메뉴 건너뛰기




Volumn 6, Issue 6, 1998, Pages 249-254

Hypoxic cell cytotoxin tirapazamine induces acute changes in tumor energy metabolism and pH: A 31P magnetic resonance spectroscopy study

Author keywords

Magnetic resonance spectroscopy; pH; Tirapazamine; Tumor energy metabolism

Indexed keywords

FLUNARIZINE; HYDRALAZINE; NICOTINAMIDE; PLATINUM DERIVATIVE; TIRAPAZAMINE;

EID: 0032432843     PISSN: 10657541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6823(1998)6:6<249::AID-ROI1>3.0.CO;2-C     Document Type: Article
Times cited : (9)

References (26)
  • 1
    • 0025646401 scopus 로고
    • Potentiation by hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors
    • Brown JM, Lemmon MJ. Potentiation by hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Res 1990;50: 7745-7749.
    • (1990) Cancer Res , vol.50 , pp. 7745-7749
    • Brown, J.M.1    Lemmon, M.J.2
  • 2
    • 84965808588 scopus 로고
    • Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin
    • Dorie MJ, Brown JM. Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Res 1993;53:4633-4636.
    • (1993) Cancer Res , vol.53 , pp. 4633-4636
    • Dorie, M.J.1    Brown, J.M.2
  • 3
    • 0030018650 scopus 로고    scopus 로고
    • The effect of tirapazamine (SR-4233) alone or combined with chemotherapeutic agents on xenografted human tumors
    • Lartigau E, Guichard M. The effect of tirapazamine (SR-4233) alone or combined with chemotherapeutic agents on xenografted human tumors. Br J Cancer 1996;73:1480-1485.
    • (1996) Br J Cancer , vol.73 , pp. 1480-1485
    • Lartigau, E.1    Guichard, M.2
  • 4
    • 0023750547 scopus 로고
    • Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233
    • Zeman EM, Hirst VK, Lemmon MJ, Brown JM. Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233. Radiother Oncol 1988; 12:209-218.
    • (1988) Radiother Oncol , vol.12 , pp. 209-218
    • Zeman, E.M.1    Hirst, V.K.2    Lemmon, M.J.3    Brown, J.M.4
  • 5
    • 0027931173 scopus 로고
    • Reduction of 3-amino-1,2,4,-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: A direct role for NADPH:cytochrome P450 oxidoreductase
    • Fitzsimmons SA, Lewis AD, Riley RJ, Workman P. Reduction of 3-amino-1,2,4,-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase. Carcinogenesis 1994;15: 1503-1510.
    • (1994) Carcinogenesis , vol.15 , pp. 1503-1510
    • Fitzsimmons, S.A.1    Lewis, A.D.2    Riley, R.J.3    Workman, P.4
  • 8
    • 8244234465 scopus 로고    scopus 로고
    • Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: Retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial
    • Graham MA, Senan S, Robin H Jr, Eckhardt N, Lendrem D, Hincks J, Greenslade D, Rampling R, Kaye SB, von Roemeling R, Workman P. Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial. Cancer Chemother Pharmacol 1997;40:1-10.
    • (1997) Cancer Chemother Pharmacol , vol.40 , pp. 1-10
    • Graham, M.A.1    Senan, S.2    Robin Jr., H.3    Eckhardt, N.4    Lendrem, D.5    Hincks, J.6    Greenslade, D.7    Rampling, R.8    Kaye, S.B.9    Von Roemeling, R.10    Workman, P.11
  • 11
    • 0030738399 scopus 로고    scopus 로고
    • Adaptation of human tumor cells to tirapazamine under aerobic conditions: Implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity
    • Elwell JH, Siim BG, Evans JW, Brown JM. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity. Biochem Pharmacol 1997;54:249-257.
    • (1997) Biochem Pharmacol , vol.54 , pp. 249-257
    • Elwell, J.H.1    Siim, B.G.2    Evans, J.W.3    Brown, J.M.4
  • 12
    • 0028235953 scopus 로고
    • Reoxygenation and rehypoxiation in the SCCVII mouse tumor
    • Kim IH, Brown JM. Reoxygenation and rehypoxiation in the SCCVII mouse tumor. Int J Radiat Oncol Biol Phys 1994;29:493-497.
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 493-497
    • Kim, I.H.1    Brown, J.M.2
  • 13
    • 0028168183 scopus 로고
    • SR-4233 (tirapazamine) acts as an uncoupler of oxidative phosphorylation in human MCF-7 breast carcinoma cells
    • Ara G, Colman CN, Teicher BA. SR-4233 (tirapazamine) acts as an uncoupler of oxidative phosphorylation in human MCF-7 breast carcinoma cells. Cancer Lett 1994;85:195-203.
    • (1994) Cancer Lett , vol.85 , pp. 195-203
    • Ara, G.1    Colman, C.N.2    Teicher, B.A.3
  • 14
    • 0015868782 scopus 로고
    • Determination of intracellular pH by 31P magnetic resonance
    • Moon RB, Richards JH. Determination of intracellular pH by 31P magnetic resonance. J Biol Chem 1973;248: 7276-7278.
    • (1973) J Biol Chem , vol.248 , pp. 7276-7278
    • Moon, R.B.1    Richards, J.H.2
  • 17
    • 0023694816 scopus 로고
    • Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy
    • Okunieff P, Kallinowski F, Vaupel P, Neuringer L. Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy. JNCI 1988; 80:745-750.
    • (1988) JNCI , vol.80 , pp. 745-750
    • Okunieff, P.1    Kallinowski, F.2    Vaupel, P.3    Neuringer, L.4
  • 18
    • 0029760073 scopus 로고    scopus 로고
    • Effects of blood flow modifiers on tumor metabolism observed in vivo by proton magnetic resonance spectroscopic imaging
    • Bhujwalla ZM, Shungu DC, Glickson JD. Effects of blood flow modifiers on tumor metabolism observed in vivo by proton magnetic resonance spectroscopic imaging. Magn Reson Med 1996;36:204-211.
    • (1996) Magn Reson Med , vol.36 , pp. 204-211
    • Bhujwalla, Z.M.1    Shungu, D.C.2    Glickson, J.D.3
  • 19
    • 0029043340 scopus 로고
    • Relationship between tumor oxygenation, bioenergetic status and radiobiological hypoxia in an experimental model
    • Nordsmark M, Grau C, Horsman MR, Jorgensen HS, Overgaard J. Relationship between tumor oxygenation, bioenergetic status and radiobiological hypoxia in an experimental model. Acta Oncol 1995;34:329-334.
    • (1995) Acta Oncol , vol.34 , pp. 329-334
    • Nordsmark, M.1    Grau, C.2    Horsman, M.R.3    Jorgensen, H.S.4    Overgaard, J.5
  • 20
    • 0026087261 scopus 로고
    • The measurement of radiosensitizer-induced changes in mouse tumor metabolism by 31P magnetic resonance spectroscopy
    • Wood PJ, Counsell CJR, Bremner JCM, Horsman MR, Adams GE. The measurement of radiosensitizer-induced changes in mouse tumor metabolism by 31P magnetic resonance spectroscopy. Int J Radiat Oncol Biol Phys 1991;20:291-294.
    • (1991) Int J Radiat Oncol Biol Phys , vol.20 , pp. 291-294
    • Wood, P.J.1    Counsell, C.J.R.2    Bremner, J.C.M.3    Horsman, M.R.4    Adams, G.E.5
  • 21
    • 0030669672 scopus 로고    scopus 로고
    • Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice
    • Durand RE, Olive PL. Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice. Radiat Oncol Invest 1997;5:213-219.
    • (1997) Radiat Oncol Invest , vol.5 , pp. 213-219
    • Durand, R.E.1    Olive, P.L.2
  • 24
    • 0027316026 scopus 로고
    • Potentiation of DNA-adduct formation and cytotoxicity of platinum-containing drugs by low pH
    • Atema A, Buurman KJH, Noteboom E, Smets LA. Potentiation of DNA-adduct formation and cytotoxicity of platinum-containing drugs by low pH. Int J Cancer 1993;54:166-172.
    • (1993) Int J Cancer , vol.54 , pp. 166-172
    • Atema, A.1    Buurman, K.J.H.2    Noteboom, E.3    Smets, L.A.4
  • 25
    • 0024348433 scopus 로고
    • Hydrogen-ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro
    • Jahde E, Glusenkamp KH, Kunder I, Hulser DF, Tietze LF, Rajewsky MF. Hydrogen-ion-mediated enhancement of cytotoxicity of bis-chloroethylating drugs in rat mammary carcinoma cells in vitro. Cancer Res 1989; 49:2965-2972.
    • (1989) Cancer Res , vol.49 , pp. 2965-2972
    • Jahde, E.1    Glusenkamp, K.H.2    Kunder, I.3    Hulser, D.F.4    Tietze, L.F.5    Rajewsky, M.F.6
  • 26
    • 0028820843 scopus 로고
    • Influence of pH on the cytotoxicity of cisplatin in EMT6 mouse mammary tumor cells
    • Laurencot CM, Kennedy KA. Influence of pH on the cytotoxicity of cisplatin in EMT6 mouse mammary tumor cells. Oncol Res 1995;7:371-379.
    • (1995) Oncol Res , vol.7 , pp. 371-379
    • Laurencot, C.M.1    Kennedy, K.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.