Catabolism of Ap4A and Ap5A by rat brain synaptosomes

Brazilian Journal of Medical and Biological Research

Volumn 31, Issue 12, 1998, Pages 1529-1532

  Emanuelli, T ^a   Bonan, C D ^a   Sarkis, J J F ^a   Battastini, A M O ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Ap4A; Ap5A; ApnAaSe; Brain synaptosomes; Diadenosine polyphosphate hydrolase

Indexed keywords

DIADENOSINE TETRAPHOSPHATE; DINUCLEOSIDE PHOSPHATE; P(1),P(5) DI(ADENOSINE 5' )PENTAPHOSPHATE; P(1),P(5)-DI(ADENOSINE-5'-)PENTAPHOSPHATE;

ANIMAL; ARTICLE; BRAIN CORTEX; CHEMISTRY; ENZYMOLOGY; MALE; METABOLISM; PHYSIOLOGY; RAT; SECOND MESSENGER; SYNAPTOSOME; WISTAR RAT;

ANIMALS; CEREBRAL CORTEX; DINUCLEOSIDE PHOSPHATES; MALE; RATS; RATS, WISTAR; SECOND MESSENGER SYSTEMS; SYNAPTOSOMES;

EID: 0032234461     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1998001200003     Document Type: Article

References (18)

1. 5A - in rat brain adrenal medulla: presence in chromaffin granules. Journal of Neurochemistry, 51: 1696-1703.
2. +2-dependent release evoked by 4-aminopyridine and veratridine. Neuroscience Letters, 136: 141-144.
3. Miras-Portugal MT, Castro E, Mateo J & Pintor J (1996). The diadenosine polyphosphate receptors: P2D purinoceptors. In: Chadwick DJ & Goodee JA (Editors), P2 Punnoceptors: Localization, Function and Transduction Mechanisms. Ciba Foundation Symposium, John Wiley & Sons Ltd., West Sussex, England.
4. 3H]diadenosine tetraphosphate binding sites in rat brain Neuroscience, 77: 247-255.
5. Ramos A, Pintor J, Miras-Portugal MT & Rotlán P (1995). Use of fluorogenic substrates for detection and investigation of ectoenzymatic hydrolysis of diadenosine polyphosphates: A fluorometric study on chromaffin cells. Analytical Biochemistry, 228: 74-82.
6. Pintor J & Miras-Portugal MT (1995). A novel receptor for diadenosine polyphosphates coupled to calcium increase in rat midbrain synaptosomes, British Journal of Pharmacology, 115: 895-902.
7. 1 purinoceptors. British Journal of Pharmacology, 119: 1006-1012.
8. Rodnguez-Pascual F, Torres M, Rotlán P & Miras-Portugal MT (1992). Extracellular hydrolysis of diadenosine polyphosphates, ApnA, by bovine chromaffin cells in culture. Archives of Biochemistry and Biophysics, 297: 176-183.
9. Rodríguez-Pascual F, Torres M & Miras-Portugal MT (1992). Studies on the turnover of ecto-nucleotidases and ecto-dinucleoside-polyphosphate hydrolase in cultured chromaffin cells. Neuroscience Research Communications, 11: 101-107.
10. Mateo J, Rotllán P, Marti E, Gomez De Aranda I, Solsona C & Miras-Portugal MT (1997). Diadenosine polyphosphate hydrolase from presynaptic plasma membranes of Torpedo electric organ. Biochemical Journal, 323: 677-684.
11. Battastini AMO, Rocha JB, Barcelos CK, Dias RD & Sarkis JJF (1991). Characterization of an ATP diphosphohydrolase (EC 3.6.1.5) in synaptosomes from cerebral cortex of adult rats. Neurochemical Research, 16: 1303-1310.
12. Zimmermann H (1996). Extracellular purine metabolism. Drug Development Research, 39: 337-352.
13. Wang T-F, Rosenberg PA & Guidotti G (1997). Characterization of brain ecto-apyrase: evidence for only one ecto-apyrase (CD39) gene. Molecular Brain Research, 47: 295-302.
14. Nagy A & Delgado-Escueta AV (1984). Rapid preparation of synaptosomes from mammalian brain using nontoxic isoosmotic gradient material (Percoll). Journal of Neurochemistry, 43: 1114-1123.
15. Keiding R, Horder M & Gerhardt W (1974). Recommended methods for determination of four enzymes in blood. Scandinavian Journal of Clinical Laboratory Investigation, 33: 291-306.
16. Bradford MM (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72: 218-254.
17. Johnson MK & Whittaker VP (1963). Lactate dehydrogenase as a cytoplasmic marker in brain. Biochemical Journal, 88: 404-409.
18. Sarkis JJF & Salto C (1991). Characterization of a synaptosomal ATP diphosphohydrolase from the electric organ of Torpedo marmorata. Brain Research Bulletin, 26: 871-876.