Action of angiotensin receptor subtypes on the renal tubules and vasculature: Implications for volume homeostasis and atherosclerosis

Mineral and Electrolyte Metabolism

Volumn 24, Issue 6, 1998, Pages 362-370

  Zitnay, Christopher ^a   Siragy, Helmy M ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Angiotensin II; AT 1 receptor; AT 2 receptor; Atherosclerosis; Kidney

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PHOSPHOLIPASE D;

ALDOSTERONE RELEASE; ATHEROGENESIS; CARDIOMYOPATHY; DIABETIC NEPHROPATHY; GLOMERULUS FILTRATION RATE; HORMONAL REGULATION; HORMONE RECEPTOR INTERACTION; HUMAN; HYPERTENSION; KIDNEY BLOOD FLOW; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR DENSITY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SODIUM ABSORPTION; TISSUE DISTRIBUTION;

ANIMALS; ARTERIOSCLEROSIS; BLOOD VESSELS; HOMEOSTASIS; HUMANS; ISOMERISM; KIDNEY TUBULES; RECEPTORS, ANGIOTENSIN; RENAL CIRCULATION;

EID: 0032427661     PISSN: 03780392     EISSN: None     Source Type: Journal    
DOI: 10.1159/000057397     Document Type: Review

References (93)

1. Moe O, Ujiie K, Star R, Miller T, Widell J, Alpein R, Henrich W: Renin expression in renal proximal tubule. J Clin Invest 1993;91:774-779.
2. Ingelfinger J, Zuo W, Fon E, Ellison K, Dzau V: In-situ hybridization evidence for angiotensinogen messenger mRNA in the rat proximal tubule. J Clin Invest 1990;85:417-423.
3. Johnston C, Fabris B, Jandeleit K: Intrarenal renin-angiotensin system in renal physiology and pathophysiology. Kidney Int 1993; 44(suppl 42):59-63.
4. Seikaly M, Arant B, Seney F: Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest 1990;86:1352-1357.
5. Gomez R, Lynch K, Sturgill B, Elwood J, Chevalier R, Carey R, Peach M: Distribution of rcnin mRNA and its protein in the developing kidney. Am J Physiol 1989;257:F850-F858.
6. Mulrow P: The intrarenal renin-angiotensin system. Curr Opin Nephrol Hypertens 1993;2:41-44.
7. Danser A, Schalekamp MA: Is there an internal cardiac renin-angiotensin system? Heart 1996; 76(suppl 3):28-32.
8. Re R, Fallen J, Dzav V, Quay S, Habor E: Renin synthesis by canine aortic smooth muscle cells. Life Sci 1982;30:99-100.
9. Kifor I, Dzav V: Endothelial renin-angiotensin pathway: Evidence for intracellular synthesis and secretion of angiotensin. Circ Res 1987;60: 422-128.
10. Ohkubo H, Nakayayama K, Tanaka T, Nakanishi S: Tissue distribution of rat angiotensinogen mRNA and structural analysis of its heterogeneity. J Biol Chem 1986;262:319.
11. Navar L, Inscho E, Majid S, Imig J, Harrison-Bernard L, Mitchell K: Paracrine regulation of the renal microcirculation. Physiol Rev 1996;76: 425-436.
12. Dorrer F, Lentz K, Kahn J: A comparison of the substrate specificities of cathepsin D and psucdorenin. J Biol Chem 1987;243:31-40.
13. Hackenthal E, Hackenthal R, Helgenfeld U: Purification and partial characterization of rat brain acid proteinase (isorenin). Biochim Biophys Acta 1978;522:561.
14. Urata H, Strobel F, Ganten D: Widespread tissue distribution of human chymase. J Hypertens 1994;12(suppl 9):17-22.
15. Churnow K, Pascoe L, White P: Genetic analysis of the human type-1 angiotensin II receptor. Mol Endocrinol 1992;6:1113-1118.
16. Goodfriend T, Elliot M, Catt K: Angiotensin receptors and their antagonists. N Engl J Med 1996;334:1649-1654.
17. Ullian M, Linas S: Role of receptor cycling in the regulation of angiotensin II surface receptor number and angiotensin II uptake in rat vascular smooth muscle. J Clin Invest 1989;84:840-846.
18. Hein L, Sasamuara H, Pratt R, Dzau V, Kibilka B: Cellular trafficking of angiotensin-II and its AT-1 receptor. Circulation 1993;88(suppl 1):281.
19. 2-adrenergic receptor desensitization. J Biol Chem 1990;265:3202-3209.
20. 2-adrenergic receptor. J Biol Chem 1989;264:16786-16792.
21. 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J Biol Chem 1989;264:12657-12655.
22. Kai H, Griendling K, Lassegue B, Ollerenshaw J, Runge M, Alexander W: Agonist-induced phosphorylation of the vascular type I angiotensin receptor. Hypertension 1994;24:523-527.
23. Nickening G, Murphy T: Down-regulation by growth factors of vascular smooth muscle angiotensin receptor gene expression. J Mol Pharmacol 1994;46:653-659.
24. Murphy T, Nickening G: Enhanced mRNA degradation in vascular smooth muscle cells: A mechanism for heterologous down-regulation of AT-1, 5ht2 and thrombin receptor. FASEB J 1995;9:271.
25. Yamazaki T, Shiojima I, Komuro I, Nagai R, Yazaki Y: Involvement of the renin-angiotensin system in the development of left ventricular hypertrophy and dysfunction. J Hypertens 1994; 12(suppl9):23-27.
26. Mendelsohn F, Jenkins T, Berkovic S: Effects of angiotensin on dopaminc and serotonin turn-over in the striatum of conscious rats. Brain Res 1993;613:221-229.
27. Regitz-Zargosek V, Neub M, Holzmeister J, Warnecke C, Fleck E: Molecular biology of angiotensin receptors and their role in human cardiovascular disease. J Mol Med 1996;74:233-251.
28. Zhuo J, Allen A, Alcorn D, Aldrer P, MacGregor D, Mendelsohn F: The distribution of angiotensin II receptors; in Laragh J, Brenner B (eds): Hypertension: Pathophysiology, Diagnosis, and Management. New York. Raven Press, 1995.
29. Barnes J, Steward L, Barber P, Barnes N: Identification and characterization of angiotensin II receptor subtypes in human brain. Eur J Pharmacol 1993;230:251-258.
30. Allen A, Paxinos G, McKinley M, Chai S, Mendelsohn F: Localization and characterization of angiotensin II receptor binding sites in the human basal ganglion, thalamus, midbrain pons, and cerebellum. J Comp Neurol 1987;312:291-298.
31. Allen A, MacGregor D, Chai S, Donnan Ga, Kaczmarczyk S, Richardson K, Kalnins R, Ireton J, Mendelsohn F: Angiotensin II receptor binding associated with nigrostriatal dopaminergic neurons in human basal ganglia. Ann Neurol 1992;32:339-344.
32. Sasaki K, Yamano Y, Bardhan S, Iwai N, Murray J, Hasegawa M, Matsuda Y: Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin 11 type receptor. Nature 1991;351:230-233.
33. Murphy T, Alexander R, Griendling K, Runge M, Bernstein K: Isolation of cDNA encoding the vascular type-1 angiolensin II receptor. Nature 1991;351:233-235.
34. Ruan X, Wagber C, Chatiantoniou C, Kurtz A, Arendshorst W: Regulation of angiotensin II receptor AT-1 subtypes in renal afferent arterioles during chronic changes in sodium diet. J Clin Invest 1997;99:1072-1081.
35. Catt K, Balla A, Hausdorff W, Aguilera G: Control of glomerulosa cell function by angiotensin-II: Transduction by G-proteins and inositol polyphosphates. Clin Exp Pharmacol Physiol 1988;15:501-505.
36. Pfeilschifter J, Huwiler A, Merriweather C, Brier V: Angiotensin II stimulation of phospholipase D in rat mesangial cells is mediated by the AT-1 receptor subtype. Eur J Pharmacol 1992;225:57-62.
37. Pfeilschifter J, Bauer P: Pertussis toxin abolishes angiotensin-II induced phosphoinositide hydrolysis and prostaglandin synthesis in rat mesangial cells. J Biochem 1985;236:289-294.
38. Yoshida M, Kikukawa M, Hisa H, Satoh S: Modulation by nitric oxide and prostaglandin of the renal vascular response to angiotensin-II. Br J Pharmacol 1996;117:885-890.
39. Siragy H, Jaffa A, Margolius H, Carey R: Renin-angiotensin system modulates renal bradykinin production. Am J Physiol 1996;271: R1090-R1095.
40. Marrrero M, Schieffer B, Paxton W, Heerdt L, Berk N, Delafontain P, Bernstein K.: Direct stimulation of JAK/Stat pathway by the angiotensin II AT-1 receptor. Nature 1995;375:247-250.
41. Alcorn D, McMausland J, Marie C: Angiotensin receptors and development: The kidney. Clin Exp Pharmacol Physiol 1996;3(suppl 3): 88-92.
42. Tufro-McReddie A, Romano L, Harris J, Ferder L, Gomez R: Angiotensin II regulates nephrogenesis and renal vascular development. Am J Physiol 1995;269:F110-F115.
43. Takahasi K, Bardhan S, Kambayashi Y, Shirai H, Inagami T: Protein tyrosine phosphatase inhibition by angiotensin II in rat pheochromocytoma through type 2 receptor AT-2. Biochem Biophys Res Commun 1994;198:60-66.
44. Mukoyama M, Nakajima M, Horiiuchi M, Sasamura H, Prat R, Dzau V: Expression cloning of type 2 angiotensin receptor reveals a unique class of seven transmembrane receptors. J Biol Chem 1993;268:24539-24542.
45. Siragy H, Carey R: The subtype-2 (AT2) angiotensin receptor regulates renal production of nitric oxide in conscious rats. J Clin Invest 1997; 100:264-269.
46. 2 production in conscious rats. J Clin Invest 1996;97:1978-1982.
47. Moncada S, Palmer R, Higgs E: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;262:F417-F424.
48. Lo M, Liu K, Lantelme P, Sassard J: Subtype 2 of angiotensin II receptors controls pressure natriuresis in rats. J Clin Invest 1995;95:1394-1397.
49. Xie M, Liu F, Wong P, Timmerman P, Cogan M: Proximal nephron and renal effects of DuPt53, a nonpeptide angiotensin II receptor antagonist. Kidney Int 1990;38:473-479.
50. Lorenz J, Weihprecht H, He X, Skott O, Briggs J, Schnermann J: Effect of adenosine and angiotensin on macula densa-stimulated renin secretion. Am J Physiol 1993;265:F187-F194.
51. Ozono R, Wang ZQ, Moore A, Inagami T, Siragy H, Carey R: Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidney. Hypertension 1997.30:1238-1246.
52. Arima S, Eado Y, Yaoita H, Omaha V, Ogaua S, Tsunoda K, Abe M, Teikeuchi K, Abe K, Ito S: Possible role of p450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin type 2 receptors in isolated microperfused rabbit afferent arteriole. J Clin Invest 1997;100: 2816-2823.
53. Ajikobi D, Novak P, Salevsky F, Cupples W: Pharmacologic modulation of spontaneous renal blood flow dynamics. Can J Physiol Pharmacol 1996;74:964-972.
54. Ghandi S, Ryder D, Brown N: Losartan blocks aldosterone and renal vascular responses to angiotensin II in humans. Hypertension 1996; 28:961-966.
55. Yamada T, Horiuchi M, Dzau V: Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 1996;93:156-160.
56. Tanaka M, Ohnishi J, Ozawa Y, Sugimoto M, Usuki S, Naruse M, Murakami K, Yazaki H: Characterization of angiotensin II receptor type 2 during differentiation and apoptosis of the rat ovarian cultured granulosa cells. Biochem Biophys Res Commun 1995;207:593-598.
57. Kajstua J, Cigola E, Malhorta A, Li P, Cheng W, Meggs L, Anversa P: Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol 1997;29:859-870.
58. Stroll M, Steckelings M, Paul M, Bottari P, Metzger R, Unger T: The angiotensin AT2 receptor mediates inhibition of cal proliferation in coronary endothelial cells. J Clin Invest 1995; 95:651-657.
59. Nakajitna M, Hutchinson H, Fujinaga M, Hayashida W, Morishita R, Horiuchi M, Pratt R, Dzau V: The angiotensin 11 type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: Gain of function study using gene transfer. Proc Natl Acad Sci USA 1995;92: 10663-10667.
60. Nakamura M, Yoshida H, Hiramori K: Effect of angiotensin 11 receptor blockade on angiotensin II stimulated DNA synthesis of cultured human aortic smooth muscle cells. Life Sci 1995; 56:PL383-PL388.
61. Pollman M, Yamada T, Horiuchi M, Gibbons G: Vasoactive substances regulate smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin II. Circ Res 1996; 79:748-756.
62. Mento P, Malta M, Wilkes B: Renal hemodynamics in rats with myocardial infarction: Selective antagonism of angiotensin receptor subtypes. Division of Nephrology and Hypertension. Department of Medicine. North Shore University Hospital, and the Department of Medicine, Cornell University Medical College, Manhasset, New York APStracts 1996;3: 0209H.
63. Yoshimura Y: The ovarian renin-angiotensin system in reproductive physiology. Front Neuroendocrinol 1997;18:247-291.
64. Simon G, Abraham G: Angiotensin II administration as an experimental model of hypertension; in Laragh J, Brenner B (eds): Hypertension: Pathophysiology, Diagnosis, and Management. New York, Raven Press, 1995.
65. Robertson J, Morton J, Tillman D, Lever A: The pathophysiology of renovascular hypertension. J Hypertens 1986;4(suppl 4):95-103.
66. Fitzgerald S, Stevenson K, Evans R, Anderson W: Low dose angiotensin II infusions into the renal artery induce chronic hypertension in conscious dogs. Blood Press 1997;6:52-61.
67. Schmieder R, Veelken R, Schobel H, Dominiak P, Mann J, Luft F: Glomerular hyperfiltration during sympathetic nervous system activation in early essential hypertension. J Am Soc Nephrol 1997;8:893-900.
68. Kost CK, Herzer W, Li P, Notoya M, Mizuhira V, Inagami T, Jackson E: Angiotensin II-induced structural and functional alterations in spontaneously hypertensive rat kidney. Am J Physiol 1996;270:F229-F236.
69. Brannstrom K, Morsing P, Arendshorst W: Exaggerated tubuloglomerular feedback activity in genetic hypertension is mediated by ANG-II and AT-II. Am J Physiol 1996;270:F749-F755.
70. Liu K, Sassard J, Benzoni D: In the Lyon hypertensive rat, renal functional alterations are angiotensin II dependent. Am J Physiol 1996;217: R346-R356.
71. Hickey H, Makdissi M, Hyland R, Wilks D, Dustin G: Perindopril treatment prevents the loss of endothelial NO function and development of neointima in rabbit. J Mol Cell Cardiol 1996;28:1985-1994.
72. Bentos A, Safar M: Aortic collagen, aortic stiffness, and AT-1 receptors in experimental and human hypertension. Can J Physiol Pharmacol 1996;74:862-866.
73. Sugano M, Makino N, Yanaga T: The effects of renin-angiotensin system inhibition on aortic cholesterol content in cholesterol-feed rabbits. Atherosclerosis 1996;127:123-129.
74. Kim J, Benlries J, Nadler J: Angiotensin II increases monocyte binding to endothelial cell. Biochem Biophys Res Commun 1996;226:862-868.
75. Cachofeiro V, Maeso R, Munoz-Garcia R, Lahera V: The potential role of nitric oxide in angiotensin II receptor blockade. Blood Press 1996;2(suppl):29-35.
76. 2+ concentrations in essential hypertension. Hypertension 1993;22: 853-862.
77. Koppel H, Eber B, Gasser R, Klein W: Recent molecular and pharmacologic aspects of ACE inhibitors. Wien Med Wochenschr 1995;145: 633-637.
78. Kerins D, Hao Q, Vaughn D: Angiotensin induction of PAI-1 expression in endothelial cells is mediated by the hexapeptide angiotensin IV. J Clin Invest 1995;96:2515-2520.
79. Parving H, Anderson A, Smidt U, Oxenboll B, Edsberg B, Christiansen J: Diabetic nephropathy and arterial hypertension. Diabetologia 1983;20:10-12.
80. Mogensen C: Diabetes mellitus and the kidney. Kidney Int 1982;21:673-675.
81. Adler S: Structure-function relationships associated with extracellular matrix alteration in diabetic glomerulopathy. J Am Soc Nephrol 1994; 5:1165-1172.
82. Ziyadeh F: Renal tubular membrane and collagen type IV in diabetes mellitus. Kidney Int 1993;43:114-120.
83. Ballerman B, Skorecki K, Brenner B: Reduced glomerular angiotensin-II receptor density in early untreated diabetes mellitus in the rat. Am J Physiol 1984;247:F110-F116.
84. Cheng H, Burns K, Harris R: Reduced proximal tubule angiotensin-II receptor expression in streptozotocin-induced diabetes mellitus. Kidney Int 1994;46:1603-1610.
85. Williams B, Tsai P, Schrier R: Glucose-induced downregulation of angiotensin II and arginine vasopressin receptors in cultures of rat aortic smooth muscle cells: Possible role of protein kinase. J Clin Invest 1992;90:1992-1999.
86. Lassegue B, Alexander R, Nickening G, Clark M, Murphy T, Griendling K: Angiotensin II down-regulates the vascular smooth muscle AT 1 receptor by transcriptional and post-transeriptional mechanism: Evidence for homologous and heterologus regulation. Mol Pharmacol 1995;48:601-609.
87. Wolf G, Neilson E, Goldfarb S, Ziyadeh F: The influence of glucose concentration on angiotensin-II-induced hypertrophy of proximal tubular cells in culture. Biochem Biophys Res Commun 1991;176:902-909.
88. Wolf G, Ziyadeh F: The role of angiotensin II in diabetic ncphropathy: Emphasis on nonhemodynamic mechanisms. Am J Kidney Dis 1997;29:153-163.
89. Young B, Johnson R, Alpers C, Eng E, Gordon K, Floege J, Couser W: Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int 1995;47:935-944.
90. Di Paolo S, Gesualdo L, Ranieri E, Schena F: High glucose modulates growth factor expression in human mesangial cells. Kidney Int 1995; 47:693.
91. Wolf G, Heeger P, Neilson E: Proto-oncogenes as targets of hormone and growth factor actions in the kidney; in Goldfarb S, Ziyadeh F (eds): Hormones, Autocoids, and the Kidney. Contemp Issues Nephrol. Edinburgh, Churchill Livingstone, 1991, vol 23, pp 111-139.
92. 2+ in vascular smooth muscle. Hypertension 1985;7:447-451.
93. Natarajan R, Stern N, Nadler J: Arachidonic acid metabolites on renin and vascular smooth muscle cell growth: in Sowers J (ed): Contemporary Endocrinology: Endocrinology of the Vasculature. Clifton. Humana Press Inc, 1996.