Augmentation of in vitro interleukin 10 production after in vivo administration of interleukin 18 is activated macrophage-dependent and is probably not involved in the antitumor effects of interleukin 18

Anticancer Research

Volumn 18, Issue 6 A, 1998, Pages 4267-4274

  Micallef, Mark J ^a   Tanimoto, Tadao ^a   Kohno, Keizo ^a   Ikeda, Masao ^a   Ikegami, Hakuo ^a   Kurimoto, Masashi ^a  

^a HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

Author keywords

Antitumor effect; CD8+ cells; IL 10; IL 18

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; GLYCOPROTEIN GP 39; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; MONOCLONAL ANTIBODY CD3; NEUTRALIZING ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CULTURE; CELL STIMULATION; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SPLEEN CELL; SUPERNATANT; T LYMPHOCYTE;

ANIMALS; ANTIBODIES; ANTINEOPLASTIC AGENTS; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CONCANAVALIN A; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-18; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; SARCOMA, EXPERIMENTAL; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 0032410959     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Okamura H, Tsutsui T, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, Akita K, Namba M, Tanabe F, Konishi K, Fukuda S and Kurimoto M: Cloning of a novel cytokine that induces IFN-γ production by T cells. Nature 378: 88-91, 1995.
2. Micallef MJ, Ohtsuki T, Kohno K, Tanabe F, Ushio S, Namba M, Tanimoto T, Torigoe K, Fujii M, Ikeda M, Fukuda S and Kurimoto M: Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Europ J Immunol 26: 1647-1651, 1996.
3. Kohno K, Kataoka J, Ohtsuki T, Suemoto Y, Okamoto I, Usui M, Ikeda M and Kurimoto M: IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12. J Immunol 158: 1541-1550, 1997.
4. Yoshimoto T, Okamura H, Tagawa Y-I, Iwakura Y and Nakanishi K: Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells. Proc Natl Acad Sci USA 94: 3948-3953, 1997.
5. Tsutsui H, Nakanishi K, Matsui K, Higashino K, Okamura H, Miyazawa Y and Kaneda K: IFN-γ-inducing factor up-regulates fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J Immunol 157: 3967-3973, 1996.
6. Micallef MJ, Yoshida K, Kawai S, Hanaya T, Kohno K, Arai S, Tanimoto T, Torigoe K, Fujii M, Ikeda M and Kurimoto M: In vivo antitumor effects of murine interferon-γ-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites. Cancer Immunol Immunother 43: 361-367, 1997.
7. Micallef MJ, Tanimoto T, Kohno K, Ikeda M and Kurimoto M: Interleukin 18 induces the sequential activation of natural killer cells and cytotoxic T lymphocytes to protect syngeneic mice from transplantation with Meth A sarcoma. Cancer Res 57: 4557-4563, 1997.
8. Carson GE, Lindemann MJ, Baiocchi R, Linett M, Tan JC, Chou CC, Narula S and Caligiuri MA: The functional characterization of interleukin-10 receptor expression on human natural killer cells. Blood 85(12): 3577-3585, 1995.
9. Giovarelli M, Musiani P, Modesti A, Dellabona P, Casorati G, Allione A, Consalvo M, Cavallo F, di Pierro F, De Giovanni C, Musso T and Forni G: Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J Immunol 155: 3112-3123, 1995.
10. Picker LJ, Singh MK, Zdraveski Z, Treer JR, Waldrop SL, Bergstresser PR and Maino VC: Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry. Blood 86: 1408-1419, 1995.
11. Shu U, Kiniwa M, Wu CY, Maliszewski C, Vezzio N, Hakimi J, Gately M and Delespesse G: Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Europ J Immunol 25: 1125-1128, 1995.
12. Noguchi Y, Jungbluth A, Richards EC and Old LJ: Effect of interleukin 12 on tumor induction by 3-methylcholanthrene. Proc Natl Acad Sci USA 93(21): 11798-11801, 1996.
13. Windhagen A, Anderson DE, Carrizosa A, Williams RE and Hafler DA: IL-12 induces human T cells secreting IL-10 with IFN-gamma. J Immunol 157(3): 1127-1131, 1996.
14. Maruo S, Ahn HJ, Yu WG, Tomura M, Wysoka M, Yamamoto M, Kobayashi M, Hamaoka T, Trinchieri G and Fujiwara H: Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity. J Leuk Biol 61(3): 346-352, 1997.
15. Peng X, Kasran A and Ceuppens JL: Interleukin 12 and B7/CD28 interaction synergistically upregulate interleukin 10 production by human T cells. Cytokine 9(7): 499-506, 1997.
16. Wang L, Goillot E and Tepper RI: IL-10 inhibits alloreactive cytotoxic T lymphocyte generation in vivo. Cell Immunol 159(2): 152-169, 1994.
17. + T lymphocytes. Int J Cancer 1995. 62(1): 5-10, 1995.
18. Kim J, Modlin RL, May RL, Dubinett SM, McHugh T, Nickoloff BJ and Uyemura K: IL-10 production in basal and squamous cell carcinoma. A mechanism for evading the local T cell immune response. J Immunol 155(4): 2240-2247, 1995.
19. Kruger-Krasagakis S, Krasagakis K, Garbe C, Schmitt E, Huls C, Blankenstein T and Diamantstein T: Expression of interleukin 10 in human melanoma. Br J Cancer 70(6): 1182-1185, 1994.
20. Zheng LH, Ojcius DM, Garaud F, Roth C, Maxwell E, Li Z, Rong H, Chen J, Wang XY, Catino JJ and King I: Interleukin-10 inhibits tumor metastasis through an NK cell dependent mechanism. J Exp Med 184(2): 579-584, 1996.
21. Grohmann U, Silla S, Belladona ML, Bianchi R, Orabona C, Puccetti P and Fioretti MC: Circulating levels of IL-10 are critically related to growth and rejection patterns of murine mastocytoma cells. Cell Immunol 181: 109-119, 1997.