Similar responses by macrophages from young and old mice infected with Mycobacterium tuberculosis

Mechanisms of Ageing and Development

Volumn 106, Issue 1-2, 1998, Pages 145-153

  Rhoades, Elizabeth R ^a,b   Orme, Ian M ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone marrow derived macrophages; C57BL 6 mice; Culture; Mycobacterium tuberculosis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; MESSENGER RNA; NITRIC OXIDE;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; EARLY RESPONSE GENE; FEMALE; GENE EXPRESSION; IN VITRO STUDY; MACROPHAGE FUNCTION; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

AGING; ANIMALS; CELLS, CULTURED; GENE EXPRESSION REGULATION; GENES, IMMEDIATE-EARLY; INTERFERON TYPE II; MACROPHAGES; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; NITRIC OXIDE; RNA, MESSENGER;

ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 0032401926     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(98)00113-4     Document Type: Article

References (26)

1. Bruley-Rosset, M., Vergnon, I., 1984. Interleukin-1 synthesis and activity in aged mice. Mech. Ageing Dev. 24, 247-264.
2. Chan, J., Tanaka, K., Carroll, D., Flynn, J., Bloom, B.R., 1995. Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect. Immun. 63, 736-740.
3. Cooper, A.M., Dalton, D.K., Stewart, T.A., Griffin, J.P., Russell, D.G., Orme, I.M., 1993. Disseminated tuberculosis in gamma interferon gene-disrupted mice. J. Exp. Med. 178, 2243-2247.
4. Cooper, A.M., Callahan, J.E., Griffin, J.P., Roberts, A.D., Orme, I.M., 1995. Old mice resist low dose aerosol infections with Mycobacterium tuberculosis. Infect. Immun. 63, 3259-3265.
5. Cooper, A.M., Magram, J., Ferrante, J., Orme, I.M., 1997. Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J. Exp. Med. 186, 39-45.
6. Davila, D.R., Edwards, C.K., Arkins, S., Simon, J., Kelley, K.W., 1990. Interferon-induced priming for secretion of super-oxide anion and tumor necrosis factor declines in macrophages from aged rats. FASEB J. 4, 2906-2911.
7. Ding, H.A., Nathan, C.F., Stuehr, D.J., 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141, 2407-2412.
8. Ding, A., Hwang, S., Schwab, R., 1994. Effect of aging on murine macrophages. J. Immunol. 153, 2146-2152.
9. Johnson, C.M., Cooper, A.M., Frank, A.A., Orme, I.M., 1998. Adequate expression of protective immunity in the absence of granuloma formation in Mycobacterium tuberculosis-infected mice with a disruption in the intracellular adhesion molecule 1 gene. Infect. Immun. 66, 1666-1670.
10. Murray, H.W., Cohn, Z.A., 1980. Macrophage oxygen-dependent antimicrobial activity. III. Enhanced oxidative metabolism as an expression of macrophage activation. J. Exp. Med. 152, 1596-1609.
11. Nathan, C.F., 1982. Secretion of oxygen intermediates: role in effector functions of activated macrophages. Fed. Proc. 41, 2206-2211.
12. Nathan, C.F., Hibbs, J.B., 1991. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr. Opin. Immunol. 3, 65-70.
13. Ordway, D.J., Sonnenberg, M.G., Donahue, S.A., Belisle, J.T., Orme, I.M., 1995. Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for mice. Infect. Immun. 63, 741-743.
14. Orme, I.M., 1987. Aging and immunity to tuberculosis: increased susceptibility of old mice reflects a decreased capacity to generate mediator T lymphocytes. J. Immunol. 138, 4414-4418.
15. Orme, I.M., 1993. The response of macrophages from old mice to Mycobacterium tuberculosis and its products. Aging Immunol. Infect. Dis. 4, 187-195.
16. Orme, I.M., 1995. Mechanisms underlying the increased susceptibility of aged mice to tuberculosis. Nutr. Rev. 53, S35-S40.
17. Orme, I.M., 1998. The immunopathology of tuberculosis: a new working hypothesis. Trends Microbiol. 6, 94-97.
18. Orme, I.M., Andersen, P., Boom, W.H., 1993a. The T cell response to Mycobacterium tuberculosis. J. Infect. Dis. 167, 1481-1497.
19. Orme, I.M., Griffin, J.P., Roberts, A.D., Ernst, D.N., 1993b. Evidence for a defective accumulation of protective T cells on old mice infected with Mycobacterium tuberculosis. Cell Immunol. 147, 222-229.
20. Rhoades, E.R., Orme, I.M., 1997. Susceptibility of a panel of virulent strains of Mycobacterium tuberculosis to reactive nitrogen intermediates. Infect. Immun. 65, 1189-1195.
21. Rhoades, E.R., Cooper, A.M., Orme, I.M., 1995. Chemokine response in mice infected with Mycobacterium tuberculosis. Infect. Immun. 63, 3871-3877.
22. Roach, T.I., Chatterjee, D., Blackwell, J.M., 1994. Induction of early-response genes KC and JE by mycobacterial lipoarabinomannans: regulation of KC expression in murine macrophages by Lsh/Ity/ Bcg (candidate Nramp). Infect. Immun. 62, 1176-1184.
23. Stuehr, D.J., Marletta, M.A., 1985. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. Proc. Natl. Acad. Sci. U.S.A. 82, 7738-7742.
24. Sturgill-Koszycki, S., Schlesinger, P.H., Chakraborty, P., Haddix, P.L., Collins, H.L., Fok, A.K., Allen, R.D., Gluck, S.L., Heuser, J., Russell, D.G., 1994. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263, 678-681.
25. Vetvicka, V., Tlaskalova-Hogenova, H., Pospisil, M., 1985. Impaired antigen presenting function of macrophages from aged mice. Immunol. Invest. 14, 105-114.
26. Xie, Q.W., Cho, H.J., Calycay, J., Mumford, R.A., Swiderek, K.A., Lee, T.D., Ding, A., Troso, T., Nathan, C., 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science 256, 225-228.