Power, mode of inheritance, and type I error in lod scores and affecteds-only methods: Reply to Kruglyak [5]

American Journal of Human Genetics

Volumn 62, Issue 1, 1998, Pages 202-204

  Greenberg, D A ^a   Hodge, S E ^a   Vieland, V J ^a   Spence, M A ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERROR; GENETIC LINKAGE; INHERITANCE; LETTER; METHODOLOGY; PARAMETER; PRIORITY JOURNAL;

EID: 0031892437     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301690     Document Type: Letter

References (17)

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2. M-H Dizier M-C Babron F Clerget-Darpoux Conclusions of LOD-score analysis for family data generated under two-locus models Am J Hum Genet 58 1996 1338 1346
3. M Durner VJ Vieland DA Greenberg Increased power of lod scores over ASP methods Am J Hum Genet Suppl 61 1997 A274
4. RC Elston Algorithms and inferences: the challenge of multifactorial diseases Am J Hum Genet 60 1997 255 262
5. M Farrall LOD wars: the affected-sib-pair paradigm strikes back! Am J Hum Genet 60 1997 735 737
6. LR Goldin DE Weeks Two-locus models of disease: comparison of likelihood and nonparametric linkage methods Am J Hum Genet 53 1993 908 915
7. DA Greenberg SE Hodge VJ Vieland MA Spence Affecteds-only linkage methods are not a panacea Am J Hum Genet 58 1996 892 895
8. DA Greenberg SE Hodge VJ Vieland MA Spence Reply to Farrall Am J Hum Genet 60 1997 738
9. Hodge SE. Exact ELODs and exact power for affected sib pairs analyzed for linkage under simple right and wrong models. Am J Med Genet (Neuropsychiatr Genet) (in press)
10. SE Hodge PC Abreu DA Greenberg Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study Am J Hum Genet 60 1997 217 227
11. SE Hodge RC Elston Lods, wrods, and mods: the interpretation of lod scores calculated under different models Genet Epidemiol 11 1994 329 342
12. M Knapp SA Seuchter MP Baur Linkage analysis in nuclear families. II. Relationship between affected sib-pair tests and lod score analysis Hum Hered 44 1994 44 51
13. L Kruglyak Nonparametric linkage tests are model free Am J Hum Genet 61 1997 254 255
14. VJ Vieland DA Greenberg SE Hodge Adequacy of single-locus approximations for linkage analyses of oligogenic traits: extension to multigenerational pedigree structures Hum Hered 43 1993 329 336
15. VJ Vieland SE Hodge DA Greenberg Adequacy of single-locus approximations for linkage analyses of oligogenic traits Genet Epidemiol 9 1992 45 59
16. AS Whittemore Genome scanning for linkage: an overview Am J Hum Genet 59 1996 704 716
17. JA Williamson CI Amos On the asymptotic behavior of the estimate of the recombination fraction under the null hypothesis of no linkage when the model is misspecified Genet Epidemiol 7 1990 309 318