Monoclonal antibody 91.9H raised against sulfated mucins is specific for the 3'-sulfated Lewisa tetrasaccharide sequence

Glycobiology

Volumn 8, Issue 12, 1998, Pages 1237-1242

  Loveless, R Wendy ^a   Yuen, Chun Ting ^a,c   Tsuiji, Hitomi ^b   Irimura, Tatsuro ^b   Feizi, Ten ^a  

^a NORTHWICK PARK HOSPITAL   (United Kingdom)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Carbohydrate antigen; Mucins; Neoglycolipids; Selectin ligand; Sulfated Lewisa

Indexed keywords

CARBOHYDRATE ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLYCOLIPID; IMMUNOGLOBULIN G ANTIBODY; L SELECTIN; MONOCLONAL ANTIBODY; MUCIN; OLIGOSACCHARIDE; SELECTIN;

ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; COLON CARCINOMA; COLON MUCOSA; CONTROLLED STUDY; INTESTINE METAPLASIA; PRIORITY JOURNAL; SMALL INTESTINE; STOMACH; TISSUE SPECIFICITY;

ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; COLON; EPITOPES; GLYCOLIPIDS; HUMANS; LEWIS BLOOD-GROUP SYSTEM; MOLECULAR SEQUENCE DATA; MUCINS; OLIGOSACCHARIDES; PROTEIN BINDING;

EID: 0032415075     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/8.12.1237     Document Type: Article

References (31)

1. x analogues. In Chapleur, Y. (ed.), Carbohydrate Mimics: Concepts and Methods. Verlag Chemie, Weinheim, Germany, pp. 365-383.
2. Bevilacqua, M.P. and Nelson, R.M. (1993) Selectins. J. Clin. Invest., 91, 379-387.
3. Brandley, B.K., Swiedler, S.J. and Robbins, P.W. (1990) Carbohydrate ligands of the LEC cell adhesion molecules. Cell, 63, 861-863.
4. Capon, C., Leroy, Y., Wheruszeski, J.-M., Ricardi, G., Streker, G., Montreuil, J. and Fournet, B. (1989) Structures of O-glycosidically linked oligosaccharides isolated from human meconium glycoproteins. Eur. J. Biochem., 182, 139-152.
5. Capon, C., Wieruszeski, J.-M., Lemoine, J., Byrd, J.C., Leffler, H. and Kim, Y.S. (1997) Sulfated Lewis X determinants as a major structural motif in glycans from LS174T-HM7 human colon carcinoma mucin. J. Biol. Chem., 272, 31957-31968.
6. Feizi, T. (1981) The blood group Ii system: a carbohydrate antigen system defined by naturally monoclonal or oligoclonal autoantigens of man. Immunol. Commun., 10, 127-156.
7. Feizi, T. (1985) Demonstation by monoclonal antibodies that carbohydrate structures of glycoproteins and glycolipids are onco-developmental antigens. Nature, 314, 53-57.
8. Feizi, T. (1991) Cell-cell adhesion and membrane glycosylation. Curr. Opin. Struct. Biol., 1, 766-770.
9. Feizi, T., Stoll, M.S., Yuen, C.-T., Chai, W. and Lawson, A.M. (1994) Neoglycolipids: probes of oligosaccharide structure, antigenicity, and function. Methods Enzymol., 230, 484-519.
10. x types: relevance to anti-adhesion therapeutics. Biochemistry, 36, 5260-5266.
11. x sequence 6-O-sulfated at N-acetylglucosamine rather than at galactose is the preferred ligand for 1-selectin and de-N-acetylation of the sialic acid enhances the binding strength. Biochem. Biophys. Res. Commun., 240, 748-751.
12. x oligosaccharides and the predominance of sulfate in this interaction demonstrated by binding studies with a series of lipid-linked oligosaccharides. Biochem. Biophy. Res. Commun., 188, 244-251.
13. Green, P.Y., Yuen, C.-T., Childs, R.A., Chai, W., Miyasaka, M., Lemoine, R., Lubineau, A., Smith, B., Ueno, H., Nicolaou, K.C. and Feizi, T. (1995) Further studies of the binding specificity of the leukocyte adhesion molecule, 1-selectin, towards sulfated oligosaccharides suggestion of a link between the selectin- and the integrin-mediated lymphocyte adhesion systems. Glycobiology, 5, 29-38.
14. Hakkinen, I., Jarvi, O. and Grönroos, J. (1968) Sulfoglycoprotein antigens in the human alimentary canal and gastric cancer. An immunohistological study. Int. J. Cancer, 3, 572-581.
15. Hakomori, S. (1985) Aberrant glycosylation in cancer cell membranes as focussed on glycolipids: overview and perspectives. Cancer Res., 45, 2405-2414.
16. Hasegawa, A., Ando, T., Kameyama, A. and Kiso, M. (1992) Synthetic studies on sialoglycoconjugates 40: stereocontrolled synthesis of sialyl Lewis X epitope and its ceramide derivative. J. Carbohydr. Chem., 11, 645-658.
17. Hemmerich, S., Leffler, H. and Rosen, S. (1995) Structure of the O-glycans in GlyCAM-1, an endothelial-derived ligand for 1-selectin. J. Biol. Chem., 270, 12035-12047.
18. Irimura, T., Wynn, D.M., Hager, L.G., Cleary, K.R. and Ota, D.M. (1991) Human colonic sulfomucin identified by a specific monoclonal antibody. Cancer Res., 51, 5728-5735.
19. x ganglioside analogues for clarifying the real carbohydrate ligand structure of L-selectin. Bioorg. Med. Chem., 4, 1833-1847.
20. Lo-Guidice, J.M., Wieruszeski, J.M., Lemoine, J., Verbert, A., Roussel, P. and Lamblin, G. (1994) Sialylation and sulfation of the carbohydrate chains in respiratory mucins from a patient with cystic fibrosis. J. Biol. Chem., 269, 18794-18813.
21. a trisaccharide, putative ligand for the leucocyte homing receptor. J. Chem. Soc., Chem. Commun., 1419-1420.
22. a pentasaccharide, the most potent human E-selectin ligand so far. Bioorg. Med. Chem., 2, 1143-1151.
23. Matsushita, Y., Yamamoto, N., Shirahama, H., Tanaka, S., Yonezawa, S., Yamori, T., Irimura, T. and Sato, E. (1995) Expression of sulfomucins in normal mucosae, colorectal adenocarcinomas, and metastases. Jpn. J. Cancer Res., 86, 1060-1067.
24. a-type oligosaccharide selectin ligands. J. Am. Chem. Soc., 115, 8843-8844.
25. Nieuw Amerongen, A.V., Bolscher, J.G.M., Bloemena, E. and Veerman, E.C.I. (1998) Sulfomucins in the human body. Biol. Chem., 379, 1-18.
26. Ohe, Y., Hinoda, Y., Irimura, T., Imai, K. and Yachi, A. (1994) Expression of sulfated carbohydrate chains detected by monoclonal antibody 91.9H in human gastric cancer tissues. Jpn. J. Cancer Res., 85, 400-408.
27. Stoll, M.S., Mizuochi, T., Childs, R.A. and Feizi, T. (1988) Improved procedure for the construction of neoglycolipids having antigenic and lectin-binding activities, from reducing oligosaccharides. Biochem. J., 256, 661-664.
28. a: a histochemical survey of human and rat tissue. Glycobiology, 7, 37-43.
29. Yamori, T., Ota, D.M., Cleary, K.R., Hoff, S., Hager, L.G. and Irimura, T. (1989) Monoclonal antibody against human colonic sulfomucin: immunochemical detection of its binding sites in colonic mucosa, colorectal primary carcinoma, and metastases. Cancer Res., 49, 887-894.
30. Yuen, C.-T., Lawson, A.M., Chai, W., Larkin, M., Stoll, M.S., Stuart, A.C., Sullivan, F.X., Ahern, T.J. and Feizi, T. (1992) Novel sulfated ligands for the cell adhesion molecule E-selectin revealed by the neoglycolipid technology among O-linked oligosaccharides on an ovarian cystadenoma glycoprotein. Biochemistry, 31, 9126-9131.
31. a: a superior oligosaccharide ligand for human E-selectin. J. Biol. Chem., 269, 1595-1598.