Up- and down-regulation by glucocorticoids of the constitutive expression of the mast cell growth factor stem cell factor by human lung fibroblasts in culture

Molecular Pharmacology

Volumn 54, Issue 6, 1998, Pages 1073-1079

  Kassel, Olivier ^a   Schmidlin, Fabien ^a   Duvernelle, Catherine ^a   De Blay, Frédéric ^a   Frossard, Nelly ^a,b  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; DEXAMETHASONE; GLUCOCORTICOID; INTERLEUKIN 3; MESSENGER RNA; PROTEIN; STEM CELL FACTOR;

ARTICLE; ASTHMA; CELL DIFFERENTIATION; CHEMOTAXIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; FIBROBLAST CULTURE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MAST CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

EID: 0032421247     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.6.1073     Document Type: Article

References (19)

1. Andersen DM, Williams DE, Tushinski R, Gimpel S, Eisenman J, Cannizzaro LA, Aronson M, Croce CM, Huebner K, Cosman D, and Lyman SD (1991) Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24. Cell Growth Differ 2:373-378.
2. Barnes PJ and Adcock IM (1993) Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 14:436-441.
3. Bischoff SC and Dahinden CA (1992) c-kit ligand: a unique potentiator of mediator release by human lung mast cells. J Exp Med 175:237-244.
4. Cairns C, Cairns W, and Okret S (1993) Inhibition of gene expression by steroid hormone receptors via a negative glucocorticoid response element: evidence for the involvement of DNA-binding and agonistic effects of the antiglucocorticoid/ antiprogestin RU486. DNA Cell Biol 12:695-702.
5. Costa JJ, Demetri GD, Harrist TJ, Dvorak AM, Hayes DF, Merica EA, Menchaca DM, Gringeri AJ, Schwartz LB, and Galli SJ (1996) Recombinant human stem cell factor (Kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med 183:2681-2686.
6. Diamond MI, Miner JN, Yoshinaga SK, and Yamamoto KR (1990) Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science (Washington D C) 249:1266-1272.
7. Finotto S, Mekori YA, and Metcalfe DD (1997) Glucocorticoids decrease tissue mast cell number by reducing the production of the c-kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems. J Clin Invest 99:1721-1728.
8. d mutant. Cell 64:1025-1035.
9. Galli SJ (1990) New insights into "the riddle of mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity. Lab Invest 62:5-33.
10. Galli SJ, Tsai M, Wershil BK, Iemura A, Ando A, Tarn SY, and Costa JJ (1995) The effects of stem cell factor, the ligand for the c-kit receptor, on mouse and human mast cell development, survival, and function, in Biological and Molecular Aspects of Mast Cell and Basophil Differentiation and Function (Kitamura Y, Yamamoto S, Galli SJ, and Greaves MW, eds) pp 1-11, Raven Press, New York.
11. 2 receptor mRNA in a human lung cell line. Br J Pharmacol 116:2027-2032.
12. Haynesworth S E, Baber MA, and Caplan AI (1996) Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cell Physiol 166:585-592.
13. Heck S, Kullmann M, Gast A, Ponta H, Rahmsdorf HJ, Herrlich P, and Cato ACB (1994) A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1. EMBO J 13:4087-4095.
14. Huang E, Nocka K, Beier DR, Chu T-Y, Buck J, Lahm H-W, Wellner D, Leder P, and Besmer P (1990) The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell 63:225-233.
15. Iemura A, Tsai M, Ando A, Wershil BK, and Galli SJ (1994) The c-Kit ligand, stem cell factor, promotes mast cell survival by suppressing apoptosis. Am J Pathol 144:321-328.
16. Jarvis BW and Qureshi N (1997) Inhibition of lipopolysaccharide-induced transcription factor Sp1 binding by spectrally pure diphosphoryl lipid A from Rhodobacter sphaeroides, protein kinase inhibitor H-8, and dexamethasone. Infect Immunol 65:1640-1643.
17. Jeffery PK, Godfrey RW, Adelroth E, Nelson F, Rogers A, and Johansson S-A (1992) Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. Am Rev Respir Dis 145:890-899.
18. Kassel O, Wallaert B, Vandezande L-M, Akoum H, and Frossard N (1998) Increased expression of the mast cell growth factor SCF mRNA in the minor salivary glands of asthmatic patients. Am J Respir Crit Care Med 157:A398.
19. Kim Y-K, Nakagawa N, Nakano K, Sulakvelidze I, Dolovich J, and Denburg J (1997) Stem cell factor in nasal polyposis and allergic rhinitis: increased expression by structural cells is suppressed by in vivo topical corticosteroids. J Allergy Clin Immunol 100:389-399.