BEHAB/brevican: A brain-specific lectican implicated in gliomas and glial cell motility

Current Opinion in Neurobiology

Volumn 8, Issue 5, 1998, Pages 576-581

  Gary, Sydney C ^a   Kelly, Gail M ^a   Hockfield, Susan ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREVICAN; HYALURONIC ACID; HYALURONIC ACID BINDING PROTEIN; PROTEOCHONDROITIN SULFATE; PROTEOGLYCAN;

BRAIN DEVELOPMENT; BRAIN INJURY; BRAIN TUMOR; CELL DIVISION; CELL MATURATION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GLIA CELL; GLIOMA; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW;

EID: 0032192418     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80083-4     Document Type: Article

References (31)

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29. of outstanding interest Zhang H, Kelly G, Zerillo C, Jaworski DM, Hockfield S. Expression of a cleaved brain-specific extracellular matrix protein mediates glioma cell invasion in vivo. J Neurosci. 18:1998;2370-2376 This study reports the cleavage of the BEHAB/brevican protein in invasive human gliomas and rodert experimental tumor models. It further demonstrates that both expression of the BEHAB/brevican protein and its cleavage are required for glioma cell invasion. Regulated expression and cleavage of ECM proteins may be a general mechanism for the control of cell motility, providing a novel therapeutic target for gliomas.
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