Pathomorphological response to Encephalitozoon cuniculi infection in cyclophosphamide-treated rabbits

Acta Veterinaria Brno

Volumn 67, Issue 1, 1998, Pages 37-42

  Horvath M ^a   Svicky E ^a   Sevcikova Z ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Slovakia)

Author keywords

Giant multinucleated cells; Granulomatous inflammation; Lymphocytes; Microsporidia

Indexed keywords

ANIMALIA; ENCEPHALITOZOON CUNICULI; MICROSPORIDIA; ORYCTOLAGUS CUNICULUS;

EID: 0032392732     PISSN: 00017213     EISSN: None     Source Type: Journal    
DOI: 10.2754/avb199867010037     Document Type: Article

References (30)

1. ALBRECHT, H. 1997: Redefining AIDS: Towards a modification of the current AIDS case definition. Clin. Infect. Dis. 24: 64-74
2. CALABRESE, K. S., LAGRANGE, P., Da COSTA, S. C. G. 1996: Chagas'disease: enhancement of systemic inflammatory reaction in cyclophosphamide treated mice. Int. J. Immunopharmac. 18: 505-514
3. COFFMAN, R. L., MOSMANN, T. R. 1991: CD4+ T-cell subsets: regulation of differentiation and function. Res. Immunol. 142: 7-9
4. COLVIN, M. 1982: The alkylating agents. In: Pharmacologic principles of cancer treatment. Ed: B. A. Chanber, Saunders Co., Philadelphia, pp. 276-308
5. COX, P. J., PHILIPS B. J., THOMAS, P. 1975: The enzymatic basis of the selective action of cyclophosphamide. Cancer. Res. 35: 3755-3761
6. COX, J. C., HAMILTON, R. C., ATTWOOD, H. D. 1979: An investigation of the route and progression of Encephalitozoon cuniculi infection in adult rabbits. J. Protozool. 26: 260-265
7. DIDIER, E. S., SHADDUCK, J. A. 1994: INF-g and LPS induce murine macrophages to kill Encephalitozoon cuniculi in vitro. J. Euk. Microbiol. 41: 34
8. FUENTEALBA, I. C., MAHONEY, N. T., SHADDUCK, J. A., HARVILL, J., WICHER, V., WICHER, K. 1992: Hepatic lesions in rabbits infected with Encephalitozoon cuniculi administered per rectum. Vet Pathol. 29: 536-540
9. GORDON, S., KESHAV, S., CHUNG, L.P. 1988: Mononuclear phagocytes: tissue distribution and functional heterogenity. Curr. Opin. Immunol. 1: 26-35
10. HANANO, R., REIFENBERG, K., KAUFFMAN, S. H. E. 1996: T- and B-lymphocyte-independent formation of alveolar macrophage-derived multinucleated giant cells in murine Pneumocystis carinii pneumonia. Infect. Immunity. 64: 2821-2823
11. HEŘMÁNEK, J., KOUDELA, B., KUČEROVÁ, Z., DITRICH, O., TRÁVNÍČEK, J. 1993: Prophylactic and therapeutic immune reconstruction of SCID mice infected with Encephalitozoon cuniculi. Folia Parasitol. 40: 287-291
12. CHALUPSKÝ, J., VÁVRA, J., BEDRNÍK, P. 1973: Detection of antibodies to Encephalitozoon cuniculi in rabbits by indirect immunofluorescence antibody test. Folia Parasitol. 20: 281-284
13. CHENSUE, S. W., WARMINGTON, K. S., HERSHEY, S. D., TEREBUH, P. D., OTHMAN, M., KUNKEL, S. L. 1993: Evolving T cell responses in murine schisostomiasis. J. Immunol. 151: 1391-1400
14. CHENSUE, S. W., WARMINGTON, K. S., LUKACS, N. W., LINCOLN, P. M., BURDICK, M. D., STRIETER, R., M., KUNKEL, S. L. 1995: Monocyte chemotactic protein expression during schisostome egg granuloma formation. Am. J. Pathol. 146: 130-138
15. KOUDELA, B., VÍTOVEC, J., KUČEROVÁ, Z., DITRICH, O., TRÁVNÍČEK, J. 1993: The severe combined immunodeficient mouse as a model for Encephalitozoon cuniculi microsporidiosis. Folia Parasitol. 40: 279-286
16. LEE, T. T., MARTIN, F. C., MERRILL, J. E. 1993: Lymphokine induction of rat microglia multinucleated giant cell formation. Glia 8: 51-61
17. LEVKUT, M., LEŠNÍK, F., KORIM, P., DANKOVČÍKOVÁ, Z., TIMKOVÁ, J., BÁLENT, P. 1993: Pathological morphological changes in rabbits infected with the bovine leukaemia virus (BLV). Folia Microbiol. 138: 128
18. LEVKUT, M., LEŠNÍK, F., BALENT, P., ZAJAC, V., KORIM, P., SLÁVIKOVÁ, K. 1997a: Bovine leukaemia virus-induced clinical changes of encephalitozoonosis in rabbits. Folia Parasitol. 44: 249-259
19. LEVKUT, M., LEDECKÝ, V., KOLODZIEYSKI, L., ŠEVČÍK, A. 1997b: Calcified cystic granuloma in dog. Indian Vet. J. 74: 788-789
20. LIN, D. S., BOWMAN, D., JACOBSON, R. 1992: Immunological changes in cats with concurrent T. gondii and feline immunodeficiency virus infection. J. Clin. Microbiol. 30: 17-24
21. LYNCH, J. P., Mc CUNE, J. W. 1997: Immunosuppressive and cytotoxic pharmacotherapy for pulmonary disorders. Am. J. Respir. Crit. Care Med. 155: 395-142
22. MALIK, S. W., MYERS, J. L., DeREME, R. A., SPECKS, U. 1996: Lung toxicity associated with cyclophosphamide use: Two distinct patterns. Am. J. Respir. Crit. Care Med. 154: 1851-1856
23. MERTENS, R. B., DIDIER, E. S., FISHBEIN, M. C., BERTUCCI, D. C., ROGERS, L. B., ORENSTEIN, J. M. 1997: Encephalitozoon cuniculi microsporidiosis: Infection of the brain, heart, kidneys, trachea, adrenal glands, and urinary bladder in a patient with AIDS. Mod. Pathol. 10:68-77
24. MITTSUOKA, A., MORIKAWA, S., MITSUO, B., HARADA, T. 1979: Cyclophosphamide eliminates supressor T-cells in age-associated central regulation of delayed hypersensitivity in mice. J. Exp. Med. 149: 1018-1022
25. MOST, J., NEUMAYER, H. P., DIETRICH, M. P. 1990: Cytokine-induced generation of multinucleated giant cells in vitro requires interferon-γ and expression of LFA-1. Eur. J. Immunol. 20: 1661-1667
26. NAST, R., MIDDLETON, M., WHELER, C. L. 1996: Generalized encephalitozoonosis in a Jersey wooly rabbit. Can. Vet. J. 37: 303-305
27. PEARCE, E. J., GASPAR, P., GRZYCH, J. M., LEWIS, F. A., SHER, A. 1991 : Downregulation of Th 1 cytokine production accompanies induction of Th2 responses by parasitic helminth, Schisostoma mansoni. J. Exp. Med. 173: 159-166
28. SCHMIDT, E. C., SHADDUCK, J. A. 1984: Mechanisms of resistance to the intracellular protozoan Encephalitozoon cuniculi in mice. J. Immunol. 133: 2712-2719
29. WHEATER, P., BURKITT, P., STEVENS, A., LOWE, J. 1991: Chronic inflammation. In: Basic Histopathology, (2. ed.), Churchill Livingstone, pp. 23-39
30. WICHER, V., BAUGHN, R. E., FUENTEALBA, C., SHADDUCK, J. A., ABBRUSCATO, F., WICHER, K. 1991: Enteric infection with an obligate intracellular parasite, Encephalitozoon cuniculi, in an experimental model. Infect. Immun. 59: 2225-2231