Characterization of two monoclonal antibodies against the RON tyrosine kinase receptor

Hybridoma

Volumn 17, Issue 6, 1998, Pages 541-551

  Montero Julian, F A ^a   Dauny, I ^a   Flavetta, S ^a   Ronsin, C ^b   Andre F ^c   Xerri, L ^d   Wang, M H ^e   Marvaldi, J ^c   Breathnach, R ^b   Brailly, H ^a  

^a Immunotech   (France)

^b INSTITUT DE BIOLOGIE   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d INSTITUT PAOLI CALMETTES   (France)

^e WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROPHAGE ACTIVATING FACTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY ID 1; MONOCLONAL ANTIBODY ID 2; SCATTER FACTOR RECEPTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL SHAPE; COLON ADENOCARCINOMA; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE; HEMATOPOIETIC CELL; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LEUKEMIA CELL; LIVER CELL CARCINOMA; LYMPHOMA CELL; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032426047     PISSN: 0272457X     EISSN: None     Source Type: Journal    
DOI: 10.1089/hyb.1998.17.541     Document Type: Article

References (38)

1. Rosin C, Muscatelli F, Mattei M-G, and Breathnac R: Novel putative receptor protein tyrosine kinase of the met family. Oncogene 1993;8:1195-1202.
2. Bottaro D, Rubin JS, Faletto DL, Chan AML, Kmiecik TE, Vande Woude GF, and Aaronson SA: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991;251:802-804.
3. Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK, Birchmeier W, and Comoglio PM: Scatter factor and hepatocyte growth factor are indistinguishable ligands for the Met receptor. EMBO J 1991;10:2687-2878.
4. Rosen EM, Knesel J, and Goldberg ID: Scatter factor and its relationship to hepatocyte growth factor and met. Cell Growth Differ. 1991;2:603-607.
5. Whang-Peng J, Kao-Shan CS, Lee EC, Bunn PA, Carney DN, Gazdar AF, and Minna JD: Specific chromosoma defect associated with human small-cell lung cancer. Science 1982;215:181-182.
6. Brauch H, Johnson B, Hovis J, Yano T, Gazdar A, Pettengill OS, Graziano S, Sorenson GD, Poiesz B, Minna JD, Linehan M, and Zbar B: Molecular analysis of the short arm of chromosome 3 in small-cell and non-small-cell carcinoma of the lung. N Engl J Med 1987;317:1109-1113.
7. Kok K, Osinaga J, Carrit B, Davis MB, van der Hout AH, van der Veen AY, Landswatter RM, de Leij LFMH, Berendsen HH, Postmus PE, Poppema S, and Buys CHCM: Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer. Nature 1987;330:578-581.
8. Zbar B, Brauch H, Talmadge C, and Linehan M: Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 1987;327:721-724.
9. Kovacs G, Erlandsson R, Boldg F, Inguarsson S, Muller-Breshlin R, Klein G, and Sumegi J: Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. Proc Natl Acad Sci USA 1988;85:1571-1575.
10. Weston A, Willey JC, Modali R, Sugimura H, McDowell EM, Resau J, Light B, Haugen A, Mann DL, Trump BF, and Harris CC: Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung. Proc Natl Acad Sci USA 1989;86:5099-5130.
11. Anglard P, Trahan E, Liu S, Latif F, Merino MJ, Lerman MI, Zbar B, and Linehan WM: Molecular and cellular characterization of human renal cell carcinoma cell lines. Cancer Res 1992; 52:348-356.
12. Wang M-H, Ronsin C, Gesnel MC, Coupey L, Skeel A, Leonard EJ, and Breathnach R: Identification of the RON gene product as the receptor for the human macrophage stimulating protein. Science 1994;266:117-119.
13. Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski P, and Comoglio PM: RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J 1994;13:3524-3532.
14. Han S, Stuart LA, and Friezner Degen SJ: Characterization of the DNF15S2 locus on human chromosome 3: Identification of a gene coding for four kringle domains with homology to hepatocyte growth factor. Biochemistry 1991;30:9768-9780.
15. Skeel A, Yoshimura T, Showalter S, Tanaka S, Appella E, Leonard EJ: Macrophage stimulating protein: purification, partial amino acid sequence, and cellular activity. J Exp Med 1991;173: 1227-1234.
16. Yoshimura T, Yuhki N, Wang M-H, Skeel A, and Leonard E: Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of Kringle proteins and locates the MSP gene on chromosome 3. J Biol Chem 1993;268:15461-15468.
17. Iwama A, Okano K, Sudo T, Matsuda Y, and Suda T: Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells. Blood 1994;83:3160-3169.
18. Huff JL, Jelinek MA, Borgman CA, Lansing TJ, and Parsons JT: The proto-oncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor. Proc Natl Acad Sci USA 1993;90:6140-6144.
19. Wang M-H, Iwama A, Skeel A, and Leonard E: The murine stk gene product, a transmembrane protein tyrosine kinase, is a receptor for macrophage-stimulating protein. Proc Natl Acad Sci USA 1995;92:3933-3937.
20. Leonard EJ, and Skeel A: A serum protein that stimulates macrophage movement, chemotaxis and spreading. Exp Cell Res 1976;102:434-438.
21. Banu N, Price DJ, London R, Deng B, Mark M, Godowski PJ, and Avraham H: Modulation of megakaryocytopoiese by human macrophage-stimulating protein, the ligand for the RON receptor. J Immunol 1996;156:2933-2940.
22. Broxmeyer HE, Cooper S, Li ZH, Lu L, Sarris A, Wang MH, Chang MS, Donner DB, and Leonard J: Macrophage stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family. Ann Hematol 1996;73:1-9.
23. Kurihara N, Iwama A, Tatsumi J, Ikeda K, and Suda T: Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells. Blood 1996;87:3704-3710.
24. Wang M-H, Dlugosz A, Sun Y, Suda T, Skeel A, and Leonard EJ: Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes. Exp Cell Res 1996;226:39-46.
25. Bürk RR: A factor from a transformed cell line that affects cell migration. Proc Natl Acad Sci USA 1973;70:369-372.
26. Fantini J, Abadie B, Tirard A, Remy L, Ripert JP, el Battari A, and Marvaldi J: Spontaneous and induced clone formation by two clonal populations derived from a human adenocarcinoma cell line, HT29. J Cell Sci 1986;83:235-249.
27. Shiota G, Rhoads DB, Wang TC, Nakamura T, and Schmidt EV: Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells. Proc Natl Acad Sci USA 1992;89:373-377.
28. Giordano S, Ponzetto C, Di Renzo MF, Cooper CS, and Comoglio PM: Tyrosine kinase receptor indistinguishable from the c-met protein. Nature 1989;339:155-156.
29. Mark MR, Lokker NA, Zioncheck TF, Luis EA, and Godowski PJ: Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding. J Biol Chem 1992;267:2666-2671.
30. Crepaldi T, Prat M, Gioradno S, Medico E, and Comoglio PM: Generation of the truncated hepatocyte growth factor receptor in the endoplasmic reticulum. J Biol Chem 1994;269:1750-1755.
31. Iwama A, Wang M-H, Yamaguchi N, Ohno N, Okano K, Sudo T, Takeya M, Gervais F, Morissette C, Leonard E, and Suda T: Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein. Blood 1995;86: 3394-3403.
32. Huff JL, Jelinek MA, Jamieson TA, and Parson JT: Expression and maturation of the cellular sea receptor, a member of the hepatocyte growth factor (HGF) receptor family of protein tyrosine kinases. Oncogene 1996;12:299-307.
33. Skeel A, and Leonard EJ: Action and target cell specificity of human macrophage-stimulating protein. J Imunol 1994;152: 4618-4623.
34. Wang M-H, Montero-Julian FA, Dauny I, and Leonard EJ: Requirement of phosphatidylinositol-3 kinase for epithelial cell migration activated by human macrophage stimulating protein. Oncogene 1996;13:2167-2175.
35. Chen Q, Seol DW, Carr B, and Zamegar R: Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines. Hepatology 1997;26:59-66.
36. Sakamoto O, Iwama A, Amitani R, Takehara T, Yamaguchi N, Yamamoto T, Masuyama K, Yamanaka T, Ando M, and Suda T: Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary Motility. J Clin Invest 1997;99:701-709.
37. Quantin B, Schuhbaur B, Gesnel M, Dollé P, and Breathnach R: Restricted expression of the RON gene encoding the macrophage stimulating protein receptor during mouse development. Develop Dynamic 1995;204:383-390.
38. van der Voort R, Thaer EIT, Keehnen RMJ, Smit L, Groenik M, and Pals ST: Paracrine regulation of germinal center B cell adhesion through the c-Met-Hepatocyte Growth factor/scatter factor pathway. J Exp Med 1997;185:2121-2131.