Nicotinamide-adenine dinucleotide phosphate oxidase assembly and activation in EBV-transformed B lymphoblastoid cell lines of normal and chronic granulomatous disease patients

Journal of Immunology

Volumn 161, Issue 9, 1998, Pages 4968-4974

  Dusi, Stefano ^a,e   Nadalini, Katyuscia A ^a   Donini, Marta ^a   Zentilin, Lorena ^b   Wientjes, Frans B ^c   Roos, Dirk ^d   Giacca, Mauro ^b   Rossi, Filippo ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e Istituto di Patologia Generale   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; CHRONIC DISEASE; DRUG RECEPTOR BINDING; ELECTRON TRANSPORT; ENDOTHELIUM CELL; ENZYME ACTIVATION; EPSTEIN BARR VIRUS; GRANULOMATOUS INFLAMMATION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; VIRUS TRANSFORMATION;

B-LYMPHOCYTES; BIOLOGICAL TRANSPORT; CELL LINE, TRANSFORMED; CELL MEMBRANE; CYTOCHROME B GROUP; ENZYME ACTIVATION; GRANULOMATOUS DISEASE, CHRONIC; HERPESVIRUS 4, HUMAN; HUMANS; MACROMOLECULAR SUBSTANCES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MUTATION; NADPH DEHYDROGENASE; NADPH OXIDASE; NEUTROPHILS; PHOSPHOPROTEINS; PROTEIN CONFORMATION; RESPIRATORY BURST; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES; TETRADECANOYLPHORBOL ACETATE; X CHROMOSOME;

EID: 0032212140     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. 2-forming NADPH oxidase of phagocytes: nature, mechanisms of activation and function. Biochim. Biophys. Acta 853:65.
2. Segal, A. W., and A. Abo. 1993. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem. Sci. 18:43.
3. Malech, H. L. 1993. Phagocyte oxidative mechanisms. Curr. Opin. Hematol. 0:123.
4. Bokoch, G. M., and U. G. Knaus. 1994. Ras-related GTP-binding proteins and leukocyte signal transduction. Curr. Opin. Hematol. 1:60.
5. Chanock, S., J. El Benna, R. M. Smith, and B. M. Babior. 1994. The respiratory burst oxidase. J. Biol. Chem. 269:24519.
6. McPhail, L. C. 1994. SH3-dependent assembly of the phagocyte NADPH oxidase. J. Exp. Med. 180:2011.
7. De Leo, F. R., and M. T. Quinn. 1996. Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J. Leukocyte Biol. 60:677.
8. Leusen, J. H. W., A. J. Verhoeven, and D. Roos. 1996 Interactions between the components of the human NADPH oxidase: intrigues in the phox family. J. Lab. Clin. Med. 128:461.
9. phox. Blood 76:2622.
10. Heyworth, P. G., and J. A. Badway. 1990. Continuous phosphorylation of both the 47 and the 49 kDa proteins during superoxide production by neutrophils. Biochim. Biophys. Acta 1052:299.
11. Rotrosen, D., and T. L. Leto. 1990. phosphorylation of neutrophil 47-kDa cytosolic oxidase factor: translocation to membrane is associated with distinct phosphorylation events. J. Biol. Chem. 265:19910.
12. phox. Biochem. J. 296:367.
13. phox) is phosphorylaled during activation in differentiated HL60 cells. Eur. J. Biochem. 249:531.
14. 558. J. Clin. Invest. 87:352.
15. phox is required for the translocation of Rac 1 but not of Rac 2 from cytosol to the membranes. Biochem. J. 308:991.
16. phox. Biochem. J. 314:409.
17. Sumimoto, H., Y. Kage, H. Nunoi, H. Sasaki, T. Nose, Y. Fukimaki, M. Ohno, S. Minakami, and K. Takeshige. 1994. Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase. Proc. Natl. Acad. Sci. USA 91:5345.
18. Leto, T. L., A. G. Adams, and I. De Mendez. 1994. Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. Proc. Natl. Acad. Sci. USA 91:10650.
19. Finan, P., Y. Shimizu, I. Gout, J. Hsuan, O. Truong, C. Butcher, P. Bennet, M. D. Waterfield, and S. Kellie. 1994. An SH3 domain and proline rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex. J. Biol. Chem. 269:13752.
20. phox is required for activation of the NADPH oxidase. J. Biol. Chem. 271:22152.
21. phox and flavocytochrome b with random-sequence peptide phage display libraries. Proc. Natl. Acad. Sci. USA 92:7110.
22. Matsubara, T., and M. Ziff. 1986. Increased superoxide anion release from human endothelial cells in response to cytokines. J. Immunol. 137:3295.
23. Murrel, G. A. C., M. J. O. Francis, and L. Bromley. 1990. Modulation of fibroblast proliferation by oxygen free radicals. Biochem. J. 265:659.
24. Meier, B. M., H. H. Radeke, S. Selle, M. Younes, H. Sies, K. Resch, and G. G. Habermehl. 1989. Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumor necrosis factor-α. Biochem. J. 263:539.
25. Radeke, H. H., B. Meier, N. Topley, J. Floge, G. G. Habermehl, and K. Resch. 1990. Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells. Kidney Int. 37:767.
26. 558 and 45-kDa flavoprotein) by intrinsic human glomerular mesangial cells. J. Biol. Chem. 266:21025.
27. phox subunit. Biochem. J. 329:449.
28. Fukui, T., B. Lassegue, H. Kai, R. Wayne Alexander, and K. K. Griendling. 1995. Cytochrome b558 α-subunit cloning and expression in rat aortic smooth muscle cells. Biochim. Biophys. Acta 1231:215.
29. Meier, B., A. R. Cross, J. T. Hancock, F. J. Kaup, and O. T. G. Jones. 1991. Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. Biochem. J. 275:241.
30. Sen, C. K., and L. Packer. 1996. Antioxidant and redox regulation of gene transcription. FASEB J. 10:709.
31. Roos, D., M. de Boer, F. Kuribayashi, C. Meischl, R. S. Weening, A. W. Segal, A. Ahlin, K. Nemet, J. P. Hossle, E. Bernatowska-Matuszkiewicz, et al. 1996 Mutations in the X-linked and autosomal recessive forms of chronic granulomatous disease. Blood 87:1663.
32. Volkman, D. J., E. S. Buescher, J. I. Gallin, and A. S. Fauci 1984. B cell lines as models for inherited phagocytic diseases: abnormal superoxide generation in chronic granulomatous disease and giant granules in Chediak-Higashi syndrome. J. Immunol. 133:3006.
33. Maly, F. E., A. R. Cross, O. T. G. Jones, G. Wolf-Vorbeck, C. Walker, C. A. Dahinden, and A. L. De Week. 1988. The superoxide generating system of B cell lines: structural homology with the phagocytic oxidase and triggering via surface Ig. J. Immunol. 140:2334.
34. 245 components by human tonsillar B lymphocytes and B cell lines. J. Immunol. 142:1260.
35. Hancock, J. T., L. M. Henderson, and O. T. G. Jones. 1990. Superoxide generation by EBV-transformed B lymphocytes: activation by IL-1β, TNF-α and receptor independent stimuli. Immunology 71:213.
36. Jones, O. T. G., J. T. Hancock, and L. M. Henderson. 1991. Oxygen radical production by transformed B lymphocytes. Mol. Aspects Med. 12:87.
37. Porter, C. D., M. H. Parkar, M. K. Collins, R. J. Levinsky, and C. Kinnon. 1992. Superoxide production by normal and chronic granulomatous disease (CGD) patient-derived EBV-transformed B cell lines measured by chemiluminescence-based assays. J. Immunol. Methods 155:151.
38. Hancock, J. T., F. E. Maly, and O. T. G. Jones. 1989. Properties of the superoxide-generating oxidase of B-lymphocyte cell lines: determination of Michaelis parameters. Biochem. J. 262:373.
39. 2-generating oxidase in an heterologous cell-free system derived from Epstein-Barr-virus-transformed human B lymphocytes and bovine neutrophils: application to the study of defects in cytosolic factors in chronic granulomatous disease. Eur. J. Biochem. 202:649.
40. Trasher, A., M. Chetty, C. Casimir, and A. W. Segal. 1992. Restoration of superoxide generation to a chronic granulomatous disease-derived B-cell line by retrovirus mediated gene transfer. Blood 80:1125.
41. phox-deficient chronic granulomatous disease. J. Clin. Invest. 91:201.
42. phox cDNA. J. Exp. Med. 178:2047.
43. 558 defective forms of chronic granulomatous disease. Blood 84:53.
44. phox. Blood 84:2767.
45. phox, a subunit of the respiratory burst oxidase. J. Clin. Invest. 96:1499.
46. 558. Biochem. J. 306:141.
47. 558-containing nicotinamide adenine dinucleotide phosphate oxidase. Blood 87:756.
48. Rodaway, A. R. F., C. G. Teahan, C. M. Casimir, A. W. Segal, and D. L. Bentley. 1990. Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoid acid. Mol. Cell. Biol. 10:5388.
49. Garcia, R. C., M. Whitaker, P. G. Heyworth, and A. W. Segal. 1992. Okadaic acid produces changes in phosphorylation and translocation of proteins and in intracellular calcium in human neutrophils. Biochem. J. 286:687.
50. phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains. Biochem. J. 298:585.
51. 558 of human neutrophils. Blood 73:1686.
52. 2+ changes of the neutrophil respiratory and secretory response to exogenous phospholipase C and possible involvement of diacylglycerol and protein kinase C. Biochim. Biophys. Acta 884:81.
53. Neitzel, H. 1986. A routine method for the establishment of permanent growing lymphoblastoid cell lines. Hum. Genet. 73:320.
54. Bellavite, P., P. Dri, V. Della Bianca, and M. C. Serra. 1983. The measurement of superoxide anion production by granulocytes in whole blood: a clinical test for evaluation of phagocyte function and serum opsonic capacity. Eur. J. Clin. Invest. 13:363.
55. Dorseuil, O., A. Vazquez, P. Lang, J. Bertoglio, G. Gacon, and G. Leca. 1992. Inhibition of superoxide production in B lymphocytes by Rac antisense oligonucleotides. J. Biol. Chem. 267:20540.
56. rac from its inhibitory GDP/GTP exchange protein (RhoGDI) followed by its translocation to the plasma membrane. Biochem. J. 298:585.
57. 558 biosynthesis. Biochem. J. 315:571.
58. phox of the human neutrophil NADPH oxidase that are not required for activation in the cell-free system. J. Biol. Chem. 270:11216.
59. phox. J. Clin. Invest. 93:2120.
60. Leto, T. L., A. G. Adams, and I. de Mendez. 1994. Assembly of the phagocyte NADPH oxidase: binding of src homology 3 domains to proline-rich targets. Proc. Natl. Acad. Sci. USA 91:10650.
61. r similar to 240,000 complex that acquires a membrane-binding site during activation of the oxidase in a cell-free system. J. Biol. Chem. 267:17327.
62. Park, J. W., J. El Benna, K. E. Scott, B. L. Christensen, S. J. Chanock, and B. M. Babior. 1994. Isolation of a complex of respiratory burst oxidase components from resting neutrophil cytosol. Biochemistry 33:2907.
63. phox in cytosol of unstimulated human neutrophils. J. Biol. Chem. 269:22405.
64. phox to the submembranous actin cytoskeleton during oxidase activation. J. Biol. Chem. 269:6729.
65. phox to the human neutrophil respiratory burst oxidase complex. J. Biol. Chem. 269:22095.
66. phox in vitro. J. Biol. Chem. 271:22578.
67. phox have distinct roles in the regulation of electron flow in NADPH oxidase. J. Biol. Chem. 270:6543.
68. phox is not a sine qua non participant in the activation of NADPH oxidase but is required for optimal superoxide production. J. Biol. Chem. 271:30326.