Inhibition of anaesthetic-induced emesis by a NK1 or 5-HT3 receptor antagonist in the house musk shrew, Suncus murinus

Neuropharmacology

Volumn 37, Issue 12, 1998, Pages 1643-1644

  Gardner, Christopher ^a   Perren, Marion ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT3 antagonist; Anaesthetic; Emesis; GR205171; NK1 antagonist; Ondansetron; PONV; Suncus murinus

Indexed keywords

NEUROKININ 1 RECEPTOR ANTAGONIST; ONDANSETRON; UNCLASSIFIED DRUG; VOFOPITANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; INSECTIVORE; MALE; NAUSEA; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SUBCUTANEOUS DRUG ADMINISTRATION; VOMITING;

EID: 0032401796     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00133-6     Document Type: Article

References (8)

1. Aitkenhead, A.R., Smith, G. (Eds.), 1990. Textbook of Anaesthesia. Churchill Livingstone, Edinburgh.
2. 1 receptor antagonist GR205171 in the treatment of PONV following major gynaecological surgery. Anaesth. Analg. 86(2):1998;S436.
3. Du Pen S., Scuderi P., Wetchler B.et al. Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur. J. Anaesthesiol. 9(Suppl. 6):1992;55-62.
4. 1 receptor, and potent broad-spectrum anti-emetic activity. Regul. Pept. 65:1996;45-53.
5. 1 receptor antagonist, on inhaled anaesthetic-induced emesis in suncus murinus. Jpn. J. Pharmacol. 73(Suppl. 1):1997;212P.
6. Tyers M.B., Bunce K.T., Humphrey P.P.A. Pharmacological and anti-emetic properties of ondansetron. Eur. J. Cancer Clin. Oncol. 25:1989;515-519.
7. Ueno S., Matsuki N., Saito H. Suncus murinus: a new experimental model in emesis research. Life Sci. 41:1987;513-518.
8. Watcha M.F., White P.F. Postoperative nausea and vomiting. Its aetiology, treatment and prevention. Anaesthesiology. 77:1992;162-184.