Inhibitory mechanisms for cross-bridge cycling: The nitric oxide-cGMP signal transduction pathway in smooth muscle relaxation

Acta Physiologica Scandinavica

Volumn 164, Issue 4, 1998, Pages 373-380

  Murphy, Richard A ^a   Walker, J S ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Calcium; Inhibitory innervation; Myosin light chain kinase; Myosin light chain phosphatase; Myosin regulatory light chains; Phosphorylation; Vasodilation

Indexed keywords

CALCIUM ION; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; NITRIC OXIDE; PHOSPHATASE;

CALCIUM MOBILIZATION; CONFERENCE PAPER; DEPHOSPHORYLATION; ENZYME INHIBITION; MUSCLE EXCITATION; MUSCLE FIBRIL; MUSCLE FORCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SMOOTH MUSCLE RELAXATION; THIN FILAMENT; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; CYCLIC GMP; HUMANS; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITRIC OXIDE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0032443083     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201X.1998.00434.x     Document Type: Conference Paper

References (67)

1. Bárány, M. & Bárány, K. 1993. Dissociation of relaxation and myosin light chain dephosphorylation in porcine uterine muscle. Arch Biochem Biophys 305, 202-204.
2. Bárány, M. & Bárány, K. 1996. Protein phosphorylation during contraction and relaxation. In: Bárány, M (ed). Biochemistry of Smooth Muscle Contraction, pp. 321-339. Academic Press, San Diego.
3. Beall, A.C., Kato, K., Goldenring, J.R., Rasmussen, H. & Brophy, C.M. 1997. Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related protein. J Biol Chem 272, 11283-11287.
4. i, and arterial smooth muscle relaxation. Am J Physiol 263, C468-C473.
5. Chuang, A.T., Strauss, J.D., Murphy, R.A. & Steers, W.D. 1998a. Sildenafil, a type-5 cGMP phosphodiesterase inhibitor, specifically amplifies endogenous cGMP-dependent relaxation in rabbit corpus cavernosum smooth muscle in vitro. J Uro 60, 257-261.
6. Chuang, A.T., Strauss, J.D., Steers, W.D. & Murphy, R.A. 1998b. cGMP mediates corpus cavernosum smooth muscle relaxation with altered cross-bridge function. Life Sci 63, 185-194.
7. 2+. J Clin Invest 89, 1988-1994.
8. Draznin, M.B., Rapoport, R.M. & Murad, F. 1986. Myosin light chain phosphorylation in contraction and relaxation of intact rat thoracic aorta. Internat J Biochem 18, 917-928.
9. Eto, M., Ohmori, T., Suzuki, M., Furuya, K. & Morita, F. 1995. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta media and characterization. J Biochem 118, 1104-1107.
10. Eto, M., Senba, S., Morita, F. & Yazawa, M. 1997. Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: Its specific localization in smooth muscle. FEBS Letts 410, 356-360.
11. Fuglsang, A., Khromov, A., Török, K., Somlyo, A. V. & Somlyo, A.P. 1993. Flash photolysis studies of relaxation and cross-bridge detachment: Higher sensitivity of tonic than phasic smooth muscle to MgADP. J Muscle Res Cell Motil 14, 666-677.
12. Gallagher, P.J., Herring, B.P. & Stull, J.T. 1997. Myosin light chain kinases. J Muscle Res Cell Motil 18, 1-16.
13. Gerthoffer, W.T. 1986. Calcium dependence of myosin phosphorylation and airway smooth muscle contraction and relaxation. Am J Physiol 250, C597-C604.
14. 2+, myosin phosphorylation, and relaxation of arterial smooth muscle. Am J Physiol 245, C271-C277.
15. i estimates. FASEB J 5, 2593-2599.
16. 2+ sensitization of smooth muscle. J Biol Chem 212, 10704-10709.
17. 2+ sensitization of smooth muscle. Proc Natl Acad Sci USA 93, 1340-1345.
18. Hai, C-M. & Murphy, R.A. 1988. Cross-bridge phosphorylation and regulation of latch state in smooth muscle. Am J Physiol 254, C99-C106.
19. Hamad, A.M., Range, S., Holland, E. & Knox, A.J. 1997. Regulation of cGMP by soluble and particulate guanylyl cyclases in cultured human airway smooth muscle. Am J Physiol 213, L807-L813.
20. Hirata, K., Kikuchi, A., Sasaki, T. et al. 1992. Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem 267, 8719-8722.
21. Horowitz, A., Menice, C.B., Laporte, R. & Morgan, K.G. 1996. Mechanisms of smooth muscle contraction. Physiol Rev 76, 967-1003.
22. Ignarro, L. & Murad, F. (eds) 1995. Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications, pp. 1-530. Academic Press, San Diego.
23. 2+ sensitization of myosin light chain phosphorylation in smooth muscle. Biochem J 318, 469-475.
24. Kamm, K.E. & Grange, R.W. 1996. Calcium sensitivity of contraction. In: M Bárány (ed) Biochemistry of Smooth Muscle Contraction, pp. 355-365. Academic Press, San Diego.
25. Karaki, H., Ozaki, H., Hori, M. et al. 1997. Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev 49, 157-230.
26. 2+ antagonists on myosin light chain phosphorylation in relaxation of endothelin-1-contracted tracheal smooth muscle. Pflügers Arch Eur J Physiol 433, 472-477.
27. Katsuki, S., Arnold, W., Mittal, C. & Murad, F. 1977a. Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J Cyclic Nucleotide Res 3, 23-35.
28. Katsuki, S., Arnold, W.P. & Murad, F. 1977b. Effect of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues. J Cyclic Nucleotide Res 3, 239-247.
29. Knot, H.J., Brayden, J.E. & Nelson, M.T. 1996. Calcium channels and potassium channels. In: M. Bárány (ed) Biochemistry of Smooth Muscle Contraction, pp. 203-219. Academic Press, San Diego.
30. 2+ desensitization in vascular smooth muscle by activating the myosin light chain phosphatase. J Biol Chem 272, 5063-5068.
31. Lincoln, T.M. 1989. Cyclic GMP and mechanisms of vasodilation. Pharmacol Therapeutics 41, 479-502.
32. Lincoln, T.M. & Cornwell, T.L. 1993. Intracellular cyclic GMP receptor proteins. FASEB J 7, 328-338.
33. Lincoln, T.M., Cornwell, T.L., Komalavilas, P., Macmillan-Crow, L.A. & Boerth, N.J. 1996. The nitric oxide-cyclic GMP signaling system. In: M. Bárány (ed) Biochemistry of Smooth Muscle Contraction, pp. 257-268. Academic Press, San Diego.
34. 2+ by cAMP in vascular smooth muscle cells, Am J Physiol 258, C399-C407.
35. Lincoln, T.M., Komalavilas, P., Boerth, N.J., Macmillan-Crow, L.A. & Cornwell, T.L. 1995. cGMP signaling through cAMP-and cGMP-dependent protein kinases. In: L. Ignarro & F. Murad (eds) Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications, pp. 305-322. Academic Press, San Diego.
36. Lincoln, T.M., Komalavilas, P. & Cornwell, T.L. 1994. Pleiotropic regulation of vascular smooth muscle tone by cyclic GMP-dependent protein kinase. Hypertension 23, 1141-1147.
37. Lucius, C., Arner, A., Steusloff, A. et al. 1998. Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorvlation in guinea-pig smooth muscle: role of Rho proteins. J Physiol (Lond) 506, 83-93.
38. Makhlouf, G.M. & Gruder, J.R. 1993. Nonadrenergic noncholinergic inhibitory transmitters of the gut. News Physiol Sci 8, 195-199.
39. Malmqvist, U., Trybus, K.M., Yagi, S., Carmichael, J. & Fay, F.S. 1997. Slow cycling of unphosphorylated myosin is inhibited by calponin, thus keeping smooth muscle relaxed. Proc Natl Acad Sci USA 94, 7655-7660.
40. 2+-sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase. J Gen Physiol 104, 265-286.
41. i and uncoupling stress from myosin phosphorylation. Am J Physiol 263, C461-C467.
42. McDaniel, N.L., Rembold, C.M. & Murphy, R.A. 1990. Covalent cross-bridge regulation in smooth muscle. Annal NY Acad Sci 599, 66-74.
43. McDaniel, N.I., Rembold, C.M. & Murphy, R.A. 1994. Cyclic nucleotide dependent relaxation in vascular smooth muscle. Can J Physiol Pharmacol 72, 1380-1385.
44. McDonald, L.J. & Murad, F. 1995. Nitric oxide and cGMP signaling. In: L. Ignarro, & F. Murad, (eds) Nitric Oxide: Biochemistry, Molecular Biology, and Therapeutic Implications, pp. 263-275. Academic Press, San Diego.
45. Murad, F. 1994. Regulation of cytosolic guanylyl cyclase by nitric oxide: the NO-cyclic GMP signal transduction system. Adv Pharmacol 26, 19-33.
46. Murphy, R.A. 1994. What is special about smooth muscle? The significance of covalent crossbridge regulation. FASEB J 8, 311-318.
47. Murthy, K.S., Grider, J.R., Jin, J.-G. & Makhlouf, G.M. 1996. Interplay of VIP and nitric oxide in the regulation of neuromuscular function in the gut, Annal NY Acad Sci 805, 355-362.
48. Nieznanski, K. & Sobieszek, A. 1997. Telokin (kinase-related protein) modulates the oligomeric state of smooth-muscle myosin light-chain kinase and its interaction with myosin filaments. Biochem J 322, 65-71.
49. Nishiye, E., Somlyo, A.V., Török, K. & Somlyo, A.P. 1993. The effects of MgADP on cross-bridge kinetics: a laser flash photolysis study of guinea-pig smooth muscle. J Physiol (Lond) 460, 247-271.
50. Orallo, F. 1996. Regulation of cytosolic calcium levels in vascular smooth muscle: Pharmacol Therapeutics 69, 153-171.
51. Pfitzer, G. 1996. Permeabilized smooth muscle. In: M. Bárány (ed) Biochemistry of Smooth Muscle Contraction, pp. 191-199. Academic Press, San Diego.
52. Pfitzer, G., Merkel, L., Rüegg, J.C. & Hofmann, F. 1986. Cyclic GMP-dependent protein kinase relaxes skinned fibers from guinea pig taenia coli but not from chicken gizzard. Pflügers Arch 407, 87-91.
53. Raeymaekers, L. & Wuytack, F. 1996. Calcium pumps. In: M. Bárány (ed) Biochemistry of Smooth Muscle Contraction, pp. 241-253. Academic Press, San Diego.
54. Rapoport, R.M. & Murad, F. 1983. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ Res 52, 352-357.
55. i, and the latch-bridge hypothesis in swine arterial smooth muscle. Am J Physiol 261, C41-C50.
56. Rembold, C.M. 1992. Regulation of contraction and relaxation in arterial smooth muscle. Hypertension 20, 129-137.
57. Rembold, C.M. 1996. Electromechanical and pharmacomechanical coupling. In: M. Bárány (ed). Biochemistry of Smooth Muscle Contraction, pp. 227-239. Academic Press, San Diego.
58. i can quantitatively predict stress. Am J Physiol 259, C251-C257.
59. Sacks, D.B., Davis, H.W., Williams, J.P., Sheehan, E.L., Garcia, J.G.N. & McDonald, J.M. 1992. Phosphorylation by casein kinase II alters the biological activity of calmodulin. Biochem J 283, 21-24.
60. Somlyo, A.P. & Somlyo, A.V. 1994. Signal transduction and regulation in smooth muscle. Nature 372, 231-236.
61. Stull, J.T., Hsu, L.-C., Tansey, M.G. & Kamm, K.E. 1990. Myosin light chain kinase phosphorylation in tracheal smooth muscle. J Biol Chem 265, 16683-16690.
62. Tansey, M.G., Hori, M., Karaki, H., Kamm, K.E. & Stull, J.T. 1990. Okadaic acid uncouples myosin light chain phosphorylation and tension in smooth muscle. FEBS Lett 270, 219-221.
63. Van Riper, D.A., McDaniel, N.L. & Rembold, C.M. 1997. Myosin light chain kinase phosphorylation in nitrovasodilator induced swine carotid artery relaxation. Biochim Biophys Acta 1355, 323-330.
64. Van Riper, D.A., Weaver, B.A., Stull, J.T. & Rembold, C.M. 1995. Myosin light chain kinase phosphorylation in swine carotid artery contraction and relaxation. Am J Physiol 268, H2466-H2475.
65. Vyas, T.B., Mooers, S.U., Narayan, S.R., Witherell, J.C., Siegman, M.J. & Butler, T.M. 1992. Cooperative activation of myosin by light chain phosphorylation in permeabilized smooth muscle. Am J Physiol 263, C210-C219.
66. Wu, X., Haystead, T.A.J., Nakamoto, R.K., Somlyo, A.V. & Somlyo, A.P. 1998. Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. J Biol Chem 273, 11362-11369.
67. Wu, X.Q., Somlyo, A.V. & Somlyo, A.P. 1996. Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphatase. Biochem Biophys Res Comm 220, 658-663