The inhalation acute toxic class method: Test procedures and biometric evaluations

Archives of Toxicology

Volumn 71, Issue 9, 1997, Pages 537-549

  Diener, W ^a   Kayser, D ^a   Schlede, E ^a  

^a Fed Inst Hlth Protect C   (Germany)

Author keywords

Acute toxic class (ATC) method (inhalation); Animal welfare; Classification probabilities; LC50 test; Probit model

Indexed keywords

ACUTE TOXICITY; ARTICLE; BIOMETRY; CALCULATION; CLASSIFICATION; DOSE RESPONSE; EUROPEAN UNION; EXPERIMENTAL ANIMAL; INHALATION; LC 50; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROBABILITY; STATISTICAL MODEL; TECHNIQUE; THEORETICAL STUDY; TOXICITY TESTING;

ADMINISTRATION, INHALATION; ANIMAL WELFARE; ANIMALS; BIOMETRY; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HAZARDOUS SUBSTANCES; INTERNATIONAL AGENCIES; LETHAL DOSE 50; LIKELIHOOD FUNCTIONS; MALE; PROBABILITY; RATS; SURVIVAL ANALYSIS; TOXICITY TESTS;

ANIMALIA;

EID: 0030739804     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050425     Document Type: Article

References (14)

1. Bliss CI (1934) The method of probits. Science 79: 38-39
2. Diener W, Siccha L, Mischke U, Kayser D, Schlede E (1994) The biometric evaluation of the acute-toxic-class method (oral). Arch Toxicol 68: 599-610
3. Diener W, Mischke U, Kayser D, Schlede E (1995) The biometric evaluation of the OECD modified version of the acute toxic class method (oral). Arch Toxicol 69: 729-734
4. EU Guideline 92/69/EEC (1992) Official Journal of the European Community L383 A, 35, December 29, 1992. B.2. Acute toxicity - inhalation
5. EU Guideline 96/54/EEC (1996) Official Journal of the European Communities L 248, September 30, 1996. B.1. Acute toxicity (oral) - acute toxic class method
6. Finney DJ (1971) Probit analysis. 3rd edn. Cambridge University Press, Cambridge
7. Höfer T (1992) Klassifizierungsgrenzen zur akuten Toxizität. Gefahrgutbeauftragte 3: 141-144
8. OECD (1981) Guideline for testing of chemicals no 403: acute inhalation toxicity. OECD, Paris
9. OECD (1996) Guideline for testing of chemicals no 423: acute oral toxicity - acute toxic class method. OECD, Paris
10. Pauluhn J, Bury D, Föst U, Gamer A, Hoernicke E, Hofmann T, Kunde M, Neustadt T, Schlede E, Schnierle H, Wettig K (1996) Acute inhalation toxicity testing: considerations of technical and regulatory aspects. Arch Toxicol 71: 1-10
11. 50 test. Arch Toxicol 66: 455-470
12. Schlede E, Mischke U, Diener W, Kayser D (1995) The international validation study of the acute toxic class method (oral). Arch Toxicol 69: 659-670
13. Unkelbach HD, Wolf T (1985) Qualitative Dosis-Wirkungs-Analysen. Gustav Fischer. Stuttgart New York
14. Walker AP (1990) A proposal for the harmonisation of classification schemes for chemicals. Commission of the European Communities. DC XI-A-2. contract no 56680 90 6065