Antiamnesic activity of the nicotinic agonist DBO-83 in mice

Drug Development Research

Volumn 45, Issue 2, 1998, Pages 45-51

  Ghelardini, Carla ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Amnesia; DBO 83; Learning; Memory; Nicotinic agonist; Passive avoidance

Indexed keywords

3 (4 CHLOROPYRIDAZIN 6 YL)DIAZABICYCLO[3.2.1]OCTANE; 3 (6 CHLORO 3 PYRIDAZINYL) 3,8 DIAZABICYCLO[3.2.1]OCTANE; BACLOFEN; CLONIDINE; DIHYDRO BETA ERYTHROIDINE; DIPHENHYDRAMINE; MECAMYLAMINE; NICOTINE; NICOTINIC AGENT; PHYSOSTIGMINE; PIRACETAM; SCOPOLAMINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC STIMULATION; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LATENT PERIOD; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PASSIVE AVOIDANCE;

EID: 0032408263     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199810)45:2<45::AID-DDR1>3.0.CO;2-Q     Document Type: Article

References (21)

1. Arendash GW, Sengstock GJ, Sanberg PR, Kern WR (1995): Improved learning and memory in aged rats with chronic administration of the nicotine receptor agonist GTS-21. Brain Res 674:252-259.
2. Bammer G (1982): Pharmacological investigations of neurotransmitter involvement in passive avoidance responding: A review and some new results. Neurosci Biobehav Res 6:247-296.
3. Barlocco D, Cignarella G, Tondi D, Vianello P, Villa S, Bartolini A, Ghelardini C, Galeotti N, Anderson D, Kuntzweiler TA, Colombo D, Toma L (1998): Mono- and disubstituted-3.8-diazabicylo [3.2.1]octane derivatives as analgesics structurally related to epibatidine: Synthesis, activity and modeling. J Med Chem 41:674-681.
4. B agonist baclofen impairs retention. Behav Neural Biol 52:170-179.
5. Coyle M, Geyer FD, Lin KB (1987): Central neurotransmission and learning. In Holley J (ed): Trends in Neurotransmitter Research. Amsterdam: Elsevier Science BV, pp 67-91.
6. Curzon P, Brioni JD, Decker MW (1996): Effect of intraventricular injections of dihydro-beta-erythroidine (DH beta E) on spatial memory in the rat. Brain Res 714:185-191.
7. Decker MW, Majchrzak MJ, Anderson DJ (1992): Effect of nicotine on spatial memory deficits in rats with septal lesions. Brain Res 572:281-285.
8. Decker MW, Majchrzak MJ, Arneric SP (1993): Effects of lobeline, a nicotine receptor agonist, on learning and memory. Pharmacol Biochem Behav 45:571-576.
9. Decker MW, Curzon P, Brioni JD, Arneric SP (1994): Effects of ABT 418, a novel cholinergic channel ligand, on learning and memory in septal-lesioned rats. Eur J Pharmacol 261:217-222.
10. Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, Lin N, Li Y, Daanen JE Buccafusco JJ, Predergrast MA, Jackson WJ, Arneric SP (1997): ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy) pyridine dihydrochloide]: II. A novel cholinergic channel modulator with effect on cognitive performance in rats and monkeys. J Pharmacol Exp Ther 283:247-258.
11. Dilts SL, Berry CA (1967): Effect of cholinergic drugs on passive avoidance in the mouse. J Pharmacol Exp Ther 158:279-285.
12. Elrod K, Buccafusco JJ (1991): Correlation of the amnestic effects of nicotinic antagonists with inhibition of regional brain acetylcholine synthesis in rats. J Pharmacol Exp Ther 258:403-109.
13. Elrod K, Buccafusco JJ, Jackson WJ (1988): Nicotine enhances delayed matching-to-sample performance by primates. Life Sci 43:277-287.
14. Frumier MJ, Herckar VR, Jarvik ME (1976): Amnesic actions of diazepam and scopolamine in man. Anesthesiology 45:406-410.
15. Galeotti N, Ghelardini C, Bartolini A (1998): Effect of pertussis toxin on baclofen and diphenhydramine induced amnesia. Psychopharmacology 136:328-334.
16. Ghelardini C, Galeotti N, Barlocco D, Bartolini A (1997): Antinociceptive profile of the new nicotinic agonist DBO-83. Drug Dev Res 40:251-258.
17. Haley TJ, McCormick WG (1957): Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse. Br J Pharmacol Chemother 12:12-15.
18. Hodges H, Allen Y, Sinder J, Mitchell SN, Arendt T, Lantos P, Gray JA (1991): The effect of cholinergic drugs and cholinergic-rich foetal neural transplants on alcohol-induced deficits in radial maze performance in rats. Behav Brain Res 43:7-28.
19. Jarvik ME, Kopp R (1967): An improved one-trial passive avoidance learning situation. Psychol Rep 21:221-224.
20. A receptor agonist, muscimol, on the role of the entorhinal cortex, amygdala, and hippocampus in memory processes. Behav Neural Biol 61:132-138.
21. Jones GMM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992): Effect of acute subcutaneous nicotine on attention, information processing short-term memory in Alzheimer's disease. Psychopharmacology 108:485-489.