Comparison of the DNA Damage Photoinduced by Fenofibrate and Ketoprofen, Two Phototoxic Drugs of Parent Structure

Photochemistry and Photobiology

Volumn 68, Issue 5, 1998, Pages 679-684

  Marguery, M C ^a   Chouini Lalanne, N ^a   Ader, J C ^a   Paillous, N ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; 5,5-DIMETHYL-1-PYRROLINE-1-OXIDE; AMINE OXIDE; FENOFIBRATE; KETOPROFEN; PHOTOSENSITIZING AGENT; VIRUS DNA;

ARTICLE; BACTERIOPHAGE PHI X 174; DNA DAMAGE; DNA SUPERCOILING; DRUG EFFECT; PHOTOLYSIS; RADIATION EXPOSURE; SKIN; SPIN LABELING;

BACTERIOPHAGE PHI X 174; CYCLIC N-OXIDES; DNA DAMAGE; DNA, SUPERHELICAL; DNA, VIRAL; KETOPROFEN; PHOTOLYSIS; PHOTOSENSITIZING AGENTS; PROCETOFEN; SKIN; SPIN LABELS;

EID: 0032214923     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.1998.tb02529.x     Document Type: Conference Paper

References (28)

1. Brown, W. V. (1987) Fenofibrate, a third generation fibric derivative. Am. J. Med. 83, 1-2.
2. Blane, G. F. (1989) Review of European clinical experience with fenofibrate. Cardiology 76, 1-12.
3. Leroy, D., A. Dompmartin, E. Lorler, Y. Leport and C. Audebert (1990) Photosensitivity induced by fenofibrate. Photodermatol. Photoimmunol. Photomed. 7, 136-138.
4. Serrano, G., J. M. Fortea, J. M. Latasa, F. Millan, C. James, F. Bosca and M. A. Miranda (1992) Photosensitivity induced by fibric acid derivatives and its relation to photocontact dermatitis to ketoprofen. J. Am. Acad. Dermatol. 27, 204-208.
5. Jeanmougin, M., R. Manciet, Y. De Prost, P. Reygagne, L. Pinquier and L. Dubertret (1993) Photo-allergie au fénofibrate. Ann. Dermatol. Venereol. 120, 549-554.
6. Marguery, M. C., F. El Sayed, J. Rakotondrazafy, R. Saqi, G. Samalens, B. Gorguet and J. Bazex (1995) Photoallergy and photoaggravation induced by fenofibrate: cross photoreaction and transient light reaction. Eur. J. Dermatol. 5, 204-207.
7. Vargas, F., N. Canudas, M. A. Miranda and F. Boscá (1993) Photodegradation and in vitro phototoxicity of fenofibrate, a photosensitizing anti-hyperlipoproteinemic drug. Photochem. Photobiol. 58, 471-476.
8. Miranda, M. A., F. Boscá, F. Vargas and N. Canudas (1994) Photosensitization by fenofibrate. II. In vitro phototoxicity of the major metabolites. Photochem. Photobiol. 59, 171-174.
9. Elson, L. F., D. R. Hawkons and L. F. Chasseaud (1976) Identification of a major metabolite of the new hypolipidaema agent, isopropyl 2-[4′ (p-chlorobenzoyl) phenoxy]-2-methylpropionate (procetofène) in humans by gas chromatography-mass spectrometry. J. Chromatogr. 123, 463-467.
10. Chapman, M. J. (1987) Pharmacology of fenofibrate. Am. J. Med. 83, 21-25.
11. Ophaswongse, S. and H. Maibach (1993) Topical nonsteroïdal antiinflammatory drugs: allergic and photoallergic contact dermatitis and phototoxicity. Contact Dermatitis 29, 57-64.
12. Bastien, M., B. Milpied-Homsi, S. Baudot, H. Dutartre and P. Litoux (1997) Photosensibilisation de contact au kétoprofène: 5 observations. Ann. Dermatol. Venereol. 124, 523-526.
13. Could, J. W., M. G. Mercurio and C. A. Elmets (1995) Cutaneous photosensitivity diseases induced by exogenous agents. J. Am. Acad. Dermatol. 33, 551-573.
14. Pietta, P., E. Manera and P. Ceva (1987) High-performance liquid chromatographic determination of ketoprofen degradation products. J. Chromotogr. 390, 454-457.
15. Costanzo, L. L., G. De Guidi, G. Condorelli, A. Cambria and M. Fama (1989) Molecular mechanism of drug photosensitization - II. Photohemolysis sensitized by ketoprofen. Photochem. Photobiol. 50, 359-365.
16. Bosca, F., M. A. Miranda, G. Carganico and D. Mauleon (1994) Photochemical and photobiological properties of ketoprofen associated to benzophenone chromophore. Photochem. Photobiol. 60, 96-101.
17. Artuso, T., J. Bernadou, B. Meunier and N. Paillous (1990) DNA strand breaks photosensitized by benoxaprofen and other nonsteroidal antiinflammatory agents. Biochem. Pharmacol. 39, 407-413.
18. Artuso, T., J. Bernadou, B. Meunier, J. Piette and N. Paillous (1991) Mechanism of DNA cleavage mediated by photoexcited non-steroidal antiinflammatory drugs. Photochem. Photobiol. 54, 205-213.
19. Chouini-Lalanne, N., M. Defais and N. Paillous (1998) NSAID-photosensitized formation of pyrimidine dimers in DNA. Biochem. Pharmacol. 55, 444.
20. Felsenfeld, G. and S. Z. J. Hirshaman (1965) A neighbor-interaction analysis of the hypochroism and spectra of DNA. J. Mol. Biol. 13, 407-427.
21. Lommel, L. and P. C. Hanawalt (1991) Preparation and determination of T4 endonuclease V activity. Mutat. Res. 255, 183-191.
22. Paillous, N. and P. Vicendo (1993) Mechanisms of photosensitized DNA cleavage. J. Photochem. Photobiol. 20, 203-209.
23. Condorelli, G., L. L. Costanzo, G. De Guidi, S. Guiffrida and S. Sortino (1995) Molecular mechanism of drug photosensitization. 7. Cleavage of DNA sensitized by suprofen. Photochem. Photobiol. 62, 155-161.
24. De Guidi, G., S. Guiffrida, G. Condorelli, L. L. Costanzo, P. Miano and S. Sortino (1996) Molecular mechanism of drug photosensitization IX. Effect of inorganic ions on DNA cleavage photosensitized by naproxen. Photochem. Photobiol. 63, 455-462.
25. Monti, S., S. Sortiono, G. De Guidi and G. Marconi (1997) Photochemistry of 2-(3-benzoylphenyl) propionic adic (ketoprofen). Part 1. A picosecond and nanosecond time resolved study in aqueous solution. J. Chem. Soc. Faraday Trans. 93, 13, 2269-2275.
26. Martinez, L. J. and J. C. Scaiano (1997) Transient intermediates in the laser flash photolysis of ketoprofen in aqueous solutions: unusual photochemistry for the benzophenone chromophore. J. Am. Chem. Soc. 119, 11066-11070.
27. Budac, D. and P. Wan (1992) Photodecarboxylation: mechanism and synthetic utility. J. Photochem. Photobiol. A 67, 135-166.
28. Charlier, M. and C. Helene (1972) Photochemical reactions of aromatic ketones with nucleic acids and their components I -purine and pyrimidine base and nucleosides. Photochem. Photobiol. 15, 71-87.