The role of leukocyte-endothelial cell adhesion in cardiovascular disease

Pathophysiology

Volumn 5, Issue 3, 1998, Pages 167-184

  Eppihimer, Michael J ^a  

^a PFIZER INC   (United States)

Author keywords

Adhesion; Atherosclerosis; Inflammation; Integrins; Reperfusion; Selectins

Indexed keywords

INTEGRIN; SELECTIN;

ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; ENDOTHELIUM CELL; HEMODYNAMICS; HUMAN; LEUKOCYTE ADHERENCE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SECRETION; REPERFUSION INJURY; REVIEW; VASCULAR ENDOTHELIUM;

EID: 0032403513     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4680(98)00023-6     Document Type: Review

References (194)

1. Schrnid-Schonbein G.W., Usami S., Skalak R., Chien S. The interaction of leukocytes and erythrocytes in capillary and postcapillary vessels. Microvasc. Res. 19:1980;45-70.
2. Blixt A., Johnson P., Braide M., Bagge U. Microscopic studies on the influence of erythrocyte concentration on the post-junctional radial distribution of leukocytes at small venular bifurcations. Int. J. Microcirc. Clin. Exp. 4:1985;141-156.
3. Mayrovitz H.N., Rubin R. Leukocyte distribution to arteriolar branches: dependence on microvascular blood flowm. Microvasc. Res. 29:1985;282-294.
4. Lindbom L., Xie X., Raud J., Hedqvist P. Chemoattractant-induced leukocyte adhesion to vascular endothelium in vivo is critically dependent on initial leukocyte rolling. Acta Physiol. Scand. 146:1992;415-421.
5. Mulligan M.S., Varani J., Dame M.K., Lane C.L., Smith C.W., Anderson D.C., Ward P.A. Role of ELAM-1 in neutrophil-mediated lung injury in rats. J. Clin. Invest. 88:1991;1396-1406.
6. Mulligan M.S., Polley M.J., Bayer R.J., Nunn M.E., Paulson J.C., Ward P.A. Neutrophil-dependent acute lung injury: requirement for P-selectin (GMP-140). J. Clin. Invest. 90:1992;1600-1607.
7. Ma X.L., Weyrich A.S., Lefer D.J., Buerke M., Albertine K.H., Kishimoto T.K., Lefer A.M. Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reper-fused cat myocardium. Circulation. 88:1993;649-658.
8. Ma X.L., Weyrich A.S., Lefer D.J., Lefer A.M. Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ. Res. 72(2):1993;403-412.
9. Weyrich A.S., Ma X.Y., Lefer D.J., Albertine K.H., Lefer A.M. In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J. Clin. Invest. 91(6):1993;2620-2629.
10. Bevilacqua M.P., Pober J.S., Mendrick D.L., Cotran R.S., Gimbrone M.A. Identification of an inducible endothelial-leukocyte adhesion molecule. PNAS. 84:1987;9238-9242.
11. McEver R.P., Beckstead J.H., Moore K.L., Marshall-Carlson L., Bainton D.F. GMP-140, a platelet-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J. Clin. Invest. 84:1989;92-99.
12. Kishimoto T.K., Jutila M.A., Berg E.L., Butcher E.C. Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science. 245:1989;1238-1241.
13. Johnston G.I., Cook R.G., McEver R.P. Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation. Cell. 56:1989;1033-1044.
14. Springer T.A., Lasky L.A. Sticky sugars for selecting. Nature. 349:1991;196-197.
15. Patel K.D., Moore K.L., Nollert M.U., McEver R.P. Neutrophils use both shared and distinct mechanisms to adhere to selectins. J. Clin. Invest. 96:1995;1887-1896.
16. Walcheck B., Moore K.L., McEver R.P., Kishimoto T.K. Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1: a mechanism that amplifies initial leukocyte accumulation on P-selectin in vitro. J. Clin. Invest. 98(5):1996;1081-1087.
17. Kubes P., Jutila M., Payne D. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J. Clin. Invest. 95(6):1995;2510-2519.
18. Bonfanti R., Furie B.C., Furie B., Wagner D.D. PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood. 73(5):1989;1109-1112.
19. Johnston G.I., Bliss G.A., Newman P.J., McEver R.P. Structure of the human gene encoding granule membrane protein-140, a member of the selectin family of adhesion receptors for leukocytes. J. Biol. Chem. 265:1990;21381-21385.
20. Shen J., Ham R.G., Karmiol S. Expression of adhesion molecules in cultured human pulmonary microvascular endothelial cells. Microvasc. Res. 50:1995;360-372.
21. Eppihimer M.J., Wolitzky B.A., Anderson D.C., Labow M.A., Granger D.N. Heterogeneity of E- and P-selectin expression in vivo. Circ. Res. 79:1996;560-569.
22. Hattori R., Hamilton K.K., Fugate R.D., McEver R.P., Sims P.J. Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid distribution to the cell surface of the intracellular granule membrane protein GMP-140. J. Biol. Chem. 246(14):1989;7768-7771.
23. Jones D.A., Abassi O., McIntire L.V., McEver R.P., Smith C.W. P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells. Biophys. J. 65:1993;1560-1569.
24. Kubes P., Kanwar S. Histamine induces leukocyte rolling in post-capillary venules. J. Immunol. 152:1994;3570-3577.
25. Patel K.D., Zimmerman G.A., Prescott S.M., McEver R.P., McIntyre T.M. Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J. Cell. Biol. 112(4):1991;749-759.
26. Weller A., Isenmann S., Vestweber D. Cloning of the mouse endothelial selectins: expression of both E and P selectin is inducible by tumor necrosis factor. J. Biol. Chem. 267(21):1992;15176-15183.
27. Auchampach J.A., Oliver M.G., Anderson D.A., Manning A.M. Cloning, sequence comparison and in vivo expression of the gene encoding rat P-selectin. Gene. 145:1994;251-255.
28. Hahne M., Jäger U., Isenmann S., Hallmann R., Vestweber D. Five tumor necrosis Factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes. J. Cell Biol. 121(3):1993;655-664.
29. Gamble J.R., Skinner M.P., Berndt M.C., Vadas M.A. Prevention of activated neutrophil adhesion to endothelium by soluble adehsion protein GMP-140. Science. 249:1990;414-417.
30. Wong C.S., Gamble J.R., Skinner M.P., Lucas C.M., Berndt M.C., Vadas M.A. Adhesion protein GMP140 inhibits superoxide anion release by human neutrophils. PNAS USA. 88:1991;2397-2401.
31. Dunlop L.C., Skinner M.P., Bendall L.J. Characterization of GMP-140 (P-selectin) as a circulating plasma protein. J. Exp. Med. 175:1992;1147-1150.
32. Fijnheer R., Frijns J.M., Korteweg J., Rommes H., Peters J.H., Sixma J.J., Nieuwehuis H.K. The origin of P-selectin as a circulating plasma protein. Thromb. Haemost. 77:1997;1081-1085.
33. Wu G.X., Li F.G., Li P.X., Raun C.G. Detection of plasma alpha-granule membrane protein GMP-140 using radiolabeled monoclonal antibodies in thrombotic disease. Haemostasis. 32:1993;121-128.
34. Ikeda H., Nakajima H., Oda T. et al. Soluble form of P-selectin in patients with acute myocardial infarction. Coron. Artery. Dis. 5:1994;515-518.
35. Ikeda H., Takajo Y., Ichiiki K. et al. Increased soluble form of P-selectin in patients with unstable angina. Circulation. 92:1995;1693-1696.
36. M.E. Gerritsen, C.P. Shen, M.C. McHugh, W.J. Atkinson, J.M. Kiely, D.S. Milstone, F.W. Lucinskas, M.A. Gimbrone, Jr., Activation-dependent isolation and culture of murine pulmonary icrovascular endothelium, Microcirculation 2 (2) (1995) 151-163.
37. Jones D.A., Smith C.W., Picker L.J., Mcintire L.V. Neutrophil adhesion to 24-hour IL-1-stimulated endothelial cell under conditions of flow. J. Immunol. 157:1996;858-863.
38. Haraldsen G., Kvale D., Lien B., Farstad I.N., Bradntzaeg P. Cytokine-regulated expression of E-selectin, intercaellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in human intestinal microvascular endothelial cells. J. Immunol. 156:1996;2558-2565.
39. Jung U., Ley K. Regulation of E-selectin, P-selectin and intercellular adhesion molecule 1 expression in mouse cremaster muscle vasculature. Microcirculation. 4(2):1997;311-319.
40. Lucinskas F.W., Cybulsky M.I., Kiely J.-M., Peckins C.S., Davis V.M., Gimbrone M.A. Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule-1. J. Immunol. 146:1991;1617-1625.
41. Abbassi O., Kishimoto T., McIntire L.V., Anderson D.C., Smith C.W. E-selectin supports neutrophil rolling under conditions of flow. J. Clin. Invest. 92:1993;2719-2730.
42. Olofsson A.M., Arfors K.E., Ramezani J.D., Wolitzky B.A., Butcher E.C., von Andrian U.H. E-selectin mediates leukocyte rolling in interleukin-1 treated rabbit mesentery venules. Blood. 84:1994;2749-2758.
43. R.M. Binns, S.T. Licence, A.A. Harrison, E.T.D. Keelan, M.K. Robinson, D.O. Haskard, In vivo E-selectin upregulation correlates early with infiltration of PMN, later with PBL entry: MAbs block both, Am J. Physiol. 270 (1996) H183-H193.
44. Labow M.A., Norton C.R., Rumberger J.M. et al. Characterization of E-selectin -deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity. 1:1994;709-720.
45. Ley K., Bullard D.C., Arbonés M.L., Bosse R., Vestweber D., Tedder T.F., Beaudet A.L. Sequential Contribution of L- and P-selectin to leukocyte rolling in vivo. J. Exp. Med. 181:1995;669-675.
46. Pigott R., Dillon L.P., Hemingway I.H., Gearing A.J.H. Soluble forms of E-selectin, ICAM-1, and VCAM-1 are present in the supernatant of cytokine activated cultured endothelial cells. Biochem. Biophys. Res. Comm. 187(2):1992;584-589.
47. Newman W., Beall L.D., Carson C.W. et al. Soluble E-selectin is found in supernaturants of activated endothelial cells and is elevated in the serum of patients with septic shock. J. Immunol. 150:1993;644-654.
48. Ruchard-Sparagano M.-H., Drost E.M., Donnelly S.C., Bird M.I., Haslett C., Dransfield I. Potential pro-inflammatory effects of soluble E-selectin upon neutrophil function. Eur. J. Immunol. 28:1998;80-89.
49. Lo S.K., Lee S., Ramos R.A., Lobb R., Rosa M., Chi-Rosso G., Wright S.D. Endothelial-leukocyte adhesion molecule-1 stimulates the adhesive activity of leukocyte integrins CR3 (CD11b/CD18, Mac-1, amb2) on human neutrophils. J. Exp. Med. 173:1991;1493-1500.
50. Atherton A., Born G.V.R. Relationship between the velocity of rolling granulocytes and that of blood flow in venules. J. Physiol. Lond. 233:1973;157-165.
51. House S.D., Lipowsky H.H. Leukocyte-endothelium adhesion: microhemodynamics in mesentery of the cat. Microvasc. Res. 34:1987;363-379.
52. 2 integrins and intracellular adhesion molecule type 1 in inflammation, in: D.N. Granger, G.W. Schmid-Schonbein (Eds.), Physiology and Pathophysiology of Leukocyte Adhesion, 1st ed., Oxford University Press, New York, 1995, pp. 3-42.
53. J. Panes, M.A. Perry, D.C. Anderson, A. Manning, B. Leone, G. Cepinskas, C.L. Rosenbloom, M. Miyasaka, P.R. Kvietys, D.N. Granger, Regional differences in constitutive and induced ICAM-1 expression in vivo, Am. J. Physiol. 269 6 (2) (1995) H1955-H1964.
54. Meng H., Tonnesen M.G., Marchese M.J., Clark R.A.F., Bahou W.F., Gruber B.L. Mast cell are potent regulators of endothelial cell adhesion molecule ICAM-1 and VCAM-1 expression. J. Cell. Physiol. 165:1995;40-53.
55. Henninger D.D., Panes J., Eppihimer M.J., Russell J., Gerritsen M., Anderson D.C., Granger D.N. Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J Immunol. 158(4):1997;1825-1832.
56. Rothlein R., Mainfoli E.A., Czajowski M., Marlin S.D. A form of circulating ICAM-1 in human serum. J. Immunol. 147:1991;3788-3793.
57. Seth R., Raymond F.D., Makogoba M.W. Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet. 338:1991;83-84.
58. Budnik A., Grewe M., Gyufko K., Krutmann J. Analysis of the production of soluble ICAM-1 molecules by human cells. Exp. Hematol. 24(2):1996;352-359.
59. Wakatsuki T., Kimura K., Kimura F., Shinomiya N., Ohtsubo M., Ishizawa M., Yamamoto M. A distinct mRNA encoding a soluble form of ICAM-1 molecule expressed in human tissues. Cell Adhes. Commun. 3(4):1995;283-292.
60. Komatsu S., Flores S., Gerritsen M.E., Anderson D.C., Granger D.N. Differential up-regulation of circulating soluble and endothelial cell intercellular adhesion molecule-1 in mice. Am. J. Pathol. 151(1):1997;205-214.
61. P. Rieckmann, U. Michell, M. Albrecht, W. Bruck, L. Wockel, K. Felgenhauer, Soluble forms of intercellular adhesion molecule-1 (ICAM-1) block lymphocyte attachment to cerebral endothelial cells. J. Neuroimmunol. 60 (1-2) (1995a) 9-15.
62. Gearing J.H., Newman W. Circulating adhesion molecules in disease. Immunol. Today. 14:1993;506-512.
63. Jones D.H., Andreson D.C., Burr B.L. et al. Quantitation of intracellular Mac-1 (CD11b/CD180 pools in human neutrophils. J. Leuk. Biol. 44:1988;535-544.
64. Anderson D.C., Miller L.J., Schmaltstieg F.C., Rothlein R., Springer T.A. Contribution of the Mac-1 glycoprotein family to adherence-dependence granulocyte functions: structure-function assessments employing subunit-specific monoclonal antibodies. J. Immunol. 137:1986;15-27.
65. Marlin S.D., Springer T.A. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell. 51(5):1987;813-819.
66. Makgoba M.W., Sanders M.E., Ginther-Luce G.E., Gugel E.A., Dustin M.L., Springer T.A., Shaw S. Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity. Eur. J. Immunol. 18(4):1988;637-640.
67. Smith C.W., Marlin S.D., Rothlein R., Toman C., Andersonc D.C. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J. Clin. Invest. 83(6):1989;2008-2017.
68. Diamond M.S., Staunton D.E., de Fougerolles A.R. et al. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J. Cell Biol. 111(2):1990;3129-3139.
69. Korthuis R.J., Anderson D.C., Granger D.N. Role of neutrophil-endothelial cell adhesion in inflammatory disorders. J. Crit. Care. 9(1):1994;47-71.
70. Romson J.L., Hook B.G., Kunkel S.L., Abrams G.D., Schork A., Lucchesi B.R. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog. Circulation. 67:1983;1016-1023.
71. R.J. Winquist, S. Kerr, Cerebral ischemia-reperfusion injury and adhesion. Neurology 49 (Suppl. 4) (1997) S23-S26.
72. L.A. Hernandez, M.B. Grisham, B. Twohig, K.E. Arfors, J.M. Harlan, D.N. Granger, Role of neutrophils in ischemia-reperfusion-induced microvascular injury, Am. J. Physiol. 253 3 (2) (1987) H699-H703.
73. Zweier J.L. Measurement of superoxide derived free radicals in the reperfused heart: evidence for a free radical mechanism of reperfusion injury. J. Biol. Chem. 263:1988;1353-1357.
74. Hill J.H., Ward P.A. The physiologic role of C3 leukostatic fragments in myocardial infarcts of rats. J. Exp. Med. 133:1975;885-900.
75. Crawford M.H., Grover F.L., Kolb W.P., McMahan A., O'Rourke R.A., McManus L.M., Pinckard R.N. Complement and neutrophil activation in the pathogenesis of ischemic myocardial injury. Circulation. 78:1988;1449-1458.
76. Tsao P.S., Aoki N., Lefer D.J., Johnson G. III, Lefer A.M. Time course of endothelial injury during myocardial ischemia and reperfusion in the cat. Circulation. 82(4):1990;1402-1412.
77. Ma X.L., Lefer D.J., Lefer A.M., Rothlein R. Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion. Circulation. 86(3):1992;937-946.
78. A.M. Lefer, X.L. Ma, A. Weyrich, D.J. Lefer, Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury. Agents Actions (Suppl. 41) (1993) 127-135.
79. Sheridan F.M., Dauber I.M., McFlurty I.F., Lesnefsky E.J., Horwitz L.D. Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ. Res. 69:1991;1566-1574.
80. Weyrich A.S., Buerke M., Albertine K.H., Lefer A.M. Time course of coronary vasular molecule expression during reperfusion of the ishemic feline myocardium. J. Leuk. Biol. 57:1995;45-55.
81. D.J. Lefer, D.M. Flynn, D.C. Anderson, A.J. Buda, Combined inhibition of P-selectin and ICAM-1 reduces myocardial injury following ischemia and reperfusion, Am. J. Physiol. 271 6 (2) (1996a) H2421-H2429.
82. D.J. Lefer, D.M. Flynn, A.J. Buda, Effects of a monoclonal antibody directed against P-selectin after myocardial ischemia and reperfusion, Am. J. Physiol. 270 1 (2) (1996b) H88-H98.
83. Winquist R.J., Frei P.P., Letts L.G., Van G.Y., Andrews L.K., Rothlein R., Dreyer W.J., Smith C.W. Monoclonal antibody to intercellular adhesion molecule-1, protects against myocardial ischemia/reperfusion damage in anesthetized monkeys. Circulation. 86:1992;1-79.
84. Lefer D.J., Flynn D.M., Phillips M.L., Ratcliffe M., Buda A.J. A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion. Circulation. 90(5):1994;2390-2401.
85. D.M. Flynn, A.J. Buda, P.R. Jeffords, D.J. Lefer, A sialyl Lewis(x)-containing carbohydrate reduces infarct size: role of selectins in myocardial reperfusion injury, Am. J. Physiol. 271 (5) (2) (1996) H2086-H2096.
86. Lefer D.J., Ma X.L., Zweier J.L., Smith C.W., Hildreth J.E., Becker L.C. Role of CD-18 and ICAM-1 in neutrophil adherence to coronary endothelium following myocardial ischemia and reperfusion. Circulation. 86:1992;1-78.
87. Kukielka G.L., Hawkins H.K., Michael L. et al. Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium. J. Clin. Invest. 92(3):1993;1504-1516.
88. E. Seewaldt-Becker, R. Rothlein, J.W. Damgen, CD18 dependent adhesion of leukocytes to endothelium and its relevance for cardiac reperfusion, in: T.A. Springer, D.C. Anderson, A.S. Rosenthal, R. Rothelein (Eds.), Leukocyte Adhesion Molecules: Structure, Function, and Regulation, Heidelberg, Springer-Verlag 1991, pp. 138-148.
89. Zhao Z.Q., Lefer D.J., Sato H., Hart K.K., Jefforda P.R., Vinten-Johansen J. Monoclonal antibody to ICAM-1 preserves postischemic blood flow and reduces infarct size after ischemia-reperfusion in rabbit. J. Leukoc. Biol. 62(3):1997;292-300.
90. Winquist R.J., Frei P.P., Letts L.G. et al. A monoclonal antibody directed against intercellular adhesion molecule-1, limits necrosis and improves function after myocardial ischemia and reperfusion in anesthetized monkeys. J. Vasc. Res. 29:1992;227.
91. Simpson P.J., Todd R.F., Fantone J.C., Mickelson J.K., Griffin J.D., Lucchesi B.R. Reductions of experiemtnal canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion. J. Clin. Invest. 81:1988;624-629.
92. Ma X.L., Tsao P.S., Lefer A.M. Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion. J. Clin. Invest. 88(4):1991;1237-1243.
93. D.J. Lefer, S.M. Shandelya, C.V. Serrano, Jr., L.C. Becker, P. Kuppusamy, J.L. Zweier, Cardioprotective actions of a monoclonal antibody against CD-18 in myocardial ischemia-reperfusion injury, Circulation 88 4 (1) (1993c) 1779-1187.
94. Jones S.P., Lefer D.J. Reduction of myocardial reperfusion injury in CD18 and ICAM-1 knockout mice. Circulation. 96(8):1997;1-378.
95. Li Y-H., Teng J.-K., Tsai W.-C., Tsai L.-M., Lin L.-J., Chen J.-H. Elevation of soluble adhesion molecules is associated with the severity of myocardial damage in acute myocardial infarction. Am. J. Cardiol. 80:1997;1218-1221.
96. Siminiak T., Dye J.F., Egdell R.M., More R., Wysocki H., Sheridan D.J. The release of soluble adhesion molecules ICAM-1 and E-selectin after acute myocardial infarction and following coronary angioplasty. Int. J. Cardiol. 61:1997;113-118.
97. Zeitler H., Ko Y., Zimmermann C., Nickenig G., Glanzer K., Walger P., Sachinidis A., Vetter H. Elevated serum concentrations of soluble adhesion molecules in coronary artery disease and acute myocardial infarction. Eur. J. Med. Res. 2:1997;389-394.
98. Ghaisas N.K., Shahi C.N., Foley B., Goggins M., Crean P., Kelly A., Kelleher D., Walsh M. Elevated levels of circulating soluble adhesion molecules in peripheral blood of patients with unstable angina. Am. J. Cardiol. 80:1997;617-619.
99. Ohno N., Ichikawa H., Coe L., Kvietys P.R., Granger D.N., Alexander J.S. Soluble selectins and ICAM-1 modulate neutrophil-endothelial adhesion and diapedesis in vitro. Inflammation. 21(3):1997;313-324.
100. Mulligan M.S., Schmid E., Till G.O., Hugli T.E., Friedl H.P., Roth R.A., Ward P.A. C5a-dependent up-regulation in vivo of lung vascular P-selectin. J. Immunol. 158:1997;1857-1861.
101. Buerke M., Pruffer D., Dahm M., Oelert H., Meyer J., Darius H. Blocking of classical complement pathway inhibits endothelial adhesion molecule expression and preserves ischemic myocardium from reperfusion injury. J. Pharmacol. Exp. Ther. 286(1):1998;429-438.
102. Jolly S.R., Kane W.J., Bailie M.B., Abrams G.D., Lucchesi B.R. Canine myocardial reperfusion injury: Its reduction by the combined administration of superoxide dismutase and catalase. Circ Res. 54:1984;277-285.
103. Naslund U., Haggmark S., Johansson G., Marklund S.L., Reiz S., Oberg A. Superoxide dismutase and catalase reduce infarct size in a porcine myocardial occlusion reperfusion model. J. Mol. Cell Cardiol. 18:1986;1077-1084.
104. Werns S.W., Simpson P.J., Mickelson J.K., Shea M.J., Pitt B., Lucchessi B.R. Sustained limitation by superoxide dismutase of canine myocardial injury due to regional ischemia followed by reperfusion. J. Cardiovasc. Pharmacol. 11:1988;36-44.
105. Kramer J.H., Arroyo C.M., Dickens B.F., Weglicki W.B. Spin-trapping evidence that graded myocardial ischemia alters postischemic superoxide production. Free Rad. Biol. Med. 3:1987;153-159.
106. Garlick P.B., Davies M.J., Hearse D.J., Slater T.F. Direct detection of free radicals I reprofused heart using electron spin resonance spectroscopy. Circ. Res. 61:1987;757-760.
107. Squadrito F., Ioculano M., Altavilla D. et al. Platelet activating factor interaction with tumor necrosis factor in myocardial ischemia-reperfusion injury. J. Lipid Mediat. 8(1):1993;53-65.
108. Ioculano M., Altavilla D., Squadrito F., Canale P., Squadrito G., Saitta A., Campo G.M., Caputi A.P. Tumor necrosis factor mediates E-selectin production and leukocyte accumulation in myocardial ischemia-reperfusion injury. Pharmacol. Res. 31(5):1995;281-288.
109. M.J. Eppihimer, J. Russell, D.C. Anderson, C.J. Epstein, S. Laroux, D.N. Granger, Modulation of P-selectin expression in the postischemic intestinal microvasculature, Am. J. Physiol. 273 (1997) G1326-G1332.
110. J. Gaboury, R.C. Woodman, D.N. Granger, P. Reinhardt, P. Kubes, Nitric oxide prevents leukocyte adherence: role of superoxide, Am. J. Physiol, 265 (1993) H862-H867.
111. Lefer D.J., Nakanishi K., Johnston W.E., Vinten-Johansen J. Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs. Circulation. 88:1993;2337-2350.
112. D.J. Lefer, K. Nakanishi, J. Vinten-Johansen, Endothelial and myocardial cell protection by a cysteine-containing nitric oxide donor after myocardial ischemia and reperfusion, J. Cardiovasc. Pharmacol. 22 (Suppl. 7) (1993b) S34-S43.
113. + at critical levels of brain ischemia. Stroke. 8:1977;51-57.
114. Astrup J., Siesjo B.K., Symon L. Thresholds in cerebral ischemia - the ischemic penumbra. Stroke. 12(6):1981;723-725.
115. G.J. del Zoppo, J.H. Garcia, Polymorphonuclear leukocyte adhesion in cerebrovascular ischemia, in: D.N. Granger, G.W. Schmid-Schonbein (Eds.), Physiology and Pathophysiology of Leukocyte Adhesion, 1st ed., Oxford University Press, New York, 1995, pp. 408-433.
116. C.D. Kontos, E.P. Wei, J.I. Williams, H.A. Kontos, J.T. Povlishock, Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo, Am. J. Physiol. 263 (1992) H1234-H1242.
117. Barone F.C., Schmidt D.B., Hillegrass L.M. Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia. Stroke. 23:1992;1337-1348.
118. Zhang R.L., Chopp M., Zhang Z., Jiang N., Powers C. The expression of P- and E-selectins in three models of middle cerebral artery occlusion. Brain Res. 785:1998;207-214.
119. Barkalow F.J., Goodman M.J., Gerritsen M.E., Mayadas T.N. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Blood. 88(12):1996;4585-4593.
120. Okada Y., Copeland B.R., Mori E., Tung M.M., Thomas W.S., del Zoppo G.J. P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke. 25:1994;202-211.
121. Wang X., Fuerstien G.Z. Induced expression of adhesion molecules following focal brain ischemia. J. Neurotrauma. 12(5):1995;825-832.
122. Zhang R.L., Chopp M., Jiang N., Tang W.X., Prostak J., Manning A.M., Anderson D.C. Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke. 26:1995;1438-1442.
123. Hess D.C., Wei Z., Carroll J., MeEachin M., Buchanan K. Increased expression of ICAM-1 during reoxygenation in brain endothelial cells. Stroke. 25:1994;1463-1468.
124. Wang X., Yue T.L., Barone F.C., Fuerstien G.Z. Demonstration of increased endothelial-leukocyte adhesion molecule-1 mRNA expression in the rat ischemia cortex. Stroke. 26(9):1995;1665-1668.
125. Garcia J.H., Liu K.F., Yoshida Y., Lian J., Chen S., del Zoppo G.J. Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat). Am. J. Pathol. 144:1994;188-199.
126. Garcia J.H., Yoshida Y., Chen H., Li Y., Zhang Z.G., Liian J., Chen S., Chopp M. Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am. J. Pathol. 142:1993;623-635.
127. Schroeter M., Jander S., Witte O.W., Stoll G. Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J. Neuroimmunol. 55:1994;195-203.
128. Morikawa E., Zhang S.M., Seko Y., Toyoda T., Kirino T. Treatment of focal cerebral ischemia with synthetic oligopeptide corresponding to lectin domain of selectin. Stroke. 27(5):1996;951-955.
129. Suzuki H., Abe K., Tojo S., Morooka S., Kimura K., Mizugaki M., Itoyama Y. Postichemic expression of P-selectin immunoreactivity in rat brain. Neurosci. Lett. 228:1997;151-154.
130. Connelly E.S., Winfree C.J., Prestigiacomo C.J., Kim S.C., Choudhri T.F., Hoh B.L., Naka Y., Solomon R.A., Pinsky D.J. Exacerbation of cerebral injury in mice that express the P-selectin gene. Identification of P-selectin blockade as a new target for the treatment of stroke. Circ. Res. 81:1997;304-310.
131. Haring H.P., Berg E.L., Tsurushita N., Tagaya M., del Zoppo G.J. E-selectin appears in nonischemic tissue during experimental focal cerebral ischemia. Stroke. 27:1996;1386-1391.
132. Zhang F., Casey R.M., Ross E., Iadecola C. Aminoguanidine ameliorates and L-arginine worsens brain damage form intraluminal middle cerebral artery occlusion. Stroke. 27:1996;317-323.
133. Zhang Z.G., Reif D., Macdonald J., Tang W.X., Kamp D.K., Gentile R.J., Shakespeare W.C., Murray R.J., Chopp M. ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J. Cereb. Blood Flow Metab. 16:1996;599-604.
134. Zhang R.L., Chopp M., Zhang Z.G., Phillips M.L., Rosenbloom C.L., Cruz R., Manning A. E-selectin in focal cerebral ischemia and reperfusion in the rat. J. Cereb. Blood Flow Metab. 16(6):1996;1126-1136.
135. Zhang R.L., Chopp M., Zaloga C. et al. The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat. Brain Res. 682:1995;182-188.
136. Lindsberg P.J., Carpen O., Paetau A., Karjalainen-Linsberg M.-L., Kaste M. Endothelial ICAM-1 expression associated with inflammatory cell response in human ischemic stroke. Circulation. 94:1996;939-945.
137. Fiszer U., Korczak-Kowalska G., Palasik W., Korlak J., Gorski A., Czlonkowska A. Increased expression of adhesion molecule CD18 (LFA-1beta) on the leukocytes of peripheral blood in patients with acute ischemic stroke. Acta. Neurol. Scand. 74(4):1998;221-224.
138. Chopp M., Li Y., Jiang N., Zhang R.L., Prostak J. Antibodies against adhesion molecule reduce apoptosis after transient middle cerebral artery occlusion in rat brain. J. Cereb. Blood Flow Metab. 16(4):1996;578-584.
139. Chopp M., Zhang R.L., Chen H., Li Y., Jiang N., Rusche J.R. Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke. 25(4):1994;869-875.
140. Zhang R.L., Chopp M., Li Y., Zaloga C., Jiang N., Jones M., Miyasaka M., Ward P. Anti-ICAM-1 antibody reduces ischemic cell damage after transient meddle cerebral artery occlusion in the rat. Neurology. 44:1994;1747-1751.
141. Soriano S.G., Lipton S.A., Wang Y.F., Xiao M., Gutierrez-Ramos J.-C., Springer T.A., Hickey P.R. Intercellular adhesion molecle-1 deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann. Neurol. 39:1996;618-624.
142. Frijns C.J.M., Kappelle L.J., van Gijn J., Nieuwenhuis H.K., Sixma J.J., Fijnheer R. Soluble adhesion molecules reflect endothelial cell activation in ischemic stroke and in carotid atherosclerosis. Stroke. 28:1997;2214-2218.
143. Fassbender K., Mossner R., Motsch L., Kischka U., Grau A., Hennerici M. Circulating selectin- and immunoglobulin-type adhesion molecules in acute ischemic stroke. Stroke. 26:1995;1361-1364.
144. Clark W.M., Coull B.M., Briley D.P., Mainfoli E., Rothlein R. Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke. J. Neuroimmunol. 44:1993;123-125.
145. Sobel R.A., Mitchell M.E., Fondren G. Intercellular adhesion molecuel-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am. J. Pathol. 136:1990;1309-1316.
146. Rieckmann P., Michel U., Albrecht M., Bruck W., Wockel L., Felgenhauer K. Cerebral endothelial cells are a major source for soluble intercellular adhesion molecule-1 in the human central nervous system. Neurosci. Lett. 186(1):1995;61-64.
147. Minami K., Kuraishi Y., Yabuuchi K., Yamazaki K., Satoh M. Induction of interleukin-1b mRNA in rat brain after transient forebrain ischemia. J. Neurochem. 58:1992;390-392.
148. Liu T., McDonnell P.C., Young P.R., White R.F., Siren A.L., Hallenbeck J.M., Barone F.C., Feuerstein G.Z. Interleukin-1 expression in ischemic rat cortex. Stroke. 24:1993;1746-1752.
149. Liu T., Clark R.K., McDonnell P.C., Young P.R., White R.F., Barone F.C., Feuerstein G.Z. Tumor necrosis factor in ischemic neurons. Stroke. 25:1994;1481-1488.
150. Wang X., Yue T-L., Young P.R., Barone F.C., Feuerstein G.Z. Expression of interleukin-6, c-fos and zif268 mRNAs in rat ischemic cortex. J. Cereb. Blood. Flow Metab. 15:1995;166-171.
151. Wang X., Yue T-L., Barone F.C., White R.F., Gagnon R.C., Feuerstein G.Z. Concomitant cortical expression of TNF-a and IL-1b mRNA following transient focal ischemia. Mol. Chem. Neuropathol. 23:1994;103-114.
152. Loddick S.A., Rothwell N.J. Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 16:1996;932-940.
153. Namura Y., Shio H., Kimura J. LTC4/LTB4 alterations in rat forebrain ischemia and reperfusion and effects of AA-861, CV-3988. Acta. Neurochir. Suppl. 60:1994;296-299.
154. Granger D.N., Kubes P. The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion. J. Leuk. Biol. 55:1994;662-675.
155. Lindsberg P.L., Yue T.-L., Ferichs K.U., Halleneck J.M., Feuerstein G. Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. Stroke. 21(10):1990;1452-1457.
156. Matsuo Y., Kihara T., Ikeda M., Ninomiya M., Onodera H., Kogure K. Role of neutrophils in radical production during ischemia and reperfusion of the rat brain: Effect of neutrophil depletion on extravellular ascorbyl radical formation. J. Cereb. Blood Flow Metab. 15:1995;941-947.
157. Zhao Q., Pahlmark K., Smith M.L., Siesjo B.K. Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats. Acta Physiol. Scand. 152(3):1994;349-350.
158. Kuroda S., Katsura K., Hillered L., Bates T.E., Siesjo B.K. Delayed treatment with α-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat. Neurobiol. Dis. 3:1996;149-157.
159. R.B. Mink, A.J. Dutka, K.K. Kumaroo, J.M. Hallenbeck, No conversion of xanthine dehydrogenase to oxidase in canine cerebral ischemia, Am. J. Physiol. 259 6 (2) (1990) H1655-H1659.
160. Kinuta Y., Kimura M., Itokawa Y., Ishikawa M., Kikuchi H. Changes in xanthine oxidase in ischemic rat brain. J. Neurosurg. 71:1989;417-420.
161. Malinksi T., Bailey F., Zhang Z., Choop M. Nitric oxide measured by a porphyrinic microsennsor in rat brain after transient middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 13:1993;335-338.
162. Dawson D. Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse otcome. Cerebrovsc. Brain Metab. Rev. 6:1994;299-324.
163. Nakashima M., Yamashita K., Kataoka Y., Yamashita Y., Niwa M. Time course of nitric oxide synthase activity in neuronal, glial, and endothelial cell of rat striatum following foval cerebral ischemia. Cell Mol. Neurobiol. 15:1995;341-349.
164. Hara H., Huang P.L., Panahain N., Fishman M.C., Moskowitz M.A. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow Metab. 16:1996;605-611.
165. Joris I., Zand T., Nunnari J.J., Krolikowski F.J., Majno G. Studies on the pathogenesis of atherosclerosis: I, adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats. Am. J. Pathol. 113:1983;341-358.
166. Faggiotto A., Ross R., Harker L. Studies of hypercholesteremia in the nonhuman primate: I changes that lead to fatty streak formation. Arthiosclerosis. 4:1984;323-340.
167. Munro J.M., Cotran R.S. The pathogenesis of athersclerosis: atherogenesis and inflammation. Lab. Invest. 58:1988;249-261.
168. Masuda J., Ross R. Atherogenesis during low level hypercholesterolemia in the nonhuman primate I, fatty streak formation. Artherosclerosis. 10:1990;164-177.
169. H.A. Lehr, K. Messmer, Leukocyte adhesion in atherogenesis, in: D.N. Granger, G.W. Schmid-Schonbein (Eds.), Physiology and Pathophysiology of leukocyte adhesion, 1st ed., Oxford University Press, New York, 1995, pp. 434-446.
170. Goldstein J.L., Brown M.S. The low density lipoprotein pathway and its relation to atherosclerosis. Ann. Rev. Biochem. 46:1977;897-930.
171. Alderson L.M., Endemann G., Lindsey S., Pronczuk A., Hoover R.L., Hayes K.C. LDL enhances monocyte adhesion to endothelial cells in vitro. Am. J. Pathol. 123:1986;334-342.
172. K.A. Pritchard, Jr., S.M. Schwarz, M.S. Medow, M.B. Stemerman, Effect of low-density lipoprotein on endothelial cell membrane fluidity and mononuclear cell attachment. Am. J. Physiol. 206 (1991) C43-C49.
173. Frostegard J., Nilssion J., Haegerstrand A., Hamsten A., Wigzell H., Gidlund M. Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937. PNAS USA. 87:1990;904-908.
174. Gebruhrer V., Murphy J.F., Bordet J.-C., Reck M.-P., McGregor J.L. Oxidized low density lipoprotein induces the expression of P-selectin (GMP140/PADGEM/CD62) on human endothelial cells. Biochem. J. 306:1995;293-298.
175. Lehr H.A., Hubner C., Finckh B., Angermuller S., Nolte D., Beisiegel U., Kohlschutter A., Messmer K. Role of leukotrienes in leukocyte adhesion following systemic administration of oxidatively modified human low density lipoprotein in hamsters. J. Clin. Invest. 88:1991;9-14.
176. Liao L., Starzyk R.M., Granger D.N. Molecular determinants of oxidized low-density lipoprotein-induced leukocyte adhesion and microvascular dysfunction. Arterioscler. Thromb. Vasc. Biol. 17(3):1997;437-444.
177. Henninger D.D., Gerritsen M.E., Granger D.N. Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli. Circ. Res. 81(2):1997;274-281.
178. L. Liao, N.R. Harris, D.N. Granger, Oxidized low-density lipoproteins and microvascular responses to ischemia-reperfusion. Am. J. Physiol. 271 6 (2) (1996) H2508-H2514.
179. L. Liao, D.N. Granger, Modulation of oxidized low-density lipoprotein-induced microvascular dysfunction by nitric oxide. Am. J. Physiol. 268 4 (2) (1995) H1643-H1650.
180. Cooke J.P., Singer A.H., Tsao P., Zera P., Rowan R.A., Billingham M.E. Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J. Clin. Invest. 90(3):1992;1168-1172.
181. Tsao P.S., McEvoy L.M., Drexler H., Butcher E.C., Cooke J.P. Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Circulation. 89(5):1994;2176-2182.
182. Candipan R.C., Wang B.Y., Buitrago R., Tsao P.S., Cooke J.P. Regression or progression: dependency on vascular nitric oxide. Arterioscler. Thromb. Vasc. Biol. 16(1):1996;44-50.
183. Theilmeier G., Chan J.R., Zalpour C., Anderson B., Wang B.Y., Wolf A., Tsao P.S., Cooke J.P. Adhesiveness of mononuclear cells in hypercholesterolemic humans is normalized by dietary L-arginine. Arterioscler. Thromb. Vasc. Biol. 17(12):1997;3557-3564.
184. Johnson-Tidey R.R., McGregor J.L., Taylor P.R., Poston R.N. Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques: coexpression with intercellular adhesion molecule-1. Am. J Pathol. 144:1994;952-961.
185. van der Wal A.C., Das P.K., Tigges A.J., Becker A.E. Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions. Am. J. Pathol. 141(6):1992;1427-1433.
186. Wood K.M., Cadogan M.D., Ramshaw A.L., Parums D.V. The distribution of adhesion molecules in human atherosclerosis. Histopathology. 22(5):1993;437-444.
187. Poston R.N., Haskard D.O., Coucher J.R., Gall N.P., Johnson-Tidey R.R. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am. J. Pathol. 140(3):1992;665-673.
188. Cybulsky M.I., Gimbrone M.A. Endothelial expression of a mononuclear leukocyte adhesion molecule in human atherosclerosis. Science. 251:1991;788-791.
189. O'Brien K.D., Allen M.D., McDonald T.O. et al. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques: implications for the mode of progression of advanced coronary atherosclerosis. J. Clin. Invest. 92:1993;945-951.
190. Negah M.F., Sandberg E.T., Marotti K.R., Lin A.H., Melchior E.P., Bullard D.C., Beaudet A.L. Deficiency of inflammatory cell adhesion molecules protects against atherosclerosis in mice. Arterioscler. Thromb. Vasc. Biol. 17(8):1997;1517-1520.
191. Nie Q., Fan J., Haraoka S., Shimokama T., Watanabe T. Inhibition of mononuclear cell recruitment in arotic intima by treatment with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies in hypercholesterolemic rats: implications of the ICAM-1 and LFA-1 pathway in atherogenesis. Lab Invest. 77(5):1997;469-482.
192. Peter K., Nawroth P., Conradt C. et al. Circulating vascular cell adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin. Arterioscler. Thromb. Vasc. Biol. 17:1997;505-512.
193. Nakai K., Itoh C., Kawazoe K. et al. Concentration of soluble vascular cell adhesion molecule-1 (VCAM-1) correlated with expression of VCAM-1 mRNA in the human atherosclerotic aorta. Coron. Artery Dis. 6:1995;497-502.
194. Hwang S.-J., Ballantyne C.M., Sharrett A.R., Smith L.C., Davis C.E., Gotto A.M., Boerwinkle E. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases. Circulation. 96:1997;4219-4225.