Rat somatostatin sst(2(a)) and sst2(b)) receptor isoforms mediate opposite effects on cell proliferation

British Journal of Pharmacology

Volumn 125, Issue 8, 1998, Pages 1630-1633

  Alderton, Forbes ^a   Fan, Tai Ping D ^a   Schindler, Marcus ^a   Humphrey, Patrick P A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Angiopeptin; CHO K1 cell; Proliferation; Somatostatin; Sst(2(a)) receptor; Sst(2(b)) receptor

Indexed keywords

ANGIOPEPTIN; BASIC FIBROBLAST GROWTH FACTOR; GENISTEIN; PERTUSSIS TOXIN; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOSTATIN; SOMATOSTATIN 2A RECEPTOR; SOMATOSTATIN 2B RECEPTOR; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG; BORDETELLA VIRULENCE FACTOR; DRUG DERIVATIVE; FIBROBLAST GROWTH FACTOR 2; HORMONE ANTAGONIST; HYBRID PROTEIN; OLIGOPEPTIDE; SOMATOSTATIN RECEPTOR SST2A; SSTR2 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL DIVISION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; GENETICS; HAMSTER; METABOLISM; PHYSIOLOGY; RAT;

ANIMALS; CELL DIVISION; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTOR 2; HORMONE ANTAGONISTS; OLIGOPEPTIDES; PERTUSSIS TOXIN; RATS; RECEPTORS, SOMATOSTATIN; RECOMBINANT FUSION PROTEINS; SOMATOSTATIN; VIRULENCE FACTORS, BORDETELLA;

EID: 0032217167     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702282     Document Type: Article

References (17)

1. ALDERTON, F., LAUDER, H., FENIUK, W., FAN, T.-P.D. & HUMPHREY, P.P.A. (1998). Differential effects of somatostatin and angiopeptin on cell proliferation. Br. J. Pharmacol., 124, 323-330.
2. GILLESPIE, T.J., ERENBERG, A., KIM, S., DONG, J., TAYLOR, J.E., HAU, V. & DAVIS, T.P. (1998). Novel somatostatin analogs for the treatment of acromegaly and cancer exhibit improved in vivo stability and distribution. J. Pharmacol. Exp. Ther., 285, 95-104.
3. HOYER, D., BELL, G.I., BERELOWITZ, M., EPELBAUM, J., FENIUK, W., HUMPHREY, P.P.A., O'CARROLL, A-M., PATEL, Y.C., SCHONBRUN, A., TAYLOR, J.E. & REISINE, T. (1995). Classification and nomenclature of somatostatin receptors. Trends Pharmacol. Sci., 16, 86-88.
4. 2(b) receptor splice variant in the rat gastric mucosa. Br. J. Pharmacol., 123, 125P.
5. KOPER, J.W., MARKSTEIN, R., KOHLER, C., KWEKKEBOOM, D.J., AVEZAAT, C.J., LAMBERTS, S.W. & REUBI, J.-C. (1992). Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth. J. Clin. Endocrinol. Metab., 74, 543-547.
6. LAMBERTS, S.W.J., KOPER, J.W. & REUBI, J.-C. (1987). Potential role of somatostatin analogues in the treatment of cancer. Eur. J. Clin. Invest., 17, 281-287.
7. LAUDER, H., FROST, E.E., HILEY, C.R & FAN, T.-P.D. (1998). Quantification of the repair process involved in the repair of a cell monolayer using an in vitro model of mechanical injury. Angiogenesis, 2, 67-80.
8. 5 inhibition of receptor mediated regeneration of rat aortic vascular smooth muscle cells. Br. J. Pharmacol., 122, 663-670.
9. LESZCZYNSKI, D., ZHAO, Y., CATHAPERMAL, S.S., NILSSON, J. & FOEGH, M.L. (1993). Rat heart smooth muscle cells express high and low affinity receptors for somatostatin-14, which are involved in regulatiaon of cell proliferation. Life Sciences, 53, 1663-674.
10. MASCARDO, R.N., BARTON, R.W. & SHERLINE, P. (1984). Somatostatin has an antiproliferative effect on concanavalin A-activated rat thymocytes. Clin. Immunol. Immunopath., 33, 131-138.
11. RUIZ-TORRES, P., LUCIO, F.J., GONZALEZ-RUBIO, M., RODRIGUEZ-PUYOL, M. & RODRIGUEZ-PUYOL, D. (1993). A dual effect of somatostatin on the proliferation of cultured rat mesangial cells. Biochem. Biophys. Res. Comm., 195, 1057-1062.
12. 2B receptors. Br. J. Pharmacol., 123, 110P.
13. SCHINDLER, M., HUMPHREY, P.P.A & EMSON, P.C. (1996). Somatostatin receptors in the central nervous system. Progr. Neurobiol., 50, 9-47.
14. 2(b) receptor splice variant in the rat brain and spinal cord. Neuroscience, In press.
15. 2(b) receptor splice variant. Br. J. Pharmacol., 125, 209-217.
16. VANETTI, M., KOUBA, M., WANG, X., VOGT, G. & HOLLT, V. (1992). Cloning and expression of a novel mouse somatostatin receptor (SSTR2B). FEBS Lett., 311, 290-294.
17. WYATT, M.A., LAUDER, H., SELLERS, L.A., FENIUK, W. & HUMPHREY, P.P.A. (1997). Functional effects of somatostatin on cellular proliferation of HGT-1 cells. Br. J. Pharmacol., 122, 221P.