Shift of glycaemic thresholds for cognitive function in hypoglycaemia unawareness in humans

Diabetologia

Volumn 41, Issue 6, 1998, Pages 720-723

  Fanelli, C G ^a   Pampanelli, S ^a   Porcellati, F ^a   Bolli, G B ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; BRAIN FUNCTION; CLINICAL PRACTICE; COGNITION; CORRELATION FUNCTION; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; HUMAN; HYPOGLYCEMIA; NEUROPSYCHOLOGICAL TEST; PERFORMANCE; PRIORITY JOURNAL; REVIEW; TECHNIQUE;

BLOOD GLUCOSE; COGNITION DISORDERS; HUMANS; HYPOGLYCEMIA; PERCEPTION;

EID: 0031841524     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050974     Document Type: Review

References (29)

1. Mitrakou A, Ryan C, Veneman T et al. (1991) Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 260: E67-E74
2. Fanelli C, Pampanelli S, Epifano L et al. (1994) Relative role of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans. Diabetologia 37: 797-807
3. Cranston I, Lomas J, Maran A, Macdonald I, Amiel S (1994) Restoration of hypoglycaemia awareness in patients with long-duration insulin dependent diabetes. Lancet 344: 283-287
4. Maran A, Lomas J, Macdonald IA, Amiel SA (1995) Lack of preservation of higher brain function during hypoglycaemia in patients with intensively-treated IDDM. Diabetologia 38: 1412-1418
5. Jones TW, Borg WP, Borg MA et al. (1997) Resistance to neuroglycopenia: an adaptative response during intensive insulin treatment in IDDM. J Clin Endocrinol Metab 82: 1713-1718
6. Heller SR, Macdonald IA (1996) The measurement of cognitive function during acute hypoglycemia: experimental limitations and their effect on the study of hypoglycemia unawareness. Diabet Med 13: 607-615
7. Heller SR, Cryer PE (1991) Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans. Diabetes 40: 223-226
8. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J (1993) Induction of hypoglycemia unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 42: 1233-1237
9. Boyle PJ, Nagy RJ, O'Connor AM, Kempers SF, Yeo RA, Qualls C (1994) Adaptation in brain glucose uptake following recurrent hypoglycemia. Proc Natl Acad Aci USA 91: 9352-9356
10. Dagogo-Jack SE, Craft S, Cryer PE (1993) Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. J Clin Invest 91: 819-828
11. Fanelli CG, Epifano L, Rambotti AM et al. (1993) Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes 42: 1683-1689
12. Dagogo-Jack S, Rattarasarn C, Cryer PE (1994) Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 43: 1426-1434
13. Mokan M, Mitrakou A, Veneman T et al. (1994) Hypoglycemia unawareness in IDDM. Diabetes Care 17: 1397-1403
14. Maran A, Taylor J, Macdonald IA, Amiel SA (1991) Evidence for reversibility of defective counterregulation in a patient with insulinoma. Diabet Med 9: 765-768
15. Mitrakou A, Fanelli C, Veneman T et al. (1993) Reversibility of unawareness of hypoglycemia in patients with insulinoma. N Engl J Med 329: 834-839
16. Fanelli CG, Paramore D, Hershey T, Terkamp C, Craft S, Cryer P (1996) Impact of nocturnal hypoglycemia on hypoglycemic cognitive dysfunction the following morning in IDDM. Diabetes [Suppl 1] 55A: 198 (Abstract)
17. Mellman MJ, Davis M, Brisman M, Shamoon H (1994) Effect of antecedent hypoglycemia on cognitive function and on glycemic thresholds for counterregulatory hormone secretion in healthy humans. Diabetes Care 17: 183-188
18. Widom B, Simonson DC (1990) Glycemic control and neuropsychologic function during hypoglycemia in patients with insulin-dependent diabetes mellitus. Ann Intern Med 112: 904-912
19. Draelos MT, Jacobson AM, Weinger K et al. (1995) Cognitive function in patients with insulin-dependent diabetes mellitus during hyperglycemia and hypoglycemia. Am J Med 98: 135-144
20. Fanelli C, Pampanelli S, Ciofetta M et al. (1997) Effect of duration of recent antecedent hypoglycemia on responses to subsequent hypoglycemia in humans. Diabetologia 40 [Suppl 1] A235: 923 (Abstract)
21. Cryer PE (1985) Does central nervous system adaptation to antecedent glycemia occur in patients with insulin-dependent diabetes mellitus? Ann Intern Med 103: 284-286
22. Hepburn DA, MacLeod KM, Frier BM (1993) Physiological, symptomatic and hormonal responses to acute hypoglycaemia in type 1 diabetic patients with autonomic neuropathy. Diabet Med 10: 940-949
23. Cryer PE, Gerich JE (1986) Glucose counterregulation, hypoglycemia, and intensive insulin therapy in diabetes mellitus. N Engl J Med 313: 232-241
24. 13C NMR spectroscopy. Proc Natl Acad Sci USA 89: 1109-1112
25. Boyle PJ, Kempers SK, O'Connor AM, Nagy RJ (1995) Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus. N Engl J Med 333: 1726-1731
26. McCall AL, Fixman LB, Fleming N, Tornhein K, Chick W, Ruderman NB (1985) Chronic hypoglycemia increases brain glucose transport. Am J Physiol 251: E442-E447
27. Pelligrino DA, Segil LJ, Albrecht RF (1990) Brain glucose utilization and transport and cortical function in chronic vs acute hypoglycemia. Am J Physiol 259: E729-E735
28. Davis SN, Shavers C, Costa F, Mosqueda-Garcia R (1996) Role of cortisol in the pathogenesis of deficient counterregulation after antecedent hypoglycemia in normal humans. J Clin Invest 98: 680-691
29. Pampanelli S, Lalli C, Del Sindaco P et al. (1997) Effect of recent, antecedent hypoglycemia and responses of cortisol per se, on responses to subsequent hypoglycemia in humans. Diabetologia 40 [Suppl 1] A27: 99 (Abstract)