Macrophage-stimulating protein, a ligand for the RON receptor protein tyrosine kinase, suppresses myeloid progenitor cell proliferation and synergizes with vascular endothelial cell growth factor and members of the chemokine family

Annals of Hematology

Volumn 73, Issue 1, 1996, Pages 1-9

  Broxmeyer, H E ^a   Cooper, S ^a   Li, Z H ^a   Lu, L ^a   Sarris, A ^b   Wang, M H ^c   Chang, M S ^d   Donner, D B ^a   Leonard, E J ^c  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d AMGEN INC   (United States)

Author keywords

Chemokines; Macrophage stimulating protein; Progenitor cells; Suppressive synergism; Vascular endothelial cell growth factor

Indexed keywords

CD34 ANTIGEN; CHEMOATTRACTANT; CHEMOKINE; ENDOTHELIAL CELL GROWTH FACTOR; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; INTERLEUKIN 3; INTERLEUKIN 8; MACROPHAGE ACTIVATING FACTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN TYROSINE KINASE; THROMBOCYTE FACTOR 4; VASCULOTROPIN;

ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; COLONY FORMATION; COLONY FORMING UNIT GM; CONTROLLED STUDY; ERYTHROID CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; NORMAL HUMAN; PRIORITY JOURNAL; PROMYELOCYTE; STEM CELL; UMBILICAL CORD BLOOD;

BONE MARROW CELLS; CELLS, CULTURED; CHEMOKINES; CHEMOKINES, CXC; COLONY-FORMING UNITS ASSAY; ENDOTHELIAL GROWTH FACTORS; GROWTH INHIBITORS; GROWTH SUBSTANCES; HEMATOPOIESIS; HEPATOCYTE GROWTH FACTOR; HUMANS; INTERLEUKIN-8; LIGANDS; LYMPHOKINES; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0030055380     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002770050192     Document Type: Article

References (35)

1. Broxmeyer HE (1993) Role of cytokines in hematopoiesis. In: Oppenheim JJ, Rossio JL, Gearing AJH (eds) Clinical aspects of cytokines: role in pathogenesis, diagnosis and therapy. Oxford University Press, New York, pp 201-206
2. Broxmeyer HE (1995) Role of cytokines in hematopoiesis. In: Aggarwal BB, Puri RK (eds.) Human cytokines: their role in disease and therapy. Blackwell Scientific, Cambridge, MA. pp 27-36
3. Broxmeyer HE (1996) Myelosuppressive cytokines and peptides. In: Whetton T (ed) Blood cell biochemistry, vol. 7: Hemopoietic growth factors. Plenum, London (in press)
4. Broxmeyer HE, Maze R, Miyazawa K, Carow C, Hendrie PC, Cooper S, Hangoc G, Vadhan-Raj S, Lu L (1991) The Kit receptor and its ligand, steel factor, as regulators of hemopoiesis. Cancer Cells 3:480-487
5. Lyman SD (1995) Biology of Flt3 ligand and receptor. Int J Hematol 62:63-73
6. Broxmeyer HE, Lu L, Cooper S, Ruggieri L. Li ZH, Lyman SD (1995) Flt3-ligand stimulates/co-stimulates the growth of myeloid stem/progenitor cells. Exp Hematol 23:1121-1129
7. Broxmeyer HE,. Cooper S, Li ZH, Lu L, Song HO, Kwon BS, Warren RE, Donner DB (1995) Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor, a ligand for the tyrosine kinase receptor Flk-1. Int J Hematol 62:203-215
8. Broxmeyer HE, Sherry B, Lu L, Cooper S, Oh KO, Tekamp-Olson P, Kwon BS, Cerami A (1990) Enhancing and suppressing effects of recombinant murine macrophage inflammatory proteins on colony formation in vitro by bone marrow myeloid progenitor cells. Blood 76:1110-1116
9. Broxmeyer HE, Sherry B, Cooper S, Lu L, Maze R, Beckmann MP, Cerami A, Ralph P (1993) Comparative analysis of the suppressive effects of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells. J Immunol 150:3448-3458
10. Sarris AH, Broxmeyer HE, Wirthmueller U, Karasavvas N, Krueger J, Ravetch JV (1993) Human interferon inducible protein 10:expression and purification of recombinant protein demonstrate inhibition of early human hematopoietic progenitors. J Exp Med 178:1127-1132
11. Mantel C, Kim YJ, Cooper S, Kwon B, Broxmeyer HE (1993) Polymerization of murine macrophage inflammatory protein-1a inactivates its myelosuppressive effects in vitro. The active form is monomer. Proc Natl Acad Sci U S A 90:2232-2236
12. Daly TJ, LaRosa GJ, Dolich S. Maione TE, Cooper S, Broxmeyer HE (1995) High activity suppression of myeloid progenitor proliferation by chimeric mutants of interleukin 8 and platelet factor 4. J Biol Chem 270:23282-23292
13. Broxmeyer HE, Cooper S, Hague N, Benninger L, Sarris A, Cornetta K, Vadhan-Raj S, Hendrie P, Mantel C (1995) Human chemokines: enhancement of specific activity and effects in vitro on normal and leukemic progenitors and a factor dependent cell line and in vivo in mice. Ann Hematol 71:235-246
14. Youn BS, Jang IK, Broxmeyer HE, Cooper S, Jenkins NA, Gilbert DJ, Copeland NG, Elick TA, Fraser Jr, MJ, Kwon BS (1995) A novel chemokine, macrophage inflammatory protein-related protein-2, inhibits colony formation of bone marrow myeloid progenitors. J Immunol 155:2661-2667
15. +++ stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum. Exp Hematol 21:1442-1446
16. Leonard EJ, Skeel A (1976) A serum protein that stimulates macrophage movement, chemotaxis and spreading. Exp Cell Res 102:434-438
17. Leonard EJ, Skeel A (1978) Isolation of macrophage stimulating protein (MSP) from human serum. Exp Cell Res 114:117-126
18. Skeel A, Leonard EJ (1994) Action and target cell specificity of human macrophage stimulating protein (MSP). J Immunol 152:4618-4623
19. Skeel A, Yoshimura T, Showalter S, Tanaka S, Appella E, Leonard E (1991) Macrophage stimulating protein: purification, partial amino acid sequence and cellular activity. J Exp Med 173:1227-1234
20. Wang M-H, Cox GW, Yoshimura T, Sheffler LA, Skeel A, Leonard EJ (1994) Macrophage-stimulating protein inhibits induction of nitric oxide production by endotoxin- or cytokine-stimulated mouse macrophages. J Biol Chem 269:14027-14031
21. Wang M-H, Ronsin C, Gesnel MC, Coupey M, Skeel A, Leonard EJ, Breathnach R (1994) Identification of the Ron gene product as the receptor for the human macrophage stimulating protein. Science 266:117-119
22. Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo MA, Godowski PJ, Comoglio PM (1994) Ron is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J 13:3524-3532
23. Wang M-H, Iwana A, Skeel A, Suda T, Leonard EJ (1995) The mouse STK gene product, a transmembrane receptor protein tyrosine kinase, is a receptor for macrophage stimulating protein. Proc Natl Acad Sci U S A 92:3933-3937
24. Chang M-S, McNinch J, Basu R, Simonct S (1994) Cloning and characterization of the human neutrophil activating peptide (ENA-78) gene. J Biol Chem 269:25277-25282
25. Walz A, Burgener R, Car B, Baggiolini M, Kunkel SL, Strieter RM (1991) Structure and neutrophil-activating properties of novel inflammatory peptide (ENA-78) with homology to interleukin-8. J Exp Med 174:1355-1362
26. +++ human umbilical cord blood hematopoietic progenitor with high proliferative and replating potential. Blood 81:41-48
27. Hendrie PC, Miyazawa K, Yang YC, Langefeld CD, Broxmeyer HE (1991) Mast cell growth factor (c-kit ligand) enhances cytokine stimulation of proliferation of human factor-dependent cell line. M07e. Exp Hematol 19:1031-1037
28. Xiao M, Leemhuis T, Broxmeyer HE, Lu L (1992) Influence of combinations of cytokines on proliferation of isolated single cell-sorted bone marrow hematopoietic progenitor cells in the absence and presence of serum. Exp Hematol 20:276-279
29. Broxmeyer HE, Hangoc G, Cooper S, Ribeiro RC, Graves V, Yoder M, Wagner J, Vadhan-Raj S, Rubinstein P, Broun ER (1992) Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation of adults. Proc Natl Acad Sci U S A 89:4109-4113
30. Broxmeyer HE, Cooper S, Rubin BY, Taylor MW (1985) The synergistic influence of human gamma- and alpha-interferons on suppression of hematopoietic progenitor cells is additive with the enhanced sensitivity of these cells to inhibition by interferons at low oxygen tension in vitro. J Immunol 135:2502-2506
31. Broxmeyer HE, Williams DE, Lu L, Cooper S, Anderson SL, Beyer GS, Hoffman R, Rubin BY (1986) The suppressive influences of human tumor necrosis factor on bone marrow hematopoietic cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and gamma interferon. J Immunol 136:4487-4495
32. Iwama A, Okana K, Suda T, Matsuda Y, Suda T (1994) Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells. Blood 83:3160-3169
33. Mantel C, Aronica S, Luo Z, Marshall MS, Kim YJ, Broxmeyer HE (1995) Macrophage inflammatory protein 1α enhances growth-factor stimulated phospholipid turnover and increases cAMP levels in the human factor-dependent cell line, M07e. J Immunol 154:2342-2350
34. Aronica SM, Mantel C, Gonin R, Marshall MS, Sarris A, Cooper S, Hague N, Zhang XF, Broxmeyer HE (1995) Interferon-inducible protein 10 and macrophage inflammatory protein-1α inhibit growth factor stimulation of Raf-1 kinase activity and protein synthesis in a human growth factor-dependent hematopoietic cell line. J Biol Chem 270:21998-22007
35. Aronica S, Gingras A, Sonenberg N, Sarris A, Broxmeyer HE (1995) IP-10 and MIP-1α growth factor-stimulated activation of MAP kinase and phosphorylation of eukaryotic initiation factor-4E in growth factor-dependent M07e cells. Blood 86[Suppl 1]:12a (abstract)