Two-dimensional NMR analysis of selected dequalinium analogues having aralkyl linking groups

Magnetic Resonance in Chemistry

Volumn 36, Issue 12, 1998, Pages 951-955

  Campos Rosa, J ^a,b   Galanakis, D ^a,c   Ganellin, C R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Facultad de Farmacia   (Spain)

^c ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

1,1 disubstituted bis(4 aminoquinolinium) dibromides; 13C NMR; 1H NMR; COSY; Dequalinium analogues; Heteronuclear correlation; NMR

Indexed keywords

ATOMS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

1,1′-DISUBSTITUTED BIS(4-AMINOQUINOLINIA) DIBROMIDE; 13C NMR; 1H NMR; COSY; DEQUALINIA ANALOG; DIBROMIDES; HETERONUCLEAR CORRELATION; LINKING GROUPS; NMR ANALYSIS; TWO-DIMENSIONAL NMR;

BROMINE COMPOUNDS;

EID: 0032336712     PISSN: 07491581     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-458X(199812)36:12<951::AID-OMR395>3.0.CO;2-F     Document Type: Article

References (16)

1. N. A. Castle, D. G. Haylett, J. M. Morgan and D. H. Jenkinson, Eur. J. Pharmacol. 236, 201 (1993).
2. J. Campos Rosa, D. Galanakis, C. R. Ganellin and P. M. Dunn, J. Med. Chem. 39, 4247 (1996), and references cited therein.
3. SYBYL Molecular Modelling. Tripos Associates, St Louis, MO.
4. (a) M. J. S. Dewar and W. Thiel, J. Am. Chem. Soc. 99, 4899 (1977);
5. (b) very similar results are obtained using the AM1 Hamiltonian (data not shown): M. J. S. Dewar, E. G. Zoebisch, E. F. Healy and J. J. P. Stewart, J. Am. Chem. Soc. 107, 3902 (1985).
6. J. J. P. Stewart, MOPAC 5.0. (QCPE 455).
7. K. Nagayama, A. Kumar, K. Wüthrich and R. R. Ernst, J. Magn. Reson. 40, 321 (1980).
8. V. Rutar, J. Magn. Reson. 58, 306 (1984).
9. J. A. Wilde and P. H. Bolton, J. Magn. Reson. 59, 343 (1984).
10. A. Bax and G. A. Morris, J. Magn. Reson. 42, 501 (1981).
11. A. R. Katritzky and Z. Dega-Szafran, Magn. Reson. Chem. 27, 1090 (1989).
12. A. M. Kook, S. L. Smith and E. V. Brown, Org. Magn. Reson. 22, 730 (1984).
13. B. G. Griggs, W. D. Wilson and D. W. Boykin, Org Magn. Reson. 11, 81 (1978).
14. J. E. Bloor and D. L. Breen, J. Am. Chem. Soc., 89, 6835 (1967).
15. R. J. Pugmire, D. M. Grant, M. J. Robins and R. K Robins, J. Am. Chem. Soc. 91, 6381 (1969).
16. W. Adam, A. Grimison and G. Rodriguez, Tetrahedron 23, 2513 (1967).