Glucocorticoids inhibit IL-4 and mitogen-induced IL-4Rα chain expression by different posttranscriptional mechanisms

Journal of Allergy and Clinical Immunology

Volumn 102, Issue 6 II, 1998, Pages 968-976

  Mozo, Lourdes ^a   Gayo, Abel ^a   Suárez, Ana ^a   Rivas, Dolores ^a   Zamorano, Joses ^c   Gutiérrez, Carmen ^a,b  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b UNIVERSITY OF OVIEDO   (Spain)

^c AMERICAN RED CROSS   (United States)

Author keywords

Dexamethasone; Gene transcription; Glucocorticoids; IL 4R ; mRNA half life; Phorbol myristate acetate; Posttranscriptional regulation

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ALLERGY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEROID THERAPY;

EID: 0032429910     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(98)70335-5     Document Type: Article

References (45)

1. Paul WE. Interleukin 4: a prototypic immunoregulatory lymphokine. Blood 1991;77:1859-70.
2. Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, et al. Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 1993;262:1874-7.
3. Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, et al. Interleukin-2 receptor y chain: a functional component of the interleukin-4 receptor. Science 1993;262:1880-3.
4. Hilton DJ, Zhang JG, Metcalf D, Alexander WS, Nicola NA, Willson TA. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc Natl Acad Sci 1996;93:497-501.
5. Caput D, Laurent P, Kagdah M, Lelias JM, Lefort S, Vita N, et al. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J Biol Chem 1996;271:16921-6.
6. Hou J, Schlinder U, Henzel WJ, Ho TCh, Brasseur M, McKnight SL. An interleukin-4-induced transcription factor: IL-4 S tat. Science 1994;265:1701-6.
7. Quelle FW, Shimoda K, Thierfelder W, Fischer C, Kim A, Reuben SM, et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol 1995;15:3336-43.
8. Wang LM, Keegan AD, Paul WE, Heiradan MA, Gutkind JS, Pierce JH. IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. EMBO J 1992;11:4899-908.
9. Sun XJ, Wang LM, Zhang Y, Yanush L, Myers MG, Glasheen E, et al. Role of IRS-2 in insulin and cytokine signalling. Nature 1995;377:173-7.
10. Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 1996;4:313-9.
11. Kern JA, Lamb RJ, Reed JC, Daniele RP, Nowell PC. Dexamethasone inhibition of interleukin-1 beta production by human monocytes: post-transcriptional mechanisms. J Clin Invest 1998;81:237-44.
12. Boumpas DT, Anastassiou ED, Older SA, Tsokos GC, Nelson DL, Balow JE. Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription. J Clin Invest 1991;87:1739-47.
13. Tobler A, Meier R, Seitz M, Dewald B, Bagglioni M, Fey MF Glucocorticoids downregulate gene expression of GM-CSF, NAP-1/IL-8, and IL-6, but not of M-CSF in human fibroblasts. Blood 1992;79:45-51.
14. Almawi WY, Lipman ML, Stevens AC, Zanker B, Hadro ET, Strom TB. Abrogation of glucocorticoid-mediated inhibition of T cell proliferation by the synergistic action of IL-1, IL-6, and IFN-gamma. J Immunol 1991;146:3523-7.
15. Debets JMH, Ruers TJM, Van der Linden MPMH, Van der Linden CJ, Buurman WA. Inhibitory effect of corticosteroids on the secretion of tumor necrosis factor (TNF) by monocytes is dependent on the stimulus inducing TNF synthesis. Clin Exp Immunol 1989;78:224-9.
16. Strickland RW, Wahl LM, Finbloom DS. Corticosteroids enhance the binding of recombinant interferon-γ to cultured human monocytes. J Immunol 1986;137:1577-80.
17. Snyers L, de Wit L, Content J. Glucocorticoid up-regulation of high affinity interleukin 6 receptors on human epithelial cells. Proc Natl Acad Sci 1990;87:2838-42.
18. Sieh JH, Gordon M, Jakubowski A, Peterson RHF, Gabrilove JL, Moore MAS. Interleukin-1 modulation of cytokine receptors on human neutrophils: in vitro and in vivo studies. Blood 1993;81:1745-54.
19. Akahoshi T, Oppenheim JJ, Matsushima KK. Induction of high affinity interleukin 1 receptor on human peripheral blood lymphocytes by glucocorticoid hormones. J Exp Med 1988;167:924-36.
20. Lamas M, Sanz E, Martin-Parras L, Espel E, Sperisen P, Collins M, et al. Glucocorticoid hormones upregulate interleukin 2 receptor α gene expression. Cell Immunol 1993;151:437-50.
21. Reed JC, Abidi AH, Alpers JD, Hoover RG, Robb RJ, Nowell PC. Effect of cyclosporin A and dexamethasone on interleukin 2 receptor gene expression. J Immunol 1986;137:150-5.
22. H2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992;326:298-304.
23. Rivas D, Mozo L, Zamorano J, Gayo A, Torre-Alonso JC, Rodriguez A, et al. Upregulated expression of IL-4 receptors and increased levels of IL-4 in rheumatoid arthritis patients. J Autoimmun 1995;8:587-600.
24. + cells correlate with resolution of lesions in murine cutaneous Leishmaniasis. J Immunol 1992;149:2715-21.
25. Renz H, Jujo K, Bradley KL, Domenico J, Gelfand EW, Leung DY. Enhanced IL-4 production and IL-4 receptor expression in atopic dermatitis and their modulation by interferon-gamma. J Invest Dermatol 1992;99:403-8.
26. Izikawa K, Kajiwara K, Koshio T, Matsuura N, Yanagihara Y. Inhibition of IL-4 receptor up-regulation on B cells by antisense oligodeoxynucleotide suppresses IL-4 induced human IgE production. Clin Exp Immunol 1995;100:383-9.
27. Hershey GKK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the α subunit of the interleukin-4 receptor. N Engl J Med 1997;337:1720-5.
28. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
29. Dokter WHA, Borger P, Hendriks D, van der Horst I, Halie MR, Vellenga E. Interleukin-4 (IL-4) receptor expression on human T cells is affected by different intracellular signaling pathways and by IL-4 at transcriptional and posttranscriptional level. Blood 1992;80:2721-8.
30. Peppel K, Vinci JM, Baglioni C. The AU-rich sequences in the 3′untranslated region mediate the increased turnover of interferon mRNA induced by glucocorticoids. J Exp Med 1991;173:349-55.
31. Idzerda RL, March CJ, Mosley B, Lyman SD, Van den Bos T, Gimpel SD, et al. 1990. Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J Exp Med 1990;171:861-73.
32. Lee SW, Tsou AP, Chan H, Thomas J, Petrie K, Eugui EM, et al. Glucocorticoids selectively inhibit the transcription of the interleukin 1β gene and decrease the stability of interleukin 1β mRNA. Proc Natl Acad Sci 1988;85:1204-8.
33. Poyet P, Henning SJ, Rosen JM. Hormone-dependent beta-casein mRNA stabilization requires ongoing protein synthesis. Mol Endocrinol 1989;3:1961-8.
34. Ohh M, Smith CA, Carpineto C, Takei F. Regulation of intercellular adhesion molecule-1 gene expression involves multiple mRNA stabilization mechanisms: effects of interferon-γ and phorbol myristate acetate. Blood 1994;84:2632-9.
35. 2+-induced transcription followed by mRNA stabilization through activation of protein kinase C or increase in cAMP. Eur J Immunol 1995;25:889-95.
36. Suárez A, Mozo L, Gayo A, Zamorano J, Gutiérrez C. Requirement of a second signal via protein kinase C or protein kinase A for maximal expression of CD40 ligand: involvement of transcriptional and posttranscriptional mechanisms. Eur J Immunol 1997;27:2822-9.
37. Mozo L, Rivas D, Zamorano J, Gutiérrez C. Differential expression of IL-4 receptors in human T and B lymphocytes. J Immunol 1993;150:4261-9.
38. Beutler B, Krochin N, Milsark I, Luedke C, Cerami A. Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 1986;232:977-80.
39. Jonat C, Rahmsdorf HJ, Park KK, Cato ACB, Gebel S, Ponta H, et al. Antitumor promotion and antiinflammation: downmodulation of AP-1 (Fos-Jun) activity by glucocorticoid hormone. Cell 1990;62:1189-204.
40. Schüle R, Rangarajan P, Kliewer S, Ransone LJ, Bolado J, Yang N, et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 1990;62:1217-26.
41. Ray A, Prefontaine KE. Physical association and functional antagonism between the p65 subunit of the transcription factor NfκB and the glucocorticoid receptor. Proc Natl Acad Sci 1994;91:752-6.
42. Paliogianni F, Ahuja SS, Balow JP, Balow JE, Boumpas DT. Novel mechanism for inhibition of human T cells by glucocorticoids. J Immunol 1993;151:4081-9.
43. Dokter WHA, Esselink MT, Sierdsema SJ, Halie MR, Vellenga E. Transcriptional and posttranscriptional regulation of the interleukin-4 and interleukin-3 genes in human T cells. Blood 1993;81:35-40.
44. Kaufman Paterson RL, Or R, Domenico JM, Delespesse G, Gelfand EW. Regulation of CD23 expression by IL-4 and corticosteroid in human B lymphocytes. J Immunol 1994;152:2139-47.
45. Zubiaga AM, Muñoz E, Huber BT. IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis. J Immunol 1992;149:107-12.