A global collaboration on carcinogenicity screening in transgenic mouse models

Transgenic Research

Volumn 7, Issue 6, 1998, Pages 485-487

  Forster, Roy ^a  

^a CIT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENICITY; MOUSE; SCREENING; TRANSGENIC ANIMAL;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; INTERNATIONAL COOPERATION; MICE; MICE, TRANSGENIC;

EID: 0032214340     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008889427323     Document Type: Article

References (11)

1. Alden, C.L., Smith P.F., Piper, C.E. and Brej, L. (1996) A critical appraisal of the value of the mouse cancer bioassay in safety assessment. Toxicologic Pathology 24, 722-725.
2. Ames B.N., and Gold, L.S. (1990) Chemical carcinogenesis: too many rodent carcinogens. Proc. Natl. Acad. Sci. 87, 7772-7776.
3. de Vries, A., Van Oostrom, C.T.M., Dortant, P.M., Beems, R.B., Van Kreijl, C.F., Capel, P.J.A. and van Steeg, H. (1997) Spontaneous liver tumours and benzo(a)pyrene-induced lymphomas in xpa deficient mice. Mol. Carcinog. 19(1), 46-53.
4. Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Butel, J.S. and Bradley, A. (1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221.
5. Feldmann, E.B. (1980) Carcinogenicity testing - a national disaster. J. Pharm. Sci., 69(2), i.
6. Goodman, J.I., Ward, J.M., Popp, J.A., Klaunig, J.E. and Fox, T.R. (1991) Mouse liver carcinogenesis: mechanisms and relevance. Fundam. Appl. Toxicol. 17, 651-665.
7. Leder, A., Kuo, A., Cardiff, R.D., Sinn, E. and Leder, P. (1990) v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc. Natl. Acad. Sci. 87, 9178-9182.
8. Monro, A. (1993) How useful are chronic (life-span) toxicology studies in rodents in identifying pharmaceuticals that pose a carcinogenic risk to humans? Adverse Drug React. Toxicol. Rev., 12, 5-34.
9. Saitoh, A., Kimura, M., Takahashi, R., Yokoyama, M., Nomura, T., Izawa, M., Sekiya, T., Nishimura, S. and Katsuki, M. (1990) Most tumors in transgenic mice with human c-Ha-ras gene contain somatically activated transgenes. Oncogens 5, 1195-1200.
10. Sistare, F. (1998) Research on the identification of the nonresponder phenotype. The TG.AC Workgroup Newsletter, 1(2), 2.
11. Thomson, K.L., Rosenzweig, B. and Sistare, F.D. (1998) Qn evaluation of the hemizygous transgenic TG.AC mouse for carcinogenicity testing of pharmaceuticals II. Genotyping that predicts tumorigenic responsiveness. Toxicologic Pathology 26(4) (in press).