Structure and regulation of the human growth hormone-releasing hormone receptor gene

Molecular Endocrinology

Volumn 12, Issue 2, 1998, Pages 233-247

  Petersenn, Stephan ^a   Rasch, Anja C ^a   Heyens, Maria ^a   Schulte, Heinrich M ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE RELEASING FACTOR RECEPTOR; HUMAN GROWTH HORMONE;

ARTICLE; CELL PROLIFERATION; GENE ISOLATION; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HUMAN; PRIORITY JOURNAL; SOMATIC CELL; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION INITIATION;

EID: 0032230229     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.2.0057     Document Type: Article

References (84)

1. Growth hormone
2. Growth hormone-releasing hormone: Synthesis and signaling
3. Expression and localization of growth hormone-releasing hormone messenger ribonucleic acid in rat placenta: In vitro secretion and regulation of its peptide product
4. Expression of the growth hormone-releasing hormone gene and its peptide product in the rat ovary
5. Growth hormone-releasing hormone-like messenger ribonucleic acid and immunoreactive peptide are present in human testis and placenta
6. Growth hormone-releasing hormone in testicular interstitial and germ cells: Potential paracrine modulation of follicle-stimulating hormone action on Sertoli cell function
7. Receptor-mediated actions of growth hormone releasing factor on granulosa cell differentiation
8. Production of a growth hormone-releasing hormone-like peptide and its mRNA by human lymphocytes
9. Growth hormone releasing factor (GRF) immunoreactivity in human and rat gastrointestinal tract and pancreas
10. Distribution of growth hormone-releasing hormone-like immunoreactivity in human tissue extracts
11. Mechanism of action of growth-hormone-releasing hormone in stimulating insulin secretion in vitro from isolated rat islets and dispersed islet cells
12. Differential activation of type I and type II 3',5'-cyclic adenosine monophosphate-dependent protein kinases by growth hormone-releasing factor
13. Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth
14. Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone
15. Structure and functional expression of a complementary DNA for porcine growth hormone-releasing hormone receptor
16. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone
17. Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization
18. Human growth hormone-releasing hormone receptor (GHRHR) maps to a YAC at chromosome 7p15
19. GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
20. Molecular basis of the little mouse phenotype and implications for cell type-specific growth
21. Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse
22. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
23. Pituitary adenomas in mice transgenic for growth hormone-releasing hormone
24. Dramatic pituitary hyperplasia in transgenic mice expressing a human growth hormone-releasing factor gene
25. Growth hormone-releasing hormone receptor mRNA in acromegalic pituitary tumors
26. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty
27. Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
28. A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia
29. Ovalbumin gene: Evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries
30. Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas
31. Identification of human growth hormone-releasing hormone receptor splicing variants
32. The 'initiator' as a transcription control element
33. A constitutive promoter directs expression of the nerve growth factor receptor gene
34. Cloning of terminal transferase cDNA by antibody screening
35. Evidence that the upstream stimulatory factor and the Sp1 transcription factor bind in vitro to the promoter of the human-growth-hormone gene
36. Purification of nuclear factor I by DNA recognition site affinity chromatography
37. Nuclear factor-I and activator protein-2 bind in a mutually exclusive way to overlapping promoter sequences and trans-activate the human growth hormone gene
38. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP
39. A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells
40. A tissue-specific transcription factor containing a homeodomain specifies a pituitary phenotype
41. A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression
42. POU-domain proteins: Structure and function of developmental regulators
43. POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter
44. Characterization of feeding behavior induced by central injection of GRF
45. Effects of corticotropin-releasing factor and growth hormone-releasing factor on sleep and activity in rats
46. Growth hormone-releasing factor enhances sleep in rats and rabbits
47. Differential gene expression of growth hormone (GH)-releasing hormone (GRH) and GRH receptor in various rat tissues
48. Regional distribution of growth hormone-releasing hormone (GHRH) receptor mRNA in the rat brain
49. Growth hormone-releasing factor (GRF) regulates expression of its own receptor
50. Homologous down-regulation of growth hormone-releasing hormone receptor messenger ribonucleic acid levels
51. Desensitization to growth hormone-releasing factor (GRF) is associated with down-regulation of GRF-binding sites
52. Regulation of pituitary growth hormone-releasing factor (GRF) receptor gene expression by GRF
53. Different regulation of growth hormone-releasing factor-sensitive adenylate cyclase in the anterior pituitary of young and aged rats
54. Alterations of adenylyl cyclase-coupled growth hormone-releasing hormone (GHRH) pituitary receptors in different conditions of GHRH deprivation
55. Superfusion of rat anterior pituitary cells attached to Cytodex beads: Validation of a technique
56. Growth hormone-releasing factor does not activate protein kinase C in somatotrophs
57. Growth hormone axis in Cushing's syndrome
58. Binding sites for growth hormone releasing factor on rat anterior pituitary cells
59. Glucocorticoids regulate pituitary growth hormone-releasing hormone receptor messenger ribonucleic acid expression
60. Dexamethasone increases growth hormone (GH)-releasing hormone (GRH) receptor mRNA levels in cultured rat anterior pituitary cells
61. Gene expression of the receptor for growth-hormone-releasing hormone is physiologically regulated by glucocorticoids and estrogen
62. Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo
63. Synergistic action of the glucocorticoid receptor with transcription factors
64. The glucocorticoid receptor synergizes with Jun homodimers to activate AP-1-regulated promoters lacking GR binding sites
65. Acute administration of corticoids: A new and peculiar stimulus of growth hormone secretion in man
66. Growth hormone secretion: The role of glucocorticoids
67. Influence of thyroid hormones on the regulation of growth hormone secretion
68. Effects of synthetic human pancreatic (tumor) GH releasing factor and somatostatin, triiodothyronine and dexamethasone on GH secretion in vitro
69. Thyroid hormone regulation of gene expression of the pituitary growth hormone-releasing factor receptor
70. Sexual dimorphism in the control of growth hormone secretion
71. Inhibition of the pulsatile secretion of growth hormone by monoclonal antibodies to the hypothalamic growth hormone releasing factor (GRF)
72. Sexually dimorphic expression of pituitary growth hormone-releasing factor receptor in the rat
73. Estrogen and estrogen receptor antagonists stimulate transcription from the human retinoic acid receptor-alpha 1 promoter via a novel sequence
74. A novel, cell-type-specific mechanism for estrogen receptor-mediated gene activation in the absence of an estrogen-responsive element
75. The human medium chain acyl-CoA dehydrogenase gene promoter consists of a complex arrangement of nuclear receptor response elements and Spl binding sites
76. Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors
77. Identification of a new subclass of Alu DNA repeats which can function as estrogen receptor-dependent transcriptional enhancers
78. Identification of a dominant negative form of the human estrogen receptor
79. Insulin regulates prolactin secretion and messenger ribonucleic acid levels in pituitary cells