerlach JH, Wilson GM, Cole SP and Deeley RG (1996) Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter. Mol Pharmacol 49: 962-971.
29. Chang X-B, Hou Y-X, Jensen TJ and Riordan JR ( 1994) Mapping of cystic fibrosis transmembrane conductance regulator membrane topology by glycosylation site insertion. J Biol Chem 269: 18572-18575.
30. Paul S, Breuninger LM, Kruh GD (1996) ATP-dependent transport of lipophilic cytotoxic drugs by membrane vesicles prepared from MRP-overexpressing HL60/ADR cells. Biochemistry 35: 14003-14011.
31. Hipfner DR, Almquist, KC, Leslie EM, Gerlach JH, Grant, CE, Deeley RG and Cole SPC (1997) Membrane topolgy of the multidrug resitance protein (MRP). J Biol Chem 272: 23623-23630.
32. Kast C and Gros P (1997) Topology mapping of the aminoterminal half of the multidrug resitance-associated protein by epitop insertion and immunofluorescence J Biol Chem 272: 26479-26487.
33. Gao M, Loe DW, Grant CE, Cole SPC and Deeley RG (1996) Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells. J Biol Chem 271: 27782-27787.
34. Tusnády GE, Bakos É, Váradi A and Sarkadi B (1997) Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters. FEBS Letters 402: 1-3.
35. Von Heijne G (1992) Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule. J Mol Biol 225: 487-494.
36. Ortiz DF, Kreppel L, Speiser DM, Scheel G, McDonald G and Ow DW (1992) Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter. EMBO J 11: 3491-3499.
37. Tommasini R, Evers R, Vogt E, Mornet C, Zaman GJ, Schinkel AH, Borst P and Martinoia E (1996) The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1. Proc Natl Acad Sci USA 93: 6743-6748.
38. Katzmann DJ, Hallstrom TC, Voet M, Wysock W, Golin J, Volckaert G and Moye-Rowley WS (1995) Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol 15: 6875-6883.
39. Klugbauer N and Hofmann F (1996) Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein. FEBS Lett 391: 61-65.
40. Suzuki T, Nishio K, Sasaki H, Kurokawa H, Saito-Ohara F, Ikeuchi T, Tanabe S, Terada M and Saijo N (1997) cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line. Biophys Biochem Res Commun 238: 790-794.
41. Tusnády GE and Váradi A (1998) Short MRP may not be short. Biochem Biophys Res Commun 242: 465-466.