메뉴 건너뛰기




Volumn 46, Issue 1, 1998, Pages 61-74

Ex vivo and in vitro testis and ovary explants: Utility for identifying steroid biosynthesis inhibitors and comparison to a tier I screening battery

Author keywords

Ex vivo; Explants; In vitro; Ovary; Rat; Steroid biosynthesis inhibition; Testis

Indexed keywords

AMINOGLUTETHIMIDE; ANASTROZOLE; ANTIANDROGEN; AROMATASE INHIBITOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR BLOCKING AGENT; ESTRADIOL; FINASTERIDE; FLUTAMIDE; FULVESTRANT; HALOPERIDOL; KETOCONAZOLE; RESERPINE; STEROID 5ALPHA REDUCTASE INHIBITOR;

EID: 0032412395     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2560     Document Type: Article
Times cited : (19)

References (53)
  • 1
    • 0001963708 scopus 로고    scopus 로고
    • Development of a research strategy for assessing the ecological risk of endocrine disruptors
    • G.T Ankley R.D Johnson G Toth L.C Fomar N.E Detenbeck S.P Bradbury Development of a research strategy for assessing the ecological risk of endocrine disruptors Rev. Toxicol. 1 1997 231 267
    • (1997) Rev. Toxicol. , vol.1 , pp. 231-267
    • Ankley, G.T1    Johnson, R.D2    Toth, G3    Fomar, L.C4    Detenbeck, N.E5    Bradbury, S.P6
  • 3
    • 0027636188 scopus 로고
    • Altered steroidogenesis in whole-ovary and adrenal culture in cycling rats
    • E Berman J.W Laskey Altered steroidogenesis in whole-ovary and adrenal culture in cycling rats Reprod. Toxicol. 7 1993 349 358
    • (1993) Reprod. Toxicol. , vol.7 , pp. 349-358
    • Berman, E1    Laskey, J.W2
  • 4
    • 85119543899 scopus 로고
    • Isolation and primary culture of Leydig cells
    • L.B Biegel J.C Cook M.E Hurtt Isolation and primary culture of Leydig cells Methods in Reproductive Toxicology 1993 Academic Press New York p. 182–196
    • (1993)
    • Biegel, L.B1    Cook, J.C2    Hurtt, M.E3
  • 5
    • 0029112633 scopus 로고
    • Effects of ammonium perfluorooctanoate on Leydig cell function:In vitro, in vivo,ex vivo
    • L.B Biegel R.C.M Liu M.E Hurtt J.C Cook Effects of ammonium perfluorooctanoate on Leydig cell function: In vitro, in vivo, ex vivo Toxicol. Appl. Pharmacol. 134 1995 18 25
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 18-25
    • Biegel, L.B1    Liu, R.C.M2    Hurtt, M.E3    Cook, J.C4
  • 6
    • 0028025046 scopus 로고
    • Endocrine effects of prenatal exposure to PCB's dioxins, and other xenobiotics: Implications for policy and future research
    • L.S Birnbaum Endocrine effects of prenatal exposure to PCB's dioxins, and other xenobiotics: Implications for policy and future research Environ. Health Perspect. 102 1994 676 679
    • (1994) Environ. Health Perspect. , vol.102 , pp. 676-679
    • Birnbaum, L.S1
  • 7
    • 0014872551 scopus 로고
    • Estrogenic activity of DDT analogs and polychlorinated biphenyls
    • J Bitman H.C Cecil Estrogenic activity of DDT analogs and polychlorinated biphenyls J. Agr. Food Chem. 18 1970 1108 1112
    • (1970) J. Agr. Food Chem. , vol.18 , pp. 1108-1112
    • Bitman, J1    Cecil, H.C2
  • 9
    • 0020592476 scopus 로고
    • The agonistic and antagonistic effects of short acting estrogens: A review
    • J.H Clark B.M Markaverich The agonistic and antagonistic effects of short acting estrogens: A review Pharmacol. Ther. 21 1983 429 453
    • (1983) Pharmacol. Ther. , vol.21 , pp. 429-453
    • Clark, J.H1    Markaverich, B.M2
  • 10
    • 85119547768 scopus 로고    scopus 로고
    • T Colborn D Dumanoski J.P Myers Our Stolen Future: Are We Threatening Our Fertility, Intelligence, and Survival? A Scientific Detective Story 1996 Dutton Books New York
    • (1996)
    • Colborn, T1    Dumanoski, D2    Myers, J.P3
  • 11
    • 0027428381 scopus 로고
    • Developmental effects of endocrine-disrupting chemicals in wildlife and humans
    • T Colborn F.S vom Saal A.M Soto Developmental effects of endocrine-disrupting chemicals in wildlife and humans Environ. Health Perspect. 101 1993 378 384
    • (1993) Environ. Health Perspect. , vol.101 , pp. 378-384
    • Colborn, T1    vom Saal, F.S2    Soto, A.M3
  • 12
    • 0030752187 scopus 로고    scopus 로고
    • Development of a tier I screening battery for detecting endocrine active compounds
    • J.C Cook A.M Kaplan L.G Davis J.C O'Connor Development of a tier I screening battery for detecting endocrine active compounds Regul. Toxicol. Pharmacol. 26 1997 60 68
    • (1997) Regul. Toxicol. Pharmacol. , vol.26 , pp. 60-68
    • Cook, J.C1    Kaplan, A.M2    Davis, L.G3    O'Connor, J.C4
  • 13
    • 0027524416 scopus 로고
    • Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats
    • J.C Cook L.S Mullin S.R Frame L.B Biegel Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats Toxicol. Appl. Pharmacol. 119 1993 195 204
    • (1993) Toxicol. Appl. Pharmacol. , vol.119 , pp. 195-204
    • Cook, J.C1    Mullin, L.S2    Frame, S.R3    Biegel, L.B4
  • 14
    • 85119540650 scopus 로고    scopus 로고
    • Crisp, T. M. Clegg, E. D. Cooper, R. L. Anderson, D. G. Baetcke, K. P. Hoffmann, J. L. Morrow, M. S. Rodier, D. J. Schaeffer, J. E. Touart, L. W. Zeeman, M. G. Patel, Y. M. Wood, W. P. 1997, Special Report on Environmental Endocrine Disruption: An Effects Assessment and Analysis
  • 15
    • 0030200208 scopus 로고    scopus 로고
    • The preclinical pharmacology of “arimidex” (anastrozole; ZD1033)—A potent, selective aromatase inhibitor
    • M Dukes P.N Edwards M Large I.K Smith T Boyle The preclinical pharmacology of “arimidex” (anastrozole; ZD1033)—A potent, selective aromatase inhibitor J. Steroid Biochem. Mol. Biol. 58 1996 439 445
    • (1996) J. Steroid Biochem. Mol. Biol. , vol.58 , pp. 439-445
    • Dukes, M1    Edwards, P.N2    Large, M3    Smith, I.K4    Boyle, T5
  • 16
    • 0020683322 scopus 로고
    • Leydig cell structure and steroidogenic function
    • L.L Ewing B.R Zirkin Leydig cell structure and steroidogenic function Recent Prog. Horm. Res. 39 1983 599 635
    • (1983) Recent Prog. Horm. Res. , vol.39 , pp. 599-635
    • Ewing, L.L1    Zirkin, B.R2
  • 17
    • 0022815983 scopus 로고
    • Ketoconazole and other imidazole derivatives as inhibitors of steroidogenesis
    • D Feldman Ketoconazole and other imidazole derivatives as inhibitors of steroidogenesis Endoc. Rev. 7 1986 409 420
    • (1986) Endoc. Rev. , vol.7 , pp. 409-420
    • Feldman, D1
  • 19
    • 85119544016 scopus 로고    scopus 로고
    • Goodman Gilman J.G Hardman A G. Gilman L.E Limbird Goodman & Gilman's Pharmacologic Basis of Therapeutics 1996 McGraw–Hill New York
    • (1996)
    • Goodman1    Gilman2
  • 20
    • 0028904417 scopus 로고
    • Hamster Leydig cells are less sensitive to ethane dimethanesulfonate when compared to rat Leydig cells bothin vivoin vitro.
    • L.E Gray Jr. G Klinefelter W Kelce J Laskey J Ostby L Ewing Hamster Leydig cells are less sensitive to ethane dimethanesulfonate when compared to rat Leydig cells both in vivo in vitro. Toxicol. Appl. Pharmacol. 130 1995 248 256
    • (1995) Toxicol. Appl. Pharmacol. , vol.130 , pp. 248-256
    • Gray, L.E1    Klinefelter, G2    Kelce, W3    Laskey, J4    Ostby, J5    Ewing, L6
  • 22
    • 0015225140 scopus 로고
    • Adenocarcinoma of the vagina: Association of maternal stilbestrol therapy with tumor appearance in young women
    • A Herbst H Ulfelder D.C Poskanzer Adenocarcinoma of the vagina: Association of maternal stilbestrol therapy with tumor appearance in young women N. Engl. J. Med. 284 1971 878 881
    • (1971) N. Engl. J. Med. , vol.284 , pp. 878-881
    • Herbst, A1    Ulfelder, H2    Poskanzer, D.C3
  • 23
    • 85119546103 scopus 로고    scopus 로고
    • P Holmes C Humfrey M Scullion Appraisal of Test Methods for Sex-Hormone Disrupting Chemicals 1998 OECD Environment DirectorateEnvironmental Health and Safety Division Paris
    • (1998)
    • Holmes, P1    Humfrey, C2    Scullion, M3
  • 25
    • 85119547196 scopus 로고
    • Environmental Oestrogens: Consequences to Human Health and Wildlife 1995 Institute for Environment and Health Norwich
    • (1995)
  • 26
    • 0022297735 scopus 로고
    • Inhibition of steroidogenic cytochrome P-450 enzymes in rat testis by ketoconazole and related imidazole anti-fungal drugs
    • P.B Kan M.A Hirst D Feldman Inhibition of steroidogenic cytochrome P-450 enzymes in rat testis by ketoconazole and related imidazole anti-fungal drugs J. Steroid Biochem. 23 1985 1023 1029
    • (1985) J. Steroid Biochem. , vol.23 , pp. 1023-1029
    • Kan, P.B1    Hirst, M.A2    Feldman, D3
  • 28
    • 0002960665 scopus 로고    scopus 로고
    • Leydig cell responsiveness to hormonal and nonhormonal factorsin vivoin vitro.
    • G Klinefelter W.R Kelce Leydig cell responsiveness to hormonal and nonhormonal factors in vivo in vitro. A.H Payne M.P Hardy L.D Russell The Leydig Cell 1996 Cache River Press Vienna 535 553
    • (1996) , pp. 535-553
    • Klinefelter, G1    Kelce, W.R2
  • 29
    • 0027351251 scopus 로고
    • Steroidogenic assessment using ovary culture in cycling rats: Effects of bis(2-diethylhexyl)phthalate on ovarian steroid production
    • J.W Laskey E Berman Steroidogenic assessment using ovary culture in cycling rats: Effects of bis(2-diethylhexyl)phthalate on ovarian steroid production Reprod. Toxicol. 7 1993 25 33
    • (1993) Reprod. Toxicol. , vol.7 , pp. 25-33
    • Laskey, J.W1    Berman, E2
  • 30
    • 0029265276 scopus 로고
    • The use of cultured ovarian fragments to assess toxicant alterations in steroidogenesis in the Sprague–Dawley rat
    • J.W Laskey E Berman J.M Ferrell The use of cultured ovarian fragments to assess toxicant alterations in steroidogenesis in the Sprague–Dawley rat Reprod. Toxicol. 9 1995 131 141
    • (1995) Reprod. Toxicol. , vol.9 , pp. 131-141
    • Laskey, J.W1    Berman, E2    Ferrell, J.M3
  • 31
    • 0028353479 scopus 로고
    • Effects of ethane dimethanesulfonate (EDS) on adult and immature rabbit Leydig cells: comparison with EDS-treated rat Leydig cells
    • J.W Laskey G.R Klinefelter W.R Kelce L.L Ewing Effects of ethane dimethanesulfonate (EDS) on adult and immature rabbit Leydig cells: comparison with EDS-treated rat Leydig cells Biol. Reprod. 50 1994 1151 1160
    • (1994) Biol. Reprod. , vol.50 , pp. 1151-1160
    • Laskey, J.W1    Klinefelter, G.R2    Kelce, W.R3    Ewing, L.L4
  • 32
    • 0023023246 scopus 로고
    • Physical methods in the study of the active site geometry of cytochromes P-450
    • D Lewis Physical methods in the study of the active site geometry of cytochromes P-450 Drug Metab. Rev. 17 1986 1 66
    • (1986) Drug Metab. Rev. , vol.17 , pp. 1-66
    • Lewis, D1
  • 33
    • 0023856581 scopus 로고
    • Comparison of components of the testis interstitium with testosterone secretion in hamster, rat and guinea pig testes perfusedin vitro.
    • S.L.M.C Mendis-Handagama B.R Zirkin L.L Ewing Comparison of components of the testis interstitium with testosterone secretion in hamster, rat and guinea pig testes perfused in vitro. Am. J. Anat. 181 1988 12 22
    • (1988) Am. J. Anat. , vol.181 , pp. 12-22
    • Mendis-Handagama, S.L.M.C1    Zirkin, B.R2    Ewing, L.L3
  • 34
    • 0015377166 scopus 로고
    • A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4′-nitro-3′-trifluoromethylisobutyranilide)
    • R Neri K Florance P Koziol S.V Cleave A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4′-nitro-3′-trifluoromethylisobutyranilide) Endocrinology 91 1972 427 437
    • (1972) Endocrinology , vol.91 , pp. 427-437
    • Neri, R1    Florance, K2    Koziol, P3    Cleave, S.V4
  • 37
    • 0032430502 scopus 로고    scopus 로고
    • An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs)
    • J.C O'Connor J.C Cook T.W Slone S.R Frame L.D Davis An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs) Toxicol. Sci. 46 1998 45 60
    • (1998) Toxicol. Sci. , vol.46 , pp. 45-60
    • O'Connor, J.C1    Cook, J.C2    Slone, T.W3    Frame, S.R4    Davis, L.D5
  • 38
    • 0022615075 scopus 로고
    • The effect of neuroleptic drugs on serum testosterone level in the male rat
    • A.D Okonmah W.G Bradshaw P Coueyro K.F.A Soliman The effect of neuroleptic drugs on serum testosterone level in the male rat Gen. Pharmacol. 17 1986 235 238
    • (1986) Gen. Pharmacol. , vol.17 , pp. 235-238
    • Okonmah, A.D1    Bradshaw, W.G2    Coueyro, P3    Soliman, K.F.A4
  • 39
    • 85119543225 scopus 로고    scopus 로고
    • Physicians' Desk Reference 1996 Medical Economics Data Oradell
    • (1996)
  • 40
    • 0028535260 scopus 로고
    • Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats
    • M Piasek J.W Laskey Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats Reprod. Toxicol. 8 1994 495 507
    • (1994) Reprod. Toxicol. , vol.8 , pp. 495-507
    • Piasek, M1    Laskey, J.W2
  • 43
    • 26844495001 scopus 로고    scopus 로고
    • Survey and assessment of mammalian estrogen biological assays for hazard characterization
    • J Reel J Lamb B Neal Survey and assessment of mammalian estrogen biological assays for hazard characterization Fundam. Appl. Toxicol. 34 1996 288 305
    • (1996) Fundam. Appl. Toxicol. , vol.34 , pp. 288-305
    • Reel, J1    Lamb, J2    Neal, B3
  • 44
    • 0024849811 scopus 로고
    • Effects of treatment with various doses of haloperidol on the pituitary–gonadal axis in male schizophrenic patients
    • P Rinieris J Hatzimanolis M Markianos C Stefanis Effects of treatment with various doses of haloperidol on the pituitary–gonadal axis in male schizophrenic patients Neuropsychobiology 22 1990 146 149
    • (1990) Neuropsychobiology , vol.22 , pp. 146-149
    • Rinieris, P1    Hatzimanolis, J2    Markianos, M3    Stefanis, C4
  • 46
    • 0029045537 scopus 로고
    • Environmental and dietary estrogens and human health: Is there a problem
    • S.H Safe Environmental and dietary estrogens and human health: Is there a problem Environ. Health Perspect. 103 1995 346 351
    • (1995) Environ. Health Perspect. , vol.103 , pp. 346-351
    • Safe, S.H1
  • 47
    • 0020325107 scopus 로고
    • Basic studies on aminoglutethimide
    • H.A Shalanick Basic studies on aminoglutethimide Cancer Res. 42 1982 3315s 3321s
    • (1982) Cancer Res. , vol.42 , pp. 3315s-3321s
    • Shalanick, H.A1
  • 48
    • 0030498123 scopus 로고    scopus 로고
    • Assessing environmental chemicals for estrogenicity using a combination ofin vitroin vivo
    • M.D Shelby R.R Newbold D.B Tully K Chae V.L Davis Assessing environmental chemicals for estrogenicity using a combination of in vitro in vivo Environ. Health Perspect. 104 1996 1296 1300
    • (1996) Environ. Health Perspect. , vol.104 , pp. 1296-1300
    • Shelby, M.D1    Newbold, R.R2    Tully, D.B3    Chae, K4    Davis, V.L5
  • 49
    • 0022639044 scopus 로고
    • Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues
    • J Simard I Luthy J Guay A Belanger F Labrie Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues Mol. Cell. Endocrinol. 44 1986 261 270
    • (1986) Mol. Cell. Endocrinol. , vol.44 , pp. 261-270
    • Simard, J1    Luthy, I2    Guay, J3    Belanger, A4    Labrie, F5
  • 50
    • 0022002612 scopus 로고
    • Effects of aminoglutethimide on cervical dilatability and serum immunoreactive relaxin in pregnant rats (41989)
    • B.G Steinetz E.M O'Byrne W.K Sawyer M.C Butler J Munigle R.E Steele Effects of aminoglutethimide on cervical dilatability and serum immunoreactive relaxin in pregnant rats (41989) Proc. Soc. Exp. Biol. Med. 178 1985 101 104
    • (1985) Proc. Soc. Exp. Biol. Med. , vol.178 , pp. 101-104
    • Steinetz, B.G1    O'Byrne, E.M2    Sawyer, W.K3    Butler, M.C4    Munigle, J5    Steele, R.E6
  • 51
    • 0023022060 scopus 로고
    • Acquisition of estradiol-mediated regulatory mechanism of steroidogenesis in cultured fetal rat Leydig cell
    • C.H Tsai-Morris G Knox S Luna M.L Dufau Acquisition of estradiol-mediated regulatory mechanism of steroidogenesis in cultured fetal rat Leydig cell J. Biol. Chem. 261 1986 3471 3474
    • (1986) J. Biol. Chem. , vol.261 , pp. 3471-3474
    • Tsai-Morris, C.H1    Knox, G2    Luna, S3    Dufau, M.L4
  • 52
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • A.E Wakeling M Dukes J Bowler A potent specific pure antiestrogen with clinical potential Cancer Res. 51 1991 3867 3873
    • (1991) Cancer Res. , vol.51 , pp. 3867-3873
    • Wakeling, A.E1    Dukes, M2    Bowler, J3
  • 53
    • 0021718674 scopus 로고
    • Effect of LH withdrawal on Leydig cell smooth endoplasmic reticulum and steroidogenic reactions which convert pregnenolone to testosterone
    • T.-Y Wing L.L Ewing B.R Zirkin Effect of LH withdrawal on Leydig cell smooth endoplasmic reticulum and steroidogenic reactions which convert pregnenolone to testosterone Endocrinology 115 1984 2290 2296
    • (1984) Endocrinology , vol.115 , pp. 2290-2296
    • Wing, T.-Y1    Ewing, L.L2    Zirkin, B.R3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.