The nitric oxide synthase inhibitor, L-NAME, blocks certain phencyclidine-induced but not amphetamine-induced effects on behaviour and brain biochemistry in the rat

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 22, Issue 8, 1998, Pages 1341-1360

  Johansson, Christina ^a   Magnusson, Olle ^a   Deveney, Aaron M ^a   Jackson, David M ^a   Zhang, Jianhua ^b   Engel, Jörgen A ^b   Svensson, Lennart ^b  

^a Depts of Pharmacol/Gen Pharmacol   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Amphetamine; Dopamine; Nitric oxide; Phencyclidine; Rat; Serotonin

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; AMPHETAMINE; DEXAMPHETAMINE; DOPAMINE; HOMOVANILLIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHENCYCLIDINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN; BRAIN LEVEL; CONTROLLED STUDY; FRONTAL CORTEX; MALE; MICRODIALYSIS; NONHUMAN; NUCLEUS ACCUMBENS; OLFACTORY BULB; PREPULSE INHIBITION; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STARTLE REFLEX;

EID: 0032213058     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(98)00074-8     Document Type: Article

References (26)

1. BARTSCHAT, D. K. and BLAUSTEIN, M. P. (1988) Psychotomimetic sigma-ligands, dexoxadrol and phencyclidine block the same presynaptic potassium channel in rat brain. J Physiol (Lond). 403: 341-353.
2. BOWERS, M. B. J. and MORTON, J. B. (1994) Regional brain catecholamines and metabolites following THC, PCP and MK-801. Prog Neuropsychopharmacol Biol Psychiatry. 18: 961-964.
3. BUBSER, M. and KOCH, M. (1994) Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex. Psychopharmacology (Berl). 113: 487-492.
4. CASTAGNOLI, K., PALMER, S., ANDERSON, A., BUETERS, T. and CASTAGNOLI, N. J. (1997) The neuronal nitric oxide synthase inhibitor 7-nitroindazole also inhibits the monoamine oxidase-B-catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine. Chem Res Toxicol. 10: 364-368.
5. CREESE, I. and IVERSEN, S. D. (1973) Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine. Brain Res. 55: 369-382.
6. DEUTCH, A. Y., TAM, S. Y., FREEMAN, A. S., BOWERS, M. B. J. and ROTH, R. H. (1987) Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response. Eur J Pharmacol. 134: 257-264.
7. DRUHAN, J. P., RAJABI, H. and STEWART, J. (1996) Mk-801 increases locomotor activity without elevating extracellular dopamine levels in the nucleus accumbens. Synapse. 24: 135-146.
8. ELCHISAK, M. A., MURRIN, L. C., ROTH, R. H. and MAAS, J. W. (1976) Free and conjugated dihydroxyphenylacetic acid: effect of alterations in impulse flow in rat neostriatum and frontal cortex. Psychopharmacol Commun. 2: 411-420.
9. FRAY, P. J., SAHAKIAN, B. J., ROBBINS, T. W., KOOB, G. F. and IVERSEN, S. D. (1980) An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine. Psychopharmacology (Berl). 69: 253-259.
10. GREEN, A. R. and HEAL, D. J. (1985) The effects of drugs on serotonin-mediated behavioural models. In: Neuropharmacology of Serotonin, A. R. Green (Eds.), pp 326-365, Oxford University Press, Oxford.
11. JACKSON, D. M., JOHANSSON, C., LINDGREN, L. M. and BENGTSSON, A. (1994) Dopamine receptor antagonists block amphetamine and phencyclidine-induced motor stimulation in rats. Pharmacol Biochem Behav. 48: 465-471.
12. JENTSCH, J. D., ELSWORTH, J. D., REDMOND, D. E. J. and ROTH, R. H. (1997) Phencyclidine increases forebrain monoamine metabolism in rats and monkeys: modulation by the isomers of HA966. J Neurosci. 17: 1769-1775.
13. JOHANSSON, C., JACKSON, D. M. and SVENSSON, L. (1997) Nitric oxide synthase inhibition blocks phencyclidine-induced behavioural effects on prepulse inhibition and locomotor activity in the rat. Psychopharmacology (Berl). 131: 167-173.
14. JOHANSSON, C., JACKSON, D. M., ZHANG, J. and SVENSSON, L. (1995) Prepulse inhibition of acoustic startle, a measure of sensorimotor gating: effects of antipsychotics and other agents in rats. Pharmacol Biochem Behav. 52: 649-654.
15. KAROUM, F., CHRAPUSTA, S. J. and EGAN, M. F. (1994) 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model. J Neurochem. 63: 972-979.
16. LEHMANN-MASTEN, V. D. and GEYER, M. A. (1991) Spatial and temporal patterning distinguishes the locomotor activating effects of dizocilpine and phencyclidine in rats. Neuropharmacol. 30: 629-636.
17. MAGNUSSON, O., NILSSON, L. B. and WESTERLUND, D. (1980) Simultaneous determination of dopamine, DOPAC and homovanillic acid. Direct injection of supernatants from brain tissue homogenates in a liquid chromatography - electrochemical detection system. J Chromatogr. 221: 237-247.
18. MANSBACH, R. S., GEYER, M. A. and BRAFF, D. L. (1988) Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology (Berl). 94: 507-514.
19. MATTSON, M. P., RYCHLIK, B. and CHENG, B. (1992) Degenerative and axon outgrowth-altering effects of phencyclidine in human fetal cerebral cortical cells. Neuropharmacology. 31: 279-291.
20. PAXINOS, G. and WATSON, C. (1998) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
21. RANDRUP, A. and MUNKVAD, I. (1967) Stereotyped activities produced by amphetamine in several animal species and man. Psychopharmacologia. 11: 300-310.
22. ROTH, R. H., MURRIN, L. C. and WALTERS, J. R. (1976) Central dopaminergic neurons: effects of alterations in impulse flow on the accumulation of dihydroxyphenylacetic acid. Eur J Pharmacol. 36: 163-171.
23. SVENSSON, L., ZHANG, J. and ENGEL, J. A. (1996) Concomitant measurement of prepulse inhibition and dopamine release in rats. In: Monitoring Molecules in Neuroscience, J. L. González-Mora, R. Borges and M. Mas (Eds.), pp 345-346, 7th International Conference on in vivo Methods, Santa Cruz de Tenerife.
24. SWERDLOW, N. R., BRAFF, D. L., GEYER, M. A. and KOOB, G. F. (1986) Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics. Biol Psychiatry. 21: 23-33.
25. WADDINGTON, J. L., DALY, S. A., DOWNES, R. P., DEVENEY, A. M., MCCAULEY, P. G. and O'BOYLE, K. M. (1995) Behavioural pharmacology of 'D-1-like' dopamine receptors: further subtyping, new pharmacological probes and interactions with 'D-2-like' receptors. Prog Neuropsychopharmacol Biol Psychiatry. 19: 811-831.
26. WATERS, N., LAGERKVIST, S., LÖFBERG, L., PIERCEY, M. and CARLSSON, A. (1993) The dopamine D3 receptor and autoreceptor preferring antagonists (+)-AJ76 and (+)-UH232; a microdialysis study. Eur J Pharmacol. 242: 151-163.