Lipase-catalyzed transesterification of trans-2,5-disubstituted pyrrolidines: Effect of substituent on enantioselectivity

Chemistry Letters

Volumn , Issue 12, 1998, Pages 1231-1232

  Kawanami, Yasuhiro ^a   Iizuna, Noriko ^a   Okano, Kiyoka ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0032273093     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.1998.1231     Document Type: Article

References (25)

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24. CHIRALCEL OJ (Daicel Chemical Industries, Ltd.), for example, 1g: 19 and 27 min, 2g: 17 and 25 min, hexane/2-propanol=20/1. The diacetate 2f could not be separated and so it was determined after conversion to 2a.
25. Kazlauskas et al. also found that increasing the difference in the size of the substituents of primary alcohols did not always provided an increase in the enantioselectivity of PCL, see Ref. 8.