Prevention and treatment of hypoglycaemia unawareness in type 1 diabetes mellitus

Acta Diabetologica

Volumn 35, Issue 4, 1998, Pages 183-193

  Bolli, G B ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Cognitive function; Counter regulation; Hypoglycaemia unawareness; Insulin therapy; Intensive therapy

Indexed keywords

INSULIN; INSULIN LISPRO;

BLOOD GLUCOSE MONITORING; COGNITION; CONFERENCE PAPER; DIABETES CONTROL; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; IATROGENIC DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; PATIENT EDUCATION; PREVENTION; PRIORITY JOURNAL;

AWARENESS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; HUMANS; HYPOGLYCEMIA;

EID: 0032443594     PISSN: 09405429     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005920050129     Document Type: Conference Paper

References (50)

1. Gerich J, Mokan M, Veneman T, Korytkowski M, Mitrakou A (1991) Hypoglycemia unawareness. Endo Rev 12:356-371
2. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986
3. Shade DS, Santiago JV, Skyler JS, Rizza RA (1993) Intensive insulin therapy. Excerpta Medica, Amsterdam
4. 1c, risk for severe and mild hypoglycaemia, status of counterregulation and unawareness of hypoglycaemia. Diabetologia 39:677-686
5. Amiel S, Archibald H, Chusney G, Williams A, Gale E (1991) Ketone infusion lowers hormonal responses to hypoglycaemia: evidence for acute cerebral utilization of a non-glucose fuel. Clin Sci 81:189-194
6. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J (1994) Effect of hyperketonemia and hyperlactacidemia on symptoms, cognitive dysfunction and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes 43:1311-1317
7. Maran A, Cranston I, Lomas J, Macdonald I, Amiel S (1994) Protection by lactate of cerebral function during hypoglycaemia. Lancet 343:16-20
8. Fanelli C, Di Vincenzo A, Modarelli F, Lepore M, Ciofetta M, Epifano L, Pampanelli S, Brunetti P, Bolli GB (1993) Post-hypoglycaemic hyperketonaemia does not contribute to brain metabolism during insulin-induced neuroglycopenia in humans. Diabetologia 36:1191-1197
9. Bolli GB (1990) From physiology of glucose counterregulation to prevention of hypoglycaemia in type 1 diabetes mellitus. Diab Nutr Metab 3:333-349
10. Schwartz N, Clutter W, Shah S, Cryer P (1987) Glycemic thresholds for activation of glucose counterregulatory systems are higher than the thresholds for symptoms. J Clin Invest 79:777-781
11. Mitrakou A, Ryan C, Veneman T, Mokan M, Jenssen T, Kiss I, Durrant J, Cryer P, Gerich J ( 1991) Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 260:E67-E74
12. Fanelli C, Pampanelli S, Epifano L, Rambotti AM, Ciofetta M, Modarelli F, Di Vincenzo A, Annibale B, Lepore M, Lalli C, Del Sindaco P, Brunetti P, Bolli GB (1994) Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in, hypoglycaemia in humans. Diabetologia 37:797-807
13. Foster DW, Rubenstein AH (1991) Hypoglycemia. In: Wilson JD, Braunwald E, Isselbacher KJ, Petersdorf RG, Martin JB, Fauci AS, Root RK (eds) Harrison's principles of internal medicine. McGraw-Hill, Inc., New York, p 1759
14. Young CW, Karam JH (1991) Hypoglycemic disorders. In: Greenspan FS (ed) Basic and clinical endocrinology. Appleton & Lange, East Norwalk, Connecticut, p 651
15. Bolli GB, Perriello G, Fanelli C, De Feo (1993) Nocturnal blood glucose control in type 1 diabetes mellitus. Diabetes Care [Suppl 3]:71-89
16. Bolli GB, Dimitriadis GD, Pehling GB, Baker BA, Haymond MW, Cryer PE, Gerich JE (1984) Abnormal glucose counterregulation after subcutaneous insulin in insulin-dependent diabetes mellitus. N Engl J Med 310:1706-1711
17. Fanelli C, Pampanelli S, Epifano L, Rambotti AM, Di Vincenzo A, Modarelli F, Ciofetta M, Lepore M, Annibale B, Torlone E, Perriello G, De Feo P, Santeusanio F, Brunetti P, Bolli GB (1994) Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of a rational, intensive insulin therapy in IDDM. Diabetologia 37:1265-1276
18. Mitrakou A, Fanelli C, Veneman T, Perriello G, Calderone S, Platanisiotis D, Rambotti AM, Raptis S, Brunetti P, Cryer P, Gerich J, Bolli GB (1993) Reversibility of unawareness of hypoglycemia in patients with insulinomas. N Engl J Med 329:834-839
19. Amiel S, Sherwin R, Simonson D, Tamborlane W (1988) Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 37:901-907
20. Maran A, Lomas J, Macdonald IA, Amiel SA (1995) Lack of preservation of higher brain function during hypoglycaemia in patients with intensively treated IDDM. Diabetologia 38:1412-1418
21. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J ( 1993) Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 42:1233-1237
22. Mokan M, Mitrakou A, Veneman T, Ryan C, Korytkowski M, Cryer P, Gerich J (1994) Hypoglycemia unawareness in IDDM. Diabetes Care 17:1397-403
23. Hvidberg A, Fanelli CG, Hershey T, Cryer PE (1996) Impact of recent antecedent hypoglycemia on hypoglycemic cognitive dysfunction in nondiabetic humans. Diabetes 45:1030-1036
24. Fanelli C, Paramore D, Hershey T, Craft S, Cryer P (1998) Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction in type 1 diabetes mellitus. Diabetes 47 [Suppl 1]:A109
25. Fanelli CG, Pampanelli S, Porcellati F, Bolli GB (1998) Shift of glycaemic thresholds for cognitive function in hypoglycaemia unawareness in humans. Diabetologia 41:720-723
26. Fanelli C, Epifano L, Rambotti AM, Pampanelli S, Di Vincenzo A, Modarelli F, Lepore M, Annibale B, Ciofetta M, Bottini P, Porcellati F, Scionti L, Santeusanio F, Brunetti P, Bolli GB (1993) Meticulous prevention of hypoglycemia (near-)normalizes magnitude and glycemic thresholds of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with IDDM of short duration. Diabetes 42:1683-1689
27. Cranston I, Lomas J, Maran A, Macdonald I, Amiel SA (1994) Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes. Lancet 344:283-287
28. Dagogo-Jack S, Rattarasarn C, Cryer PE (1994) Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 43:1426-1434
29. Heller S, Cryer P (1991) Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans. Diabetes 40:223-226
30. Dagogo-Jack SE, Cryer PE (1993) Hypoglycemia-associated autonomie failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomie responses to, symptoms of, and defense against subsequent hypoglycemia. J Clin Invest 91:819-818
31. Ovalle F, Fanelli CG, Paramore DS, Hershey T, Craft S, Cryer PE (1998) Brief twice-weekly episodes of hypoglycemia reduce detection of clinical hypoglycemia in type 1 diabetes mellitus. Diabetes 47:1472-1479
32. Fanelli C, Pampanelli S, Lalli C, Del Sindaco P, Ciofetta M, Lepore M, Porcellati F, Bottini P, Di Vincenzo A, Bottini P, Brunetti P, Bolli GB (1997) Long-term intensive therapy of IDDM diabetic patients with clinically overt autonomie neuropathy: effects on awareness of, and counterregulation to hypoglycemia. Diabetes 46:1172-1181
33. McCall A, Fixman L, Fleming N, Tornheim K, Chick W, Ruderman NB (1986) Chronic hypoglycemia increases brain glucose transport. Am J Physiol 251:E442-E447
34. McCall AL, Millington WR, Wurtman RJ (1982) Metabolic fuel and aminoacid transport into the brain in experimental diabetes mellitus. Proc Natl Acad Sci USA 79:5406-5410
35. Boyle PJ, Nagy RJ, O'Connor AM, Kempers SF, Yeo RA, Qualls C (1994) Adaptation in brain glucose uptake following recurrent hypoglycemia. Proc Natl Acad Sci USA 91:9352-9356
36. Boyle P, Kempers S, O'Connor AM, Nagy RJ (1995) Brain glucose uptake and hypoglycemia unwareness in patients with insulin-dependent diabetes mellitus. N Engl J Med 333:1726-1731
37. Davis SN, Shavers C, Costa F, Mosqueda-Garcia R (1996) Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans. J Clin Invest 98:680-691
38. Bolli GB (1989) The pharmacokinetic basis of insulin therapy in diabetes mellitus. Diab Res Clin Pract 6:S3-S16
39. Dimitriadis G, Gerich J (1983) Importance of timing of preprandial subcutaneous insulin administration in the management of diabetes mellitus. Diabetes Care 6:374-377
40. Torlone E, Pampanelli S, Lalli C, Del Sindaco P, Di Vincenzo A, Rambotti AM, Modarelli F, Epifano L, Kassi G, Perriello G, Brunetti P, Bolli GB (1996) Effects of the short-acting insulin analog [LYS(B28),PRO(B29)] on postprandial blood glucose control in IDDM. Diabetes Care 19:945-952
41. Dimitriadis G, Gerich J (1985) Effect of twice daily subcutaneous administration of a long-acting somatostatin analog on 24-hour plasma glucose profiles in patients with insulin-dependent diabetes mellitus. Horm Metab Res 10:510-511
42. Fanelli C, Pampanelli S, Lepore M, Porcellati F, Bartocci L, Brunetti P, Bolli GB (1998) Prevention of nocturnal hypoglycemia in intensive therapy of IDDM. Diabetes 47 [Suppl 1]:A109
43. Brunelle RL, Llewelyn J, Anderson JH, Gale E, Koivisto VA (1998) Meta-analysis of the effect of insulin lispro on severe hypoglycemia in IDDM patients. Diabetes Care 21:1726-1731
44. Ahmed ABE, Home PD (1998) The effect of insulin analog lispro on nighttime blood glucose control in type 1 diabetic patients. Diabetes Care 21:32-37
45. Zinman B, Tildesley H, Chiasson JL, Tsui E, Strack TR (1997) Insulin Lispro in CSII: results of a double-blind crossover study. Diabetes 46:440-443
46. Del Sindaco P, Ciofetta M, Lalli C, Perriello G, Pampanelli S, Torlone E, Brunetti P, Bolli GB (1998) Use of the short-acting insulin analogue lispro in intensive treatment of IDDM: importance of appropriate replacement of basal insulin and time-interval injection-meal. Diabet Med 15:592-600
47. Jansson P-A, Ebeling P, Smith U, Conget I, Coves MJ, Gomis R, Lalli C, Del Sindaco P, Bolli GB, Koivisto VA (1998) Improved glycemic control can be better maintained with insulin lispro than with human regular insulin. Diab Nutr Metab 11: 194-199
48. Anderson JH, Brunelle R, Koivisto VA, Pfuetzner A, Trautman M, Vignati L, Di Marchi R (1997) Insulin analogue treatment reduces postprandial hyperglycemia and frequency of hypoglycemia in IDDM patients. Diabetes 46:265-270
49. Jacobs MAJM, Keulen ETP, Kanc K, Casteleijn S, Scheffer P, Deville W, Heine RJ (1997) Metabolic efficacy of preprandial administration of Lys(B28),Pro(B29) human insulin analog in IDDM patients. Diabetes Care 20:1279-1292
50. Bott S, Bott U, Berger M, Mühlhauser I (1997) Intensified insulin therapy and the risk for severe hypoglycaemia. Diabetologia 40:926-932