Effects of steroid hormones on gene expression of glial markers in the central and peripheral nervous system: Variations induced by aging

Experimental Gerontology

Volumn 33, Issue 7-8, 1998, Pages 827-836

  Melcangi, Roberto Cosimo ^a   Magnaghi, Valerio ^a   Cavarretta, Ilaria ^a   Riva, Marco Andrea ^a   Piva, Flavio ^a   Martini, Luciano ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Aging; GFAP; MBP; Nervous system; Po; Steroids

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; STEROID HORMONE;

AGING; ANIMAL CELL; ASTROCYTE; CELL COMPARTMENTALIZATION; CELL FUNCTION; CONFERENCE PAPER; DRUG EFFECT; GENE EXPRESSION REGULATION; GLIA CELL; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; SCHWANN CELL; SCIATIC NERVE;

AGING; ANIMALS; BIOLOGICAL MARKERS; BRAIN; GENE EXPRESSION; GONADAL STEROID HORMONES; MALE; NEUROGLIA; PERIPHERAL NERVES; RATS; SEX CHARACTERISTICS;

EID: 0032430320     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(98)00020-5     Document Type: Conference Paper

References (42)

1. Adinolfi A.M., Yamury J., Morales F.R., Chase M.H. Segmental demyelination in peripheral nerves of old cats. Neurobiol. Aging. 12:1991;175-179.
2. Baulieu E-E, Robel P. Neurosteroids A new brain function? J. Steroid Biochem. Mol. Biol. 37:1990;395-403.
3. Brockes J.P., Raff M.C., Nishiguchi D.J., Winter J. Studies on cultured rat Schwann cells Assay for peripheral myelin proteins . J. Neurocytol. 9:1980;67-77.
4. Celotti F., Melcangi R.C., Martini L. The 5α-reductase in the brain Molecular aspects and relation to brain function . Front. Neuroendocrinol. 13:1992;163-215.
5. Chowen, J.A., Busiguina, S., and Garcia-Segura, L.M., Sexual dimorphism and sex steroid modulation of glial fibrillary acidic protein (GFAP) mRNA and immunoreactive levels in the rat hypothalamus, Neuroscience 69, 519-532, 1995.
6. Day J.R., Laping N.J., McNeill T.H., Schreiber S.S., Pasinetti G., Finch C.E. Castration enhances expression of glial fibrillary acidic protein and sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat. Mol. Endocrinol. 4:1990;1995-2002.
7. Day J.R., Laping N.J., Lampert-Etchells M., Brown S.A., O'Callaghan J.P., McNeill T.H., Finch C.E. Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus. Neuroscience. 55:1993;435-443.
8. Downie A.W., Newell D.J. Sensory nerve conduction in patients with diabetes mellitus and controls. Neurology. 11:1961;876-882.
9. D'urso D., Brophy P.J., Staugaitus S.M., Gillespie C.S., Frey A.B., Stempak J.G., Colman D.R. Protein zero of peripheral nerve myelin Biosynthesis, membrane insertion, and evidence for homotypic interaction . Neuron. 4:1990;449-460.
10. Finch C.E., Felicio L.S., Mobbs C.V., Nelson J.F. Ovarian and steroidal influences on neuroendocrine aging processes in female rodents. Endocr. Rev. 5:1984;467-497.
11. Garcia-Segura L.M., Luquin S., Parducz A., Naftolin F. Gonadal hormone regulation of glial fibrillary acidic protein immunoreactivity and glial ultrastructure in the rat neuroendocrine hypothalamus. Glia. 10:1994;59-69.
12. Garcia-Segura L.M., Chowen J.A., Naftolin F. Endocrine glia Roles of glial cells in the brain actions of steroid and thyroid hormone and in the regulation of hormone secretion . Front. Neuroendocrinol. 17:1996;180-211.
13. Goss J.R., Finch C.E. and Morgan D.G., Age-related changes in Glial Fibrillary Acidic Protein mRNA in the mouse brain. Neurobiol. Aging. 12:1991;165-170.
14. Grover-Johnson N., Spencer P.S. Peripheral nerve abnormalities in aging rats. J. Neurophatol. Exp. Neurol. 40:1981;155-165.
15. Ishaque A., Roomi M.W., Szymanska I., Kowalski S., Eylar E.H. The Po glycoprotein of peripheral nerve myelin. Can. J. Biochem. 58:1980;913-921.
16. Johansson C.S., Stenstrom M., Hildebrand C. Target influence on aging of myelinated sensory nerve fibres. Neurobiol. Aging. 17:1986;61-66.
17. Jung-Testas, I., RENOIR, M., BUGNARD, H., GREENE, G.L., and Baulieu, E-E., Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells, J. Steroid Biochem. Mol. Biol., 41 621-631, 1992.
18. Jung-Testas I., Schumacher M., Robel P., Baulieu E-E. Demonstration of progesterone receptors in rat Schwann cells. J. Steroid Biochem. Mol. Biol. 58:1996;77-82.
19. Kitamura K., Suzuki M., Uyemura K. Purification and partial characterization of two glycoproteins in bovine peripheral nerve myelin membrane. Biochim. Biophys. Acta. 455:1976;806-816.
20. Koenig H.L., Schumacher M., Ferzaz B., Do Thi A.N., Ressouches A., Guennoun R., Jung-Testas I., Robel P., Akwakwa Y., Baulieu E-E. Progesterone synthesis and myelin formation by Schwann cells. Science. 268:1995;1500-1503.
21. Laping, N.J., Teter, B., Nichols, N.R., Rozovsky, I., and Finch, C.E., Glial fibrillary acidic protein: Regulation by hormones, cytokines, and growth factors. Brain Pathol. 1, 259-275, 1994.
22. Luquin, S., Naftolin, F., and Garcia-Segura, L.M., Natural fluctuation and gonadal hormone regulation of astrocyte immunoreactivity in dentate gyrus. J. Neurobiol.24, 913-924, 1993.
23. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007.
24. McQueen, J.K., Wright, A.K., Arbuthnott, G.W., and Fink, G., Glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes are increased in the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice, Neurosci. Lett. 118, 77-81, 1990.
25. McQueen J.K. Glial cells and neuroendocrine function. J. Endocrinol. 143:1994;411-415.
26. Melcangi R.C., Celotti F., Ballabio M., Castano P., Massarelli R., Poletti A., Martini L. 5α-Reductase activity in isolated and cultured neuronal and glial cells of the rat. Brain Res. 516:1990;229-236.
27. Melcangi R.C., Celotti F., Ballabio M., Poletti A., Martini L. Testosterone metabolism in peripheral nerves Presence of the 5α-reductase-3α-hydroxysteroid-dehydrogenase enzymatic system in the sciatic nerve of adult and aged rats . J. Steroid Biochem. 35:1990;145-148.
28. Melcangi, R.C., Celotti, F., Castano, P., and Martini, L., Differential localization of the 5α-reductase and the 3α-hydroxysteroid dehydrogenase in neuronal and glial cultures, Endocrinology 132, 1252-1259, 1993.
29. Melcangi R.C., Celotti F., Martini L. Progesterone 5α-reduction in neuronal and in different types of glial cell cultures Type 1 and 2 astrocytes and oligodendrocytes . Brain Res. 639:1994;202-206.
30. Melcangi R.C., Riva M.A., Fumagalli F., Magnaghi V., Racagni R., Martini L. Effect of progesterone, testosterone and their 5α-reduced metabolites on GFAP gene expression in type 1 astrocytes. Brain Res. 711:1996;10-15.
31. Melcangi R.C., Magnaghi V., Cavarretta I., Martini L., Piva F. Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives. Neuroscience. 85:1998;569-578.
32. Mellon S.H., Deschepper C.F. Neurosteroid biosynthesis Genes for adrenal steroidogenic enzymes are expressed in the brain . Brain Res. 629:1993;283-292.
33. Morales J.F.R., Boxer P.A., Fung S.J., Chase M.H. Basic electrophysiological properties of spinal cord motoneurons during old age in the cat. J. Neurophysiol. 58:1987;180-194.
34. Morgan, D.G. and May, P.C., Age-related changes in synaptic neurochemistry. In: Handbook of the Biology of Aging, 3rd ed., Schneider, E.L. and Rowe, J.W. (Editors), pp. 219-254, Academic Press, New York, 1990.
35. Nichols N.R., Day J.R., Laping N.J., Johson S.A., Finch C.E. GFAP mRNA increases with age in rat and human brain. Neurobiol. Aging. 14:1993;421-429.
36. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
37. Rupprecht R., Reul M.H.M., Trapp T., Steensel B.V., Wetzel C., Damm K., Zieglgansberger W., Holsboer F. Progesterone receptor-mediated effects of neuroactive steroids. Neuron. 11:1993;523-530.
38. Spencer, P.S. and Thomas, P.K., The examination of isolated nerve fibres by light and electron microscopy with observations on demyelination proximal to neuromas. Acta Neuropathol. (Berlin) 16, 177-186, 1970.
39. Spencer P.S., Thomas P.K. Ultrastructural studies with the dying back process. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axons. J. Neurocytol. 3:1974;763-783.
40. Stahl N., Harry J., Popko B. Quantitative analysis of myelin protein gene expression during development in the rat sciatic nerve. Mol. Brain Res. 8:1990;209-212.
41. Thomas P.K., King R.H.M., Sharma A.K. Changes with age in the peripheral nerves of the rat. Acta Neuropathol. (Berlin). 52:1980;417-428.
42. Wang C., Leung A., Sinha-Hikim A.P. Reproductive aging in the male Brown-Norway rat - a model for human. Endocrinology. 133:1993;2773-2781.