The dermal acute toxic class method: Test procedures and biometric evaluations

Archives of Toxicology

Volumn 72, Issue 12, 1998, Pages 751-762

  Diener, W ^a   Kayser, D ^a   Schlede, E ^a  

^a Fed Inst Hlth Protect C   (Germany)

Author keywords

Acute toxic class (ATC) method (dermal); Animal welfare; Classification probabilities; LD50 test; Probit model

Indexed keywords

PESTICIDE; TOXIC SUBSTANCE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL WELFARE; ARTICLE; BIOMETRY; CLASSIFICATION; CONTROLLED STUDY; EUROPEAN UNION; FEMALE; LD 50; MALE; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; SKIN TOXICITY; TOXICITY TESTING;

ANIMALS; BIOMETRY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOXICITY; LETHAL DOSE 50; LOGISTIC MODELS; PROBABILITY; RATS; SKIN TESTS; TOXICITY TESTS;

EID: 0032419361     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050570     Document Type: Article

References (14)

1. Bliss CI (1934) The method of probits. Science 79: 38-39
2. Diener W, Siccha L, Mischke U, Kayser D, Schlede E (1994) The biometric evaluation of the acute-toxic-class method (oral). Arch Toxicol 68: 599-610
3. Diener W, Mischke U, Kayser D, Schlede E (1995) The biometric evaluation of the OECD modified version of the acute toxic class method (oral). Arch Toxicol 69: 729-734
4. Diener W, Kayser D, Schlede E (1997) The inhalation acute toxic class method: test procedures and biometric evaluations. Arch Toxicol 71: 537-549
5. EU Guideline 92/69/EEC (1992) Official Journal of the European Community L251, July 1992. B.3. Acute toxicity - dermal
6. EU Guideline 96/54/EEC (1996) Official Journal of the European Communities L248, September 30, 1996. B.I. tris Acute toxicity (oral) - acute toxic class method
7. Finney DJ (1971) Probit analysis, 3rd edn. Cambridge University Press, Cambridge
8. Höfer T (1992) Klassifizierungsgrenzen zur akuten Toxizität. Gefahrgutbeauftragte 3: 141-144
9. OECD (1987) Guideline for testing of chemicals no. 402: acute dermal toxicity. OECD, Paris
10. OECD (1996) Guideline for testing of chemicals no. 423: acute oral toxicity - acute toxic class method. OECD, Paris
11. 50 test. Arch Toxicol 66: 455-470
12. Schlede E, Mischke U, Diener W, Kayser D (1995) The international validation study of the acute toxic class method (oral). Arch Toxicol 69: 659-670
13. Unkelbach HD, Wolf T (1985) Qualitative Dosis-Wirkungs-Analysen. Gustav Fischer Verlag, Stuttgart New York
14. Walker AP (1990) A proposal for the harmonisation of classification schemes for chemicals. Commission of the European Communities, DC XI-A-2, contract no. 56680/90/6065