In vitro lymphocyte proliferation in the diagnosis of allergy to phenoxymethylpenicillin

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 53, Issue 12, 1998, Pages 1155-1161

  Cederbrant, K ^a,d   Stejskal, V ^b   Broman, P ^c   Lindkvist, L ^c   Sundell, K ^c  

^a ASTRAZENECA R AND D   (Sweden)

^b DANDERYD HOSPITAL   (Sweden)

^c Department of Allergology ^*  (Sweden)

^d LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Antibiotics; Benzylpenicillin; Challenge test; Drug hypersensitivity; Human lymphocytes; Lymphocyte transformation test; Phenoxymethylpenicillin; Polylysine; RAST

Indexed keywords

BACAMPICILLIN; PENICILLIN V;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG STRUCTURE; FEMALE; HUMAN; LYMPHOCYTE PROLIFERATION; MALE; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL;

EID: 0032440164     PISSN: 01054538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1398-9995.1998.tb03835.x     Document Type: Article

References (33)

1. DeSwarte Richard D. Drug allergy. In: Patterson R, editor. Allergic diseases: diagnostics and management. 3rd ed. Philadelphia: JB Lippincott, 1985:505-661.
2. Bruze M, Isaksson M, Edman B, Björkner B, Fregert S, Möller H. A study on expert reading of patch test reactions: inter-individual accordance. Contact Dermatitis 1995;32: 331-7.
3. Parker CW, de Weck AL, Kern M, Eisen HN. The preparation and some properties of penicillenic acid derivatives relevant to penicillin hypersensitivity. J Exp Med 1962;115:803.
4. de Weck AL. Studies on penicillin hypersensitivity. I. The specificity of rabbit anti-penicillin antibodies. Int Arch Allergy Appl Immunol 1962;21:20.
5. Levine BB, Ovary Z. Studies of the mechanism of the formation of the penicillin antigen. III. The N(α-D benzylpenicilloyl) group as an antigenic determinant responsible for hypersensitivity to penicillin G. J Exp Med 1961; 114:875.
6. Haan P, Jonge AJ. Verbrugge R, Boorsma DM. Three epitope-specific monoclonal antibodies against the hapten penicillin. Int Arch Allergy Appl Immunol 1985;76:42-6.
7. Blanca M, Perez E, Garcia J, et al. Anaphylaxis to amoxycillin but good tolerance for benzylpenicillin. Allergy 1988;43:508-10.
8. Blanca M, Mayorga C, Sanchez F, et al. Differences in serum IgE antibody activity to benzylpenicillin and amoxycillin measured by RAST in a group of penicillin allergic patients. Allergy 1991;46:632-8.
9. Blanca M, Mayorga C, Perez E, et al. Determination of IgE antibodies to the benxyl penicilloyl determinant. J Immunol Methods 1992;153:99-105.
10. Christie G, Coleman JW, Newby S, et al. A survey of the prevalence of penicillin-specific IgG, IgM and IgE antibodies detected by ELISA and defined by hapten inhibition, in patients with suspected penicillin allergy and in healthy volunteers. Br J Clin Pharmacol 1988;25:381-6.
11. Daxun Z, Adriansson J, Martin AT, Malmberg E, Ahlstedt S. Diagnostic capabilities of penicillin-based structures as tools in the in vitro diagnosis of penicillin allergy. J Invest Allergol Clin Immunol 1992;2:240-6.
12. Mayorga C, Obispo T, Jimeno L, et al. Epitope mapping of β-lactam antibiotics with the use of monoclonal antibodies. Toxicology 1995;97:225-34.
13. Vega JM, Blanca M, García JJ, et al. Immediate allergic reactions to amoxicillin. Allergy 1994;49:317-22.
14. Stejskal VDM, Olin RG, Forsbeck M. The lymphocyte transformation lest for diagnosis of drug-induced occupational allergy. J Allergy Clin Immunol 1986;77:411-26.
15. Stejskal VDM, Forsbeck M, Olin R. Side chain-specific lymphocyte responses in workers with occupational allergy induced by penicillins. Int Arch Allergy Appl Immunol 1987;82:461-4.
16. Bell SJD, Pichler WJ. Penicillin-allergic patients react to penicillin-modified "self". Allergy 1989;44:199-203.
17. Brander C, Mauri-Hellweg D, Bettens F, Rolli H, Goldman M, Pichler WJ. Heterogeneous T cell responses to β-lactam-modified self-structures are observed in penicillin-allergic individuals. J Immunol 1995;155:2670-8.
18. Levine B. N(α-D-penicilloyl)amines as univalent hapten inhibitors of antibody-dependent allergy reactions to penicillin. J Med Pharm Chem 1962;5:1025-34.
19. Juhlin L, Ahlstedt S, Andal L, et al. Antibody reactivity in penicillin-sensitive patients determined with different penicillin derivatives. Int Arch Appl Immunol 1977;54: 19-28.
20. Neftel KA, Wälti M, Schulthess HK, Gubler J. Adverse reactions following intravenous penicillin-G relate to degradation of the drug in vitro. Klin Wochenschr 1984;62:25-9.
21. Nyfeler B, Pichler WJ. The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin Exp Allergy 1997;27:175-81.
22. Bircher AJ. Lymphocyte transformation test in the diagnosis of immediate type hypersensitivity reactions to penicillins. Curr Prob Dermatol 1995;22:31-7.
23. Boguníewicz M. Adverse reactions to antibiotics. Is the patient really allergic? Drug Saf 1995;13:273-80.
24. Warbrick EV, Thomas AL, Stejskal V, Coleman JW. An analysis of beta-lactam-derived antigens on spleen cell and serum proteins by ELISA and Western blotting. Allergy 1995;50:910-17.
25. Sinigaglia F. The molecular basis of metal recognition by T-cells. J Clin Invest 1994;102:398-401.
26. Nalefski EA, Rao A. Nature of the ligand recognized by a hapten- and carrier-specific, MHC restricted T cell receptor. J Immunol 1993;150:3806-16.
27. Martin S, von Bonin A, Fessier C, Pflugfelder U, Weltzien HU. Structural complexity of antigenic determinants for class I MHC-restricted, hapten-specific T-cells. J Immunol 1993;151:678-87.
28. Ortmann B, Martin S, von Bonin A, Schiltz E, Hoschützky H, Weltzien HU. Synthetic peptides anchor T-cell specific TNP epitopes to MHC antigens. J Immunol 1992;148:1445-50.
29. Romangnoli P, Labhardt AM, Sinigaglia F. Selective interaction of Ni with a MHC-bound peptide. EMBO J 1991;10:1303-6.
30. Romangnoli P, Spinas GA, Sinigaglia F. Gold-specific T cells in rheumatoid arthritis patients treated with gold. J Clin Invest 1992;89:254-8.
31. Blanca M, Carmona MJ, Moreno F, et al. Selective immediate allergic response to penicillin V. Allergy 1996;51:960-2.
32. Blanca M, Vega JM, Garcia J, et al. Allergy to penicillin with good tolerance to other penicillins; study of the incidence in subjects allergic to betalactams. Clin Exp Allergy 1990;20:475-81.
33. Blanca M, Vega JM, Garcia J, et al. New aspects of allergic reactions to betalactams: crossreactions and unique specificities. Clin Exp Allergy 1994;24:407-15.