Age-associated memory impairment. Assessing the role of nitric oxide

Annals of the New York Academy of Sciences

Volumn 854, Issue , 1998, Pages 307-317

  Meyer, Robert C ^a   Spangler, Edward L ^a   Kametani, Hideki ^b   Ingram, Donald K ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b Fukuoka Prefectural University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLUTAMIC ACID; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTRANSMITTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

AGE; AGING; ALZHEIMER DISEASE; AMNESIA; CALCIUM TRANSPORT; CELL LOSS; CONFERENCE PAPER; ENZYME INHIBITION; HIPPOCAMPUS; INFORMATION PROCESSING; LEARNING; MAZE TEST; MICRODIALYSIS; NERVE CELL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0032424804     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb09911.x     Document Type: Conference Paper

References (62)

1. BELLEVILLE, S., I. PERETZ & D. MALENFANT. 1996. Examination of the working memory components in normal aging and in dementia of the Alzheimer's type. Neuropsychologia 34: 195-207.
2. CROOK, T., R.T. BARTUS, S. FERRIS, P. WHITEHOUSE, G. COHEN & S. GERSHON. 1986. Age-associated memory impairment: Proposed diagnostic criteria and measures of clinical change - Report of a National Institute of Mental Health Work Group. Dev. Neuropsychiatry 2: 261-276.
3. ARNSTEN, A.F. & P.S. GOLDMAN-RAKIC. 1987. Noradrenergic mechanisms in age-related cognitive decline. J. Neural. Transm. Suppl. 24: 317-324.
4. ALTMAN, H.J. & H.J. NORMILE. 1988. What is the nature of the role of the serotonergic nervous system in learning and memory: Prospects for developent of an effective treatment strategy for senile dementia. Neurobiol. Aging 9: 627-638.
5. NAGAHARA, A.H., T.M. GILL, M. NICOLLE & M. GALLAGHER. 1996. Alterations in opiate receptor binding in the hippocampus of aged Long-Evans rats. Brain Res. 707: 22-30.
6. MOORE, H., M. SARTER & J.P. BRUNO. 1992. Age-dependent modulation of in vivo cortical acetylcholine release by benzodiazepine receptor ligands. Brain Res. 596: 17-29.
7. BARTUS, R.T., R.L. DEAN, B. BEER & A.S. LIPPA. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408-412.
8. GREENAMYRE, J.T. & A.B. YOUNG. 1989. Excitatory amino acids and Alzheimer's disease. Neurobiol. Aging 10: 593-602.
9. POMPONI, M., E. GIACONINI & M. BRUFANT. 1990. Present state and future development of the therapy of Alzheimer's disease. Aging 2: 125-153.
10. HAGAN, J.J. 1994. The status of the cholinergic hypothesis of dementia. In Anti-Dementia Agents. D. Nicholson, Ed.: 86-138. Academic Press. San Diego, CA.
11. EAGGER, S.A., R. LEVY & B.J. SAHAKIAN. 1991. Tacrine in Alzheimer's disease. Lancet 337: 989-992.
12. KAWAKAMI, Y., A. INOUE, T. KAWAI, M. WAKITA, H. SUGIMOTO & A.J. HOPFINGER. 1996. The rationale for E2020 as a potent acetylcholinesterase inhibitor. Bioorg. & Med. Chem. 4: 1429-1446.
13. STONE, T.W. 1994. Excitatory amino acids and dementia. In Anti-Dementia Agents. D. Nicholson, Ed.: 229-249. Academic Press. San Diego, CA.
14. CHOI, D.W. & S.M. ROTHMAN. 1990. The role of glutamate neurotoxicity in hypoxia-ischemic neuronal death. Annu. Rev. Neurosci. 13: 171-182.
15. LYNCH, D.R. & T.M. DAWSON. 1994. Secondary mechanisms in neuronal trauma. Curr. Opin. Neurol. 7: 510-516.
16. INGRAM, D.K. 1988. Complex maze learning in rodents as a model of age-related memory impairment. Neurobiol. Aging 9: 475-485.
17. INGRAM, D.K., E.L. SPANGLER, S. IIJIMA, H. IKARI, H. KUO, N.H. GREIG; & E.D. LONDON. 1994. Rodent models of memory dysfunction in Alzheimer's disease and normal aging: Moving beyond the cholinergic hypothesis. Life Sci. 55: 2037-2049.
18. INGRAM, D.K., A. SHIMADA, E.L. SPANGLER, H. IKARI, J. HENGEMIHLE, H. KUO & N. GREIG. 1996. Cognitive enhancement: New strategies for stimulating cholinergic, glutamatergic, and nitric oxide systems. Ann. N.Y. Acad. Sci. 786: 348-361.
19. SPANGLER, E.L., P. RIGBY & D.K. INGRAM. 1986. Scopolamine impairs learning performance of rats in a 14-unit T-maze. Pharmacol. Biochem. Behav. 25: 673-679.
20. SPANGLER, E.L., M.E. CHACHICH, N.J. CURTIS & D.K. INGRAM. 1989. Age-related impairment in complex maze learning in rats: Relationship to neophobia and cholinergic antagonism. Neurobiol. Aging 10: 133-141.
21. KAMETANI, H., E.L. SPANGLER, E.L. BRESNAHAN, S. KOBAYOSHI, J.M. LONG & D.K. INGRAM. 1993. Impaired acquisition in a 14-unit T-maze following septal lesions in rats is correlated with lesion size and hippocampal acetylcholinesterase staining. Physiol. & Behav. 53: 221-228.
22. IIJIMA, S., N.H. GREIG, P. GAROFALO, E.L. SPANGLER, B. HELLER, A. BROSSI & D.K. INGRAM. 1993. Phenserine: A physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze. Psychopharmacology 112: 415-420.
23. GREIG, N.H., X-F. PEI, T.T. SONCRANT, D.K. INGRAM & A. BROSSI. 1995. Phenserine and ring C hetero-analogues: Drug candidates for the treatment of Alzheimer's disease. Med. Res. Rev. 15: 3-31.
24. IKARI, H., E.L. SPANGLER, N.H. GREIG, X-F. PEI, A. BROSSI, D. SPEER, N. PATEL & D.K. INGRAM. 1995. Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase. Neuroreport. 6: 481-484.
25. PALMER, A.M. & S. GERSON. 1990. Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? FASEB J. 4: 2745-2752.
26. GARTHWATTE, J. 1991. Glutamate, nitric oxide, and cell-cell signaling in the nervous system. Trends Neurosci. 14: 60-67.
27. BANNERMAN, D.M., P.F. CHAPMAN, P.A.T. KELLY, S.P. BUTCHER & R.G.M. MORRIS. 1994. Inhibilion of nitric oxide synthase does not impair spatial learning. J. Neurosci. 14: 7404-7414.
28. BARNES, C.A., B.L. MCNAUGHTON, D.S. BREDT, C.D. FERRIS & S. SNYDER. 1994. Nitric oxide synthase inhibition in vivo: Lack of effect on hippocampal synaptic enhancement or spatial memory. In Long-term Potentiation: A Debate of Current Issues. M. Baudry & J. Davis, Eds.: 37-43. MIT Press. Cambridge, MA.
29. CHAPMAN, P.F., C.M. ATKINS, M.T. ALLEN, J.E. HALEY & J.E. STEINMETZ. 1992. Inhibition of nitric oxide synthase impairs two different forms of learning. Neuroreport 3: 567-570.
30. ESTALL, L.B., S.J. GRANT & G.A. CICALA. 1993. Inhibition of nitric oxide (NO) production selectively impairs learning and memory in the rat. Pharmacol. Biochem. Behav. 46: 959-962.
31. MOGENSEN, J., G. WORTWEIN, A. HASMAN, P. NIELSEN & Q. WANG. 1995. Functional and neurochemical profile of place learning after L-nitro-arginine in the rat. Neurobiol. Learn. Mem. 63: 54-65.
32. MOGENSEN, J., G. WORTWEIN, B. GUSTAFSON & P. ERMENS. 1995. L-Nitro-arginine reduces hippocampal mediation of place learning in the rat. Neurobiol. Learn. Mem. 64: 17-24.
33. BOHME, G.A., C. BON, J-M. STUTZMANN, A. Doble & J-C. BLANCHARD. 1991. Possible involvement of nitric oxide in long-term potentiation. Eur. J. Pharmacol. 199: 379-381.
34. MADISON, D.V. & E.M. SCHUMAN. 1991. A requirement for the intercellular messenger nitric oxide in long-term potentiation. Science 254: 1503-1506.
35. MEYER, R.C., J.K. KNOX, D. PURWIN, E.L. SPANGLER & D.K. INGRAM. 1997. Combined modulation of the glycine and polyamine sites or the NMDA receptor attenuates CPP-induced learning deficits of rats in a 14-unit T-maze. Psychopharmacology 135: 196-304.
36. BAXTER, M.G., T.H. LANTHORN, K.M. FRICK, S. GOLDSKI et al. 1994. D-Cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. Neurobiol. Aging 15: 207-213.
37. FLOOD, J.F., J.E. MORLEY & T.H. LANTHORN. 1992. Effects on memory processing by D-cycloscrine, an agonist of the NMDA/glycine receptor. Eur. J. Pharmacol. 221: 249-254.
38. HERTING, R.L. 1991. Milacemide and other drugs active at glutamate NMDA receptors as potential treatment for dementia. Ann. N.Y. Acad. Sci. 640: 237-240.
39. SCHWARTZ, B.L., R.L. HASHTROUDI, H. HERTING, H. ANDERSON & S.I. DEUTCSH. 1991. Glycine prodrug facilitates memory retrieval in humans. Neurology 41: 1341-1343.
40. SHIMADA, A., E.D. LONDON, A. MUKHIN, E.L. SPANGLER & D.K. INGRAM. 1994. Polyamine modulation of NMDA receptors as a strategy for cognitive enhancement in aged rats. Soc. Neurosci. Abst. 21: 198.
41. SPANGLER, E.L., E.L. BRESNAHAN, P. GAROFALO, N.J. METH, B. & D.K. INGRAM. 1991. NMDA receptor channel antagonist by dizocilpine (MK801) impairs performance of rats in aversively-motivated complex maze tasks. Pharmacol. Biochem. Behav. 40: 949-958.
42. INGRAM, D.K., P. GAROFALO, E.L. SPANGLER, C.R. MANITONE, I. ODANO & F.D. LONDO. 1992. Reduced density of NMDA receptors and increased sensitivity to dizocilpine-induced learning impairment in aged rats. Brain Res. 580: 273-280.
43. 3H]CGS19755: Effects of aging and chronic nimodipine. Neurobiol. Aging 17: 453-457.
44. SHIMADA, A., A. MUKHEN, D.K. INGRAM & E.D. LONDON. 1997. N-Methyl-D-aspartate receptor binding in brains of rats of different ages. Neurobiol. Aging 18: 329-333.
45. INGRAM, D.K., A. SHIMADA, A. MUKHIN & E.D. LONDON. 1996. Current assessment of the glutamate hypothesis of geriatric memory impairment: Focus on hippocampal NMDA receptors. Perspect. Brain Aging Res. 1: 30-35.
46. PALMER, A.M. & M.A. BURNS. 1994. Preservation of redox, polyamine, and glycine modulatory domains of the N-methyl-D-aspartate receptor in Alzheimer's disease. J. Neurochem. 62: 187-196.
47. STEELE, J.E., A.M. PALMER, G.C. STRATEMANN & D.M. BOWEN. 1989. The N-methyl-D-aspartate receptor complex in Alzheimer's disease: Reduced regulation by glycine but not zinc. Brain Res. 500: 369-373.
48. G-nitro-L-arginine in brain in vitro and in vivo. Biochem. Biophys. Res. Commun. 176: 1136-1141.
49. G-nitro-L-arginine, in rats impairs learning in a 14-unit T-maze. Eur. J. Pharmacol., 341: 11-16.
50. Gnitro-L-arginine. Eur. J. Pharmacol. 341: 1-9.
51. CABRERA, C. & D. BOHR. 1995. The role of nitric oxide in the central control of blood pressure. Biochem. Biophys. Res. Commun. 206: 77-81.
52. G-nitro-L-arginine in rabbit by angiotensin II and alpha-I adrenergic receptor blockade. J. Pharmacol. Exp. Ther. 270: 1152-1157.
53. NANAEV, A., K. CHWALISZ, H.G. FRANK, G. KOHNEN, C. HEGELE-HARTUNG & P. KAUFMANN. 1995. Physiological dilation of uteroplacental arteries in the guinea pig depends on nitric oxide synthase activity of extravillous trophoblast. Cell Tissue Res. 282: 407-421.
54. NEMADE, R.V., A.I. LEWIS, M. ZUCCARELLO & J.T. KELLER. 1995. Immunohistochemical localization of endothelial nitric oxide synthase in vessels of the dura mater of the Sprague-Dawley rat. Neurosci. Lett. 197: 78-80.
55. TORRES, D., G. FERRARIO, G. BONETTA, L. PERVERSI & F. SPERANZA. 1996. In vitro and in vivo induction of nitric oxide by murine macrophages stimulated with Bordetella pertussis. FEMS Immunol. Med. Microbiol. 13: 95-99.
56. KELLY, P.A., I.M. RITCHIE & G.W. ARBUTHNOTT. 1995. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: Effects upon local cerebral blood flow and glucose use in the rat. J. Cereb. Blood Flow Metab. 15: 766-773.
57. MEYER, R.C., E.L. SPANGLER, N. PATEL, E.D. LONDON & D.K. INGRAM. 1997. Impaired learning in rats on a 14-unit T-maze by 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, is attenuated by the nitric oxide donor, molsidomine. Eur. J. Pharmacol. 341: 17-22.
58. KUO, H., J. HENGEMIHLE & D.K. INGRAM. 1997. Nitric oxide synthase in rat brain: Age comparisons quantitated with NADPH-diaphorase histochemistry. J. Gerontol: Biol. Sci. 52A: B146-151.
59. YAMADA, K., Y. NODA, Y. KOMORI, H. SUGIHARA, T. HASEGAWA & T. NABESHIMA. 1996. Reduction in the number of NADPH-diaphorase-positive cells in the cerebral cortex and strialum in aged rats. Neurosci. Res. 24: 393-402.
60. REBECK, G.W., W.K. MARZLOGG & B.T. HYMAN. 1993. The pattern of NADPH-diaphorase staining, a marker of nitric oxide synthase activity, is altered in the perforant pathway terminal zone in Alzheimer's disease. Neurosci. Lett. 152: 165-168.
61. VALLEBUONA, F. & M. RAITERI. 1995. Age-related changes in the NMDA receptor/nitric oxide/cGMP pathway in the hippocampus and cerebellum of freely moving rats subjected to transcerebral microdialysis. Eur. J. Neurosci. 7: 694-701.
62. VALLEBUONA, F. & M. RAITERI. 1994. Extracellular cGMP in the hippocampus of freely moving rats as an index of nitric oxide (NO) synthase activity. J. Neurosci. 14: 134-139.